Endothelial cell oxidant production: Effect of NADPH oxidase inhibitors

Endothelium: Journal of Endothelial Cell Research

Volumn 7, Issue 2, 2000, Pages 109-119

  Holland, James A ^a,b,c,d   O'Donnell, Robert W ^a   Chang, Ming Mei ^a   Johnson, David K ^a   Ziegler, Linda M ^a,b  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^d STRATTON VA MEDICAL CENTER   (United States)

Author keywords

Endothelium; NADPH oxidase; Reactive oxygen species

Indexed keywords

1,4 BENZOQUINONE; 1,4 NAPHTHOQUINONE; 3,4,5 TRIMETHOXYBENZOIC ACID 8 (DIETHYLAMINO)OCTYL ESTER; APOCYNIN; CAFFEIC ACID; CALCIUM ANTAGONIST; CALMODULIN INHIBITOR; CATECHOL; CIBACRON BLUE F3GA; DIPHENYLIODONIUM SALT; DISULFIRAM; ENZYME INHIBITOR; ESCULETIN; FLAVOPROTEIN; GUAIACOL; HYDROGEN PEROXIDE; IMIDAZOLE; MEPACRINE; OXIDIZING AGENT; PENICILLAMINE; PHORBOL MYRISTATE; PROTOCATECHUALDEHYDE; PROTOCATECHUIC ACID; PYRIDINE; QUERCETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRIFLUOPERAZINE; VANILLIN;

ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOTHELIUM CELL; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0033509231     PISSN: 10623329     EISSN: None     Source Type: Journal    
DOI: 10.3109/10623320009072206     Document Type: Article

References (66)

1. Al-Mehdi, A.B., Zhoa, G., Dodia, C., Tozawa, K., Costa, K., Muzykantov, V., Ross, C., Blecha, F., Dinauer, M. and Fisher, A.B. (1998) Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischemia or high K+. Circulation Research, 83(7), 730-737.
2. Alric, L., Pinelli, E., Carrera, G., Vinel, J.P., Beraud, M., Duffaut, M., Pascal, J.P. and Pipy, B. (1996) Involvement of calcium in macrophage leukotriene release during experimental cirrhosis. Hepatology, 23, 614-622.
3. Babior, B.M. (1999) NADPH oxidase: an update. Blood, 93(5), 1464-1476.
4. Bayraktutan, U., Draper, N., Lang, D. and Shah, A.M. (1998) Expression of a functional neutrophil-type NADPH oxidase in cultured rat coronary microvascular endothelial cells. Cardiovascular Research, 38, 256-262.
5. Bokoch, G.M. (1995) Chemoattractant signaling and leukocyte activation. Blood, 86(5), 1649-1660.
6. Brady, J.F., Xiao, F., Wang, M.H., Li, Y., Ning, S.M. and Gapac, J.M. (1991) Effects of disulfiram on hepatic P450IIE1, other microsomal enzymes, and hepatotoxicity in rats. Toxicology and Applied Pharmacology, 108, 366-373.
7. Cathcart, R., Schwiers, E. and Ames, B.N. (1983) Detection of picomoles of hydroperoxides using a fluorescent dichlorofluorescein assay. Analytical Biochemistry, 134, 111-116.
8. Chabin, R.M., McCauley, E., Calaycay, J.R., Kelly, T.M., MacNaul, K.L., Wolfe, G.C., Hutchinson, N.I., Madhusudanaraju, S., Schmidt, J.A., Korarich, J.W. and Wong, K.K. (1996) Active-site structure analysis of recombinant human inducible nitric oxide syntase using imidazole. Biochemistry, 35, 9567-9575.
9. Chang, W.-S., Chang, Y.-H., Lu, F.-J. and Chiang, H.-C. (1994) Inhibitory effects of phenolics on xanthine oxidase. Anticancer Research, 14, 501-506.
10. Choo, L.Y. (1987) Disulfiram is a potent inhibitor of rat 5-lipoxygenase. Canadian Journal of Physiology and Pharmacology, 65(12), 2503-2506.
11. Crawford, D.R. and Schneider, D.L. (1983) Ubiquinone content and respiratory burst activity of latex filled phagolysozomes isolated from human neutrophils and evidence for the probable involvement of a third granule. Journal of Biological Chemistry, 259, 5363-5367.
12. Cross, A.R. and Jones, O.T.G. (1986) The effect of the inhibitor diphenylene iodonium on the superoxide generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase. Biochemical Journal, 237, 111-116.
13. Cross, A.R. (1990) Inhibitors of the leukocyte superoxide generating oxidase: Mechanisms of action and methods for their elucidation. Free Radical Biology & Medicine, 8, 71-93.
14. Crow, J.P. (1997) Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species. Nitric Oxide, 1(2), 145-157.
15. 2 for activation of the assembled NADPH oxidase in human neutrophils. Biochemical Journal, 297, 217-223.
16. Engels, F., Renirie, B.F., 't Hart, B.A., Labadie, R.P. and Nijkamp, F.P. (1992) Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism. Federation of European Biochemical Societies Letters, 305(3), 254-256.
17. Greene, E.L. and Paller, M.S. (1994) Calcium and free radicals in hypoxia/reoxygenation injury of renal epithelial cells. American Journal of Physiology, 266, F13-F20.
18. Griendling, K.K., Minieri, C.A., Ollerenshaw, J.D. and Alexander, R.W. (1994) Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circulation Research, 74, 1141-1148.
19. Holland, J.A., Pritchard, K.A., Rogers, N.J. and Stemerman, M.B. (1988) Perturbation of cultured human endothelial cells by atherogenic levels of low density lipoprotein. American Journal of Pathology, 132, 474-478.
20. Holland, J.A., Pritchard, K.A., Pappolla, M.A., Wolin, M.S., Rogers, NJ. and Stemerman, M.B. (1990) Bradykinin induces superoxide anion release from human endothelial cells. Journal of Cellular Physiology, 143, 21-25.
21. Holland, J.A., Pritchard, K.A., Rogers, N.J. and Stemerman, M.B. (1992) Atherogenic levels of low-density lipoprotein increase endocytotic activity in cultured human endothelial cells. American Journal of Pathology, 140, 551-558.
22. Holland, J.A., Ziegler, L.M. and Meyer, J.W. (1996) Atherogenic levels of low density lipoprotein increase hydrogen peroxide generation in cultured human endothelial cells: Possible mechanism of heightened endocytosis. Journal of Cellular Physiology, 166, 144-151.
23. Holland, J.A., Meyer, J.W., Schmitt, M.E., Sauro, M.D., Johnson, D.K., Abdul-Karim, R.W., Patel, V., Ziegler, L.M., Schillinger, K.J., Small, R.F. and Lemanski, L.F. (1997) Low-density lipoprotein stimulated peroxide production and endocytosis in cultured human endothelial cells: Mechanisms of action. Endothelium, 5, 191-207.
24. Holland, J.A., Meyer, J.W., Chang, M.-M., O'Donnell, R.W., Johnson, D.K. and Ziegler, L.M. (1998) Thrombin stimulated reactive oxygen species production in cultured human endothelial cells. Endothelium, 6(2), 113-121.
25. Ibe, B.O., Falck, J.R., Johnson, A.R. and Campbell, W.B. (1989) Regulation of synthesis of prostacyclin and HETEs in human endothelial cells. American Journal of Physiology, 256, C1168-1175.
26. 558 in the reaction. Biochemical and Biophysical Research Communications, 130, 621-626.
27. Jones, H.P., Ghal, G., Petrone, W. and McCord, J.M. (1982) Calmodulin-dependent stimulation of the NADPH oxidase of human neutrophils. Biochimica et Biophysica Acta, 714, 152-156.
28. Jones, S.A., O'Donnell, V.B., Wood, J.D., Broughton, J.P., Hughes, EJ. and Jones, O.T.G. (1996) Expression of phagocyte NADPH oxidase components in human endothelial cells. American Journal of Physiology, 271, H1626-H1634.
29. Kooy, N.W., Royall, J.A. and Ischiropoulos, H. (1997) Oxidation of 2′,7′-dichlorofluorescin by peroxynitrite. Free Radical Research, 27(3), 245-254.
30. Kukreja, R.C., Kontos, H.A., Hess, M.L. and Ellis, E.F. (1986) PGH synthase and lipoxygenase generate superoxide in the presence of NADH and NADPH. Circulation Research, 59, 612-619.
31. Kurose, I., Saito, H., Miura, S., Ebinuma, H., Higuchi, H., Watanabe, N., Zeki, S., Nakamura, T., Takaishi, M. and Ishii, H. (1997) CD18/ICAM-1-dependent oxidative NF-kB activation leading to nitric oxide production in rat kupffer cells cocultured with syngeneic hepatoma cells. Journal of Clinical Investigation, 99(5), 867-878.
32. Kuthan, H. and Ullrich, V. (1982) Oxidase and oxygen function of the microsomal cytochrome P450 monooxygenase system. European Journal of Biochemistry, 126, 583-588.
33. Laughton, M.J., Evans, P.J., Moroney, M.A., Hoult, J.R.S. and Halliwell, B. (1991) Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives. Biochemical Pharmacology, 42(9), 1673-1681.
34. 4 synthesis in human neutrophils by ethacrynic acid. Biochemical and Biophysical Research Communications, 137(1), 195-200.
35. Lopes, L.R., Hoyal, C.R., Knaus, U.G. and Babior, B.M. (1999) Activation of leukocyte NADPH oxidase by protein kinase C in a partially recombinant cell-free system. Journal of Biological Chemistry, 274(22), 15533-15537.
36. Matsumoto, T., Takeshige, K. and Minakami, S. (1979) Inhibition of phagocytic metabolic changes of leukocytes by an intracellular calcium antagonist 8-(N, N-diethylamine)-octyl-3,4,5-tri-methoxy benzoate. Biochemical and Biophysical Research Communications, 88, 974-975.
37. Meyer, J.W., Holland, J.A., Ziegler, L.M., Chang, M.-M., Beebe, G. and Schmitt, M.E. (1999) Identification of a functional leukocyte-type NADPH oxidase in human endothelial cells: A potential atherogenic source of reactive oxygen species. Endothelium, 7(1), 11-22.
38. Minta, J.O. and Williams, M.D. (1986) Interactions of anti-rheumatic drugs with the superoxide generating system of activated human polymorphonuclear leukocytes. Journal of Rheumatology, 13, 498-504.
39. Mohazzab-H, K.M., Kaminski, P.M. and Wolin, M.S. (1994) NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. Ameican Journal of Physiology, 266, H2568-H2572.
40. Ohara, Y., Peterson, T.E. and Harrison, D.G. (1993) Hypercholesterolemia increases endothelial superoxide anion production. Journal of Clinical Investigation, 91, 2546-2551.
41. Patel, V., Meyer, J.W., Johnson, D.K., Abdul-Karim, R.W., Ziegler, L.M., Kauffman, L., Schillinger, K.J., Lemanski, L.F. and Holland, J.A. (1996) Protein kinase C inhibitors prevent cultured human endothelial cell stress fiber formation, but not heightened endocytosis. Endothelium, 4, 207-218.
42. Phan, S.H., Cannon, D.E., Varani, J., Ryan, U.S. and Ward, P.A. (1989) Xanthine oxidase activity in rat pulmonary artery endothelial cells and its alteration by activated neutrophils. American Journal of Pathology, 134(6), 1201-1211.
43. Pritchard, K.A., Tota, R.R., Lin, J.H.-C., Danishefsky, K.J., Kurilla, B.A., Holland, J.A. and Stemerman, M.B. (1991) Native low density lipoprotein endothelial cell recruitment of mononuclear cells. Arteriosclerosis and Thrombosis, 11, 1175-1181.
44. Pritchard, K.A., Grozsek, L., Smalley, D.M., Sessa, W.C., Wu, M., Villalon, P., Wolin, M.S. and Stemerman, M.B. (1995) Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circulation Researh, 77, 510-518.
45. Pueyo, M.E., Arnal, J.-F., Rami, J. and Michel; J.-B. (1998) Angiotensin II stimulates the production of NO and peoxynitrate in endothelial cells. American Journal of Physiology, 274, C214-C220.
46. Quinn, M.T., Mullen, M.L. and Jesaitis, A.J. (1992) Human neutrophil cytochrome b contains multiple hemes. Evidence for heme associated with both subunits. Journal of Biological Chemistry, 267, 7303-7309.
47. Rachmilewitz, D., Okon, E. and Karmeli, F. (1997) Sulphydryl blocker induced small intestinal inflammation in rats: a new model mimicking Crohn's disease. Gut, 41, 358-365.
48. Roos, D., de Boer, M., Kuribayashi, F., Weening, R.S., Segal, A.W., Ahlin, A., Nemet, K., Hossle, J.P., Bernatowska-Matuszkiewicz, E. and Middleton-Price, H. (1996) Mutations in the X-linked and autosomal recessive forms of Chronic Granulomatous Disease. Blood, 87, 1663-1681.
49. Rossi, F., Della Bianca, V. and Bellavite, P. (1981) Inhibition of the respiratory burst and of phagocytosis by nordihydroguaiaretic acid in neutrophils. Federation of European Biochemical Societies Letters, 127, 183-187.
50. Roth, R.A. and Hewett, J.A. (1990) The cholestatic agent, alpha-naphthyl-isothiocyanate, stimulates superoxide release by rat neutrophils in vitro. Laboratory Investigation, 62(6), 736-741.
51. Sanders, S.A., Eisenthal, R. and Harrison, R. (1997) NADH oxidase activity of human xanthine oxidoreductase: Generation of superoxide anion. European Journal of Biochemistry, 245(3), 541-548.
52. 245is a flavocytochrome containing FAD and the NADPH-binding site of the microbiocidal oxidase of phagocytes. Biochemical Journal, 284, 781-788.
53. Simmet, T and Luck, W. (1989) H1-antihistamines and calmodulin antagonists inhibit the ionophore A23187-induced eicosanoid formation by human leukocytes. Agents and Actions, 26(3-4), 273-278.
54. Simons, J.M., 't Hart, B.A., Ip Vai Ching, T.R.A.M., Van Dijk, H. and Labadie, R.P. (1990) Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils. Free Radical Biology & Medicine, 8, 251-258.
55. Soliman, K.F.A. and Mazzio, E.A. (1998) In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds. Proceedings of the Society of Experimental Biology and Medicine, 218(4), 390-397.
56. Stemerman, M.B., Colton, C. and Morrel, E. (1984) Perturbation of the endothelium. In Progress in Hemostasis and Thrombosis (ed. T.H. Spaet), Grune & Stratton, Inc., New York, Vol. 7, pp. 289-324.
57. Stuehr, D.J., Fasehun, O.A., Kwon, N.S., Gross, S.S., Gonzalez, J.A., Levi, R. and Nathan, C.F. (1991) Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. Federation of the American Society of Experimental Biology Journal, 5, 98-103.
58. Tauber, A.I. (1980) Flavonoid inhibition of human neutrophil NADPH-oxidase. Biochemical Pharmacology, 33, 1367-1369.
59. Tauber, A.I. and Simons, E.R. (1985) Dissociation of human neutrophil membrane depolarization, respiratory burst stimulation and phospholipid metabolism by quinacrine. Federation of European Biochemical Societies Letters, 156, 61-164.
60. 't Hart, B.A., Simons, J.M., Rijkers, G.T., Hoogvliet, J.C., van Dijk, H. and Labadie, R.P. (1990) Reaction products of 1-naphthol with reactive oxygen species prevent NADPH-oxidase assembly in activated human neutrophils, but leave phagocytosis intact. Free Radical Biology & Medicine, 8, 241-249.
61. van Hinsbergh, V.W.M., Scheffer, M., Havekes, L. and Kempen, H.J.M. (1986) Role of endothelial cells and their products in the modification of low-density lipoproteins. Biochimica et Biophysica Acta, 878, 49-64.
62. Weber, C., Erl, W., Pietsch, A., Strobel, M., Ziegler-Heitbrock, H.W.L. and Weber, P.C. (1994) Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kB mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulate to generate radicals. Arteriosclerosis and Thrombosis, 14, 1665-1673.
63. - generating enzyme of guinea-pig polymorphonuclear leukocytes. Biochemical and Biophysical Research Communications, 104, 200-205.
64. Zar, J.H. (1974) Biostatistical analysis. Prentice-Hall Inc., Englewoods Cliffs, New Jersey.
65. Ziganshina, L.E. (1996) Acute paw oedema formationinduced by ATP: re-evaluation of the mechanisms involved. Inflammation Research,. 45(2), 96-102.
66. Zulueta, J.J., Yu, F.-S., Hertig, I.A., Thannickal, V.J. and Hassoun, P.M. (1995) Release of hydrogen peroxide in response to hypoxia-regeneration: Role of an NAD(P)H oxidase-like enzyme in endothelial cell plasma membrane. American Journal of Respiratory Cell and Molecular Biology, 12, 41-19.