메뉴 건너뛰기




Volumn 5, Issue 3, 1997, Pages 191-207

Low-density lipoprotein stimulated peroxide production and endocytosis in cultured human endothelial cells: Mechanisms of action

Author keywords

Arachidonic acid; Endocytosis; Endothelial cells; Low density lipoprotein; NADPH oxidase; Reactive oxygen species

Indexed keywords

4 BROMOPHENACYL BROMIDE; ARACHIDIC ACID; ARACHIDONIC ACID; ENZYME INHIBITOR; HYDROGEN PEROXIDE; INDOMETACIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NORDIHYDROGUAIARETIC ACID; PEROXIDE; PROADIFEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

EID: 9844249671     PISSN: 10623329     EISSN: None     Source Type: Journal    
DOI: 10.3109/10623329709053398     Document Type: Article
Times cited : (27)

References (51)
  • 1
    • 84912946980 scopus 로고
    • Report by National Heart, Lung, and Blood Institute Task Force on Arteriosclerosis DHEW Publication No. 13
    • Arteriosclerosis, Report by National Heart, Lung, and Blood Institute Task Force on Arteriosclerosis (1972) DHEW Publication No. 13, pp. 72-219.
    • (1972) Arteriosclerosis , pp. 72-219
  • 2
    • 0019802590 scopus 로고
    • Cispolyunsaturated fatty acids induce high levels of superoxide production by human neutrophils
    • Badwey, J. A., Curnutte, J. T. and Karnovsky, M. L. (1981) Cispolyunsaturated fatty acids induce high levels of superoxide production by human neutrophils. J. Biol. Chem., 256: 12640-12643.
    • (1981) J. Biol. Chem. , vol.256 , pp. 12640-12643
    • Badwey, J.A.1    Curnutte, J.T.2    Karnovsky, M.L.3
  • 3
    • 0019314510 scopus 로고
    • Surface functions during mitosis: II. Quantitation of pinocytosis and kinetic characterization of mitotic cycle with a new fluorescence technique
    • Berlin, R. D. and Oliver, J. M. (1980) Surface functions during mitosis: II. Quantitation of pinocytosis and kinetic characterization of mitotic cycle with a new fluorescence technique. J. Cell Bio., 85:660-671.
    • (1980) J. Cell Bio. , vol.85 , pp. 660-671
    • Berlin, R.D.1    Oliver, J.M.2
  • 4
    • 0017738596 scopus 로고
    • Selective release of arachidonic acid from the phospholipids of human platelets in response to thrombin
    • Bills, T. K., Smith, J. B. and Silver, M. J. (1977) Selective release of arachidonic acid from the phospholipids of human platelets in response to thrombin. J. Clin. Invest., 60:1-6.
    • (1977) J. Clin. Invest. , vol.60 , pp. 1-6
    • Bills, T.K.1    Smith, J.B.2    Silver, M.J.3
  • 5
    • 0022380809 scopus 로고
    • Oxidized low density lipoprotein can reduce the pinocytotic activity in cultured human endothelial cells as measured by cellular uptake of [14C]sucrose
    • Borsum, T., Henriksen, T. and Reisvaag, A. (1985) Oxidized low density lipoprotein can reduce the pinocytotic activity in cultured human endothelial cells as measured by cellular uptake of [14C]sucrose. Atherosclerosis, 58:81-96.
    • (1985) Atherosclerosis , vol.58 , pp. 81-96
    • Borsum, T.1    Henriksen, T.2    Reisvaag, A.3
  • 7
    • 0020573287 scopus 로고
    • Unsaturated fatty acids as second messengers of superoxide generation by macrophages
    • Bromberg, Y. and Pick, E. (1983) Unsaturated fatty acids as second messengers of superoxide generation by macrophages. Cell. Immunol., 79:240-252.
    • (1983) Cell. Immunol. , vol.79 , pp. 240-252
    • Bromberg, Y.1    Pick, E.2
  • 8
    • 0028369668 scopus 로고
    • Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells
    • Carter, R., Schwiers, E. and Ames, B. N. (1994) Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells. J. Leukocyte Biol., 55:253-258.
    • (1994) J. Leukocyte Biol. , vol.55 , pp. 253-258
    • Carter, R.1    Schwiers, E.2    Ames, B.N.3
  • 9
    • 0021027358 scopus 로고
    • Detection of picomoles of hydroperoxides using a fluorescent dichlorofluorescein assay
    • Cathcart, R., Schwiers, E. and Ames, B. N. (1983) Detection of picomoles of hydroperoxides using a fluorescent dichlorofluorescein assay. Anal. Biochem., 134:111-116.
    • (1983) Anal. Biochem. , vol.134 , pp. 111-116
    • Cathcart, R.1    Schwiers, E.2    Ames, B.N.3
  • 10
    • 0021869042 scopus 로고
    • Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system
    • Curnutte, J. T. (1985) Activation of human neutrophil nicotinamide adenine dinucleotide phosphate, reduced (triphosphopyridine nucleotide, reduced) oxidase by arachidonic acid in a cell-free system. J. Clin. Invest., 75:1740-1743.
    • (1985) J. Clin. Invest. , vol.75 , pp. 1740-1743
    • Curnutte, J.T.1
  • 11
    • 0028181632 scopus 로고
    • 2 for activation of the assembled NADPH oxidase in human neutrophils
    • 2 for activation of the assembled NADPH oxidase in human neutrophils. Biochem. J., 297:217-223.
    • (1994) Biochem. J. , vol.297 , pp. 217-223
    • Dana, R.1    Malech, H.L.2    Levy, R.3
  • 12
    • 0022998686 scopus 로고
    • Superoxide perturbation of the organization of vascular endothelial cell membranes
    • Freeman, B. A., Rosen, G. M. and Barber, M. J. (1986) Superoxide perturbation of the organization of vascular endothelial cell membranes. J. Biol. Chem., 261(14):6590-6593.
    • (1986) J. Biol. Chem. , vol.261 , Issue.14 , pp. 6590-6593
    • Freeman, B.A.1    Rosen, G.M.2    Barber, M.J.3
  • 13
    • 0027395762 scopus 로고
    • The immediate activator of the NADPH oxidase is arachidonate not phosphorylation
    • Henderson, L. M., Moule, S. K. and Chappell, J. B. (1993) The immediate activator of the NADPH oxidase is arachidonate not phosphorylation. Eur. J. Biochem., 211:157-162.
    • (1993) Eur. J. Biochem. , vol.211 , pp. 157-162
    • Henderson, L.M.1    Moule, S.K.2    Chappell, J.B.3
  • 14
    • 0023677144 scopus 로고
    • Perturbation of cultured human endothelial cells by atherogenic levels of low density lipoprotein
    • Holland, J. A., Pritchard, K. A., Rogers, N. J. and Stemerman, M. B. (1988) Perturbation of cultured human endothelial cells by atherogenic levels of low density lipoprotein. Am. J. Pathol., 132:474-478.
    • (1988) Am. J. Pathol. , vol.132 , pp. 474-478
    • Holland, J.A.1    Pritchard, K.A.2    Rogers, N.J.3    Stemerman, M.B.4
  • 15
    • 0026551211 scopus 로고
    • Atherogenic levels of low-density lipoprotein increase endocytotic activity in cultured human endothelial cells
    • Holland, J. A., Pritchard, K. A., Rogers, N. J. and Stemerman, M. B. (1992) Atherogenic levels of low-density lipoprotein increase endocytotic activity in cultured human endothelial cells. Am. J. Pathol., 140:551-558.
    • (1992) Am. J. Pathol. , vol.140 , pp. 551-558
    • Holland, J.A.1    Pritchard, K.A.2    Rogers, N.J.3    Stemerman, M.B.4
  • 16
    • 0030058122 scopus 로고    scopus 로고
    • Atherogenic levels of low density lipoprotein increase hydrogen peroxide generation in cultured human endothelial cells: Possible mechanism of heightened endocytosis
    • Holland, J. A., Ziegler, L. M. and Meyer, J. W. (1996) Atherogenic levels of low density lipoprotein increase hydrogen peroxide generation in cultured human endothelial cells: Possible mechanism of heightened endocytosis. J. Cell. Physiol., 166:144-151.
    • (1996) J. Cell. Physiol. , vol.166 , pp. 144-151
    • Holland, J.A.1    Ziegler, L.M.2    Meyer, J.W.3
  • 17
    • 0024402914 scopus 로고
    • Regulation of synthesis of prostacyclin and HETEs in human endothelial cells
    • Ibe, B. O., Falck, J. R., Johnson, A. R. and Campbell, W. B. (1989) Regulation of synthesis of prostacyclin and HETEs in human endothelial cells. Am. J. Physiol., 256:C1168-C1175.
    • (1989) Am. J. Physiol. , vol.256
    • Ibe, B.O.1    Falck, J.R.2    Johnson, A.R.3    Campbell, W.B.4
  • 18
    • 0019961652 scopus 로고
    • How is the level of free arachidonic acid controlled in mammalian cells?
    • Irvine, R. F. (1982) How is the level of free arachidonic acid controlled in mammalian cells? Biochem. J., 204:3-16.
    • (1982) Biochem. J. , vol.204 , pp. 3-16
    • Irvine, R.F.1
  • 19
    • 0028963098 scopus 로고
    • Suppression of cytochrome P450 (Cypla-1) induction in mouse hepatoma Hepa-1c1c7 cells by methoxsalen
    • Jeong, H. G., Yun, C.-H., Jeon, Y. J., Lee, S. S. and Yang, K.-H. (1995) Suppression of cytochrome P450 (Cypla-1) induction in mouse hepatoma Hepa-1c1c7 cells by methoxsalen. Biochem. Biophys. Res. Comm., 208(3):1124-1130.
    • (1995) Biochem. Biophys. Res. Comm. , vol.208 , Issue.3 , pp. 1124-1130
    • Jeong, H.G.1    Yun, C.-H.2    Jeon, Y.J.3    Lee, S.S.4    Yang, K.-H.5
  • 20
    • 0023492518 scopus 로고
    • Reductive inactivation of soybean lipoxygenase 1 by catechols: A possible mechanism for regulation of lipoxygenase activity
    • Kemal, C., Louis-Flamberg, P., Krupinski-Olsen, R. and Shorter, A. L. (1987) Reductive inactivation of soybean lipoxygenase 1 by catechols: A possible mechanism for regulation of lipoxygenase activity. Biochem., 26:7064-7072.
    • (1987) Biochem. , vol.26 , pp. 7064-7072
    • Kemal, C.1    Louis-Flamberg, P.2    Krupinski-Olsen, R.3    Shorter, A.L.4
  • 21
    • 0028340912 scopus 로고
    • Bioactivation of arachidonic acid by the cytochrome P450 monooxygenase of guinea pig lung: The orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids
    • Knickle, L. C. and Bend, J. R. (1994) Bioactivation of arachidonic acid by the cytochrome P450 monooxygenase of guinea pig lung: The orthologue of cytochrome P450 2B4 is solely responsible for formation of epoxyeicosatrienoic acids. Mol. Pharmacol., 45:1273-1280.
    • (1994) Mol. Pharmacol. , vol.45 , pp. 1273-1280
    • Knickle, L.C.1    Bend, J.R.2
  • 22
    • 0026813471 scopus 로고
    • Regulation of hydrogen peroxide generation in cultured endothelial cells
    • Kinnula, V. L., Whorton, A. R., Chang, L.-Y. and Crapo, J. D. (1992) Regulation of hydrogen peroxide generation in cultured endothelial cells. J. Resp. Cell Mol. Biol., 6:175-182.
    • (1992) J. Resp. Cell Mol. Biol. , vol.6 , pp. 175-182
    • Kinnula, V.L.1    Whorton, A.R.2    Chang, L.-Y.3    Crapo, J.D.4
  • 23
    • 0022884922 scopus 로고
    • PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH
    • Kukreja, R. C., Kontos, H. A., Hess, M. L. and Ellis, E. F. (1986) PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH. Circ. Res., 59:612-619.
    • (1986) Circ. Res. , vol.59 , pp. 612-619
    • Kukreja, R.C.1    Kontos, H.A.2    Hess, M.L.3    Ellis, E.F.4
  • 24
    • 0020188453 scopus 로고
    • Oxidase and oxygen function of the microsomal cytochrome P450 monooxygenase system
    • Kuthan, H. and Ullrich, V. (1982) Oxidase and oxygen function of the microsomal cytochrome P450 monooxygenase system. Eur. J. Biochem., 126:583-588.
    • (1982) Eur. J. Biochem. , vol.126 , pp. 583-588
    • Kuthan, H.1    Ullrich, V.2
  • 26
    • 0006155436 scopus 로고
    • Response of endocytosis to altered fatty acyl composition of macrophage phospholipids
    • Mahoney, E. M., Hamill, A. L., Scott, W. A. and Cohn, Z. A. (1977) Response of endocytosis to altered fatty acyl composition of macrophage phospholipids. Proc. Natl. Acad. Sci. USA, 74(11):4895-4899.
    • (1977) Proc. Natl. Acad. Sci. USA , vol.74 , Issue.11 , pp. 4895-4899
    • Mahoney, E.M.1    Hamill, A.L.2    Scott, W.A.3    Cohn, Z.A.4
  • 27
    • 0022979861 scopus 로고
    • Identification of distinct activation pathways of the human neutrophil NADPH-Oxidase
    • Maridonneau-Parini, I., Tringale, S. M. and Tauber, A. I. (1986) Identification of distinct activation pathways of the human neutrophil NADPH-Oxidase. J. Immunol., 137(9):2925-2929.
    • (1986) J. Immunol. , vol.137 , Issue.9 , pp. 2925-2929
    • Maridonneau-Parini, I.1    Tringale, S.M.2    Tauber, A.I.3
  • 29
    • 0028233138 scopus 로고
    • NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium
    • Mohazzab-H, K. M., Kaminski, P. M. and Wolin, M. S. (1994) NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. Am. J. Physiol., 266: H2568-H2572.
    • (1994) Am. J. Physiol. , vol.266
    • Mohazzab-H, K.M.1    Kaminski, P.M.2    Wolin, M.S.3
  • 32
    • 0025334538 scopus 로고
    • Atherogenic concentrations of low-density lipoprotein enhance endothelial cell generation of epoxyeicosatrienoic acid products
    • Pritchard, K. A., Wong, P. Y.-K. and Stemerman, M. B. (1990) Atherogenic concentrations of low-density lipoprotein enhance endothelial cell generation of epoxyeicosatrienoic acid products. Am. J. Pathol., 136(6):1383-1391.
    • (1990) Am. J. Pathol. , vol.136 , Issue.6 , pp. 1383-1391
    • Pritchard, K.A.1    Wong, P.Y.-K.2    Stemerman, M.B.3
  • 34
    • 0025125387 scopus 로고
    • Inhibition of arachidonic acid release by Nordihydroguaiaretic acid and its antioxidant action in rat alveolar macrophages and chinese hamster lung fibroblasts
    • Robison, T. W., Sevanian, A. and Forman, H. J. (1990) Inhibition of arachidonic acid release by Nordihydroguaiaretic acid and its antioxidant action in rat alveolar macrophages and chinese hamster lung fibroblasts. Toxicol. Appl. Pharmacol., 105: 113-122.
    • (1990) Toxicol. Appl. Pharmacol. , vol.105 , pp. 113-122
    • Robison, T.W.1    Sevanian, A.2    Forman, H.J.3
  • 35
    • 0019480245 scopus 로고
    • Inhibition of the respiratory burst and of phagocytosis by nordihydroguaiaretic acid in neutrophils
    • Rossi, F., Della Bianca, V. and Bellavite, P. (1981) Inhibition of the respiratory burst and of phagocytosis by nordihydroguaiaretic acid in neutrophils. FEBBS Lett., 127:183-187.
    • (1981) FEBBS Lett. , vol.127 , pp. 183-187
    • Rossi, F.1    Della Bianca, V.2    Bellavite, P.3
  • 36
    • 0025303467 scopus 로고
    • The cholestatic agent, alpha-naphthyl-isothiocyanate, stimulates superoxide release by rat neutrophils in vitro
    • Roth, R. A. and Hewett, J. A. (1990) The cholestatic agent, alpha-naphthyl-isothiocyanate, stimulates superoxide release by rat neutrophils in vitro. Lab. Invest., 62(6):736-741.
    • (1990) Lab. Invest. , vol.62 , Issue.6 , pp. 736-741
    • Roth, R.A.1    Hewett, J.A.2
  • 38
    • 0023272270 scopus 로고
    • Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc receptor-mediated superoxide generation in macrophages
    • Sakata, A., Ida, E., Tominaga, M. and Onoue, K. (1987) Arachidonic acid acts as an intracellular activator of NADPH-oxidase in Fc receptor-mediated superoxide generation in macrophages. J. Immunol., 138(12):4353-4359.
    • (1987) J. Immunol. , vol.138 , Issue.12 , pp. 4353-4359
    • Sakata, A.1    Ida, E.2    Tominaga, M.3    Onoue, K.4
  • 39
    • 0025851358 scopus 로고
    • Prolactin induces proliferation of vascular smooth muscle cells through a protein kinase C-dependent mechanism
    • Sauro, M. D. and Zom, N. E. (1991) Prolactin induces proliferation of vascular smooth muscle cells through a protein kinase C-dependent mechanism. J. Cell. Physiol., 148:133-138.
    • (1991) J. Cell. Physiol. , vol.148 , pp. 133-138
    • Sauro, M.D.1    Zom, N.E.2
  • 40
    • 0023690817 scopus 로고
    • Exogenous oxidants initiate hydrolysis of endothelial cell inositol phospholipids
    • Shasby, D. M., Yorek, M. and Shasby, S. S. (1988) Exogenous oxidants initiate hydrolysis of endothelial cell inositol phospholipids. Blood, 72(2):491-499.
    • (1988) Blood , vol.72 , Issue.2 , pp. 491-499
    • Shasby, D.M.1    Yorek, M.2    Shasby, S.S.3
  • 41
    • 0018915727 scopus 로고
    • Effect of indomethacin, 5,8,11,14-licosatetraynoic acid and p-bromophenacyl bromide on lysosomal enzyme release and superoxide anion generation by human polymorphonuclear leukocytes
    • Smolen, J. E. and Weissmann, G. (1980) Effect of indomethacin, 5,8,11,14-licosatetraynoic acid and p-bromophenacyl bromide on lysosomal enzyme release and superoxide anion generation by human polymorphonuclear leukocytes. Biochem. Pharmacol., 29:533-538.
    • (1980) Biochem. Pharmacol. , vol.29 , pp. 533-538
    • Smolen, J.E.1    Weissmann, G.2
  • 42
    • 0019426739 scopus 로고
    • Effects of moderate hypercholesterolemia on rabbit endothelium
    • Stemerman, M. B. (1981) Effects of moderate hypercholesterolemia on rabbit endothelium. Arteriosclerosis, 1:25-32.
    • (1981) Arteriosclerosis , vol.1 , pp. 25-32
    • Stemerman, M.B.1
  • 43
    • 0021669718 scopus 로고
    • Perturbation of the endothelium
    • T.H. Spaet, ed. Grune & Stratton, Inc.
    • Stemerman, M. B., Colton, C. and Morrel, E. (1984) Perturbation of the endothelium. In: Progress in Hemostasis and Thrombosis. T.H. Spaet, ed. Grune & Stratton, Inc., Vol. 7, pp. 289-324.
    • (1984) Progress in Hemostasis and Thrombosis , vol.7 , pp. 289-324
    • Stemerman, M.B.1    Colton, C.2    Morrel, E.3
  • 44
    • 0022626228 scopus 로고
    • Local variation in arterial wall permeability to low density lipoprotein in normal rabbit aorta
    • Stemerman, M. B., Morrel, E. M., Burke, K. R., Colton, C. K., Smith, K. A. and Lees, R. S. (1986) Local variation in arterial wall permeability to low density lipoprotein in normal rabbit aorta. Arteriosclerosis, 6:64-69.
    • (1986) Arteriosclerosis , vol.6 , pp. 64-69
    • Stemerman, M.B.1    Morrel, E.M.2    Burke, K.R.3    Colton, C.K.4    Smith, K.A.5    Lees, R.S.6
  • 45
    • 0028473441 scopus 로고
    • Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol
    • Stolk, J., Hiltermann, T. J. N., Dijkman, J. H. and Verhoeven, A. J. (1994) Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am. J. Resp. Cell Mol. Biol., 11:95-102.
    • (1994) Am. J. Resp. Cell Mol. Biol. , vol.11 , pp. 95-102
    • Stolk, J.1    Hiltermann, T.J.N.2    Dijkman, J.H.3    Verhoeven, A.J.4
  • 47
    • 0020963907 scopus 로고
    • Visualization of the binding, endocytosis, and transcytosis, of low-density lipoprotein in the arterial endothelium in situ
    • Vasile, E., Simionescu, M. and Simionescu, N. (1983) Visualization of the binding, endocytosis, and transcytosis, of low-density lipoprotein in the arterial endothelium in situ. J. Cell Biol., 96:1677-1689.
    • (1983) J. Cell Biol. , vol.96 , pp. 1677-1689
    • Vasile, E.1    Simionescu, M.2    Simionescu, N.3
  • 48
    • 0028148369 scopus 로고
    • Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kB mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulate to generate radicals
    • Weber, C., Erl, W., Pietsch, A., Strobel, M., Ziegler-Heitbrock, H. W. L. and Weber, P. C. (1994) Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kB mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulate to generate radicals. Arterioscler. Thromb., 14:1665-1673.
    • (1994) Arterioscler. Thromb. , vol.14 , pp. 1665-1673
    • Weber, C.1    Erl, W.2    Pietsch, A.3    Strobel, M.4    Ziegler-Heitbrock, H.W.L.5    Weber, P.C.6
  • 49
    • 77956815952 scopus 로고
    • Enzymes in the arachidonic acid cascade
    • C. Pace-Ascieak and E. Granstrom, eds. Elsevier Science Publishers B.V., Amsterdam
    • Yamamoto, S. (1983) Enzymes in the arachidonic acid cascade. In: Prostaglandins and related substances. C. Pace-Ascieak and E. Granstrom, eds. Elsevier Science Publishers B.V., Amsterdam, pp. 171-202.
    • (1983) Prostaglandins and Related Substances , pp. 171-202
    • Yamamoto, S.1
  • 50
    • 0004232308 scopus 로고
    • Prentice-Hall Inc., Englewood Cliffs, New Jersey
    • Zar, J. H. (1974) Biostatistical Analysis, Prentice-Hall Inc., Englewood Cliffs, New Jersey.
    • (1974) Biostatistical Analysis
    • Zar, J.H.1
  • 51
    • 0029194524 scopus 로고
    • Release of hydrogen peroxide in response to hypoxia-regeneration: Role of an NAD(P)H oxidase-like enzyme in endothelial cell plasma membrane
    • Zulueta, J. J., Yu, F.-S., Hertig, I. A., Thannickal, V. J. and Hassoun, P. M. (1995) Release of hydrogen peroxide in response to hypoxia-regeneration: Role of an NAD(P)H oxidase-like enzyme in endothelial cell plasma membrane. Am. J. Respir. Cell Mol. Biol., 12:41-49.
    • (1995) Am. J. Respir. Cell Mol. Biol. , vol.12 , pp. 41-49
    • Zulueta, J.J.1    Yu, F.-S.2    Hertig, I.A.3    Thannickal, V.J.4    Hassoun, P.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.