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Volumn 22, Issue 5, 1999, Pages 475-480

Oral fluoropyrimidines: A closer look at their toxicities

Author keywords

Adverse reactions; Capecitabine Eniluracil; Emitefur (BOF A2); Oral fluorinated pyrimidines; S 1; Tegafur; UFT

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; 5 ETHYNYLURACIL; CAPECITABINE; EMITEFUR; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; PACLITAXEL; PROCHLORPERAZINE; UFT;

EID: 0033508649     PISSN: 02773732     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000421-199910000-00011     Document Type: Article
Times cited : (22)

References (49)
  • 1
    • 0030826303 scopus 로고    scopus 로고
    • Adjuvant therapy for colon cancer
    • Macdonald J. Adjuvant therapy for colon cancer. CA Cancer J Clin 1997;47:243-56.
    • (1997) CA Cancer J Clin , vol.47 , pp. 243-256
    • Macdonald, J.1
  • 2
    • 0023520170 scopus 로고
    • A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma
    • Petrelli N, Herrera L, Rustum Y, et al. A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 1987; 5:1559-65.
    • (1987) J Clin Oncol , vol.5 , pp. 1559-1565
    • Petrelli, N.1    Herrera, L.2    Rustum, Y.3
  • 3
    • 0031056423 scopus 로고    scopus 로고
    • Phase II study of trimetrexate fluorouracil, and leucovorin for advanced colorectal cancer
    • Blanke C, Kasimis B, Schein P, et al. Phase II study of trimetrexate fluorouracil, and leucovorin for advanced colorectal cancer. J Clin Oncol 1997;15:915-20.
    • (1997) J Clin Oncol , vol.15 , pp. 915-920
    • Blanke, C.1    Kasimis, B.2    Schein, P.3
  • 4
    • 0024834136 scopus 로고
    • Fluorouracil and recombinant alpha-2a-interferon: An active regimen against advanced colorectal carcinoma
    • Wadler S, Schwanz E, Goldman M, et al. Fluorouracil and recombinant alpha-2a-interferon: an active regimen against advanced colorectal carcinoma. J Clin Oncol 1989;7:1769-75.
    • (1989) J Clin Oncol , vol.7 , pp. 1769-1775
    • Wadler, S.1    Schwanz, E.2    Goldman, M.3
  • 5
    • 0026006962 scopus 로고
    • Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer
    • Poon M, O'Connell M, Wieand H, et al. Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J Clin Oncol 1991;9:1967-72.
    • (1991) J Clin Oncol , vol.9 , pp. 1967-1972
    • Poon, M.1    O'Connell, M.2    Wieand, H.3
  • 6
    • 0024992069 scopus 로고
    • Phase II study of biochemical modulation of fluorouracil by low-dose PALA in patients with colorectal cancer
    • O'Dwyer P, Paul A, Walczak J, et al. Phase II study of biochemical modulation of fluorouracil by low-dose PALA in patients with colorectal cancer. J Clin Oncol 1990;8:1497-1503.
    • (1990) J Clin Oncol , vol.8 , pp. 1497-1503
    • O'Dwyer, P.1    Paul, A.2    Walczak, J.3
  • 7
    • 0024539308 scopus 로고
    • A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program study
    • Lokich J, Ahlgren J, Gullo J, et al. A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program study. J Clin Oncol 1989;7:425-32.
    • (1989) J Clin Oncol , vol.7 , pp. 425-432
    • Lokich, J.1    Ahlgren, J.2    Gullo, J.3
  • 8
    • 0029012118 scopus 로고
    • Phase II study of fluorouracil and its modulation in advanced colorectal cancer: A Southwest Oncology Group study
    • Leichman C, Fleming T, Muggia F, et al. Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study. J Clin Oncol 1995;13:1303-11.
    • (1995) J Clin Oncol , vol.13 , pp. 1303-1311
    • Leichman, C.1    Fleming, T.2    Muggia, F.3
  • 9
    • 0029923720 scopus 로고    scopus 로고
    • Phase ID study of bolus versus infusion fluorouracil with or without cisplatin in advanced colorectal cancer
    • Hansen R, Ryan L, Anderson T, et al. Phase ID study of bolus versus infusion fluorouracil with or without cisplatin in advanced colorectal cancer. J Natl Cancer Inst 1996;88:668-74.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 668-674
    • Hansen, R.1    Ryan, L.2    Anderson, T.3
  • 10
    • 0024595925 scopus 로고
    • Clinical pharmacology of 5-fluorouracil
    • Diasio R. Clinical pharmacology of 5-fluorouracil. Clin Pharmacokinet 1989;16:215-37.
    • (1989) Clin Pharmacokinet , vol.16 , pp. 215-237
    • Diasio, R.1
  • 11
    • 0028006858 scopus 로고
    • Population study of dihydropyrimidine dehydrogenase in cancer patients
    • Etienne M, Lagrange J, Dassonville O, et al. Population study of dihydropyrimidine dehydrogenase in cancer patients. J Clin Oncol 1994;12:2248-53.
    • (1994) J Clin Oncol , vol.12 , pp. 2248-2253
    • Etienne, M.1    Lagrange, J.2    Dassonville, O.3
  • 12
    • 0028577327 scopus 로고
    • Dihydropyrimidine dehydrogenase (DPD) and clinical pharmacology of 5-fluorouracil
    • Milano G, Etienne M. Dihydropyrimidine dehydrogenase (DPD) and clinical pharmacology of 5-fluorouracil (review). Anticancer Res 1994;14:2295-7.
    • (1994) Anticancer Res , vol.14 , pp. 2295-2297
    • Milano, G.1    Etienne, M.2
  • 13
    • 0019275803 scopus 로고
    • A review of the United States clinical experience of the fluoropyrimidine, Ftorafur (NSC-148958)
    • Friedman M, Ignoffo R. A review of the United States clinical experience of the fluoropyrimidine, Ftorafur (NSC-148958). Cancer Treat Rev 1980;7:205-13.
    • (1980) Cancer Treat Rev , vol.7 , pp. 205-213
    • Friedman, M.1    Ignoffo, R.2
  • 14
    • 0017281187 scopus 로고
    • Clinical evaluation of ftorafur (pyrimidine-deosyribox N1,-2′furanddyl-5-fluorouracil)
    • Valdivieso T, Bodey G, Gottlieb J, Freireich E. Clinical evaluation of ftorafur (pyrimidine-deosyribox N1,-2′furanddyl-5-fluorouracil). Cancer Res 1976;36:1821-4.
    • (1976) Cancer Res , vol.36 , pp. 1821-1824
    • Valdivieso, T.1    Bodey, G.2    Gottlieb, J.3    Freireich, E.4
  • 15
    • 0030223052 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil
    • Muggia F, Xiaoyang W, Spicer D, et al. Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil. Clin Cancer Res 1996;2:1461-7.
    • (1996) Clin Cancer Res , vol.2 , pp. 1461-1467
    • Muggia, F.1    Xiaoyang, W.2    Spicer, D.3
  • 16
    • 0029972388 scopus 로고    scopus 로고
    • A phase 1 and pharmacokinetic study of oral uracil, ftorafur, and leucovorin in patients with advanced cancer
    • Meropol N, Rustum Y, Petrelli N, et al. A phase 1 and pharmacokinetic study of oral uracil, ftorafur, and leucovorin in patients with advanced cancer. Cancer Chemother Pharmacol 1996;37:581-6.
    • (1996) Cancer Chemother Pharmacol , vol.37 , pp. 581-586
    • Meropol, N.1    Rustum, Y.2    Petrelli, N.3
  • 17
    • 0030981514 scopus 로고    scopus 로고
    • Phase I trial of uracil-tegafur (UFT) plus oral leucovorin: 14 day schedule
    • Pazdur R, Lassere Y, Diaz-Canton E, et al. Phase I trial of uracil-tegafur (UFT) plus oral leucovorin: 14 day schedule. Invest New Drugs 1997;15:123-8.
    • (1997) Invest New Drugs , vol.15 , pp. 123-128
    • Pazdur, R.1    Lassere, Y.2    Diaz-Canton, E.3
  • 18
    • 0031921541 scopus 로고    scopus 로고
    • Phase I trial of uracil-tegafur (UFT) plus oral leucovorin: 28 day schedule
    • Pazdur R, Lassere Y, Diaz-Canton E, et al. Phase I trial of uracil-tegafur (UFT) plus oral leucovorin: 28 day schedule. Cancer Invest 1998;16:145-51.
    • (1998) Cancer Invest , vol.16 , pp. 145-151
    • Pazdur, R.1    Lassere, Y.2    Diaz-Canton, E.3
  • 19
    • 0026329661 scopus 로고
    • Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously
    • Priest D, Schmitz J, Bunni M, Stuart R. Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously. J Natl Cancer Inst 1991; 83:1806-12.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 1806-1812
    • Priest, D.1    Schmitz, J.2    Bunni, M.3    Stuart, R.4
  • 20
    • 0025604967 scopus 로고
    • Phase II trial of UFT in advanced colorectal and gastric cancer
    • Malik S, Talbot D, Clarke P, et al. Phase II trial of UFT in advanced colorectal and gastric cancer. Br J Cancer 1990;62: 1023-5.
    • (1990) Br J Cancer , vol.62 , pp. 1023-1025
    • Malik, S.1    Talbot, D.2    Clarke, P.3
  • 21
    • 0028099423 scopus 로고
    • Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal carcinoma
    • Pazdur R, Lassere Y, Rhodes V, et al. Phase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma. J Clin Oncol 1994; 12:2296-300.
    • (1994) J Clin Oncol , vol.12 , pp. 2296-2300
    • Pazdur, R.1    Lassere, Y.2    Rhodes, V.3
  • 22
    • 0028820944 scopus 로고
    • A fixed-ratio combination of uracil and ftorafur (UFT) with low dose leucovorin
    • Saltz L, Leichman C, Young C, et al. A fixed-ratio combination of uracil and ftorafur (UFT) with low dose leucovorin. Cancer 1995; 75:782-5.
    • (1995) Cancer , vol.75 , pp. 782-785
    • Saltz, L.1    Leichman, C.2    Young, C.3
  • 23
    • 0029563823 scopus 로고
    • Efficacy of oral tegafur modulation by uracil and leucovorin in advanced colorectal cancer. A phase II study
    • González-Barón M, Feliu J, de la Gandara I, et al. Efficacy of oral tegafur modulation by uracil and leucovorin in advanced colorectal cancer. A phase II study. Eur J Cancer 1995;31A:2215-9.
    • (1995) Eur J Cancer , vol.31 A , pp. 2215-2219
    • González-Barón, M.1    Feliu, J.2    De La Gandara, I.3
  • 24
    • 1842409638 scopus 로고    scopus 로고
    • Uracil and tegafur modulated with leucovorin
    • Feliu J, González-Barón M, Espinosa E, et al. Uracil and tegafur modulated with leucovorin. Cancer 1997;79:1884-9.
    • (1997) Cancer , vol.79 , pp. 1884-1889
    • Feliu, J.1    González-Barón, M.2    Espinosa, E.3
  • 25
    • 0029762711 scopus 로고    scopus 로고
    • Thymidylate synthase inhibition by an oral regimen consisting of tegafur-uracil (UFT) and low dose leucovorin for patients with gastric cancer
    • Ichikura T, Tomimatsu S, Okusa Y, et al. Thymidylate synthase inhibition by an oral regimen consisting of tegafur-uracil (UFT) and low dose leucovorin for patients with gastric cancer. Cancer Chemother Pharmacol 1996;38:401-5.
    • (1996) Cancer Chemother Pharmacol , vol.38 , pp. 401-405
    • Ichikura, T.1    Tomimatsu, S.2    Okusa, Y.3
  • 26
    • 0031859855 scopus 로고    scopus 로고
    • Preliminary studies of a novel oral fluoropyrimidine carbamate: Capecitabine
    • Budman D, Meropol N, Reigner B, et al. Preliminary studies of a novel oral fluoropyrimidine carbamate: capecitabine. J Clin Oncol 1998;16:1795-1802.
    • (1998) J Clin Oncol , vol.16 , pp. 1795-1802
    • Budman, D.1    Meropol, N.2    Reigner, B.3
  • 27
    • 0002407449 scopus 로고    scopus 로고
    • A phase I study of intermittent twice daily oral therapy with capecitabine in patients with advanced and/or metastatic solid cancer
    • Hughes M, Planting A, Twelves C, et al. A phase I study of intermittent twice daily oral therapy with capecitabine in patients with advanced and/or metastatic solid cancer [Abstract]. Ann Oncol 1996;7(suppl 1):87.
    • (1996) Ann Oncol , vol.7 , Issue.1 SUPPL. , pp. 87
    • Hughes, M.1    Planting, A.2    Twelves, C.3
  • 28
    • 0002407449 scopus 로고    scopus 로고
    • A Japanese phase I study of continuous twice daily treatment with capecitabine in patients with advanced and/or metastatic solid tumors
    • Taguchi T, Ishitani F, Saitoh K, et al. A Japanese phase I study of continuous twice daily treatment with capecitabine in patients with advanced and/or metastatic solid tumors [Abstract]. Ann Oncol 1996;7(suppl 1):87.
    • (1996) Ann Oncol , vol.7 , Issue.1 SUPPL. , pp. 87
    • Taguchi, T.1    Ishitani, F.2    Saitoh, K.3
  • 29
    • 0000344523 scopus 로고    scopus 로고
    • A randomized phase II study of Xeloda (capecitabine) in patients with advanced colorectal cancer
    • Findlay M, Van Cutsem E, Kocha W, et al. A randomized phase II study of Xeloda (capecitabine) in patients with advanced colorectal cancer [Abstract]. Proc Am Soc Clin Oncol 1997;16:227a.
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Findlay, M.1    Van Cutsem, E.2    Kocha, W.3
  • 30
    • 0000709431 scopus 로고    scopus 로고
    • A randomized phase II study of Xeloda (capecitabine) vs CMF as first line chemotherapy of breast cancer in women aged ≥55 years
    • O'Shaughnessy J, Moiseyenko V, Bell D, et al. A randomized phase II study of Xeloda (capecitabine) vs CMF as first line chemotherapy of breast cancer in women aged ≥55 years [Abstract], Proc Am Soc Clin Oncol 1998;17:103a.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • O'Shaughnessy, J.1    Moiseyenko, V.2    Bell, D.3
  • 31
    • 0000972173 scopus 로고    scopus 로고
    • A multicenter phase II trial of Xeloda (capecitabine) in paclitaxel-refractory metastatic breast cancer
    • Blum J, Buzdar A, LaRusso P, et al. A multicenter phase II trial of Xeloda (capecitabine) in paclitaxel-refractory metastatic breast cancer [Abstract]. Proc Am Soc Clin Oncol 1998;17:125a.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Blum, J.1    Buzdar, A.2    LaRusso, P.3
  • 32
    • 0001432831 scopus 로고    scopus 로고
    • A randomized phase II study of Xeloda (capecitabine) vs paclitaxel in breast cancer patients failing previous anthrocycline therapy
    • O'Reilly S, Moiseyenko V, Talbot D, et al. A randomized phase II study of Xeloda (capecitabine) vs paclitaxel in breast cancer patients failing previous anthrocycline therapy [Abstract]. Proc Am Soc Clin Oncol 1998;17:163a.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • O'Reilly, S.1    Moiseyenko, V.2    Talbot, D.3
  • 33
    • 0001589411 scopus 로고    scopus 로고
    • Phase I study of capecitabine in combination with paclitaxel in patients with previously treated metastatic breast cancer
    • Koury P, Villalona-Clero M, Blum J, et al. Phase I study of capecitabine in combination with paclitaxel in patients with previously treated metastatic breast cancer [Abstract]. Proc Am Soc Clin Oncol 1998;17:206a.
    • (1998) Proc Am Soc Clin Oncol , vol.17
    • Koury, P.1    Villalona-Clero, M.2    Blum, J.3
  • 34
    • 10544243363 scopus 로고    scopus 로고
    • Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase
    • Baker S, Khor S, Adjei A, et al. Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase. J Clin Oncol 1996;14:3085-96.
    • (1996) J Clin Oncol , vol.14 , pp. 3085-3096
    • Baker, S.1    Khor, S.2    Adjei, A.3
  • 35
    • 0000008509 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of S-1, an oral 5-fluorouracil (5-FU)-based antineoplastic agent
    • Peters G, Van Groenningen C, Schmoage J, et al. Phase I clinical and pharmacokinetic study of S-1, an oral 5-fluorouracil (5-FU)-based antineoplastic agent [Abstract]. Proc Am Soc Clin Oncol 1997;16:227a.
    • (1997) Proc Am Soc Clin Oncol , vol.16
    • Peters, G.1    Van Groenningen, C.2    Schmoage, J.3
  • 36
    • 0003296409 scopus 로고    scopus 로고
    • Early phase II study of S-1 in patients with advanced head and neck cancer
    • Fuji M, Kansaki J, Satake B, et al. Early phase II study of S-1 in patients with advanced head and neck cancer [Abstract]. Proc Am Soc Clin Oncol 1996;15:316.
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 316
    • Fuji, M.1    Kansaki, J.2    Satake, B.3
  • 37
    • 0003296411 scopus 로고    scopus 로고
    • Early phase II study of S-1 in patients with advanced breast cancer
    • Taguchi T, Horikoshi N, Kinoshita H, et al. Early phase II study of S-1 in patients with advanced breast cancer [Abstract]. Proc Am Soc Clin Oncol 1996;15:121.
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 121
    • Taguchi, T.1    Horikoshi, N.2    Kinoshita, H.3
  • 38
    • 0000636054 scopus 로고    scopus 로고
    • S-1, new oral fluoropyrimidine, is very active in patients with advanced gastric cancer (early phase II study)
    • Horikoshi N, Mitachi Y, Sakata Y, et al. S-1, new oral fluoropyrimidine, is very active in patients with advanced gastric cancer (early phase II study) [Abstract]. Proc Am Soc Clin Oncol 1996; 15:206.
    • (1996) Proc Am Soc Clin Oncol , vol.15 , pp. 206
    • Horikoshi, N.1    Mitachi, Y.2    Sakata, Y.3
  • 39
    • 0027964405 scopus 로고
    • Efficacy of a new 5-fluorouracil derivative, BOF-A2, in advanced non-small cell lung cancer. A multi-center phase II study
    • Nakai Y, Furuse K, Ohta M, et al. Efficacy of a new 5-fluorouracil derivative, BOF-A2, in advanced non-small cell lung cancer. A multi-center phase II study. Acta Oncol 1994;33:523-6.
    • (1994) Acta Oncol , vol.33 , pp. 523-526
    • Nakai, Y.1    Furuse, K.2    Ohta, M.3
  • 40
    • 4244057795 scopus 로고
    • Clinical effect of a new 5-FU derivative BOF-A2 for patients with advanced gastric cancer: A multicenter late phase II study
    • Sugimachu K, Maehara Y. Clinical effect of a new 5-FU derivative BOF-A2 for patients with advanced gastric cancer: a multicenter late phase II study [Meeting abstract]. Can J Infect Dis 1995; 6(suppl C):209C.
    • (1995) Can J Infect Dis , vol.6 , Issue.SUPPL. C
    • Sugimachu, K.1    Maehara, Y.2
  • 41
    • 24444454653 scopus 로고
    • Multicenter late phase II study of BOF-A2 in colorectal cancer
    • Kobayashi S, Maekawa T, Sakakibara N. Multicenter late phase II study of BOF-A2 in colorectal cancer [Meeting abstract]. Can J Infect Dis 1995;6(suppl C):289C.
    • (1995) Can J Infect Dis , vol.6 , Issue.SUPPL. C
    • Kobayashi, S.1    Maekawa, T.2    Sakakibara, N.3
  • 42
    • 0018885426 scopus 로고
    • Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous infusion, and by slow infusion
    • Fraile R, Baker L, Buroker T, Horwitz J, Vaitkevicius V. Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous infusion, and by slow infusion. Cancer Res 1980;40:2223-8.
    • (1980) Cancer Res , vol.40 , pp. 2223-2228
    • Fraile, R.1    Baker, L.2    Buroker, T.3    Horwitz, J.4    Vaitkevicius, V.5
  • 43
    • 0343835681 scopus 로고
    • 5-Fluorouracil infusional schedules
    • Milano G. 5-Fluorouracil infusional schedules. J Infus Chemother 1992;3:160-3.
    • (1992) J Infus Chemother , vol.3 , pp. 160-163
    • Milano, G.1
  • 44
    • 0024262909 scopus 로고
    • Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass-spectrophotometric method in patients on a dose escalation schedule
    • Van Groenningen C, Pinedo H, Heddes J, et al. Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass-spectrophotometric method in patients on a dose escalation schedule. Cancer Res 1988;48:6956-61.
    • (1988) Cancer Res , vol.48 , pp. 6956-6961
    • Van Groenningen, C.1    Pinedo, H.2    Heddes, J.3
  • 45
    • 0026079516 scopus 로고
    • Pharmacokinetic and pharmacodynamic analysis of fluorouracil during 72 h continuous infusion with and without dipyridimole
    • Trump D, Egorin M, Forrest A, et al. Pharmacokinetic and pharmacodynamic analysis of fluorouracil during 72 h continuous infusion with and without dipyridimole. J Clin Oncol 1991;9: 2027-35.
    • (1991) J Clin Oncol , vol.9 , pp. 2027-2035
    • Trump, D.1    Egorin, M.2    Forrest, A.3
  • 46
    • 0024385167 scopus 로고
    • The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: A prospective randomized phase II trial
    • Petrelli N, Douglass H, Herrera L. The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase II trial. J Clin Oncol 1989;7:1419-26.
    • (1989) J Clin Oncol , vol.7 , pp. 1419-1426
    • Petrelli, N.1    Douglass, H.2    Herrera, L.3
  • 47
    • 0344109583 scopus 로고    scopus 로고
    • Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer
    • The Meta-analysis Group in Cancer. Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J Clin Oncol 1998;16:301-8.
    • (1998) J Clin Oncol , vol.16 , pp. 301-308
  • 48
    • 0028175144 scopus 로고
    • Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer
    • Buroker T, O'Connell M, Wieand S, et al. Randomized comparison of two schedules of fluorouracil and leucovorin in the treatment of advanced colorectal cancer. J Clin Oncol 1994;12:14-20.
    • (1994) J Clin Oncol , vol.12 , pp. 14-20
    • Buroker, T.1    O'Connell, M.2    Wieand, S.3
  • 49
    • 0031868962 scopus 로고    scopus 로고
    • UFT and leucovorin: A review of its clinical development and therapeutic potential in the oral treatment of cancer
    • Hoff P, Pazdur R, Benner S, Canetta R. UFT and leucovorin: a review of its clinical development and therapeutic potential in the oral treatment of cancer. Anticancer Drugs 1998;9:479-90.
    • (1998) Anticancer Drugs , vol.9 , pp. 479-490
    • Hoff, P.1    Pazdur, R.2    Benner, S.3    Canetta, R.4


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