Expression of COX-1, COX-2, and inducible nitric oxide synthase protein in human gastric antrum with Helicobacter pylori infection

Prostaglandins and Other Lipid Mediators

Volumn 58, Issue 1, 1999, Pages 9-17

  Franco, L ^a   Talamini, G ^b   Carra, G ^a   Doria, D ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b POLICLINICO BORGO ROMA   (Italy)

Author keywords

Cyclo oxygenase; Helicobacter pylori; Nitric oxide; Prostaglandin E2

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; NITRITE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GASTRITIS; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MALE; PATHOGENESIS; PROTEIN EXPRESSION; STOMACH ANTRUM; STOMACH BIOPSY;

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; GASTRITIS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYLORIC ANTRUM;

EID: 0033508425     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(99)00020-9     Document Type: Article

References (26)

1. Konturek S.J. The physiological role of prostaglandins in cytoprotection. Cheli R. Gastric protection. 1988;13 Raven Press, New York.
2. Whittle B.J.R., Lopez-Belmonte J., Moncada S. Regulation of gastric mucosal integrity by endogenous nitric oxide interactions with prostanoids and sensory neuropeptides in the rat . Br J Pharmacol. 99:1990;607.
3. Franco L., Velo G.P. A copper-complex reduced gastric damage caused by acetylsalicylic acid and ethanol. Prostaglandins. 51:1996;331.
4. Wallace J.L., Reuter B., Cicala C., McKnight W., Grisham M.B., Cirino G. Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology. 107:1994;173.
5. Mitchell J.A., Akarasereenont P., Thiemermann C., Flower R.J., Vane J.R. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci USA. 90:1993;11693.
6. Moncada S., Palmer R.M.J., Higgs E.A. Nitric oxide. Physiology, pathophysiology and pharmacology. Pharmacol Rev. 43:1991;109.
7. 2+-independent nitric oxide synthase activity in rat gastric mucosal cells. Eur J Pharmacol. 292:1994;111.
8. Franco L., Doria D. Nitric oxide enhances prostaglandin production in ethanol-induced gastric mucosal injury in rats. Eur J Pharmacol. 348:1998;247.
9. Boughton-Smith N.K., Evans S.M., Laszlo F., Whittle B.J.R., Moncada S. The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat. Br J Pharmacol. 110:1993;1189.
10. Tepperman B.L., Brown J.F., Whittle B.J.R. Nitric oxide synthase induction and intestinal epithelial cell viability in rats. Am J Physiol. 265:1993;G214.
11. Tepperman B.L., Soper B.D. Nitric oxide synthase induction and cytoprotection of rat gastric mucosa from injury by ethanol. Can J Physiol Pharmacol. 72:1994;1308.
12. Helicobacter pylori in peptic ulcer disease. JAMA. 272:1994;65.
13. Parsonett J., Hanson S., Rodriguez L., et al. Helicobacter pylori infection and gastric lymphoma. N Engl J Med. 330:1994;1267.
14. Dooley C.P., Cohen H., Fitzgibbons P.L., et al. Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med. 321:1989;1562.
15. Dixon M.F., Genta M.G., Yardley J.H., Pelayo Correa. Classification and grading of gastritis. Am J Surg Pathol. 20:1996;1161.
16. Bradford M.M. A rapid and sensitive method for the quantification of microgram protein utilizing the principle of protein binding. Anal Biochem. 72:1976;248.
17. Mai U.E., Perez-Perez G.I., Whal L.M., Whal S.M., Blaser M.J., Smith P.D. Soluble surface proteins from Helicobacter pylori activate monocytes/macrophages by lypopolisaccharide-indipendent mechanism. J Clin Invest. 87:1991;894.
18. Wilson K.T., Ramanujam K.S., Mobley H.L.T., Musselman R.F., James S.P., Meltzer S.J. Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophages cell line. Gastroenterology. 111:1996;1524.
19. Boughton-Smith N.K., Evans S.M., Hawkey C.J., Cole A.T., Balsitis M., Whittle B.J., Moncada S. Nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet. 342:1993;338.
20. Mahida Y.R., Beltinger J., Makh S., Goke M., Gray T., Podosky D.K., Hawkey C.J. Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and 2. Am J Physiol. 273:1997;G1341.
21. Miller M.J., Sadowska-Krowicka H., Chotinaruemol S., Kakkis J.L., Clark D.A. Amelioration of chronic ileitis by nitric oxide synthase inhibition. J Pharmacol Exp Ther. 264:1993;11.
22. Boughton-Smith N.K., Evans S.M., Whittle B.J., Moncada S. Induction of nitric oxide synthase in rat intestine and its association with tissue injury. Agents and Actions. 38:1993;C125.
23. Miller M.J.S., Thompson J.H., Zhang X.-J., et al. Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology. 109:1995;1475.
24. Beckman J.S., Chen J., Ischiropoulos H., Crow J.P. Oxidative chemistry of peroxynitrite. Methods Enzymol. 233:1994;229.
25. Rautelin H., Blomberg B., Fredlund H., Jarnerot G., Danielsson D. Incidence of Helicobacter pylori strains activating neutrophilis in patients with peptic ulcer disease. Gut. 34:1993;599.
26. Seibert K., Zhang Y., Leahy K., et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci USA. 91:1994;12013.