Wild-type p53 expression overcomes p21-mediated G1 arrest and induces apoptosis in cancer cells expressing Bax

Tumor Research

Volumn 34, Issue , 1999, Pages 69-81

  Nakaya, Uichiro ^a   Yamashita, Toshiharu ^a   Odajima, Tetsuyo ^a   Shindoh, Masanobu ^b   Tokino, Takashi ^a   Fujinaga, Kei ^a,c   Kohama, Geniku ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c TAKARA SHUZO CO LTD   (Japan)

Author keywords

Apoptosis; G1 arrest; p21Waf1 Cip1; p53; Recombinant adenovirus

Indexed keywords

PROTEIN BAX; PROTEIN P21; PROTEIN P53;

ADENOVIRUS; APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOSIS INHIBITION; PROTEIN EXPRESSION; VIRUS RECOMBINANT;

EID: 0033495786     PISSN: 00414093     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Symonds H, Krall L, Remington L, Saenz-Robles M, Lowe S, Jacks T. Van Dyke T, p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell 1994, 78: 703-711.
2. Bates S, Vousden KH, p53 in signaling checkpoint arrest or apoptosis. Curr Opin Genet Dev 1996, 6: 12-18.
3. El-Deiry WS, Harper JW, O' Connor PM, Velculescu VE, Canman CE, Jackman J, Pietenpol JA, Burrell M, Hill DE, Wang Y, Wiman KG, Mercer WE, Kastan MB, Kohn KW, Elledge SJ, Kinzler KW, Vogelstein B. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 1994, 54: 1169-1174.
4. Deng C, Zhang P, Harper JW, Elledge SJ, Leder P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 1995, 82: 675-684.
5. Brugarolas J, Chandrasekaran C, Gordon JI, Beach D, Jacks T, Hannon GJ, Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 1995, 377: 552-557.
6. Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993, 362: 849-852.
7. Clarke AR, Gledhill S, Hooper ML, Bird CC, Wyilie AH. p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. Oncogene 1994, 9: 1767-1773.
8. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993, 362: 847-849
9. Merritt AJ, Potten CS, Kemp CJ, Hickman JA, Balmain A, Lane DP, Hall PA. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res 1994, 54: 614-617.
10. Polyak K, Waldman T, He TC, Kinzler KW, Vogelstein B. Genetic determinants of p53-induced apoptosis and growth arrest. Genes Dev 1996, 10: 1945-1952.
11. Sakai E, Tsuchida N. Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes. Oncogene 1992, 7: 927-933.
12. Bartek J, Iggo R, Gannon J, Lane DP. Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene 1990, 5: 893-899.
13. Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994, 211: 90-98.
14. Takahashi M, Dan Y, Chowdhury NR, Guida J, Horwitz M, Chowdhury JR. Long term correction of bilirubin-UDP-glucuronosyltransferase deficiency in Gunn rats by administration of a recombinant adenovirus during the neonatal period, J Biol Chem 1996, 271: 26536-26542.
15. Ishida S, Yamashita T, Nakaya U, Tokino T, Adenovirus-mediated transfer of p53-related genes induces apoptosis of human cancer cells. Jpn J Cancer Res 2000, 91: 174-180.
16. Yamano S, Tokino T, Yasuda M, Kaneuchi M, Takahashi M, Niitsu Y, Fujinaga K, Yamashita T. Induction of transformation and p53-dependent apoptosis by adenovirus type 5 E4orf6/7 cDNA. J Virol 1999, 73: 10095-10103.
17. Baker SJ, Markowitz S, Fearon ER, Willson JK, Vogelstein B. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 1990, 249: 912-915.
18. van der Eb AJ, Graham FL. Assay of transforming activity of tumor virus DNA. Methods Enzymol 1980, 65: 826-839.
19. Kagawa S, Fujiwara T, Hizuta A, Yasuda T, Zhang WW, Roth JA, Tanaka N. p53 expression overcomes p21WAF1/CIP1-mediated G1 arrest and induces apoptosis in human cancer cells. Oncogene 1997, 15: 1903-1909.
20. Zhang Y, Fujita N, Tsuruo T. Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis. Oncogene 1999, 18: 1131-1138.
21. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transecriptional activator of the human bax gene. Cell 1995, 80: 293-299.
22. Oltvai ZN, Korsmeyer SJ. Checkpoints of dueling dimers foil death wishes. Cell 1994, 79:189-192.
23. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. A model for p53-induced apoptosis. Nature 1997, 389: 300-305.
24. Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR, Kley N. Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature 1995, 377: 646-649.