Brave little yeast, please guide us to Thebes: Sphingolipid function in S. cerevisiae

BioEssays

Volumn 21, Issue 12, 1999, Pages 1004-1010

  Schneiter, Roger ^a  

^a GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; FUNGAL PROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL; MEMBRANE LIPID; SPHINGOLIPID;

CELL MEMBRANE; METABOLISM; PHYSIOLOGY; REVIEW; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

CALCIUM; CELL MEMBRANE; FUNGAL PROTEINS; GLYCOSYLPHOSPHATIDYLINOSITOLS; MEMBRANE LIPIDS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; SPHINGOLIPIDS;

EID: 0033486326     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-1878(199912)22:1<1004::AID-BIES4>3.0.CO;2-Y     Document Type: Review

References (72)

1. Merrill AH, Sweeley CC. Sphingolipids: metabolism and cell signaling. In: Vance DE, Vance JE, editors. Biochemistry of lipids, lipoproteins and membranes. New York: Elsevier Science; 1996 p 309-339.
2. Ichikawa S, Hirabayashi Y. Glucosylceramide synthase and glycosphingolipid synthesis. Trends Cell Biol 1998;8:198-202.
3. Dickson RC. Sphingolipid functions in Saccharomyces cerevisiae: comparison to mammals. Annu Rev Biochem 1998;67:27-48.
4. Daum G, Lees ND, Bard M, Dickson R. Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast 1998;14: 1471-1510.
5. Dickson RC, Lester RL. Yeast sphingolipids. Biochim Biophys Acta 1999;1426:347-357.
6. Buede R, Rinker-Schaffer C, Pinto WJ, Lester RL, Dickson RC. Cloning and characterization of LCB1. a Saccharomyces gene required for biosynthesis of long-chain base components of sphingolipids. J Bacteriol 1991;173:4325-4332.
7. Pinto WJ, Srinivasan B, Shepherd S. Schmidt A, Dickson RC, Lester RL. Sphingolipid long-chain-base auxotrophs of Saccharomyces cerevisiae: genetics physiology and a method for their selection. J Bacteriol 1992;174: 2565-2574.
8. 2+-sensitive yeast mutant (csg2) identify genes involved in sphingolipid biosynthesis. J Biol Chem 1994;269:21480-21488.
9. Nagiec MM, Baltisberger JA, Wells GB, Lester RL, Dickson RC. The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Proc Natl Acad Sci USA 1994;91:7899-7902.
10. Mandon EC, Ehses I, Rother J, van Echten G, Sandhoff K. Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. J Biol Chem 1992;267:11144-11148.
11. Wells GB, Dickson RC, Lester RL. Heat-induced elevation of ceramide in Saccharomyces cerevisiae via de novo synthesis. J Biol Chem 1998;273: 7235-7243.
12. Haak D, Gable K, Beeler T, Dunn T. Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p. J Biol Chem 1997;272: 29704-29710.
13. Grilley MM Stock SD, Dickson RC, Lester RL, Takemoto JY. Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae. J Biol Chem 1998;273:11062-11068.
14. 2+ -sensitive csg2 Delta mutant. J Biol Chem 1998;273:30688-30694.
15. Lester RL, Dickson RC. Sphingolipids with inositolphosphate-containing head groups. Adv Lipid Res 1993;26:253-274.
16. Oh CS, Toke DA, Mandala S, Martin CE. ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene. function in fatty acid elongation and are required for sphingolipid formation. J Biol Chem 1997;272: 17376-17384.
17. Mitchell AG, Martin CE. Fah1p, a Saccharomyces cerevisiae cytochrome b(5) fusion protein, and its Arabidopsis thaliana homolog that lacks the cytochrome b(5) domain both function in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. J Biol Chem 1997;272: 28281-28288.
18. Dunn TM, Haak D, Monaghan E, Beeler TJ Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b(5)-like domain and a hydroxylase/desaturase domain. Yeast 1998;14:311-321.
19. Hashida-Okado T, Ogawa A, Endo M, Yasumoto R, Takesako K, Kato I. AUR1, a novel gene conferring aureobasidin resistance on Saccharomyces cerevisiae: a study of defective morphologies in Aur1p-depleted cells. Mol Gen Genet 1996;251:236-244.
20. Nagiec MM, Nagiec EE, Baltisberger JA, Wells GB, Lester RL. Dickson RC. Sphingolipid synthesis as a target for antifungal drugs - Complementation of the inositol phosphorylceramide synthase defect in strain of Saccharomyces cerevisiae by the AUR1 gene. J Biol Chem 1997;272: 9809-9817.
21. Puoti A, Desponds C, Conzelmann A. Biosynthesis of mannosylinositol-phosphoceramide in Saccharomyces cerevisiae is dependent on genes controlling the flow of secretory vesicles from the endoplasmic reticulum to the Golgi. J Cell Biol 1991;113:515-525.
22. Abeijon C, Orlean P, Bobbins PW, Hirschberg CB. Topography of glycosylation in yeast: characterization of GDP-mannose transport and lumenal guanosine diphosphatase activities in Golgi-like vesicles. Proc Natl Acad Sci USA 1989;86:6935-6939.
23. Abeijon C, Yanagisawa K, Mandon EC, Häusler A, Moremen K, Hirschberg CB, Robbins PW. Guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae. J Cell Biol 1993;122:307-323.
24. 2+ regulation in Saccharomyces cerevisiae. J Biol Chem 1994;269:7279-7284.
25. 2+ tolerance in yeast. Mol Gen Genet 1995;246:269-281.
26. 2+ concentrations at 37 degrees C, is required for mannosylation of inositolphosphorylceramide. Mol Gen Genet 1997;255:570-579.
27. Dickson RC, Naglec EE, Wells GB, Nagiec MM, Lester RL. Synthesis of manrose-(inositol-P)(2)-ceramide, the major sphingolipid in Saccharomyces cerevisiae, requires the IPT1 (YDR072c) gene. J Biol Chem 1997;272: 29620-29625.
28. Patton JL, Lester RL. The phosphoinositol sphingolipids of Saccharomyces cerevisiae are highly localized in the plasma membrane. J Bacteriol 1991;173:3101-3108.
29. Nagiec MM, Skrzypek M, Nagiec EE, Lester RL, Dickson RC. The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. J Biol Chem 1998;273:19437-19442.
30. Lanterman MM, Saba JD. Characterization of sphingosine kinase (SK) activity in Saccharomyces cerevisiae and isolation of SK-deficient mutants. Biochem J 1998;332:525-531.
31. Spiegel S. Sphingosine 1-phosphate: a prototype of a new class of second messengers. J Leukocyte Biol 1999;65:341-344.
32. Saba JD, Nara F, Bielawska A, Garrett S, Hannun YA. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J Biol Chem 1997;272:26087-26090.
33. Oie L, Nagiec MM, Baltisberger JA, Lester RL, Dickson RC. Identification of a Saccharomyces gene, LCB3, Necessary for incorporation of exogenous long chain bases into sphingolipids. J Biol Chem 1997;272:16110-16117.
34. Mao C Wadleigh M, Jenkins GM, Hannun YA, Obeid LM. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphatase. J Biol Chem 1997;272:28690-28694.
35. Mandala SM, Thornton R, Tu Z, Kurtz MB, Nickels J, Broach J, Menzeleev R Spiegel S. Sph ngoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Proc Natl Acad Sci USA 1998;95:150-155.
36. Wu WI, McDonough VM, Nickels JT, Ko JS, Fischl AS, Vales TR, Merrill AH, Carman GM. Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin b-1. J Biol Chem 1995;270:13171-13178.
37. Fishbein JD, Dobrowsky RT, Bielawska A, Garret S, Hannun YA. Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J Biol Chem 1993;268:9255-9261.
38. Nickels JT, Broach JR. A cermide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. Genes Dev 1996;10:382-394.
39. Ella KM, Qi C, Dolan JW, Thompson RR Meier KE. Characterization of a sphingomyelinase activity in Saccharomyces cerevisiae. Arch Biochem Biophys 1997;340:101-110.
40. Cleves AE, McGee TP, Whitters EA, Champion KM, Aitken JR, Dowhan W, Goebl M, Bankaitis VA. Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein. Cell 1991;64:789-800.
41. Sreenivas A, PattonVogt JL, Bruno V, Griac P, Henry SA. A role for phospholipase D (PId1p) in growth, secretion, and regulation of membrane lipid synthesis in yeast. J Biol Chem 1998;273:16635-16638.
42. Xie ZG, Fang M, Rivas MP, Faulkner AJ, Sternweis PC, Engebrecht J, Bankaitis VA. Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects. Proc Natl Acad Sci USA 1998;95:12346-12351.
43. Kearns BG, McGee TP, Mayinger P, Gedvilaite A, Phillips SE, Kagiwada S, Bankaitis VA. Essential role for diacylglycerol in protein transport from the yeast Golgi complex. Nature (London) 1997;387:101-105.
44. Ganong BR, Bell RM. Transmembrane movement of phosphatidylglycerol and diacylglycerol sulfhydryl analogues. Biochemistry 1984;23:4977-4983.
45. Schnetler R, Kohlwein SD. Organelle structure, function, and inheritance in yeast: a role for fatty acid synthesis? Cell 1997;88:431-434.
46. Dickson RC, Wells GB, Schmidt A, Lester RL. Isolation of mutant Saccharomyces cerevisiae strains that survive without spingolipids. Mol. Cell Biol 1990;10:2176-2181.
47. Nagiec MM, Wells GB, Lester RL, Dickson RC. A suppressor gene that enables Saccharomyces cerevisiae to grow without making sphingolipids encodes a protein that resembles an Escherichia coli fatty acyltransferase. J Biol Chem 1993;268:22156-22163.
48. Lester RL, Wells GB, Oxford G, Dickson RC. Mutant strains of Saccharomyces cerevisiae lacking sphingolipids synthesize novel inositol glycerolipids that mimic sphingolipid structure. J Biol Chem 1993;268:845-856.
49. Patton JL, Srinivasan B, Dickson RC, Lester RL. Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae. J Bacteriol 1992; 174:7180-7184.
50. Jenkins GM, Richards A, Wahl T, Mao CG, Obeid L, Hannun Y. Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae. J Biol Chem 1997;272:32566-32572.
51. Dickson RC, Nagiec EE, Skrzypek M, Tillman P, Wells GB, Lester RL. Sphingolipids are potential heat stress signals in Saccharomyces. J Biol Chem 1997;272:30196-30200.
52. Skrzypek MS, Nagiec MM, Lester RL, Dickson RC. Analysis of phosphorylated sphingolipid long-chain bases reveals potential roles in heat stress and growth control in Saccharomyces. J Bacteriol 1999;181:1134-1140.
53. Hannun YA. Functions of ceramide in coordinating cellular responses to stress. Science 1996;274:1855-1859.
54. Skrzypek MS, Nagiec MM, Lester RL, Dickson RC. Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae. J Biol Chem 1998;273:2829-2834.
55. Mandala SM, Thornton RA, Frommer BR, Curotto JE, Rozdilsky W, Kurtz MB, Giacobbe RA, Bills GF, Cabello MA, Martin I, Pelaez F, Harris GH. The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporormiella australis. Producing organism, fermentation, isolation, and biological activity. J Antibiot (Tokyo) 1995;48:349-356.
56. Merrill AH, Liotta DC, Riley RT. Fumonisins: fungal toxins that shed lighten sphingolipid function. Trends Cell Biol 1996;6:218-223.
57. Mandala SM, Thornton RA, Rosenbach M, Milligan J, GarciaCalvo M, Bull HG, Kurtz MB. Khafrefungin, a novel inhibitor of sphingolipid synthesis. J Biol Chem 1997;272:32709-32714.
58. Leber A, Fischer P, Schneiter R, Kohlwein SD, Daum G. The yeast mic2 mutant is defective in the formation of mannosyl-diinositolphosphorylceramide, FEBS Lett 1997;411:211-214.
59. Desfarges L, Durrens P, Juguelin H, Cassagne C, Bonneu M, Aigle M. Yeast mutants affected in viability upon starvation have a modified phospholipid composition. Yeast 1993;9:267-277.
60. Conzelmann A, Puoti A, Lester RL, Desponds C. Two different types of lipid moieties are present in glycophosphoinositol-anchored membrane proteins of Saccharomyces cerevisiae. EMBO J 1992;11:457-466.
61. Sipos G, Reggiori F, Vionnet C, Conzelmann A. Alternative lipid remodelling pathways for glycosylphosphatidylinositol membrane anchors in Saccharomyces cerevisiae. EMBO J 1997;16:3494-3505.
62. Reggiori F, Canivenc-Gansel E, Conzelmann A. Lipid remodeling leads to the introduction and exchange of defined ceramides on GPI proteins in the ER and Golgi of Saccharomyces cerevisiae. EMBO J 1997;16:3506-3518.
63. Reggiori F, Conzelmann A. Biosynthesis of inositol phosphoceramides and remodeling of glycosylphosphatidylinositol anchors in Saccharomyces cerevisiae are mediated by different enzymes. J Biol Chem 1998;273: 30550-30559.
64. Horvath A, Sütterlin C, Manning-Krieg U, Movva NR, Riezman H. Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast. EMBO J 1994;13:3687-3695.
65. Skrzypek M, Lester RL, Dickson RC. Suppressor gene analysis reveals an essential role for sphingolipids in transport of glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae. J Bacteriol 1997;179: 1513-1520.
66. Doering TL, Schekman R. GPI anchor attachment is required for Gas1p transport from the endoplasmic reticulum in COP II vesicles. EMBO J 1996;15:182-191.
67. Sütterlin C, Doering TL, Schimmoller F, Schroder S, Riezman H. Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast. J Cell Sci 1997;110:2703-2714.
68. Schönbächler M, Horvath A, Fassler J, Riezman H. The yeast SPT14 gene is homologous to the human PIG-A gene and is required for GPI anchor synthesis. EMBO J 1995;14:1637-1645.
69. Crouzet M, Urdaci M, Dulau L, Aigle M. Yeast mutant affected for viability upon nutrient starvation: characterization and cloning of the RVS161 gene. Yeast 1991;7:727-743.
70. Munn AL, Stevenson BJ, Geli MI, Riezman H. end5, end6, and end7: Mutations that cause actin delocalization and block receptor mediated internalization of α-factor in Saccharomyces cerevisiae. Mol Biol Cell 1995;6:1721-1742.
71. Sivadon P, Bauer F, Aigle M, Crouzet M. Actin cytoskeleton and budding pattern are altered in the yeast rvs161 mutant: the Rvs161 protein shares common domains with the brain protein amphiphysin. Mol Gen Genet 1995;246:485-495.
72. Gu M, Kerwin JL, Watts JD, Aebersold R. Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry. Anal Biochem 1997;244:347-356.