Structural forms of phenprocoumon and warfarin that are metabolized at the active site of CYP2C9

Archives of Biochemistry and Biophysics

Volumn 372, Issue 1, 1999, Pages 16-28

  He, Minxia ^a   Korzekwa, Kenneth R ^b   Jones, Jeffrey P ^c   Rettie, Allan E ^a   Trager, William F ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

(S) and (R) 2 methoxyphenprocoumon; (S) and (R) 2 methoxywarfarin; (S) and (R) 4 methoxyphenprocoumon; (S) and (R) 4 methoxywarfarin; (S) and (R) phenprocoumon; (S) and (R) warfarin; 9(S) and 9(R) cyclocoumarol; Active site; Anionic binding site; Chromone; CoMFA model; Coumarin; CYP2C9; Electrostatic binding site; Hemiketal; Human liver microsomes; Structural mimics; Tautomers; stacking site

Indexed keywords

ANTICOAGULANT AGENT; COMPLEMENTARY DNA; COUMARIN DERIVATIVE; CYTOCHROME P450; PHENPROCOUMON; SULFAPHENAZOLE; WARFARIN;

ARTICLE; DRUG BINDING SITE; DRUG METABOLISM; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; LIVER MICROSOME; PRIORITY JOURNAL;

EID: 0033485933     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1006/abbi.1999.1468     Document Type: Article

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