Differential impact of substitution of amino acids 9-13 and 91-101 of human CD14 on soluble CD14-dependent activation of cells by lipopolysaccharide

Journal of Immunology

Volumn 163, Issue 11, 1999, Pages 6035-6044

  Stelter, Felix ^a   Loppnow, Harald ^b   Menzel, René ^a   Grunwald, Uwe ^a   Bernheiden, Martin ^a   Jack, Robert S ^a   Ulmer, Artur J ^c   Schütt, Christine ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c RESEARCH CENTER BORSTEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; CD14 ANTIGEN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 6;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; ASTROCYTOMA CELL; CELL ACTIVATION; CHO CELL; CONTROLLED STUDY; DELETION MUTANT; HUMAN; HUMAN CELL; MEMBRANE BINDING; MONONUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ALANINE; ANTIGENS, CD14; ASTROCYTES; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HUMANS; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MUSCLE, SMOOTH, VASCULAR; MUTAGENESIS; PROTEIN BINDING; RESPIRATORY BURST; SEQUENCE DELETION; SIGNAL TRANSDUCTION; SOLUBILITY;

EID: 0033485433     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Pugin, J., D. Heumann, A. Tomasz, V. V. Kravchenko, Y. Akamatsu, M. Nishijima, M. P. Glauser, P. S. Tobias, and R. J. Ulevitch. 1994. CD14 is a pattern recognition receptor. Immunity 1:509.
2. Goyert, S. M., and E. Ferrero. 1987. Biochemical analysis of myeloid antigens and cDNA expression of gp 55 (CD14). In Leukocyte Typing III. A. McMichael, ed. Oxford University Press, Oxford, p. 613.
3. Bazil, V., V. Horejsi, M. Baudys, H. Kristofova, J. L. Strominger, W. Kostka, and I. Hilgert. 1986. Biochemical characterization of a soluble form of the 53-kDa monocyte surface antigen. Eur. J. Immunol. 16:1583.
4. Wright, S. D., R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. C. Mathison. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431.
5. Dentener, M. A., V. Bazil, E. J. von Asmuth, M. Ceska, and W. A. Buurman. 1993. Involvement of CD14 in lipopolysaccharide-induced tumor necrosis factor-α, IL-6 and IL-8 release by human monocytes and alveolar macrophages. J. Immunol. 150:2885.
6. Couturier, C., G. Jahns, M. D. Kazatchkine, and N. Haeffner-Cavaillon. 1992. Membrane molecules which trigger the production of interleukin-1 and tumor necrosis factor-α by lipopolysaccharide-stimulated human monocytes. Eur. J. Immunol. 22:1461.
7. Haziot, A., E. Ferrero, F. Kontgen, N. Hijiya, S. Yamamoto, J. Silver, C. L. Stewart, and S. M. Goyert. 1996. Resistance to endotoxin shock and reduced dissemination of Gram-negative bacteria in CD14-deficient mice. Immunity 4:407.
8. Frey, E. A., D. S. Miller, T. Gullstein Jahr, A. Sundan, V. Bazil, T. Espevik, B. B. Finlay, and S. D. Wright. 1992. Soluble CD14 participates in the response of cells to lipopolysaccharide. J. Exp. Med. 176:1665.
9. Pugin, J., C .C. Schürer-Maly, D. Leturcq, A. Moriarty, R. J. Ulevitch, and P. S. Tobias. 1993. Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc. Natl. Acad. Sci. USA 90:2744.
10. Read, M. A., S. R. Cordle, R. A. Veach, C. D. Carlisle, and J. Hawiger. 1993. Cell-free pool of CD14 mediates activation of transcription factor NF-κB by lipopolysaccharide in human endothelial cells. Proc. Natl. Acad. Sci. USA 90: 9887.
11. Haziot, A., G. W. Rong, J. Silver, and S. M. Goyert. 1993. Recombinant soluble CD14 mediates the activation of endothelial cells by lipopolysaccharide. J. Immunol. 151:1500.
12. Loppnow, H., F. Stetler, U. Schönbeck, C. Schlüter, M. Ernst, C. Schütt, and H.-D. Flad. 1995. Endotoxin activates human smooth muscle cells despite lack of expression of CD14 mRNA or endogenous membrane CD14. Infect. Immun. 63:1020.
13. Duchow, J., A. Marchant, A. Crusiaux, C. Husson, C. Alonso-Vega, D. De-Groote, P. Neve, M. Goldman. 1993. Impaired phagocyte responses to lipopolysaccharide in paroxysmal nocturnal hemoglobinuria. Infect. Immun. 61: 4280.
14. Sundan, A., L. Ryan, L. Brinch, T. Espevik, and A. Waage. 1995. The involvement of CD14 in stimulation of TNF production from peripheral mononuclear cells isolated from PNH patients. Scand. J. Immunol. 41:603.
15. Schütt, C., T. Schilling, U. Grunwald, F. Stelter, S. Witt, C. Krüger, and R. S. Jack. 1995. Human monocytes lacking the membrane- bound form of the bacterial lipopolysaccharide (LPS) receptor CD14 can mount an LPS-induced oxidative burst response mediated by a soluble form of CD14. Res. Immunol. 146:339.
16. Hailman, E., T. Vasselon, M. Kelley, L. A. Busse, M. C. Hu, H. S. Lichenstein, P. A. Detmers, and S. D. Wright. 1996. Stimulation of macrophages and neutrophils by complexes of lipopolysaccharide and soluble CD14. J. Immunol. 156: 4384.
17. Blondin, C., A. Le Dur, B. Cholley, M. Caroff, and N. Haeffner-Cavaillon. 1997. Lipopolysaccharide complexed with soluble CD14 binds to normal human monocytes. Eur. J. Immunol. 27:3303.
18. Schletter, J., H. Brade, L. Brade, C. Krüger, H. Loppnow, S. Kusumoto, E. T. Rietschel, H.-D. Flad, and A. J. Ulmer. 1995. Binding of lipopolysaccharide (LPS) to an 80-kilodalton membrane protein of human cells is mediated by soluble CD14 and LPS-binding protein. Infect. Immun. 63:2576.
19. El-Samalouti, V. T., J. Schletter, I. Chyla, A. Lentschat, U. Mamat, L. Brade, H.-D. Flad, A. J. Ulmer, and L. Hamann. 1999. Identification of the 80 kDa LPS-binding protein (LMP80) as decay accelerating factor (DAF, CD55). FEMS Immunol. Med. Microbiol. 23:259.
20. Zarewych, D. M., A. L. Kindzelskii, R. F. Todd, 3rd, and H. R. Petty. 1996. LPS induces CD14 association with complement receptor type 3, which is reversed by neutrophil adhesion. J. Immunol. 156:430.
21. Ingalls, R. R., M. A. Arnaout, and D. T. Golenbock. 1997. Outside-in signaling by lipopolysaccharide through a tailless integrin. J. Immunol. 159:433.
22. Vita, N., S. Lefort, P. Sozzani, R. Reeb, S. Richards, L. K. Borysiewicz, P. Ferrara, and M. O. Labeta. 1997. Detection and biochemical characteristics of the receptor for complexes of soluble CD14 and bacterial lipopolysaccharide. J. Immunol. 158:3457.
23. Yang, R. B., M. R. Mark, A. Gray, A. Huang, M. H. Xie, M. Zhang, A. Goddard, W. I. Wood, A. L. Gurney, and P. J. Godowski. 1998. Toll-like receptor-2 mediates lipopolysaccharide induced cellular signalling. Nature 395:284.
24. Kirschning, C. J., H. Wesche, T. Merrill Ayres, and M. Rothe. 1998. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J. Exp. Med. 188:2091.
25. Poltorak, A., X. He, I. Smirnova, M. Y. Liu, C. V. Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, B. Ricciardi-Castagnoli, B. Layton, and B. Beutler. 1998. Defective LPS signaling in C3H/HeJ and C57 BL/10ScCr mice: mutations in TLR4 gene. Science 282:2085.
26. Qureshi, S. T., L. Larivière, G. Leveque, S. Clermont, K. J. Moore, P. Gros, and D. Malo. 1999. Endotoxin-tolerant mice have mutations in toll-like receptor 4 (Tlr4). J. Exp. Med. 189:615.
27. Joseph, C. K., S. D. Wright, W. G. Bornmann, J. T. Randolph, E. R. Kumar, R. Bittman, J. Liu, and R. N. Kolesnick. 1994. Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells. J. Biol. Chem. 269:17606.
28. Juan, T. S. C., M. J. Kelley, D. A. Johnson, L. A. Busse, E. Hailman, S. D. Wright, and H. S. Lichenstein. 1995. Soluble CD14 truncated at amino acid 152 binds lipopolysaccharide (LPS) and enables cellular response to LPS. J. Biol. Chem. 270:1382.
29. McGinley, M. D., L. O. Narhi, M. J. Kelley, E. Davy, J. Robinson, M. F. Rohde, S. D. Wright, and H. S. Lichenstein. 1995. CD14: physical properties and identification of an exposed site that is protected by lipopolysaccharide. J. Biol. Chem. 270:5213.
30. Juan, T. S. C., E. Hailman, M. J. Kelley, L. A. Busse, E. Davy, C. J. Empig, L. O. Narhi, S. D. Wright, and H. S. Lichenstein. 1995. Identification of a lipopolysaccharide binding domain in CD14 between amino acids 57 and 64. J. Biol. Chem. 270:5219.
31. Juan, T. S. C., E. Hailman, M. J. Kelley, S. D. Wright, and H. S. Lichenstein. 1995. Identification of a domain in soluble CD14 essential for lipopolysaccharide (LPS) signaling but not LPS binding. J. Biol. Chem. 270:17237.
32. Steiler, F., M. Bernheiden, R. Menzel, R. S. Jack, S. Win, X. Fan, M. Pfister, and C. Schütt. 1997. Mutation of amino acids 39-44 of human CD14 abrogates binding of lipopolysaccharide and Escherichia coli. Eur. J. Biochem. 243:100.
33. Kitchens, R. L., and R. S. Munford. 1995. Enzymatically deacylated lipopolysaccharide (LPS) can antagonize LPS at multiple sites in the LPS recognition pathway. J. Biol. Chem. 270:9904.
34. Bufler, P., G. Stiegler, M. Schuchmann, S. Hess, C. Krüger, F. Stelter, C. Schütt, C. Eckershom, and H. Engelmann. 1995. Soluble LPS receptor (CD14) is released via two different mechanisms from human monocytes and CD14 transfectants. Eur. J. Immunol. 25:604.
35. Ross, R., and B. Kariya. Morphogenesis of vascular smooth muscle in atherosclerosis and cell structure. 1980. In Handbook of Physiology: The Cardiovascular System, Section 2. D. F. Bohr, A. P. Somlyo, and H. Y. Sparks, eds. American Physiological Society, Bethesda, MD, p. 66.
36. Loppnow, H., R. Bil, S. Hirt, U. Schönbeck, M. Herzberg, E. T. Rietschel, E. Brandt, and H. D. Flad. 1998. Platelet-derived interleukin-1 induces cytokine production, but not proliferation of human vascular smooth muscle cells. Blood 91:134.
37. 2-terminal amino acid sequence of a T-cell derived lymphokine with growth factor activity for B-cell hybridomas. Proc. Natl. Acad. Sci. USA 83:9679.
38. Kirkland, T. N., F. Finley, D. Leturcq, A. Moriarty, J. D. Lee, R. J. Ulevitch, and P. S. Tobias. 1993. Analysis of lipopolysaccharide binding by CD14. J. Biol. Chem. 268:24818.
39. Haziot, A., I. Katz, G. W. Rong, X. Y. Lin, J. Silver, and S. M. Goyert. 1997. Evidence that the receptor for soluble CD14:LPS complexes may not be the putative signal-transducing molecule associated with membrane-bound CD14. Scand. J. Immunol. 46:242.
40. Cunningham, M. D., C. Seachord, K. Ratcliffe, B. Bainbridge, A. Aruffo, and R. P. Darveau. 1996. Helicobacter pylori and Porphyromonas gingivalis lipopolysaccharides are poorly transferred to recombinant soluble CD14. Infect. Immun. 64:3601.
41. Shapiro, R. A., M. D. Cunningham, K. Ratcliffe, C. Seachord, J. Blake, J. Bajorath, A. Aruffo, and R. P. Darveau. 1997. Identification of CD14 residues involved in specific lipopolysaccharide recognition. Infect. Immun. 65:293.
42. Cunningham, M. D., J. Bajorath, J. E. Somerville, and R. P. Darveau. 1999. Escherichia coli and Porphyromonas gingivalis lipopolysaccharide interactions with CD14: implications for myeloid and nonmyeloid cell activation. Clin. Infect. Dis. 28:497.
43. Loppnow, H., and P. Libby. 1990. Proliferating or interleukin 1-activated human vascular smooth muscle cells secrete copious interleukin 6. J. Clin. Invest. 85: 731.
44. Loppnow, H., K. Werdan, G. Reuter, and H.-D. Flad. 1998. The interleukin-1 and interleukin-1 converting enzyme families in the cardiovascular system. Eur. Cytokine Netw. 9:675.
45. Haziot, A., G. W. Rong, X. L. Lin, J. Silver, and S. M. Goyert. 1995. Recombinant soluble CD14 prevents mortality in mice treated with endotoxin (lipopolysaccharide). J. Immunol. 154:6529.
46. Stelter, F., S. Witt, B. Fürll, R. S. Jack, T. Hartung, and C. Schütt. 1998. Different efficacy of soluble CD14-treatmem in high and low dose LPS-models. Eur. J. Clin. Invest. 28:205.