Real-time breath analysis of vapor phase uptake of 1,1,1 trichloroethane through the forearm: Implications for daily absorbed dose of volatile organic compounds at work

Applied Occupational and Environmental Hygiene

Volumn 14, Issue 11, 1999, Pages 719-727

  Giardino, Nicholas J ^a   Gordon, Sydney M ^b   Brinkman, Marielle C ^b   Callahan, Patrick J ^b   Kenny, Donald V ^b  

^a USAF   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1,1 TRICHLOROETHANE; VOLATILE ORGANIC COMPOUND;

ABSORPTION; ADULT; ARTICLE; BREATH ANALYSIS; FEMALE; FOREARM; HUMAN; HUMAN EXPERIMENT; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; VAPOR;

ADULT; AIR POLLUTANTS, OCCUPATIONAL; BREATH TESTS; FEMALE; HUMANS; LINEAR MODELS; MALE; ORGANIC CHEMICALS; SKIN ABSORPTION; SOLVENTS; TRICHLOROETHANES; UNITED STATES;

EID: 0033454091     PISSN: 1047322X     EISSN: None     Source Type: Journal    
DOI: 10.1080/104732299302116     Document Type: Note

References (34)

1. Grandjean, P.: Skin Penetration: Hazardous Chemicals at Work. Taylor & Francis, London (1990).
2. Jepson, G.W.; McDougal, J.N.: Physiologically Based Modeling of Nonsteady State Dermal Absorption of Halogenated Methanes from an Aqueous Solution. Toxicol Appl Pharmacol 144:315–324 (1997).
3. Riihimaki, V.; Pfaffli, P.: Percutaneous Absorption of Solvent Vapors in Man. Scand J Work Environ Health 4:73–85 (1978).
4. McDougal, J.N.; Jepson, G.W.; Clewell, H.J., III, et al.: A Physiologically Based Pharmacokinetic Model for Dermal Absorption of Vapors in the Rat. Toxicol Appl Pharmacol 85:286–294 (1986).
5. McDougal, J.N.; Jepson, G.W.; Clewell, H.J., III, et al.: Dermal Absorption of Organic Chemical Vapors in Rats and Humans. Fundam Appl Toxicol 14:299-308 (1990).
6. Corley, R.A.; Markham, D.A.; Banks, C., et al.: Physiologically Based Pharmacokinetics and the Dermal Absorption of 2-Butoxyethanol Vapor by Humans. FundamAppl Toxicol 39:120–130 (1997).
7. Johanson, G.; Boman, A.: Percutaneous Absorption of 2-Butoxyethanol Vapour in Human Subjects. Brit J Ind Med 48:788–792 (1991).
8. Brooke, I.; Cocker, J.; Delic, J.I., et al.: Dermal Uptake of Solvents from the Vapour Phase: An Experimental Study in Humans. Ann Occup Hyg 42:531–540 (1998).
9. Wallace, L.A.; Buckley, T.; Pellizzari, E., et al.: Breath Measurements as Volatile Organic Compound Biomarkers. Environ Health Perspect 104 (Suppl. 5):861-869 (1996).
10. Weisel, C.P.; Jo, W.K.; Lioy, P.J.: Utilization of Breath Analysis for Exposure and Dose Estimates of Chloroform. J Expos Anal Environ Epidemiol Suppl 1:55–69 (1992).
11. Raymer, J.H.; Pellizzari, E.D.; Thomas, K.W., et al.: Elimination of Volatile Organic Compounds in Breath After Exposure to Occupational and Environmental Microenvironments. J Expos Anal Environ Epidemiol 1:439–451 (1991).
12. Gordon, S.M.; Kenny, D.V.; Kelly, T.J.: Continuous Real Time Breath Analysis for the Measurement of Half Lives of Expired Volatile Organic Compounds. J Expos Anal Environ Epidemiol Suppl 1:41–54 (1992).
13. Wallace, L.A.; Pellizzari, E.D.; Gordon, S.M.: A Linear Model Relating Breath Concentrations to Environmental Exposures: Application to a Chamber Study of Four Volunteers Exposed to Volatile Organic Chemicals. J Expos Anal Environ Epidemiol 3:75–102 (1993).
14. Gordon, S.M.; Wallace, L.A.; Callahan, P.J., et al.: Effect of Water Temperature on Dermal Exposure to Chloroform. Environ Health Perspect 106:337–345 (1998).
15. Jo, W.K.; Weisel, C.P.; Lioy, P.J.: Routes of Chloroform Exposure and Body Burden from Showering with Contaminated Tap Water. Risk Anal 10:575–580 (1990).
16. Andelman, J.B.: Human Exposures to Volatile Halogenated Organic Chemicals in Indoor and Outdoor Air. Environ Health Perspect 62:313–318 (1985).
17. Weisel, C.P.; Jo, W.K.: Ingestion, Inhalation, and Dermal Exposures to Chloroform and Trichloroethene from Tap Water. Environ Health Perspect 104:48–51 (1996).
18. Wester, R.C.; Maibach, H.I.: Percutaneous Absorption of Chemicals fromWater Simulating Swimming and Bathing and from Vapor Exposure. In: Environ. Sci. Pollut. Control Ser. 9 (Water Contamination and Health), pp. 149–165 (1994).
19. Wilkes, C.R.; Small, M.J.; Davidson, C.I., et al.: Modeling the Effects of Water Usage and Co-Behavior on Inhalation Exposures to Contaminants Volatilized from Household Water. J Expos Anal Environ Epidemiol 6:393-412 (1996).
20. Giardino, N.J.; Wireman, J.R.: Total Body Burden from Inhalation During Showering with Benzene-Contaminated Drinking Water: Implications for Cancer Risk. J Haz Mat 62:35–40 (1998).
21. Giardino, N.J.; Andelman, J.B.: Characterization of the Emissions of Trichloroethylene, Chloroform, and 1,2- Dibromo-3-chloropropane in a Full- Size, Experimental Shower. J Expos Anal Environ Epidemiol 6:413–423 (1996).
22. Cox, L.A.: Simple Relations Between Administered and Internal Doses in Compartmental FlowModels. Risk Anal 15:197–204 (1995).
23. Meuling, W.J.; Franssen, A.C.; Brouwer, D.H., et al.: The Influence of Skin Moisture on the Dermal Absorption of Propoxur in Human Volunteers: A Consideration for Biological Monitoring Practices. Sci Total Environ 199:165-172 (1997).
24. Kelly, T.J.; Kenny, D.V.; Spicer, C.W., et al.: Continuous Analysis of Human Breath Using Atmospheric Pressure Ionization MS/MS with a Novel Inlet Design. In: Proceedings of the 1989 U.S. EPA/A&WMA International Symposium on Measurement of Toxic and Related Air Pollutants, pp. 478–483. VIP-13, Air & Waste Management Association, Pittsburgh (1989); U.S. Patent 5,042,501, August 27, 1991.
25. McLuckey, S.A.; Glish, G.L.; Asano, K.G., et al.: Atmospheric Sampling Glow Discharge Ionization Source for the Determination of Trace Organic Compounds in Ambient Air. Anal Chem 60:2220–2227 (1988).
26. McLuckey, S.A.; Glish, G.L.; Asano, K.G.: The Coupling of an Atmospheric Sampling Ion Source with an Ion Trap Mass Spectrometer. Anal Chim Acta 225:25–35 (1989).
27. Asano, K.G.; McLuckey, S.A.; Glish, G.L.: Comparison of Atmospheric Sampling Glow Discharge Ionization with Electron Ionization. Spectroscopy 8:191–209 (1990).
28. Gordon, S.M.; Callahan, P.J.; Kenny, D.V., et al.: Direct Trace Analysis of Volatile Organic Compounds in Air Using Ion Trap Mass Spectrometers with Filtered Noise Fields. In: Proceedings of the 1995 EPA/A&WMA International Symposiumon Field Screening Methods for HazardousWastes and Toxic Chemicals, Vol. 1, pp. 670–679. VIP-47; Air & Waste Management Association, Pittsburgh (1995).
29. Kenny, D.V.; Callahan, P.J.; Gordon, S.M., et al.: Simultaneous Isolation of Two Different m/z Ions in an Ion Trap Mass Spectrometer and Their Tandem Mass Spectra Using Filtered Noise Fields. Rapid Commun Mass Spectrom 7:1086–1089 (1993).
30. Winberry Jr., W.T.; Murphy, N.T.; Riggin, R.M.: Methods for Determination of Toxic OrganicCompounds in Air: EPA Methods. Noyes Data Corporation, Park Ridge, NJ (1990).
31. Sato, A.; Nakajima, T.: Pharmacokinetics of Organic Solvent Vapors in Relation to Their Toxicity. Scand J Work Environ Health 13:81–93 (1987).
32. Gargas, M.L.; Burgess, R.J.; Voisard, D.E., et al.: Partition Coefficients of Low-Molecular-Weight Volatile Chemicals in Various Liquids and Tissues. Toxicol Appl Pharmacol 98:87–99 (1989).
33. Lindstrom, A.B.; Pleil, J.D.: A Methodological Approach for Exposure Assessment Studies in Residences Using Volatile Organic Compound—Contaminated Water. J Air &Waste Manage Assoc 46:1058–1066 (1996).
34. Wallace, L.A.; Nelson, W.C.; Pellizzari, E.D., et al.: Uptake and Decay of Volatile Organic Compounds at Environmental Concentrations: Application of a Four-Compartment Model to a Chamber Study of Five Human Subjects. J Expos Anal Environ Epidemiol 7:141–163 (1997).