Growth hormone, insulin-like growth factor I and sex hormones: Effects on protein and calcium metabolism

Acta Paediatrica, International Journal of Paediatrics, Supplement

Volumn 88, Issue 433, 1999, Pages 81-83

  Mauras, N ^a  

^a NEMOURS CHILDREN S CLINIC   (United States)

Author keywords

Anabolic; Androgen; Calcium flux; Growth hormone; Insulin like growth factor I; Lipolysis; Oestrogen; Testosterone

Indexed keywords

CALCIUM; ESTROGEN; GROWTH HORMONE; M PROTEIN; SEX HORMONE; SOMATOMEDIN C; TESTOSTERONE;

ADOLESCENCE; BONE GROWTH; BONE METABOLISM; CALCIUM ABSORPTION; CALCIUM BONE LEVEL; CALCIUM METABOLISM; CHILD GROWTH; CHILDHOOD; CONFERENCE PAPER; HORMONAL REGULATION; HORMONE RECEPTOR INTERACTION; HORMONE RELEASE; LIPOLYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS;

ADULT; ANIMALS; BONE AND BONES; CALCIUM; CHILD; ESTROGENS; GONADAL STEROID HORMONES; GROWTH SUBSTANCES; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LIPOLYSIS;

EID: 0033452844     PISSN: 08035326     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (29)

1. Mauras N, Blizzard RM, Link K, Johnson ML, Rogol AD, Veldhuis JD. Augmentation of growth hormone secretion during puberty: evidence for a pulse amplitude-modulated phenomenon. J Clin Endocrinol Metab 1987; 64: 596-601
2. Martha PM Jr, Rogol AD, Veldhuis JD, Kerrigan JR, Goodman DW, Blizzard RM. Alterations in the pulsatile properties of circulating growth hormone concentrations during puberty in boys. J Clin Endocrinol Metab 1989; 69: 563-70
3. Mauras N, Haymond MW, Darmaun D, Vieira NE, Abrams SA, Yergey AL. Calcium and protein kinetics in prepubertal boys. Positive effects of testosterone. J Clin Invest 1994; 93: 1014-19
4. Mauras N, Rogol AD, Veldhuis JD. Specific time-dependent actions of low-dose ethinyl estradiol administration on the episodic release of GH, FSH and LH in prepubertal girls with Turner's Syndrome. J Clin Endocrinol Metab 1989; 69: 153-8
5. Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 1998; 19: 717-97
6. Metzger DL, Kerrigan JR. Oestrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous oestrogens during male adolescence. J Clin Endocrinol Metab 1994; 79: 513-8
7. Roemmich JN, Clark PA, Berr SS, Mai V, Mantzoros CS, Flier JS, et al. Gender differences in leptin levels during puberty are related to the subcutaneous fat depot and sex steroids. Am J Physiol 1998; 275: E543-51
8. Cunningham BC, Ultsch M, De Vos AM, Mulkerrin MG, Clauser KR, Wells JA. Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science 1991; 254: 821-5
9. Horber FF, Haymond MW. Human growth hormone prevents the protein catabolic side effects of prednisone in humans. J Clin Invest 1990; 86: 265-72
10. Mauras N, Beaufrere B. rhIGF-I enhances whole body protein anabolism and significantly diminishes the protein-catabolic effects of prednisone in humans, without a diabetogenic effect. J Clin Endocrinol Metab 1995; 80: 869-74
11. Kupfer SR, Underwood LE, Baxter RC, Clemmons DR. Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously. J Clin Invest 1993; 91: 391-6
12. Mauras N. Combined rhGH and rhIGF-I: lack of synergy on whole body protein anabolism in normally fed subjects. J Clin Endocrinol Metab 1995; 80: 2633-7
13. DiGirolamo M, Eden S, Enberg G, Isaksson O, Lonnroth P, Hall K, et al. Specific binding of human GH but not insulin-like growth factors by human adipocytes. FEBS Lett 1986; 205: 15- 19
14. 2-adrenoreceptors: the regulation of fat cell function and lipolysis. Endocr Rev 1995; 16: 716-38
15. Drake WM, Coyte D, Camacho-Hubner C, Jivanji NM, Kaltsas G, Wood DF, et al. Optimizing growth hormone replacement therapy by dose titration in hypopituitary adults. J Clin Endocrinol Metab 1998; 83: 3913-19
16. Burman P, Johansson AG, Siegbahn A, Vessby B, Karlsson FA. Growth hormone deficient men are more responsive to GH replacement therapy than women. J Clin Endocrinol Metab 1997; 82: 550-5
17. Yang S, Xu X, Bjorntorp P, Eden S. Additive effects of growth hormone and testosterone on lipolysis in adipocytes of hypophysectomized rats. J Endocrinol 1995; 147: 147-52
18. Mauras N, Hayes V, Welch S, Rini A, Helgeson K, Dokler M, et al. Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength and adiposity. J Clin Endocrinol Metab 1998; 83: 1886-92
19. Mauras N. Oestrogens do not affect whole body protein metabolism in the prepubertal female. J Clin Endocrinol Metab 1995; 80: 2842-5
20. Mauras N, Hayes VY, Oerter Klein K. Oestrogen suppression in males: metabolic effects. Pediatr Res 1999; 45: 543 (abstract)
21. Mauras N. Additive effects of GH and testosterone on the anabolic changes of puberty: a metabolic study. Pediatr Res 1998; 43: A459 (abstract)
22. Mauras N, Hayes VY, Vieira NE, Yergey AL, O'Brien KO. Profound hypogonadism has significant negative effects on calcium balance in males: a calcium kinetic study. J Bone Miner Res 1999; 14: 577-82
23. Mauras N, Vieira NE, Yergey AL. Oestrogen therapy enhances calcium absorption and retention and diminishes bone turnover in young girls with Turner's syndrome: a calcium kinetic study. Metabolism 1997; 46: 908-13
24. Bunt JC, Going SB, Lohman TG, Heinrich CH, Petty CD, Pamenter RW. Variation in bone mineral content and estimated body fat in young adult females. Med Sci Sports Exercise 1990; 22: 564-9
25. Buchanan JR, Lloyd T, Myers C, Leuenberger P, Demers LM. Determinants of peak trabecular bone mass in women: the roles of androgen, oestrogen and exercise. J Bone Miner Res 1988; 3: 673-80
26. Abrams SA, O'Brien KO, Stuff JE. Changes in calcium kinetics associated with menarche. J Clin Endocrinol Metab 1996; 81: 2017-20
27. Wakley GK, Schutte HD Jr, Hannon KS, Turner RT. Androgen treatment prevents loss of cancellous bone in the orchidectomized rat. J Bone Miner Res 1991; 6: 325-30
28. Goulding A, Gold E. Flutamide-mediated androgen blockade evokes osteopenia in the female rat. J Bone Miner Res 1993; 8: 763-9
29. Vanderschueren D, Bouillon R. Androgens and bone. Calcif Tissue Int 1995; 56: 341-6