Profound hypogonadism has significant negative effects on calcium balance in males: A calcium kinetic study

Journal of Bone and Mineral Research

Volumn 14, Issue 4, 1999, Pages 577-582

  Mauras, Nelly ^a   Hayes, Valerie Y ^a   Vieira, Nancy E ^b   Yergey, Alfred L ^b   O'Brien, Kimberly O ^c  

^a NEMOURS CHILDREN S CLINIC   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; CALCIUM; SOMATOMEDIN C;

ADULT; ARTICLE; BODY MASS; BONE MASS; BONE MINERAL; BONE MINERALIZATION; CALCIFICATION; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; DISEASE ASSOCIATION; HORMONAL REGULATION; HUMAN; HUMAN EXPERIMENT; HYPOGONADISM; MALE; NORMAL HUMAN; OSTEOPOROSIS;

EID: 0033034860     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1999.14.4.577     Document Type: Article

References (31)

1. Buchanan JR, Lloyd T, Myers C, Leuenberger P, Demers LM 1988 Determinants of peak trabecular bone mass in women: The roles of androgen, estrogen and exercise. J Bone Miner Res 3:673-680.
2. Bunt JC, Going SB, Lohman TG, Heinrich CH, Perry CD, Pamenter RW 1990 Variation in bone mineral content and estimated body fat in young adult females. Med Sci Sports Exerc 22:564-569.
3. Rico H, Revilla M, Gonzalez-Riola J, Villa LF, Alvarez de Buergo M 1993 Bone mineral content and anthropometric variables in men: A cross-sectional study in 324 normal subjects. Clin Rheumatol 12:485-489.
4. Matkovic V, Jelic T, Wardlaw GM, Ilich JZ, Goel PK, Wright JK, Andon MB, Smith KT, Heaney RP 1994 Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis: Inference from a cross-sectional model. J Clin Invest 93:799-808.
5. Gilbanz V, Gibbens DT, Roe TF, Carlson M, Senac MO, Boechat MI, Huang HK, Schulz EE, Libanati CR, Can CE 1988 Vertebral bone density in children: Effect of puberty. Radiology 166:847-850.
6. Bonjour JP, Theintz G, Buchs B, Slosman D, Roberts CT Jr 1991 Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab 73:555-563.
7. Orwoll ES, Klein RF 1995 Osteoporosis in men. Endocr Rev 16:87-116.
8. Finkelstein JS, Klibanski A, Neer RM 1996 A longitudinal evaluation of bone mineral density in adult men with histories of delayed puberty. J Clin Endocrinol Metab 81:1152-1155.
9. Colvard DS, Eriksen EF, Keeting PE, Wilson EM, Lubahu DB, French FS, Riggs BL, Spelsberg TC 1989 Identification of androgen receptors in normal human osteoblast-like cells. Proc Natl Acad Sci USA 86:854-857.
10. Vanderchuersen D, Bouillion R 1995 Androgens and bone. Calcif Tissue Int 56:341-346.
11. Mauras N, Rogol AD, Haymond MW, Veldhuis JD 1995 Sex steroid, growth hormone, IGF-I: Neuroendocrine and metabolic regulation in puberty. Horm Res 45:74-80.
12. Mauras N, Blizzard RM, Link K, Johnson ML, Rogol AD, Veldhuis JD 1987 Augmentation of growth hormone secretion during puberty: Evidence for a pulse amplitude-modulated phenomenon. J Clin Endocrinol Metab 64:596-601.
13. Martha PM Jr, Gorman KM, Blizzard RM, Rogol AD, Veldhuis JD 1992 Endogenous growth hormone secretion and clearance rates in normal boys, as determined by deconvolution analysis: Relationship to age, pubertal status, and body mass. J Clin Endocrinol Metab 74:336-344.
14. Mauras N, Haymond MW, Darmaun D, Vieira NE, Abrams SA, Yergey AL 1994 Calcium and protein kinetics in prepubertal boys: Positive effects of testosterone. J Clin Invest 93:1014-1019.
15. Mauras N, Hayes V, Welch S, Rini A, Helgeson K, Dokler M, Veldhuis JD, Urban RJ 1998 Testosterone deficiency in young men: Marked alterations in whole body protein kinetics, strength and adiposity. J Clin Endocrinol Metab 83:1886-1892.
16. Yergey AL, Abrams SA, Vieira NE, Eastell R, Hillman LS, Covell DG 1990 Recent studies of human calcium metabolism using stable isotope tracers. Can J Physiol Pharmacol 68:973-976.
17. Klein KO, Baron J, Collin MJ, McDonnell DP, Cutler GB Jr 1994 Estrogen levels in childhood measure by a recombinant cell bioassay. J Clin Invest 94:2475-2480.
18. Abrams SA, Esteban NV, Vieira NE, Sidbury JB, Specker BL, Yergey AL1992 Developmental changes in calcium kinetics in children assessed using stable isotopes. J Bone Miner Res 7:287-293.
19. Abrams SA, Esteban NV, Vieira NE, Yergey AL 1991 Dual tracer stable isotopic assessment of calcium absorption and endogenous fecal excretion in low birth weight infants. Pediatr Res 29:615-618.
20. Neer R, Berman N, Fisher L, Rosenberg R 1967 Multicompartmental analysis of calcium kinetics in normal adult males. J Clin Invest 46:1364-1379.
21. Berman M, Weissberger AJ 1990 SAAM Manual (Simulation, Analysis and Modeling). National Institutes of Health Bethesda, MD, U.S.A.
22. Arisaka O, Arisaka M, Nakayama Y, Fujiwara S, Yabuta K 1995 Effect of testosterone on bone density and bone metabolism in adolescent male hypogonadism. Metabolism 44:419-423.
23. Leifke E, Körner HC, Link TM, Berhre HM, Peters PE, Nieschlag E 1998 Effects of testosterone replacement therapy on cortical and trabecular bone mineral density, vertebral body area and paraspinal muscle area in hypogonadal men. Eur J Endocrinol 138:51-58.
24. Stepan JJ, Lachman M 1989 Castrated men with bone loss: Effects of calcitonin treatment on biochemical indices of bone remodeling. J Clin Endocrinol Metab 69:523-527.
25. Francis RM, Peacock M 1986 Osteoporosis in hypogonadal men: Role of decreased plasma 1,25 dihydroxyvitamin D, calcium malabsorption, and low bone formation. Bone 7:261-268.
26. Orwoll ES 1996 Androgens as anabolic agents for bone. Trends Endocrinol Metab 7:77-84.
27. 3 actions in LNCaP human prostate cancer cells are androgen-dependent. Endocrinology 138:3290-3298.
28. 3) to stimulate human osteoblastic cell differentiation. Life Sci 62:59-68.
29. Hagenfeldt Y, Linde K, Sjöberg HE, Zumkeller W, Arver S 1992 Testosterone increases serum 1,25-dihydroxyvitamin D and insulin-like growth factor-I in hypogonadal men. Int J Androl 15:93-102.
30. Wakley GK, Schutte HD, Hannon KS, Turner RT 1991 Androgen treatment prevents loss of cancellous bone in orchidectomized rat. J Bone Miner Res 6:325-330.
31. Goulding A, Gold E 1993 Flutamide-mediated androgen blockade evokes osteopenia in the female rat. J Bone Miner Res 8:763-769.