Activation of a 36-kD MBP kinase, an active proteolytic fragment of MST/Krs proteins, during anticancer drug-induced apoptosis

Annals of the New York Academy of Sciences

Volumn 886, Issue , 1999, Pages 273-275

  Kakeya, Hideaki ^a   Onose, Rie ^a   Osada, Hiroyuki ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOTRIENIN A; MYELIN BASIC PROTEIN; PHOSPHOTRANSFERASE; PROTEIN; PROTEIN MST KRS; UNCLASSIFIED DRUG;

APOPTOSIS; CELL STRAIN HL 60; CONFERENCE PAPER; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PROTEIN DEGRADATION; STRUCTURE ACTIVITY RELATION;

EID: 0033404247     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb09434.x     Document Type: Conference Paper

References (12)

1. 1. Nagata, S. 1997. Apoptosis by death factor. Cell 88: 355-365.
2. 2. Nicholson, D.W. et al. 1997. Caspases: Killer proteases. Trends Biochem. Sci. 22: 299-306.
3. 3. Kakeya, H, et al. 1997. Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells. J. Antibiot. 50: 370-372.
4. 4. Zhang, H.-P. et al. 1997. Novel Triene-ansamycins, cytotrienins A and B inducing apoptosis on human leukaemia HL-60 Cells. Tetrahedron Lett. 38: 1789-1792.
5. 5. Creasy, C.L. et al. 1995. Cloning and characterization of a human protein kinase with homology to Ste20. J. Biol. Chem. 270: 21695-21700.
6. 6. Creasy, C.L. et al. 1996. The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. J. Biol. Chem. 271: 21049-21053.
7. 7. Taylor, L.K. et al. 1996. Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. Proc. Natl. Acad. Sci. USA 93: 10099-10104.
8. 8. Kakeya, H. et al. 1997. Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high-affinity nerve growth factors. J. Med. Chem. 40: 391-394.
9. 9. Watabe, M. et al. 1999. Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis. Oncogene 18: 5211-5220.
10. 10. Graves, J. D. et al. 1998. Caspase-mediated activation and identification of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J. 17: 2224-2234.
11. 11. Lee, K.-K. et al. 1998. Proteolytic activation of MST/Krs, STE-20-related protein kinase, by caspase during apoptosis. Oncogene 16: 3029-3037.
12. 12. Kakeya, H. et al. 1998. Caspase-mediated activation of a p36 myelin basic protein kinase during anticancer drug-induced apoptosis. Cancer Res. 58: 4888-4894.