Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells

Tetrahedron Letters

Volumn 38, Issue 10, 1997, Pages 1789-1792

  Zhang, Hui Ping ^a   Kakeya, Hideaki ^a   Osada, Hiroyuki ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANSAMYCIN DERIVATIVE; CYTOTRIENIN A; CYTOTRIENIN B; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HL 60; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOCHEMISTRY;

EID: 0031562471     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00170-6     Document Type: Article

References (6)

1. 1. Hale, A. J.; Smith, C. A.; Sutherland, L. C.; Stoneman, V. E. A.; Longthorne, V. L.; Culhane, A. C.; and Williams, G. T. Eur. J. Biochem. 1996, 236, 1-26.
2. 2. The 2D NMR spectra were measured using a field gradient computer soft-ware on a JEOL ALPHA-400 spectrometer.
3. 3. Sugita, M.; Sasaki, T.; Furihata, K.; Seto, H.; and Ōtake N. J. Antibiot. 1982, 35, 1467-1473.
4. 4. Smith III, A. B.; Wood, J. L.; Ōmura, S. Tetrahedron Lett. 1991, 32, 841-842.
5. 6) δ 169.52 (s, C-1), 41.59 (t, C-2), 79.88 (d, C-3), 130.38 (d, C-4), 134.61 (d, C-5), 128.96 (d, C-6), 134.05 (d, C-7), 132.53 (d, C-8), 130.51 (d, C-9), 32.56 (t, C-10), 74.17 (d, C-11), 37.38 (d, C-12), 66.85 (d, C-13), 139.41 (s, C-14), 122.08 (d, C-15), 25.02 (t, C-16), 31.27 (t, C-17), 131.49 (s, C-18), 140.63 (s, C-19), 125.87 (s, C-20), 107.09 (d, C-21), 149.23 (s, C-22), 115.50 (d, C-23), 9.16 (q, C-24), 21.06 (q, C-25), 55.71 (q, C-26), 171.66 (s, C-27), 32.84 (s, C-28), 16.68 (t, C-29), 17.17 (t, C-30), 176.43 (s, C-31), 43.69 (d, C-32), 29.23 (t, C-33), 25.39 (t, C-34), 25.49 (t, C-35), 25.50 (t, C-36), 28.90 (t, C-37).
6. 6. Damberg, M.; Russ, P.; and Zeeck, A. Tetrahedron Lett. 1982, 23, 59-62.