Balance of cell proliferation and apoptosis in breast carcinogenesis

Breast Cancer Research and Treatment

Volumn 58, Issue 2, 1999, Pages 163-169

  Mommers, Ellen C M ^a   Van Diest, Paul J ^a   Leonhart, Angelique M ^a   Meijer, Chris J L M ^a   Baak, Jan P A ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Breast; Carcinoma in situ; Cell death; Hyperplasia; Mitosis

Indexed keywords

EOSIN; HEMATOXYLIN;

APOPTOSIS; ARTICLE; BREAST BIOPSY; BREAST CARCINOGENESIS; BREAST CARCINOMA; BREAST HYPERPLASIA; BREAST LESION; CANCER GROWTH; CANCER INVASION; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; HISTOLOGY; HUMAN; HUMAN TISSUE; HYPOTHESIS; MAJOR CLINICAL STUDY; MITOSIS INDEX; PRIORITY JOURNAL;

APOPTOSIS; BREAST NEOPLASMS; CARCINOMA, INTRADUCTAL, NONINFILTRATING; DISEASE PROGRESSION; FEMALE; HUMANS; MITOSIS; MITOTIC INDEX;

EID: 0033403733     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006396103777     Document Type: Article

References (25)

1. 1. Birchall M, Winterford C, Tripconi L, Gobé G, Harmon B: Apoptosis and mitosis in oral and oropharyngeal epithelia: evidence for a topographical switch in premalignant lesions. Cell Prolif 29: 447-456, 1996
2. 2. Christov KT, Guzman RC, Swanson SM, Thordarson G, Talamantes F, Nandi S: Cell proliferation and apoptosis during mammary carcinogenesis in pituitary isografted mice. Carcinogenesis 17: 1741-1746, 1996
3. 3. Allan DJ, Howell A, Roberts SA, Williams GT, Watson RJ, Coyne JD, Clarke RB, Laidlaw IJ, Potten CS: Reduction in apoptosis relative to mitosis in histologically normal epithelium accompanies fibrocystic change and carcinoma of the premenopausal human breast. J Pathol 167: 25-32, 1992
4. 4. Gandhi A, Holland PA, Knox WF, Potten CS, Bundred NJ: Evidence of significant apoptosis in poorly differentiated ductal carcinoma in situ of the breast. Br J Cancer 78: 788-794, 1998
5. 5. Gupta SK, Douglas-Jones AG, Fenn N, Morgan JM, Mansel RE: The clinical behavior of breast carcinoma is probably determined at the preinvasive stage (ductal carcinoma in situ). Cancer 80: 1740-1745, 1997
6. 6. Cadman BA, Ostrowski JL, Quinn CM: Invasive ductal carcinoma accompanied by ductal carcinoma in situ (DCIS): comparison of DCIS grade with grade of invasive component. The Breast 6: 132-137, 1997
7. 7. Poller DN, Roberts EC, Bell JA, Elston CW, Blamey RW, Ellis IO: p53 Protein expression in mammary ductal carcinoma in situ: relationship to immunohistochemical expression of estrogen receptor and c-erbB-2 protein. Hum Pathol 24: 463-468, 1993
8. 8. Siziopikou KP, Prioleau JE, Harris JR. Schnitt SJ: bcl-2 Expression in the spectrum of preinvasive breast lesions. Cancer 77: 499-506, 1996
9. 9. Umekita Y, Takasaki T, Yoshida H: Expression of p53 in benign epithelial hyperplasia, atypical ductal hyperplasia, non-invasive and invasive mammary carcinoma: an immunohistochemical study. Virchows Archiv 424: 491-494, 1994
10. 10. Moriki T, Takahashi T, Tanioka F, Yamane T, Hara H: Proliferative activity in breast carcinoma evaluated by BrdU and PCNA: correlation with expression of p53, c-erbB-2, estrogen receptor and P-glycoprotein. Path Res Pract 191: 1122-1132, 1995
11. 11. Page DL, Anderson TJ, Rogers LW: Epithelial hyperplasia, and carcinoma in situ (CIS). In: Page DL, Anderson TJ (eds) Diagnostic Histopathology of the Breast. Churchill Livingstone, Edinburgh, 1987, pp 120-192
12. 12. Jannink I, Van Diest PJ, Baak JPA: Comparison of the prognostic value of mitotic frequency and mitotic activity index in breast cancer. The Breast 5: 31-36, 1996
13. 13. Bloom HJG, Richardson WW: Histological grading and prognosis in breast cancer. Br J Cancer 11: 359-377, 1957
14. 14. Van Diest PJ, Baak JPA, Matze-Cok P, Wisse-Brekelmans ECM, Van Galen CM, Kurver PHJ, Bellot SM, Fijheer J, Van Gorp LHM, Kwee WS, Los J, Peterse JL, Ruitenberg HM, Schapers RFM, Schipper MEI, Somsen JG, Willig AWPM, Ariens Ath: Reproducibility of mitosis counting in 2,469 breast cancer specimens. Hum Pathol 23: 603-607, 1992
15. 15. Van de Schepop HA-M, De Jong JS, Van Diest PJ, Baak JPA: Counting of apoptotic cells: a methodological study in invasive breast cancer. J Clin Pathol: Mol Pathol 49: M214-M217, 1996
16. 16. Hawkins NJ, Lees J, Ward RL: Detection of apoptosis in colorectal carcinoma by light microscopy and in situ end labelling. Analyt Quant Cytol Histol 19: 227-232, 1997
17. 17. Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W, Schulte-Hermann R: In situ detection of fragmented DNA (TUNEL Assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology 21: 1465-1468, 1995
18. 18. Symonds H, Krall L, Remnington L, Saenz-Robles M, Lowe S, Jacks T, Van Dyke T: p53-Dependent apoptosis suppresses tumour growth and progression in vivo. Cell 78: 703-711, 1994
19. 19. Sherr CJ: Cancer cell cycles. Science 274: 1672-1677, 1996
20. 20. Liebermann DA, Hoffman B, Steinman RA: Molecular controls of growth arrest and apoptosis: p513-dependent and independent pathways. Oncogene 11: 199-210, 1995
21. 21. Pavelic ZP, Pavelic L, Lower EE, Gapany M, Gapany S, Barker EA, Preisler HD: c-myc, c-erbB-2, and Ki-67 expression in normal breast tissue and in invasive and noninvasive breast carcinoma. Cancer Res 52: 2597-2602, 1992
22. 22. Leek RD, Kaklamanis L, Pezzella F, Gatter KC, Harris AL: Bcl-2 in normal human breast and carcinoma, association with oestrogen receptor-positive, epidermal growth factor receptor-negative tumours and in situ cancer. Br J Cancer 69: 135-139, 1994
23. 23. Michalides R, Hageman P, Van Tinteren H, Houben L, Wientjens E, Klompmaker R, Peterse J: A clinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer. Br J Cancer 73: 728-734, 1996
24. 24. Leal CB, Schmitt FC, Bento MJ, Maia NC, Lopes CS: Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c-erbB-2 protein. Cancer 75: 2123-2131, 1995
25. 25. Stanta G, Bonin S, Losi L, Eusebi V: Molecular characterization of intraductal breast carcinomas. Virchows Archiv 432: 107-111, 1998