Detection of apoptosis in colorectal carcinoma by light microscopy and in situ end labelling

Analytical and Quantitative Cytology and Histology

Volumn 19, Issue 3, 1997, Pages 227-232

  Hawkins, Nicholas John ^a   Lees, Jacqueline ^a   Ward, Robyn Lynne ^a,b  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

Author keywords

Apoptosis; Colorectal neoplasm; In situ end labelling

Indexed keywords

APOPTOSIS; ARTICLE; CANCER DIAGNOSIS; CLINICAL ARTICLE; COLORECTAL CARCINOMA; COST EFFECTIVENESS ANALYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MICROSCOPY; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; REPRODUCIBILITY;

APOPTOSIS; COLORECTAL NEOPLASMS; DNA FRAGMENTATION; DNA NUCLEOTIDYLEXOTRANSFERASE; EOSINE YELLOWISH-(YS); HEMATOXYLIN; HUMANS; MICROSCOPY; OBSERVER VARIATION;

EID: 0030954446     PISSN: 08846812     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Kerr JF, Wyllie AH, Currie AR: Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-257
2. Hall P, Levison D: Assessment of cell proliferation in histological material. J Clin Pathol 1990;43:184-192
3. Kerr JF, Winterford CM, Harmon BV: Apoptosis: Its significance in cancer and cancer therapy. Cancer 1994;73:2013-2026
4. Montironi R, Magi-Galluzzi C, Fabris G: Apoptotic bodies in intraepithelial neoplasia and prostatic adenocarcinoma following total androgen ablation. Pathol Res Pract 1995;191: 873-880
5. Wyllie AH: Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980;284:555-556
6. Gold R, Schmied M, Rothe G, Zischler H, Breitschopf H, Wekerle H, Lassmann H: Detection of DNA fragmentation in apoptosis: Application of in situ nick translation to cell culture systems and tissue sections. J Histochem Cytochem 1993;41:1023-1030
7. Gorczyca W, Gong J, Darzynkiewicz Z: Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 1993;53:1945-1951
8. Gold R, Schmied M, Giegerich G, Breitschopf H, Hartung HP, Toyka KV, Lassmann H: Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques. Lab Invest 1994;71: 219-225
9. Gavrieli Y, Sherman Y, Ben-Sasson SA: Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 1992;199:493-501
10. Ansari B, Coates PJ, Greenstein BD, Hall PA: In situ labelling detects DNA strand breaks in apoptosis and other physiological and pathological states. J Pathol 1993;170:1-8
11. Grasl-Kraupp B, Ruttkaynedecky B, Koudelka H, Bukowska K, Bursch W, Schultehermann R: In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note. Hepatology 1995;21:1465-1468