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Volumn 15, Issue 5, 1999, Pages 445-457

Nitrobenzene carcinogenicity in animals and human hazard evaluation

Author keywords

Aniline; Carcinogenicity; Free radicals; Nitrosobenzene; Nitroxides; Phenylhydroxylamine

Indexed keywords

ANILINE; CARCINOGEN; CYTOCHROME P450; FREE RADICAL; GLUTATHIONE; HYDROXYLAMINE; NITROBENZENE; NITROSOBENZENE;

EID: 0033403514     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (36)

References (117)
  • 1
    • 0343032411 scopus 로고    scopus 로고
    • Intoxication due to ingestion of bitter almond oil contaminated with nitrobenzene
    • Centro de Información y Asesoramiento Toxicológoco 'Dr. Julio Velasco' (CIATO). Facultad de Farmacia, Universidad Central de Venezuela, Unidad de Cuidados Intensivos, Hospital Miltar 'Carlos Arvelo,' Caracas, Venezuela, Abstract of report appears Poster 218
    • Abbinante R., and Pasqualatto D. Intoxication due to ingestion of bitter almond oil contaminated with nitrobenzene. Centro de Información y Asesoramiento Toxicológoco 'Dr. Julio Velasco' (CIATO). Facultad de Farmacia, Universidad Central de Venezuela, Unidad de Cuidados Intensivos, Hospital Miltar 'Carlos Arvelo,' Caracas, Venezuela, pp. 1-12. Abstract of report appears in The Toxicologist 1997: 36 (1): Part 2, Poster 218.
    • (1997) The Toxicologist , vol.36 , Issue.1 PART 2 , pp. 1-12
    • Abbinante, R.1    Pasqualatto, D.2
  • 2
    • 0021865442 scopus 로고
    • Biomonitoring of aniline and nitrobenzene: Hemoglobin binding in rats and analysis of adducts
    • Albrecht W., and Neumann H. Biomonitoring of aniline and nitrobenzene: hemoglobin binding in rats and analysis of adducts. Arch. Toxicol. 1985: 57: 1-5.
    • (1985) Arch. Toxicol. , vol.57 , pp. 1-5
    • Albrecht, W.1    Neumann, H.2
  • 4
    • 0022203027 scopus 로고
    • Formation and disposition of nitrosochloramphenicol in rat liver
    • Ascherl M., Eyer P., and Kampffmeyer H. Formation and disposition of nitrosochloramphenicol in rat liver. Biochem. Pharmacol. 1985: 34: 3755-3763.
    • (1985) Biochem. Pharmacol. , vol.34 , pp. 3755-3763
    • Ascherl, M.1    Eyer, P.2    Kampffmeyer, H.3
  • 5
    • 0030846298 scopus 로고    scopus 로고
    • Tying it all together: Epigenetics, genetics, cell cycle, and cancer
    • Baylin S.B. Tying it all together: epigenetics, genetics, cell cycle, and cancer. Science 1997: 277: 1948-1949.
    • (1997) Science , vol.277 , pp. 1948-1949
    • Baylin, S.B.1
  • 7
    • 0029964695 scopus 로고    scopus 로고
    • Erythrocyte enzymes catalyze 1-nitropyrene and 3-nitrofluoanthene nitroreduction
    • Belisario M.A., Pecce R., Garofalo A., and Malorni A. Erythrocyte enzymes catalyze 1-nitropyrene and 3-nitrofluoanthene nitroreduction. Toxicology 1996: 108: 101-108.
    • (1996) Toxicology , vol.108 , pp. 101-108
    • Belisario, M.A.1    Pecce, R.2    Garofalo, A.3    Malorni, A.4
  • 8
    • 0020502004 scopus 로고
    • Formation and disposition of N-hydroxylated metabolites of aniline and nitrobenzene by isolated rat hepatocytes
    • Blaauboer B.J., and Van Holsteijn C.W.M. Formation and disposition of N-hydroxylated metabolites of aniline and nitrobenzene by isolated rat hepatocytes. Xenobiotica 1983: 13: 295-302.
    • (1983) Xenobiotica , vol.13 , pp. 295-302
    • Blaauboer, B.J.1    Van Holsteijn, C.W.M.2
  • 9
    • 0025892415 scopus 로고
    • Purification and characterization of an oxygen-insensitive NAD(P)H nitroreductase from Enterobacter cloacae
    • Bryant C., and Deluca M. Purification and characterization of an oxygen-insensitive NAD(P)H nitroreductase from Enterobacter cloacae. J. Biol. Chem. 1991: 266: 4119-4125.
    • (1991) J. Biol. Chem. , vol.266 , pp. 4119-4125
    • Bryant, C.1    Deluca, M.2
  • 10
    • 0024505282 scopus 로고
    • Use of primary cultures of human hepatocytes in toxicology studies
    • Butterworth B.E., Smith-Oliver T., Earle L., and Loury D. Use of primary cultures of human hepatocytes in toxicology studies. Cancer Res. 1989: 49: 1075-1084.
    • (1989) Cancer Res. , vol.49 , pp. 1075-1084
    • Butterworth, B.E.1    Smith-Oliver, T.2    Earle, L.3    Loury, D.4
  • 12
  • 13
    • 0027938689 scopus 로고
    • Oxy-radicals and cancer
    • Cerutti P.A. Oxy-radicals and cancer. Lancet 1994: 344: 862-863.
    • (1994) Lancet , vol.344 , pp. 862-863
    • Cerutti, P.A.1
  • 14
    • 0342598197 scopus 로고
    • Physiological action of nitrobenzene vapor on animals
    • Station N.Y.A.E. (Ed.), Cornell University, Ithaca, NY
    • Chandler W.L. Physiological action of nitrobenzene vapor on animals. In: Station N.Y.A.E. (Ed.), Cornell University Memoir, Vol. 20. Cornell University, Ithaca, NY, 1919, pp. 405-472.
    • (1919) Cornell University Memoir , vol.20 , pp. 405-472
    • Chandler, W.L.1
  • 15
    • 0018103571 scopus 로고
    • Mutagenicity of some commercially available nitro compounds for Salmonella typhimurium
    • Chiu C.W., Lee L.H. Wang C.Y., and Bryan G.T. Mutagenicity of some commercially available nitro compounds for Salmonella typhimurium. Mutat. Res. 1978: 58: 11-22.
    • (1978) Mutat. Res. , vol.58 , pp. 11-22
    • Chiu, C.W.1    Lee, L.H.2    Wang, C.Y.3    Bryan, G.T.4
  • 16
    • 4243829318 scopus 로고
    • A chronic inhalation toxicity study of nitrobenzene in B6C3F1 mice, Fischer 344 rats and Sprague-Dawley (CD) rats
    • Research Triangle Park, NC
    • Chemical Industry Institute of Toxicology (CIIT). A chronic inhalation toxicity study of nitrobenzene in B6C3F1 mice, Fischer 344 rats and Sprague-Dawley (CD) rats. In: Chronic Inhalation Bioassay for Carcinogenicity in Animals, Vols. I and II. Research Triangle Park, NC, 1993, pp. 1-440, 441-836.
    • (1993) Chronic Inhalation Bioassay for Carcinogenicity in Animals , vol.1-2 , pp. 1-440
  • 18
    • 0029864793 scopus 로고    scopus 로고
    • Effects of cell proliferation and cell death (apoptosis and necrosis) on the early stages of rat hepatocarcinogenesis
    • Columbano A., Endoh T., Denda A., and Noguchi O. Effects of cell proliferation and cell death (apoptosis and necrosis) on the early stages of rat hepatocarcinogenesis. Carcinogenesis 1996: 17: 395-400.
    • (1996) Carcinogenesis , vol.17 , pp. 395-400
    • Columbano, A.1    Endoh, T.2    Denda, A.3    Noguchi, O.4
  • 19
    • 0024438921 scopus 로고
    • Three models of free radical-induced cell injury
    • Comporti M. Three models of free radical-induced cell injury. Chem.-Biol. Interact. 1989: 72: 1-56.
    • (1989) Chem.-Biol. Interact. , vol.72 , pp. 1-56
    • Comporti, M.1
  • 20
    • 0028987899 scopus 로고
    • The effect of fuel composition on the mutagenicity of diesel engine exhaust
    • Crebelli R., Conti L., Carere A., Bertoli C., and Del Gicomo N. The effect of fuel composition on the mutagenicity of diesel engine exhaust. Mutat. Res. 1995: 346: 167-172.
    • (1995) Mutat. Res. , vol.346 , pp. 167-172
    • Crebelli, R.1    Conti, L.2    Carere, A.3    Bertoli, C.4    Del Gicomo, N.5
  • 21
    • 0024342652 scopus 로고
    • Mutagenicity of nitro compounds in Salmonella typhimurium in the presence of flavin mononucleotide in a preincubation assay
    • Dellarco V.L., and Prival M.J. Mutagenicity of nitro compounds in Salmonella typhimurium in the presence of flavin mononucleotide in a preincubation assay. Environ. Mol. Mutagen. 1989: 13: 116-127.
    • (1989) Environ. Mol. Mutagen. , vol.13 , pp. 116-127
    • Dellarco, V.L.1    Prival, M.J.2
  • 22
    • 0030434824 scopus 로고    scopus 로고
    • Cell cycle and cancer: Critical events at the G1 restriction point
    • Delsal G., Loda M., and Pagano M. Cell cycle and cancer: critical events at the G1 restriction point. Crit. Rev. Oncog. 1996: 7: 127-142.
    • (1996) Crit. Rev. Oncog. , vol.7 , pp. 127-142
    • Delsal, G.1    Loda, M.2    Pagano, M.3
  • 23
    • 0030027820 scopus 로고    scopus 로고
    • Mutation spectra of chemical fractions of a complex mixture: Role of nitroarenes in the mutagenic specificity of municipal waste incinerator emissions
    • Demarini D.M., Shelton M.L., and Bell D.A. Mutation spectra of chemical fractions of a complex mixture: role of nitroarenes in the mutagenic specificity of municipal waste incinerator emissions. Mutat. Res. 1996: 349: 1-20.
    • (1996) Mutat. Res. , vol.349 , pp. 1-20
    • Demarini, D.M.1    Shelton, M.L.2    Bell, D.A.3
  • 24
    • 0343032410 scopus 로고
    • Peroral poisoning with nitrobenzene or aniline in the newborn
    • Dollinger A. Peroral poisoning with nitrobenzene or aniline in the newborn. Monatsschr. Kinderheilkd. 1949: 97: 91-93.
    • (1949) Monatsschr. Kinderheilkd. , vol.97 , pp. 91-93
    • Dollinger, A.1
  • 25
    • 0343032409 scopus 로고
    • Hazard Evaluation for U.S. EPA. National Technical Information Service (NTIS) Accession No. PB-257776
    • Dorigan J., and Hushorn J. Air pollution assessment of nitrobenzene. Hazard Evaluation for U.S. EPA. National Technical Information Service (NTIS) Accession No. PB-257776, 1976, pp. 1-86.
    • (1976) Air Pollution Assessment of Nitrobenzene , pp. 1-86
    • Dorigan, J.1    Hushorn, J.2
  • 26
    • 0029918901 scopus 로고    scopus 로고
    • Role of oxygen free radicals in cancer development
    • Dreher D., and Junod A.F. Role of oxygen free radicals in cancer development. Eur. J. Cancer 1996: 32A: 30-38.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 30-38
    • Dreher, D.1    Junod, A.F.2
  • 27
    • 0343032408 scopus 로고
    • Nitrobenzenes and nitrotoluenes
    • Mark H.F., Othmer D.F., Overberger C.G., Seaborg G.T., and Grayson N. (Eds.), John Wiley and Sons, New York
    • Dunlap K.L. Nitrobenzenes and nitrotoluenes. In: Mark H.F., Othmer D.F., Overberger C.G., Seaborg G.T., and Grayson N. (Eds.), Kirk-Othmer Encyclopedia of Chemical Technology, Vol. 15. John Wiley and Sons, New York, 1981, pp. 916-932.
    • (1981) Kirk-othmer Encyclopedia of Chemical Technology , vol.15 , pp. 916-932
    • Dunlap, K.L.1
  • 28
    • 0018741956 scopus 로고
    • Reactions of nitrosobenzene with reduced glutathione
    • Eyer P. Reactions of nitrosobenzene with reduced glutathione. Chem.-Biol. Interact. 1979: 24: 227-239.
    • (1979) Chem.-Biol. Interact. , vol.24 , pp. 227-239
    • Eyer, P.1
  • 29
    • 0023143235 scopus 로고
    • Reactions of para-substituted nitrosoamines with human hemoglobin
    • Eyer P., and Ascherl M. Reactions of para-substituted nitrosoamines with human hemoglobin. Biol. Chem. Hoppe-Seyler 1987: 368: 285-294.
    • (1987) Biol. Chem. Hoppe-seyler , vol.368 , pp. 285-294
    • Eyer, P.1    Ascherl, M.2
  • 30
    • 0018957848 scopus 로고
    • Biotransformation of nitrosobenzene in the red blood cell and the role of glutathione
    • Eyer P., and Lierheimer E. Biotransformation of nitrosobenzene in the red blood cell and the role of glutathione. Xenobiotica 1980: 10: 517-526.
    • (1980) Xenobiotica , vol.10 , pp. 517-526
    • Eyer, P.1    Lierheimer, E.2
  • 31
    • 0018973187 scopus 로고
    • Biotransformation of nitrosoamine, phenylhydroxylamine, and aniline in the isolated perfused liver
    • Eyer P., Kampffmeyer H., Maister H., and Rösch-Oehme E. Biotransformation of nitrosoamine, phenylhydroxylamine, and aniline in the isolated perfused liver. Xenobiotica 1980: 10: 499-516.
    • (1980) Xenobiotica , vol.10 , pp. 499-516
    • Eyer, P.1    Kampffmeyer, H.2    Maister, H.3    Rösch-Oehme, E.4
  • 32
  • 33
    • 0028345763 scopus 로고
    • Reactive oxygen species in tumorigenesis
    • Feig D.I., Reid T.M., and Loeb L.A. Reactive oxygen species in tumorigenesis. Cancer Res. 1994: 54: 1890s-1894s.
    • (1994) Cancer Res. , vol.54
    • Feig, D.I.1    Reid, T.M.2    Loeb, L.A.3
  • 34
    • 0002566278 scopus 로고
    • Oxygen-centered free radicals as mediators of inflammation
    • Sies H. (Ed.), Academic Press, New York
    • Flohé L., Beckmann R., Giertz H., and Loschen G. Oxygen-centered free radicals as mediators of inflammation. In: Sies H. (Ed.), Oxidative Stress. Academic Press, New York, 1985, pp. 403-435.
    • (1985) Oxidative Stress , pp. 403-435
    • Flohé, L.1    Beckmann, R.2    Giertz, H.3    Loschen, G.4
  • 35
    • 0030889939 scopus 로고    scopus 로고
    • The role of cell proliferation in chemically induced carcinogenesis
    • Foster J.R. The role of cell proliferation in chemically induced carcinogenesis. J. Comp. Pathol. 1997: 116: 113-144.
    • (1997) J. Comp. Pathol. , vol.116 , pp. 113-144
    • Foster, J.R.1
  • 36
    • 0343725060 scopus 로고
    • The enzymatic reduction of chloramphenicol, p-nitrobenzoic acid and other nitroaromatic compounds in mammals
    • Fouts J.R., and Brodie B.B. The enzymatic reduction of chloramphenicol, p-nitrobenzoic acid and other nitroaromatic compounds in mammals. J. Pharmacol. Exp. Ther. 1957: 119: 197-207.
    • (1957) J. Pharmacol. Exp. Ther. , vol.119 , pp. 197-207
    • Fouts, J.R.1    Brodie, B.B.2
  • 37
    • 0021276579 scopus 로고
    • 14C]nitrobenzene in the erythrocyte and spleen of rats and mice
    • 14C]nitrobenzene in the erythrocyte and spleen of rats and mice. Chem.-Biol. Interact. 1984: 50: 27-37.
    • (1984) Chem.-Biol. Interact. , vol.50 , pp. 27-37
    • Goldstein, R.S.1    Rickert, D.E.2
  • 38
    • 0029855223 scopus 로고    scopus 로고
    • Reviews in genetic toxicology: Apoptosis and cancer risk assessment
    • Goldsworthy T.L., Conolly R.B., and Fransson-Steen R. Reviews in genetic toxicology: apoptosis and cancer risk assessment. Mutat. Res. 1996: 365: 71-90.
    • (1996) Mutat. Res. , vol.365 , pp. 71-90
    • Goldsworthy, T.L.1    Conolly, R.B.2    Fransson-Steen, R.3
  • 39
    • 0028792111 scopus 로고
    • Lipid peroxidation and antioxidants as biomarkers for tissue damage
    • Gutteridge J.M.C. Lipid peroxidation and antioxidants as biomarkers for tissue damage. Clin. Chem. 1995: 41: 1819-1828.
    • (1995) Clin. Chem. , vol.41 , pp. 1819-1828
    • Gutteridge, J.M.C.1
  • 40
    • 0027194309 scopus 로고
    • Oxidative mechanisms in carcinogenesis
    • Guyton K.Z., and Kensler T.W. Oxidative mechanisms in carcinogenesis. Br. Med. Bull. 1993: 49: 523-544.
    • (1993) Br. Med. Bull. , vol.49 , pp. 523-544
    • Guyton, K.Z.1    Kensler, T.W.2
  • 41
    • 0342598194 scopus 로고
    • Subchronic Bioassay. Docket #12634. Chemical Industry Institute of Toxicology (CIIT), PO Box 12137, Research Triangle Park, NC 27709
    • Hamm T.E. Ninety-day inhalation study of nitrobenzene in F344 rats, and B6C3F1 mice. Subchronic Bioassay. Docket #12634. Chemical Industry Institute of Toxicology (CIIT), PO Box 12137, Research Triangle Park, NC 27709, 1984, pp. 1-38.
    • (1984) Ninety-day Inhalation Study of Nitrobenzene in F344 Rats, and B6C3F1 Mice , pp. 1-38
    • Hamm, T.E.1
  • 42
    • 0018961221 scopus 로고
    • Participation of cytochrome P450 in the reduction of nitro compounds by rat liver microsomes
    • Harada N., and Omura T. Participation of cytochrome P450 in the reduction of nitro compounds by rat liver microsomes. J. Biochem. (Tokyo) 1980: 87: 1539-1544.
    • (1980) J. Biochem. (Tokyo) , vol.87 , pp. 1539-1544
    • Harada, N.1    Omura, T.2
  • 45
    • 0029897806 scopus 로고    scopus 로고
    • Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen
    • Hecht S.S. Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen. CRC Crit. Rev. Toxicol. 1996: 26: 163-181.
    • (1996) CRC Crit. Rev. Toxicol. , vol.26 , pp. 163-181
    • Hecht, S.S.1
  • 46
    • 0028212283 scopus 로고
    • Biomarkers for human uptake and metabolic activation of tobacco-specific nitrosoamines
    • Hecht S.S., Carmella S.G., Foiles P.G., and Murphy S.E. Biomarkers for human uptake and metabolic activation of tobacco-specific nitrosoamines. Cancer Res. 1994: 54: 1912s-1917s.
    • (1994) Cancer Res. , vol.54
    • Hecht, S.S.1    Carmella, S.G.2    Foiles, P.G.3    Murphy, S.E.4
  • 47
    • 0023812845 scopus 로고
    • Acetylator phenotype and arylamine-induced carcinogenesis
    • Hein D.W. Acetylator phenotype and arylamine-induced carcinogenesis. Biochem. Biophys. Acta 1988: 948: 37-66.
    • (1988) Biochem. Biophys. Acta , vol.948 , pp. 37-66
    • Hein, D.W.1
  • 48
    • 12644293822 scopus 로고    scopus 로고
    • Rodent models of human acetylation polymorphism: Comparisons of recombinant acetyltransferases
    • Hein D.W., Doll M.A., Fretland A.J., Gray K., Deitz A.C., et al. Rodent models of human acetylation polymorphism: comparisons of recombinant acetyltransferases. Mutat. Res. 1997: 376: 101-106.
    • (1997) Mutat. Res. , vol.376 , pp. 101-106
    • Hein, D.W.1    Doll, M.A.2    Fretland, A.J.3    Gray, K.4    Deitz, A.C.5
  • 49
    • 0022445515 scopus 로고
    • Covalent binding of the phenacetin metabolite p-nitrosophenetole to protein
    • Hinson J.A., and Mays J.B. Covalent binding of the phenacetin metabolite p-nitrosophenetole to protein. J. Pharmacol. Exp. Ther. 1986: 238: 106-112.
    • (1986) J. Pharmacol. Exp. Ther. , vol.238 , pp. 106-112
    • Hinson, J.A.1    Mays, J.B.2
  • 50
    • 0343903962 scopus 로고
    • Internal report on the current carcinogenicity status of 37 hazardous air pollutants. Office of Health and Environmental Assessment, Office of Research and Development, U.S. EPA, Washington, DC, September 28, 1992
    • Holder J.W. Weight of evidence (WOE) classification for hazardous air pollutants. Internal report on the current carcinogenicity status of 37 hazardous air pollutants. Office of Health and Environmental Assessment, Office of Research and Development, U.S. EPA, Washington, DC, September 28, 1992. 1992.
    • (1992) Weight of Evidence (WOE) Classification for Hazardous Air Pollutants
    • Holder, J.W.1
  • 51
    • 0343468106 scopus 로고    scopus 로고
    • U.S. Environmental Protection Agency, EPA/600/R-95/100. Website
    • Holder J.W. Nitrobenzene carcinogenicity (CAS No. 98-95-3). U.S. Environmental Protection Agency, 1998. EPA/600/R-95/100. Website: http://www.epa.gov/ncea/nitro.htm.
    • (1998) Nitrobenzene Carcinogenicity (CAS No. 98-95-3)
    • Holder, J.W.1
  • 52
  • 53
    • 0020966452 scopus 로고
    • Reduction of the carcinogen 1-nitropyrene to 1-aminopyrene by the rat intestinal bacteria
    • Howard P.C., Beland F.A., and Cerniglia C.E. Reduction of the carcinogen 1-nitropyrene to 1-aminopyrene by the rat intestinal bacteria. Carcinogenesis 1983: 4: 985-990.
    • (1983) Carcinogenesis , vol.4 , pp. 985-990
    • Howard, P.C.1    Beland, F.A.2    Cerniglia, C.E.3
  • 54
    • 0026438477 scopus 로고
    • Chemical toxicity and carcinogenesis: Is there a causal connection? A comparative morphological evaluation of 1500 experiments
    • Vaino H., Magee P.N., McGregor D.B., et al. (Eds.), International Agency for Research on Cancer, Lyon, France
    • Huff J.E. Chemical toxicity and carcinogenesis: Is there a causal connection? A comparative morphological evaluation of 1500 experiments. In: Vaino H., Magee P.N., McGregor D.B., et al. (Eds.), Mechanisms of Carcinogenesis in Risk Identification. International Agency for Research on Cancer, Lyon, France, 1992, pp. 437-475.
    • (1992) Mechanisms of Carcinogenesis in Risk Identification , pp. 437-475
    • Huff, J.E.1
  • 55
    • 0343903960 scopus 로고
    • Excretion of p-nitrophenol and p-aminophenol in the urine of a patient exposed to nitrobenzene
    • Ikeda M., and Kita A. Excretion of p-nitrophenol and p-aminophenol in the urine of a patient exposed to nitrobenzene. Br. J. Ind. Med. 1964: 21: 210-213.
    • (1964) Br. J. Ind. Med. , vol.21 , pp. 210-213
    • Ikeda, M.1    Kita, A.2
  • 56
    • 0016212640 scopus 로고
    • Properties of a NADH-dependent N-hydroxy amine reductase isolated from pig liver microsomes
    • Kadlubar F.F., and Ziegler D.M. Properties of a NADH-dependent N-hydroxy amine reductase isolated from pig liver microsomes. Arch. Biochem. Biophys. 1974: 162: 83-92.
    • (1974) Arch. Biochem. Biophys. , vol.162 , pp. 83-92
    • Kadlubar, F.F.1    Ziegler, D.M.2
  • 57
    • 0027408080 scopus 로고
    • Free radicals as mediators of tissue injury and disease
    • Keher J.P. Free radicals as mediators of tissue injury and disease. CRC Crit. Rev. Toxicol. 1993: 23: 21-48.
    • (1993) CRC Crit. Rev. Toxicol. , vol.23 , pp. 21-48
    • Keher, J.P.1
  • 59
    • 0028329172 scopus 로고
    • Apoptosis - Its significance in cancer and cancer therapy
    • Kerr J.F.R., Winterford C.M., and Harmon B.V. Apoptosis - its significance in cancer and cancer therapy. Cancer 1994: 73: 2013-2026.
    • (1994) Cancer , vol.73 , pp. 2013-2026
    • Kerr, J.F.R.1    Winterford, C.M.2    Harmon, B.V.3
  • 61
    • 0031896296 scopus 로고    scopus 로고
    • Phenylhydroxylamine: Role in aniline-associated splenic oxidative stress and induction of subendo-cardial necrosis
    • Khan M.F., Green S., Ansari G., and Boor P. Phenylhydroxylamine: role in aniline-associated splenic oxidative stress and induction of subendo-cardial necrosis. Toxicol. Sci. 1998: 42: 64-71.
    • (1998) Toxicol. Sci. , vol.42 , pp. 64-71
    • Khan, M.F.1    Green, S.2    Ansari, G.3    Boor, P.4
  • 62
    • 0013943926 scopus 로고
    • The biochemical production of ferrihemiglobin-forming derivatives from aromatic amines, and mechanisms of ferrihemiglobin formation
    • Kiese M. The biochemical production of ferrihemiglobin-forming derivatives from aromatic amines, and mechanisms of ferrihemiglobin formation. Pharmacol. Rev. 1966: 18: 1091-1161.
    • (1966) Pharmacol. Rev. , vol.18 , pp. 1091-1161
    • Kiese, M.1
  • 65
    • 0022108648 scopus 로고
    • On the mechanism of reactions of nitrosoarenes with thiols
    • Klehr H., Eyer P., and Schäfer W. On the mechanism of reactions of nitrosoarenes with thiols. Biol. Chem. Hoppe-Seyler 1985: 366: 755-760.
    • (1985) Biol. Chem. Hoppe-seyler , vol.366 , pp. 755-760
    • Klehr, H.1    Eyer, P.2    Schäfer, W.3
  • 66
    • 0020553770 scopus 로고
    • Analysis of cytogenetic damage in rat lymphocytes following in vivo exposure to nitrobenzene
    • Kligerman A.D., Erexson G.L., Wilmer J.L., and Phelps M.C. Analysis of cytogenetic damage in rat lymphocytes following in vivo exposure to nitrobenzene. Toxicol. Lett. 1983: 18: 219-226.
    • (1983) Toxicol. Lett. , vol.18 , pp. 219-226
    • Kligerman, A.D.1    Erexson, G.L.2    Wilmer, J.L.3    Phelps, M.C.4
  • 67
    • 0031052782 scopus 로고    scopus 로고
    • Free radical chemistry of cigarette smoke and its implication in human cancer
    • Kodama M., Kaneko M., Aida M., Inoue F., Nakayama T., and Akimoto H. Free radical chemistry of cigarette smoke and its implication in human cancer. Anticancer Res. 1997: 17: 433-437.
    • (1997) Anticancer Res. , vol.17 , pp. 433-437
    • Kodama, M.1    Kaneko, M.2    Aida, M.3    Inoue, F.4    Nakayama, T.5    Akimoto, H.6
  • 69
    • 0342598185 scopus 로고
    • Shoe-dye poisoning - relation to methemoglobin formation. Report of a case in a 2-year-old child
    • Levin S.J. Shoe-dye poisoning - relation to methemoglobin formation. Report of a case in a 2-year-old child. JAMA 1927: 89: 2178-2180.
    • (1927) JAMA , vol.89 , pp. 2178-2180
    • Levin, S.J.1
  • 70
    • 0019426350 scopus 로고
    • 14C-nitrobenzene by liver microsomes and cecal microflora from Fischer-344 rats
    • 14C-nitrobenzene by liver microsomes and cecal microflora from Fischer-344 rats. Pharmacologist 1981: 23: 171.
    • (1981) Pharmacologist , vol.23 , pp. 171
    • Levin, A.A.1    Dent, J.G.2
  • 71
    • 0019992459 scopus 로고
    • Comparison of the metabolism of nitrobenzene by hepatic microsomes and cecal microflora from Fischer-344 rats and the relative importance of each in vivo
    • Levin A.A., and Dent J.G. Comparison of the metabolism of nitrobenzene by hepatic microsomes and cecal microflora from Fischer-344 rats and the relative importance of each in vivo. Drug Metab. Dispos. 1982: 10: 450-454.
    • (1982) Drug Metab. Dispos. , vol.10 , pp. 450-454
    • Levin, A.A.1    Dent, J.G.2
  • 72
    • 0342598183 scopus 로고
    • Interactions of nitrobenzene with hepatic microsomes. Evidence for cytochrome P-450 uncoupling
    • Levin A.A., Bus J.S., and Dent J.G. Interactions of nitrobenzene with hepatic microsomes. Evidence for cytochrome P-450 uncoupling. Toxicologist 1982: 2: 17.
    • (1982) Toxicologist , vol.2 , pp. 17
    • Levin, A.A.1    Bus, J.S.2    Dent, J.G.3
  • 73
    • 0025055669 scopus 로고
    • Aniline-, phenylhydroxylamine-, and nitrobenzene-induced hemoglobin thiyl free radical formation in vivo and in vitro
    • Maples K., Eyer P., and Mason R.P. Aniline-, phenylhydroxylamine-, and nitrobenzene-induced hemoglobin thiyl free radical formation in vivo and in vitro. Mol. Pharmacol. 1989: 37: 311-318.
    • (1989) Mol. Pharmacol. , vol.37 , pp. 311-318
    • Maples, K.1    Eyer, P.2    Mason, R.P.3
  • 74
    • 0030797282 scopus 로고    scopus 로고
    • Stress, hormonal changes, alcohol, food constituents and drugs: Factors that advance the incidence of tobacco smoke-related cancer?
    • Maser E. Stress, hormonal changes, alcohol, food constituents and drugs: factors that advance the incidence of tobacco smoke-related cancer? Trends Pharmacol. Sci. 1997: 18: 270-275.
    • (1997) Trends Pharmacol. Sci. , vol.18 , pp. 270-275
    • Maser, E.1
  • 75
    • 0001372207 scopus 로고
    • Free-radical intermediates in the metabolism of toxic chemicals
    • Pryor W.A. (Ed.), Academic Press, New York
    • Mason R.P. Free-radical intermediates in the metabolism of toxic chemicals. In: Pryor W.A. (Ed.), Free Radicals in Biology, Vol. V. Academic Press, New York, 1982, pp. 161-222.
    • (1982) Free Radicals in Biology , vol.5 , pp. 161-222
    • Mason, R.P.1
  • 76
    • 0016722580 scopus 로고
    • The mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates
    • Mason R.P., and Holtzman J.L. The mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates. Biochemistry 1975: 14: 1626-1632.
    • (1975) Biochemistry , vol.14 , pp. 1626-1632
    • Mason, R.P.1    Holtzman, J.L.2
  • 78
    • 0014757218 scopus 로고
    • Carcinogenesis by chemicals: An overview - G.H.A. Clowes memorial lecture
    • Miller J.A. Carcinogenesis by chemicals: an overview - G.H.A. Clowes memorial lecture. Cancer Res. 1970: 30: 559-576.
    • (1970) Cancer Res. , vol.30 , pp. 559-576
    • Miller, J.A.1
  • 79
    • 84980055774 scopus 로고
    • Uber die zusammensetzung des nitrobenzids und sulfobenzids
    • Mitscherlich E. Uber die zusammensetzung des nitrobenzids und sulfobenzids. Ann. Phys. U. Chem. 1834: 31: 625-631.
    • (1834) Ann. Phys. U. Chem. , vol.31 , pp. 625-631
    • Mitscherlich, E.1
  • 82
    • 0343711093 scopus 로고
    • Detoxication. LXVIII. The metabolism of C14-nitrobenzene in the rabbit and guinea pig
    • Parke D.V. Detoxication. LXVIII. The metabolism of C14-nitrobenzene in the rabbit and guinea pig. Biochem. J. 1956: 62: 339-346.
    • (1956) Biochem. J. , vol.62 , pp. 339-346
    • Parke, D.V.1
  • 83
    • 0018800960 scopus 로고
    • Oxygen-sensitive and -insensitive nitroreduction by Escherichia coli and rat hepatic microsomes
    • Peterson P.J., Mason R.P., Hovsepian J., and Holtzman J.L. Oxygen-sensitive and -insensitive nitroreduction by Escherichia coli and rat hepatic microsomes. J. Biol. Chem. 1979: 254: 4009-4014.
    • (1979) J. Biol. Chem. , vol.254 , pp. 4009-4014
    • Peterson, P.J.1    Mason, R.P.2    Hovsepian, J.3    Holtzman, J.L.4
  • 84
    • 0019291735 scopus 로고
    • Guideline for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments
    • IARC Monograph Committee (Ed.), International Agency for Research on Cancer (IARC), Lyon, France
    • Peto R., Pike M.C., Day N.E., and Gray R.G. Guideline for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments. In: IARC Monograph Committee (Ed.), Long-Term and Short-Term Screening Assays for Carcinogens: A Critical Appraisal, suppl 2. International Agency for Research on Cancer (IARC), Lyon, France, 1980, pp. 311-426.
    • (1980) Long-term and Short-term Screening Assays for Carcinogens: A Critical Appraisal , Issue.SUPPL. 2 , pp. 311-426
    • Peto, R.1    Pike, M.C.2    Day, N.E.3    Gray, R.G.4
  • 85
    • 0016680787 scopus 로고
    • Excretion of p-aminophenol and p-nitrophenol in rat urine after intravenous and dermal treatment with nitrobenzene
    • Piotrowski J., Dutkiewicz B., and Popinska E. Excretion of p-aminophenol and p-nitrophenol in rat urine after intravenous and dermal treatment with nitrobenzene. Bromatol. Chem. Toksykol. 1975: 8: 271-272.
    • (1975) Bromatol. Chem. Toksykol. , vol.8 , pp. 271-272
    • Piotrowski, J.1    Dutkiewicz, B.2    Popinska, E.3
  • 86
    • 0025736092 scopus 로고
    • DNA adduct formation and tumorigenesis in livers and bladders of mice chronically fed 2-acetylaminofluorene
    • Portier M.C., Fullerton N.F., Kinouchi T., Smith B.A., and Beland F.A. DNA adduct formation and tumorigenesis in livers and bladders of mice chronically fed 2-acetylaminofluorene. Carcinogenesis 1991: 12: 895-900.
    • (1991) Carcinogenesis , vol.12 , pp. 895-900
    • Portier, M.C.1    Fullerton, N.F.2    Kinouchi, T.3    Smith, B.A.4    Beland, F.A.5
  • 88
    • 0030825040 scopus 로고    scopus 로고
    • Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity
    • Pryor W.A. Cigarette smoke radicals and the role of free radicals in chemical carcinogenicity. Environ. Health Perspect. 1997: 105: 875-882.
    • (1997) Environ. Health Perspect. , vol.105 , pp. 875-882
    • Pryor, W.A.1
  • 89
    • 0017226799 scopus 로고
    • The requirement of the gut flora in nitrobenzene-induced methemoglobinemia in rats
    • Reddy B.G., Pohl L.R., and Krishna G. The requirement of the gut flora in nitrobenzene-induced methemoglobinemia in rats. Biochem. Pharmacol. 1976: 25: 1119-1122.
    • (1976) Biochem. Pharmacol. , vol.25 , pp. 1119-1122
    • Reddy, B.G.1    Pohl, L.R.2    Krishna, G.3
  • 91
    • 0343680258 scopus 로고
    • Studies in the detoxication: 40. The metabolism of nitrobenzene in the rabbit, o-, m-, p-nitrophenols and 4-nitrocatecol as metabolites of nitrobenzene
    • Robinson D., Smith J.N., and Williams R.T. Studies in the detoxication: 40. The metabolism of nitrobenzene in the rabbit, o-, m-, p-nitrophenols and 4-nitrocatecol as metabolites of nitrobenzene. Biochem. J. 1951: 50: 228-238.
    • (1951) Biochem. J. , vol.50 , pp. 228-238
    • Robinson, D.1    Smith, J.N.2    Williams, R.T.3
  • 93
    • 0029928583 scopus 로고    scopus 로고
    • Mutagenic nitroarenes, diesel emissions, particulate-induced mutations and cancer: An essay on cancer-causation by a moving target
    • Rosenkranz H.S. Mutagenic nitroarenes, diesel emissions, particulate-induced mutations and cancer: an essay on cancer-causation by a moving target. Mutat. Res. 1996: 367: 65-72.
    • (1996) Mutat. Res. , vol.367 , pp. 65-72
    • Rosenkranz, H.S.1
  • 96
    • 0017864573 scopus 로고
    • Electron spin resonance-spin trapping. Detection of superoxide formation during aerobic microsomal reduction of nitro-compounds
    • Sealy R.C., Swartz H.M., and Olive P.L. Electron spin resonance-spin trapping. Detection of superoxide formation during aerobic microsomal reduction of nitro-compounds. Biochem. Biophys. Res. Commun. 1978: 82: 680-684.
    • (1978) Biochem. Biophys. Res. Commun. , vol.82 , pp. 680-684
    • Sealy, R.C.1    Swartz, H.M.2    Olive, P.L.3
  • 97
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr C.J. Cancer cell cycles. Science 1996: 274: 1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 98
    • 0031037572 scopus 로고    scopus 로고
    • Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and n′-nitrosonomicotine in human hepatic microsomes
    • Staretz M.E., Murphy S.E., Patten C.J., and Nunes M.G. Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and N′-nitrosonomicotine in human hepatic microsomes. Drug Metab. Dispos. 1997: 25: 154-162.
    • (1997) Drug Metab. Dispos. , vol.25 , pp. 154-162
    • Staretz, M.E.1    Murphy, S.E.2    Patten, C.J.3    Nunes, M.G.4
  • 99
    • 0342598153 scopus 로고
    • Cyanosis in infants from nitrobenzene
    • Stevens A.M. Cyanosis in infants from nitrobenzene. JAMA 1928: 90: 116.
    • (1928) JAMA , vol.90 , pp. 116
    • Stevens, A.M.1
  • 100
    • 0343032375 scopus 로고
    • Nitrobenzene poisoning
    • Stevenson A., and Forbes R.P. Nitrobenzene poisoning. J. Pediatr. 1942: 21: 224-228.
    • (1942) J. Pediatr. , vol.21 , pp. 224-228
    • Stevenson, A.1    Forbes, R.P.2
  • 101
    • 0018951160 scopus 로고
    • Redox cycle of stable mixed nitroxides formed from carcinogenic aromatic amines
    • Stier A., Clauss R., and Lücke A. Redox cycle of stable mixed nitroxides formed from carcinogenic aromatic amines. Xenobiotica 1980: 10: 661-673.
    • (1980) Xenobiotica , vol.10 , pp. 661-673
    • Stier, A.1    Clauss, R.2    Lücke, A.3
  • 102
    • 0023258714 scopus 로고
    • Dependence on Salmonella typhimurium enzymes of mutagenicities of nitrobenzene and its derivatives in the presence of rat-liver S9 and norharmon
    • Suzuki J., Takahashi N., Kobayashi Y., Miyamae R., Ohsawa M., and Suzuki S. Dependence on Salmonella typhimurium enzymes of mutagenicities of nitrobenzene and its derivatives in the presence of rat-liver S9 and norharmon. Mutat. Res. 1987: 178: 187-193.
    • (1987) Mutat. Res. , vol.178 , pp. 187-193
    • Suzuki, J.1    Takahashi, N.2    Kobayashi, Y.3    Miyamae, R.4    Ohsawa, M.5    Suzuki, S.6
  • 103
    • 0016687888 scopus 로고
    • Deuterium isotope effects during formation of phenols by hepatic monooxygenases. Evidence for an alternative to the arene pathway
    • Tomaszewski J.E., Jerina D.M., and Daly J.W. Deuterium isotope effects during formation of phenols by hepatic monooxygenases. Evidence for an alternative to the arene pathway. Biochemistry 1975: 14: 2024-2031.
    • (1975) Biochemistry , vol.14 , pp. 2024-2031
    • Tomaszewski, J.E.1    Jerina, D.M.2    Daly, J.W.3
  • 105
    • 0026093495 scopus 로고
    • An overview of the relationship between oxidative stress and chemical carcinogenesis
    • Trush M.A., and Kensler T.W. An overview of the relationship between oxidative stress and chemical carcinogenesis. Free Radical Biol. Med. 1991: 10: 201-209.
    • (1991) Free Radical Biol. Med. , vol.10 , pp. 201-209
    • Trush, M.A.1    Kensler, T.W.2
  • 106
    • 0001372175 scopus 로고
    • Guidelines for carcinogen risk assessment
    • U.S. EPA. Guidelines for carcinogen risk assessment. Federal Register 1986: 51: 33992-34003.
    • (1986) Federal Register , vol.51 , pp. 33992-34003
  • 107
    • 0003659940 scopus 로고
    • Risk Assessment for the Office of Air and Radiation, Report No. EPA/600/6-90/00F. Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC
    • U.S. EPA. Respiratory health effects of passive smoking: lung cancer and other disorders. Risk Assessment for the Office of Air and Radiation, Report No. EPA/600/6-90/00F. Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, 1992.
    • (1992) Respiratory Health Effects of Passive Smoking: Lung Cancer and Other Disorders
  • 108
    • 0000060569 scopus 로고    scopus 로고
    • Proposed guidelines for carcinogen risk assessment
    • U.S. EPA. Proposed guidelines for carcinogen risk assessment. Federal Register 1996: 61 (79): 17960-18011.
    • (1996) Federal Register , vol.61 , Issue.79 , pp. 17960-18011
  • 109
    • 0021709957 scopus 로고
    • Structural features of nitroaromatics that determine mutagenic activity in Salmonella typhimurium
    • Vance W.A., and Levin D.E. Structural features of nitroaromatics that determine mutagenic activity in Salmonella typhimurium. Environ. Mutagen. 1984: 6: 797-811.
    • (1984) Environ. Mutagen. , vol.6 , pp. 797-811
    • Vance, W.A.1    Levin, D.E.2
  • 110
    • 0029746045 scopus 로고    scopus 로고
    • 2-acetylaminofluorene mechanistic data and risk assessment: DNA reactivity, enhanced cell proliferation and tumor initiation
    • Verna L., Whysner J., and Williams G.M. 2-Acetylaminofluorene mechanistic data and risk assessment: DNA reactivity, enhanced cell proliferation and tumor initiation. Pharmacol. Ther. 1996: 71: 83-105.
    • (1996) Pharmacol. Ther. , vol.71 , pp. 83-105
    • Verna, L.1    Whysner, J.2    Williams, G.M.3
  • 111
    • 0343468068 scopus 로고
    • The aromatic amino and nitro compounds, their toxicity and potential dangers, a review of the literature
    • U.S. Public Health Service, U.S. Government Printing Office, Washington, DC
    • Von Oettinger W.F. The aromatic amino and nitro compounds, their toxicity and potential dangers, a review of the literature. Public Health Bulletin 271, U.S. Public Health Service, U.S. Government Printing Office, Washington, DC, 1941.
    • (1941) Public Health Bulletin , vol.271
    • Von Oettinger, W.F.1
  • 112
    • 0030337951 scopus 로고    scopus 로고
    • Relevance of cyclin D1 and other molecular markers to cancer chemoprevention
    • Weinstein I.B. Relevance of cyclin D1 and other molecular markers to cancer chemoprevention. J. Cell. Biochem. 1996: (suppl 25): 23-28.
    • (1996) J. Cell. Biochem. , Issue.SUPPL. 25 , pp. 23-28
    • Weinstein, I.B.1
  • 113
    • 0015793816 scopus 로고
    • Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids
    • Weisberger J.H., and Weisberger E.K. Biochemical formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids. Pharmacol. Rev. 1973: 25: 1-66.
    • (1973) Pharmacol. Rev. , vol.25 , pp. 1-66
    • Weisberger, J.H.1    Weisberger, E.K.2
  • 114
    • 0016755585 scopus 로고
    • The relationship between nitro group reduction and the intestinal microflora
    • Wheeler L.A., Soderberg F.B., and Goldman P. The relationship between nitro group reduction and the intestinal microflora. J. Pharmacol. Exp. Ther. 1975: 194: 135-144.
    • (1975) J. Pharmacol. Exp. Ther. , vol.194 , pp. 135-144
    • Wheeler, L.A.1    Soderberg, F.B.2    Goldman, P.3
  • 116
    • 0342598152 scopus 로고
    • Nitrobenzene poisoning in infants due to inunction with false bitter almond oil
    • Zeitoun M.M. Nitrobenzene poisoning in infants due to inunction with false bitter almond oil. J. Trop. Pediatr. 1959: 5: 73-75.
    • (1959) J. Trop. Pediatr. , vol.5 , pp. 73-75
    • Zeitoun, M.M.1
  • 117
    • 0342598151 scopus 로고
    • Aniline and nitrobenzene poisoning in infants
    • Zeligs M. Aniline and nitrobenzene poisoning in infants. Arch. Pediatr. 1929: 46: 502-506.
    • (1929) Arch. Pediatr. , vol.46 , pp. 502-506
    • Zeligs, M.1


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