Pseudoautosomal gene: Possible association with bipolar males but not with schizophrenia

Psychiatric Genetics

Volumn 9, Issue 3, 1999, Pages 129-134

  Hawi, Z ^a   Mynett Johnson, L ^a   Gill, M ^a   Murphy, V ^a   Straubl, R E ^b   Kendler, K S ^b   Walsh, D ^c   Machen, F ^a   Connell, H ^a   McKeon, P ^a   Shields, D ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HEALTH RESEARCH BOARD   (Ireland)

Author keywords

Anticipation; Association; Bipolar disorder; CAG repeat; Interleukin; Pseudoautosomal region; Schizophrenia

Indexed keywords

INTERLEUKIN RECEPTOR;

ALLELE; ANTICIPATION; ARTICLE; CHROMOSOME MAP; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; HUMAN; IRELAND; MAJOR CLINICAL STUDY; MALE; MANIC DEPRESSIVE PSYCHOSIS; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; SCHIZOPHRENIA; SEX DIFFERENCE; X CHROMOSOME LINKAGE; Y CHROMOSOME LINKAGE;

EID: 0033400911     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041444-199909000-00003     Document Type: Article

References (46)

1. Baron M, Risch N, Hamburger R, Mandel B, Kushner S, Newman M et al. (1987). Genetic linkage between X-chromosome and bipolar affective illness. Nature 326:289-292.
2. Barcellos LF, Klitz W, Field LL, Tobias R, Bowcock AM, Wilson R et al. (1997). Association mapping of disease loci, by use of a pooled DNA genomic screen. Am J Hum Genet 61(3):734-747.
3. Collinge JS, DeLisi LE, Boccio A, Johnstone E, Lane A, Larkin C et al. (1991). Evidence for pseudoautosomal dominant locus for schizophrenia using the method of sib pairs. Br J Psychiatry 158:624-629.
4. Coon H, Holik J, Hoff M, Relherr F, Wender P, Myles-Worsley M et al. (1994). Analysis of chromosome 22 markers in nine schizophrenia pedigrees. Am J Med Genet 5:72-79.
5. Craddock N, Owen M (1992). Christmas disease and major affective disorder. Br J Psychiatry 160:715.
6. Crow TJ (1988). Sex chromosome and psychosis: the case for pseudoautosomal locus. Br J Psychiatry 153:675-683.
7. Crow TJ, DeLisi LE (1989). Evidence for a sex chromosome locus for schizophrenia. Schiz Bull 15(3):431-437.
8. Crow TJ, DeLisi LE, Lofthouse R, Poulter R, Lehner T, Bass N et al. (1994). An examination of linkage of schizophrenia and schizoaffective disorder to the pseudoautosomal dominant region (Xp22.3). Br J Psychiatry 164:159-164.
9. D'Amato T, Waksman G, Martinez M, Laurent C, Gorwood P, Campion D et al. (1994). Pseudoautosomal region in schizophrenia: linkage analysis of 7 loci by sib pair and lod score method. Psych Res 52(2):135-147.
10. DeLisi LE, Friedrich U, Wahlsrom J, Boccio-Smith A, Forsman A, Eklund K et al. (1994a). Schizophrenia and sex chromosome anomalies. Schiz Bull 20(3):495-505.
11. DeLisi LE, Devoto M, Lofthouse R, Poulter M, Smith A, Shields G et al. (1994b). Search for linkage to schizophrenia on the X and Y chromosomes. Am J Med Genet 54(2):113-121.
12. Demoulin JB, Uyttenhove C, Van Roost E, DeLestre B, Donckers D, Van Snick J et al. (1996). A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, anti-apoptotic activity, and growth regulation by IL-9. Mol Cell Biol 16(9):4710-4716.
13. Forsman H (1970). The mental implication of sex chromosome aberration. Br J Psychiatry 117:353-363.
14. Ganguli R, Brar JS, Chengappa KR, Deleo M, Yang ZW, Shurin G et al. (1995). Mitogen-stimulated interleukin-2 product in nerve medicated, first episode schizophrenic patients: the influence of age of onset and negative symptoms. Arch Gen Psychiatry 52:668-672.
15. Gelernter J (1995). Genetics of bipolar: time for another reinvention. Am J Hum Genet 56:1262-1266.
16. Gill M, Castle D, Duggan C (1992). Cosegregation of Christmas disease and major affective disorder in pedigree. Br J Psychiatry 160:112-114.
17. Gill M, Vallada H, Collier D, Sham P, Holmans P, Murray P et al. (1996). A combined analysis of D22S278 marker allele in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22q12. Am J Med Genet 67:40-45.
18. Goldin LR, DeLisi LE, Gershon ES (1987). Genetic aspects of the biology of schizophrenia. Handbook of schizophrenia. Vol. 2: neurochemistry and neuropharmocology of schizophrenia. Henn A, DeLisi LE (editors). Amsterdam: Elsevier. pp. 467-487.
19. Gottesman H, Shields J (1982). Schizophrenia - the epigenetic puzzle. Cambridge, MA: Cambridge University Press.
20. Guy C, Bowen T, Speight G, McGuffin P, Craddock N, Owen MJ et al. (1997). Screening candidate chromosomes for expanded CAG/CTG repeat in schizophrenia and bipolar disorder. Am J Med Genet (Neuropsych Genet) 74:609.
21. Harper PS, Harley HG, Reardon W, Shaw DJ (1992). Anticipation in myotonic dystrophy: new light on an old problem. Am J Hum Genet 51:10-16.
22. Jones AL, Middle F, Guy C, Spurlock G, Cairns NJ, McGuffin P et al. (1997). No evidence for expanded polyglutamine sequence in bipolar disorder and schizophrenia. Mol Psychiatry 2:478-482.
23. Kendler KS, O'Neil FA, Murphy B, Duke F, Straub RE, Shinkwin R et al. (1996). The Irish study of high density schizophrenia families: field methods and power to detect linkage. Am J Med Genet (Neuropsych Genet) 57:179-190.
24. Kermouni A, Van Roost E, Arden KC, Vermeesch JR, Weiss S, Godelaine D et al. (1995). The IL-9 receptor gene (IL9R): genomic structure, chromosomal localisation in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter. Genomics 29(2):371-382.
25. Lindblad K, Nylander PO, Debruyn A, Sourcy D, Zander C, Engstrom C et al. (1995). Detection of expanded CAG repeat in bipolar affective disorder using the repeat expansion detection (RED) method. Neurobiol Dis 2:55-62.
26. Lucotte G, Landoulsi A, Berriche S, David F, Babron MC (1992). Manic depressive illness is linked to factor IX in French pedigree. Ann Genet 35:93-95.
27. Morris AG, Gaitonde E, McKenna PJ, Mollon JD, Hunt D (1995). CAG repeat expansion and schizophrenia: association with the disease in females and with early age of onset. Hum Mol Genet 4:1957-1961.
28. Mynett-Johnson LA, Murphy VE, Manley P, Shields DC, Humphries P, McKeon P (1997). Lack of evidence for a major locus for bipolar disorder in the pericentromeric region of chromosome 18 in Irish pedigrees. Biol Psychiatry 47:486-494.
29. O'Donovan MC, Guy C, Craddock N, Bowen T, McKeon P, Macedo A et al. (1997). Confirmation of association between expanded CAG/CTG repeats both schizophrenia and bipolar disorder. Psychol Med 26:1145-115.
30. Orue L, Lindblad K, Verheyen G, Ahlberg S, Jakovljevic M, Ivezic S et al. (1997). CAG repeat expansion in bipolar and unipolar disorder. Am J Hum Genet 60:730-733.
31. Parsian A, Todd RD (1994). Bipolar disorder and the pseudoautosomal region: an association study. Am J Med Genet 15:5-7.
32. Rapaport MH, Lohr JB (1994). Serum soluble interleukin-2 receptor in neuroleptic-naive schizophrenic subjects without tardive dyskinesia. Acta Psych Scan 90:311-315.
33. Rapaport MH, McAllister CG, Pickar D, Nelson DL, Paul SM (1989). Elevated level of interleukin-2 receptor in schizophrenia. Arch Gen Psychiatry 46:291-292.
34. Reich T, Clayton P, Winokur G (1969). Family history studies. V. The genetics of mania. Am J Psychiatry 125:1358-1369.
35. Renauld JC, Kermouni A, Vink A, Louahed J, Van Snick J (1995). Interleukin-9 and its receptor involvement in mast cell differentiation and T-cell oncogenesis. Leuk Biol 57(3):353-360.
36. Risch N, Merikangas K (1996). The future of genetic studies of complex diseases. Science 273:1516-1517.
37. Schalling M, Hudson TJ, Buetow KH, Housman DE (1993). Direct detection of novel expanded trinucleotide repeats in the human genome. Nat Genet 4:135-139.
38. Shields DC, Harmon DL, Whitehead AS (1996). Evolution of hemopoietic ligands and their receptors: influence of positive selection on correlated replacement throughout ligand and receptor prolein. J Immunol 156:1062-1070.
39. Speight G, Guy C, Bowen T, Asherson P, McGuffin P, Craddock N et al. (1997). Exclusion of CAG/CTG trinucleotide repeat loci which map to chromosome 4 in bipolar disorder and schizophrenia. Am J Med Genet (Neuropsych Genet) 74:204-206.
40. Straub RE, MacLean CJ, O'Neill AF, Burke J, Murphy B, Duke F et al. (1995). A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nat Genet 11:287-292.
41. Straub RE, MacLean CJ, O'Neill A, Walsh D, Kendler KS (1997). Support for a possible schizophrenia vulnerability locus in region 5q22-31 in Irish families. Mol Psychiatry 2:148-155.
42. Sturt E, McGuffin P (1985). Can linkage and marker association resolve the genetic actiology of psychiatric disorder: review and argument. Psychol Med 15:455-462.
43. Turecki G, Alda M, Joober R, Lafreniere RG, Grof P, Ahrens B et al. (1997). Investigating of genes containing expressed repeats in bipolar disorder. Am J Med Genet (Neuropsych Genet) 74:611.
44. Vallada H, Gill M, Sham P, Lim LC, Nanko S, Asherson P et al. (1995). Linkage studies on chromosome 22 in familial schizophrenia. Am J Med Genet 60:139-146.
45. Vincent JB, Klempan T, Parikh SS, Sasaki T, Meltzer H, Sirugo G et al. (1996). Frequency analysis of large CAG/ CTG trinucleotide repeat in schizophrenia and bipolar affective disorder. Mol Psychiatry 1:141-148.
46. Wang ZW, Black D, Andreason N, Crowe RR (1993). Pseudoautosomal locus for schizophrenia excluded in 12 pedigrees. Arch Gen Psychiatry 50:199-205.