Frequency analysis of large CAG/CTG trinucleotide repeats in schizophrenia and bipolar affective disorder

Molecular Psychiatry

Volumn 1, Issue 2, 1996, Pages 141-148

  Vincent, J B ^a   Klempan, T ^a   Parikh, S S ^a   Sasaki, T ^a   Meltzer, H Y ^b   Sirugo, G ^c   Cola, P ^b   Petronis, A ^a   Kennedy, J L ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Age of onset; Anticipation; Bipolar affective disorder; Drug response; Schizophrenia; Severity; Trinucleotide repeat expansion

Indexed keywords

DNA;

ADULT; ARTICLE; AUTORADIOGRAPHY; BIPOLAR DISORDER; FEMALE; GENETICS; HUMAN; MALE; NUCLEOTIDE REPEAT; ONSET AGE; SCHIZOPHRENIA;

ADULT; AGE OF ONSET; AUTORADIOGRAPHY; BIPOLAR DISORDER; DNA; FEMALE; HUMANS; MALE; REPETITIVE SEQUENCES, NUCLEIC ACID; SCHIZOPHRENIA;

EID: 0030133848     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Mott FW. A lecture on heredity and insanity. Lancet 1911; 1: 1251-1259.
2. Caskey TC, Pizzuti A, Fu Y-H, Fenwick RG, Nelson D. Triplet repeat mutations in human disease. Science 1992; 256: 784-789.
3. Sutherland GR, Richards RI. Dynamic mutations: a new class of mutations causing human disease. Cell 1992; 70: 709-712.
4. Richards RI, Sutherland GR. Heritable unstable DNA sequences. Nature Genet 1992; 1: 7-9.
5. Ross CA, McInnis MG, Margolis RL, Li S-H. Genes with triplet repeats: candidate mediators of neuropsychiatric disorders. TINS 1993; 16: 254-260.
6. The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's Disease Chromosomes. Cell 1993; 72: 971-983.
7. Koide R, Ikeuchi T, Onodera O, Tanaka H, Igarashi S, Endo K, Takahashi H, Kondo R, Ishikawa A, Hayashi T, Saito M, Tomoda A, Miike T, Naito H, Ikuta F, Tsuji S. Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Nature Genet 1994; 6: 9-13.
8. Nagafuchi S, Yanagisawa H, Sato K, Shirayama T, Ohsaki E, Bundo M, Takeda T, Tadokoro K, Kondo I, Murayama N, Tanaka Y, Kikushima H, Umino K, Kurosawa H, Furukawa T, Nihei K, Inoue T, Sano A, Komure O, Takahashi M, Yosizawa T, Kanazawa I, Yamada M. Denatatorubral and pallidoulysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p. Nature Genet 1994; 6: 14-18.
9. Kawaguchi Y, Okamoto T, Taniwaki M, Aizawa M, Inouo M, Katayama S, Kawakami H, Nakamura S, Nishimura M, Akiguchi I, Kimura J, Narumiya S, Kakizuka A. CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1. Nature Genet 1994; 8: 221-228.
10. Asherson P, Walsh C, Williams J, Sargeant M, Taylor C, Clements A, Gill M, Owen M, McGuffin P. Imprinting and anticipation: are they relevant to genetic, studies of schizophrenia? Psychiat Genet 1994; 3: 191.
11. Alda M, Lit W, Ahrens B, Labelle A, Zvolsky P, Jones P, Jones BD, Cameron P. Schizophrenia Res 1994; 11: 101.
12. Bassett AS, Honer WG. Evidence for anticipation in schizophrenia. Am J Hum Genet 1994; 54: 864-870.
13. Sharma T, Brynjolfsson J, Butler R, Read T, Murphy P, Sigmundsson T, Petursson H, Gurling H. Genomic imprinting in the Icelandic/British schizophrenia study: preliminary results. Schizophrenia Res 1993; 9: 124-125.
14. Aschauer HN, Heiden AM, Willinger U, Meszaros K, Miller-Reiter E, Stompe T, Lenzinger E, Resinger E, Scharfetter J, Strobl R, Kasper S. Study of anticipation in schizophrenia. Psychiat Genet 1995; 5: S7.
15. Guy C, Craddock N, Owen M, McGuffin P, O'Donovan M. The distribution of CAG/CTG trinucleotide repeats in schizophrenia and bipolar affective disorder. Psychiat Genet 1995; 5: 8.
16. Gorwood P, Leboyer M, Fallissard B, Jay M, Rouillon F, Ades J, Feingold J. Anticipation in schizophrenia: a new light on a controversial problem. Psychiat Genet 1995; 5: S7.
17. Thibaut F, Martinez M, Campion D, Jay M, Petit M. Anticipation in schizophrenia. Psychiat Genet 1995; 5: S10.
18. McInnis MG, McMahon FJ, Chase GA, Simpson SG, Ross CA, DePaulo R Jr. Anticipation in bipolar affective disorder. Am J Hum Genet 1993; 53: 385-390.
19. O'Neil J, Bryjolfsson J, Curtis D, Rifkin L, Maloney E, Murphy P, Petursson H, Gurling H. Testing the hypothesis for genomic imprinting and anticipation in bipolar and related unipolar affective disorder. Psychiat Genet 1993; 3: 151.
20. Nylander P-O, Engstrom C, Chotai J, Walstrom J, Adolfson R. Anticipation in Swedish families with bipolar affective disorder. J Med Genet 1994; 31: 686-689.
21. Serbanescu-Grigoriou M, Wickramaratne P, Hodge SE. Age of onset and current age in the estimation of genetic anticipation in bipolar I illness. Psychiat Genet 1995; 5: S10.
22. Lipp O, Souery D, Mahieu B, De Bruyn A, Van Broeckhoven C, Mendlewicz J. Anticipation in affective disorders. Psychiat Genet 1995; 5: S8.
23. Schalling M, Hudson TJ, Buetow KH, Housman DE. Direct detection of novel expanded trinucleotide repeats in the human genome. Nature Genet 1993; 4: 135-139.
24. O'Donovan MC, Guy C, Craddock N, Murphy KC, Cardno AG, Jones LA, Owen MJ, McGuffin P. Expanded CAG repeats in schizophrenia and bipolar disorder. Nature Genet 1995; 10: 380-381.
25. Lindblad K, Nylander P-O, De Bryen A, Sourey P, Zander C, Engstrom C, Holmgren C, Hudson T, Chotai J, Mendlewicz J, Broeckhoven CV, Schalling M, Adolfsson R. Detection of expanded CAG repeats in bipolar affective disorder using the repeat expansion detection (RED) method. Neurobiol Dis 1995; 2: 55-62.
26. Morris AG, Gaitonde E, McKenna PJ, Mollon JD, Hunt DM. CAG repeat expansions and schizophrenia: association with disease in females and with early age-at-onset. Hum Mol Genet 1995; 4: 1957-1961.
27. Deinard AS, Sirugo G, Wilson B, Kidd JR, Kidd KK. A meristic DNA trait: repeat expansion detection (RED) of (CTG)n repeats in humans and hominoids. Am J Hum Genet 1995; 57: A162.
28. Edwards A, Hammond HA, Jin L, Caskey CT, Chakraborty R. Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups. Genomics 1992; 12: 241-253.
29. Watkins WS, Bamshad M, Jorde LB. Population genetics of trinucleotide repeat polymorphisms. Hum Mol Genet 1995; 4: 1485-1491.
30. Sirugo G, Haaf T, Parnas J, Matthysse S, Levy D, Holzman P, Kidd KK. A (CTG)n expansion detected by RED in a schizophrenia kindred map to 18q21 by FISH with a CTG/CAG polymer. Am J Hum Genet 1995; 57: A36.
31. Spitzer RL, Endicott J. Schedule for Affective Disorders and Schizophrenia - Lifetime Version (SADS-L). New York State Psychiatric Institute: New York. 1978.
32. Burke KC, Burke JD, Regier DA, Rae DS. Age at onset of selected mental disorders in five community populations. Arch Gen Psychiatry 1990; 47: 511-518.
33. Sirugo G, Kidd KK. Repeat expansion detection using Ampligase thermostable DNA ligase. Epicentre Forum 1995; 2: 1.
34. Petronis A, Heng HHQ, Tatuch Y, Shi X-M, Tsui L-C, Ashizawa T, Surh LC, Kennedy JL. Direct detection of expanded trinucleotide repeats using DNA hybridization techniques. Am J Med Genet (Neuropsychiatric Genetics) 1995; 67: 85-91.
35. Petronis A, Bassett AS, Honer WG, Vincent J, Tatuch Y, Sasaki T, Ying D-J, Klempan TA, Kennedy JL. Search for unstable DNA in schizophrenia families with evidence for genetic anticipation. 1996; (submitted).
36. Gastier JM, Pulido JC, Sunden S, Brody T, Buetow KH, Murray JC, Weber JL, Hudson TJ, Sheffield VC, Duyk CM. Survey of trinucleotide repeats in the human genome: assessment of their utility as genetic markers. Hum Mol Genet 1995; 4: 1829-1836.
37. Riggins CJ, Lokey LK, Chastain JL, Leiner HA, Sherman SL, Wilkinson KD, Warren ST. Human genes containing polymorphic trinucleotide repeats. Nature Genet 1992; 2: 186-191.
38. Li SH, McInnis MG, Margolis RL, Antonarakis SE, Ross CA. Novel triplet repeat containing in human brain: cloning, expression and length polymorphisms. Genomics 1993; 16: 572-570.
39. Sasaki T, Billett E, Petronis A, Ying D, Parsons T, Macciardi FM, Meltzer HY, Liebermann J, Joffe RT, Ross CA, McInnis MG, Li S-H, Kennedy JL. Psychosis and genes with trinucleotide repeat polymorphism. Hum Genet 1996; 97: 244-246.