Ca2+/CaM-sensitive adenylyl cyclase activity is decreased in the Alzheimer's brain: Possible relation to type I adenylyl cyclase

Journal of Neural Transmission

Volumn 104, Issue 6-7, 1997, Pages 721-732

  Yamamoto, M ^a   Ozawa, H ^a,d   Saito, T ^b   Hatta, S ^a   Riederer, P ^c   Takahata, N ^a  

^a Sapporo Medical University   (Japan)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adenylyl cyclase; Calcium; Calmodulin; cAMPSignal transduction; Dementia of the alzheimer type (DAT); Postmortem human brain; Western blot

Indexed keywords

ADENYLATE CYCLASE; CALCIUM ION; CALMODULIN; ADCY1 PROTEIN, HUMAN; ADENYLYL CYCLASE 1; MEMBRANE PROTEIN; NERVE PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; PARIETAL LOBE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; BRAIN; COMPARATIVE STUDY; ENZYMOLOGY; IMMUNOHISTOCHEMISTRY; METABOLISM; MIDDLE AGED; NERVE CELL PLASTICITY; PHYSIOLOGY; STATISTICAL MODEL; SYNAPTIC MEMBRANE; ULTRASTRUCTURE;

ADENYLATE CYCLASE; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BRAIN; HUMANS; IMMUNOHISTOCHEMISTRY; LOGISTIC MODELS; MEMBRANE PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; NEURONAL PLASTICITY; PARIETAL LOBE; SYNAPTIC MEMBRANES;

EID: 0030608638     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01291889     Document Type: Article

References (25)

1. Bourtchuladze R, Frenguelli B, Blendy J, Cioffi D, Schutz G, Silva AJ (1994) Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell 79: 59-68
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
3. Chetkovich DM, Swcatt JD (1993) NMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase. J Neurochem 61: 1933-1942
4. Cowburn RF. O'Neil C, Ravid R, Alafuzoff I, Winblad B, Flowler CJ (1992a) Adenylyl cyclase activity in postmortem human brain: evidence of altered G protein mediation in Alzheimer's disease. J Neurochem 58: 1409-1419
5. Cowburn RF, O'Neill C, Ravid R, Winblad B, Fowler J (1992b) Preservation of Giprotein inhibited adenylyl cyclase activity in the brains of patients with Alzheimer's disease. Neurosci Lett 141: 16-20
6. 2+/Calmodulin-insensitive adenylyl cyclase from rat brain. Proc Natl Acad Sci USA 88: 10173-10177
7. Gsell W, Lange KW, Pfeuffer R, Heckers S, Heinsen H, Senitz D, Jellinger K, Ransmayr G, Wichart I, Vock R, Beckmann H, Riederer P (1993) How to run a brain bank: a report from the Austro-German brain bank. J Neural Transm [Suppl] 39: 31-70
8. Hummler E, Cole TJ, Blendy JA, Ganss R, Aguzzi A, Schmid W, Beermann F, Schütz G (1994) Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc Natl Acad Sci USA 91: 5647-5651
9. Ikezu T, Okamoto T, Komatsuzaki K (1996) Negative transduction of cAMP response element by familial Alzheimer's mutants of APP. EMBO J 15: 2468-2475
10. Iyengar R (1993) Molecular and functional diversity of mammalian Gs-stimulated adenylyl cyclase. FASEB J 7: 768-775
11. Katsushika S, Chen L, Kawabe J, Nilakantan R, Halnon NJ, Homey CJ, Ishikawa Y (1992) Cloning and characterization of a sixth adenylyl isoform: types V and VI constitute a subgroup within the mammalian adenylyl cyclase family. Proc Natl Acad Sci USA 89: 8774-8778
12. Krupinski J, Coussen F, Bakalyar HA, Tang W-J, Feinstein PG, Orth K, Slaughter C. Reed RR, Gilman AG (1989) Adenylyl cyclase amino acid sequence: possible channel-or transporter-like structure. Science 244: 1558-1564
13. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: a report of the NINCDS-ADRDA work group under the auspices of the department of health and human services task force on Alzheimer's disease. Neurology 34: 939-944
14. NcLaughlin M, Ross BM, Milligan G, McCulloch J, Knowler JT (1991) Robustness of G proteins in Alzheimer's disease: an immunoblot study. J Neurochem 57: 9-14
15. Ohm TG, Bohl J, Lemmer B (1991) Reduced basal and stimulated (isoprenaline, Gpp(NH)p, forskolin) adenylate cyclase activity in Alzheimer's disease correlated with histopathological changes. Brain Res 540: 229-236
16. Salomon Y (1979) Adenylate cyclase assay. Adv Cycl Nucl Res 10: 35-55
17. Schnecke A, Witte K, Bohl J, Ohm TG, Lemmer B (1994) Adenylyl cyclase activity in Alzheimer's disease brain: stimulatory and inhibitory signal transduction pathways are differently affected. Brain Res 644: 291-296
18. Seamon KB. Daly JW (1986) Forskolin: its biological and chemical properties. Adv Cycl Nucl Res 20:1
19. 2+-sensitive adenylyl cyclase activity is disrupted in the brains of type I adenylyl cyclase mutant mice. J Biol Chem 270: 14352-14357
20. 2+ and Gs-coupled receptors in vivo. J Biol Chem 269: 25400-25405
21. Wu Z, Wong ST, Storm DR (1993) Modification of the calcium and calmodulin sensitivity of the type I adenylyl cyclase by mutagenesis of its calmodulin binding domain. J Biol Chem 268: 23766-23768
22. Wu Z-L, Thomas SA, Villacres EC, Xia Z, Simmons ML, Chavkin C, Palmiter RD, Storm DR (1995) Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc Natl Acad Sci USA 92: 220-224
23. Xia Z, Choi E-J, Storm DR (1995) Do the calmodulin-stimulated adenylyl cyclases play a role in neuroplasticity? Behav Brain Sci 18: 429-440
24. Yamamoto M, Ozawa H, Saito T, Frölich L, Riederer P, Takahata N (1996) Reduced immunoreactivity of adenylyl cyclases in dementia of the Alzheimer type. Neuroreport 7: 2965-2970
25. Yin JCP, Wallach JS, Del Vecchio M, Wilder EL, Zhou H, Quinn WG, Tully T (1994) Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila. Cell 79: 49-58