Parallel solution synthesis of a 'carbohybrid' library designed to inhibit galactose-binding proteins

Combinatorial Chemistry and High Throughput Screening

Volumn 2, Issue 6, 1999, Pages 335-352

  Nilsson, U J ^a,b   Fournier, E J L ^a   Fryz, E J ^a   Hindsgaul, O ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b LUND INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLATION; ARTICLE; CARBOHYDRATE ANALYSIS; HYDROPHOBICITY; PRIORITY JOURNAL; STRUCTURE ANALYSIS; SYNTHESIS;

CALCIUM-BINDING PROTEINS; CARBOHYDRATES; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG EVALUATION, PRECLINICAL; GALACTOSE; HEMAGGLUTINATION TESTS; KETONES; LECTINS; MONOSACCHARIDE TRANSPORT PROTEINS; PERIPLASMIC BINDING PROTEINS; STEREOISOMERISM;

EID: 0033394141     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. McAuliffe, J.C.; Hindsgaul, O. Chem. Ind. 1997, 170-174.
2. Mamman, M.; Choi, S.-K.; Whitesides, G.M. Angew. Chem. Int. Ed. 1998, 37, 2754.
3. Liang, R.; Yan, L.; Loebach, J.; Ge, M.; Uozomi, Y.; Sekanina, K.; Horan, N.; Gildersleeve, J.; Thompson, C.; Smith, A.; Biswas, K.; Still, C.W.; Kahne, D. Science 1996, 274, 1520. Park, W.K.; Auer, M.; Jaksche, H.; Wong, C.-H. J. Am. Chem. Soc. 1996, 118, 10150. Wong, C.-H.; Hendrix, M.; Manning, D.D.; Rosenbohm, C.; Greenberg, W.A. J. Am. Chem. Soc. 1998, 120, 8319. St. Hilaire, P.M.; Lowary, T.L.; Meldal, M.; Bock, K. J. Am. Chem. Soc. 1998, 120, 13312. Lampe, T.F.J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. 1998, 37, 1707. Tsai, C.-Y.; Park, W.K.C.; Weitz-Schmidt, G.; Ernst, B.; Wong, C.-H. Bioorg. Med. Chem. Lett. 1998, 8, 2333. Lohse, A.; Jensen, K.B.; Lundgren, K.; Bols, M. Bioorg. Med. Chem. 1999, 7, 1965.
4. Liang, R.; Yan, L.; Loebach, J.; Ge, M.; Uozomi, Y.; Sekanina, K.; Horan, N.; Gildersleeve, J.; Thompson, C.; Smith, A.; Biswas, K.; Still, C.W.; Kahne, D. Science 1996, 274, 1520. Park, W.K.; Auer, M.; Jaksche, H.; Wong, C.-H. J. Am. Chem. Soc. 1996, 118, 10150. Wong, C.-H.; Hendrix, M.; Manning, D.D.; Rosenbohm, C.; Greenberg, W.A. J. Am. Chem. Soc. 1998, 120, 8319. St. Hilaire, P.M.; Lowary, T.L.; Meldal, M.; Bock, K. J. Am. Chem. Soc. 1998, 120, 13312. Lampe, T.F.J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. 1998, 37, 1707. Tsai, C.-Y.; Park, W.K.C.; Weitz-Schmidt, G.; Ernst, B.; Wong, C.-H. Bioorg. Med. Chem. Lett. 1998, 8, 2333. Lohse, A.; Jensen, K.B.; Lundgren, K.; Bols, M. Bioorg. Med. Chem. 1999, 7, 1965.
5. Liang, R.; Yan, L.; Loebach, J.; Ge, M.; Uozomi, Y.; Sekanina, K.; Horan, N.; Gildersleeve, J.; Thompson, C.; Smith, A.; Biswas, K.; Still, C.W.; Kahne, D. Science 1996, 274, 1520. Park, W.K.; Auer, M.; Jaksche, H.; Wong, C.-H. J. Am. Chem. Soc. 1996, 118, 10150. Wong, C.-H.; Hendrix, M.; Manning, D.D.; Rosenbohm, C.; Greenberg, W.A. J. Am. Chem. Soc. 1998, 120, 8319. St. Hilaire, P.M.; Lowary, T.L.; Meldal, M.; Bock, K. J. Am. Chem. Soc. 1998, 120, 13312. Lampe, T.F.J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. 1998, 37, 1707. Tsai, C.-Y.; Park, W.K.C.; Weitz-Schmidt, G.; Ernst, B.; Wong, C.-H. Bioorg. Med. Chem. Lett. 1998, 8, 2333. Lohse, A.; Jensen, K.B.; Lundgren, K.; Bols, M. Bioorg. Med. Chem. 1999, 7, 1965.
6. Liang, R.; Yan, L.; Loebach, J.; Ge, M.; Uozomi, Y.; Sekanina, K.; Horan, N.; Gildersleeve, J.; Thompson, C.; Smith, A.; Biswas, K.; Still, C.W.; Kahne, D. Science 1996, 274, 1520. Park, W.K.; Auer, M.; Jaksche, H.; Wong, C.-H. J. Am. Chem. Soc. 1996, 118, 10150. Wong, C.-H.; Hendrix, M.; Manning, D.D.; Rosenbohm, C.; Greenberg, W.A. J. Am. Chem. Soc. 1998, 120, 8319. St. Hilaire, P.M.; Lowary, T.L.; Meldal, M.; Bock, K. J. Am. Chem. Soc. 1998, 120, 13312. Lampe, T.F.J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. 1998, 37, 1707. Tsai, C.-Y.; Park, W.K.C.; Weitz-Schmidt, G.; Ernst, B.; Wong, C.-H. Bioorg. Med. Chem. Lett. 1998, 8, 2333. Lohse, A.; Jensen, K.B.; Lundgren, K.; Bols, M. Bioorg. Med. Chem. 1999, 7, 1965.
7. Liang, R.; Yan, L.; Loebach, J.; Ge, M.; Uozomi, Y.; Sekanina, K.; Horan, N.; Gildersleeve, J.; Thompson, C.; Smith, A.; Biswas, K.; Still, C.W.; Kahne, D. Science 1996, 274, 1520. Park, W.K.; Auer, M.; Jaksche, H.; Wong, C.-H. J. Am. Chem. Soc. 1996, 118, 10150. Wong, C.-H.; Hendrix, M.; Manning, D.D.; Rosenbohm, C.; Greenberg, W.A. J. Am. Chem. Soc. 1998, 120, 8319. St. Hilaire, P.M.; Lowary, T.L.; Meldal, M.; Bock, K. J. Am. Chem. Soc. 1998, 120, 13312. Lampe, T.F.J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. 1998, 37, 1707. Tsai, C.-Y.; Park, W.K.C.; Weitz-Schmidt, G.; Ernst, B.; Wong, C.-H. Bioorg. Med. Chem. Lett. 1998, 8, 2333. Lohse, A.; Jensen, K.B.; Lundgren, K.; Bols, M. Bioorg. Med. Chem. 1999, 7, 1965.
8. Liang, R.; Yan, L.; Loebach, J.; Ge, M.; Uozomi, Y.; Sekanina, K.; Horan, N.; Gildersleeve, J.; Thompson, C.; Smith, A.; Biswas, K.; Still, C.W.; Kahne, D. Science 1996, 274, 1520. Park, W.K.; Auer, M.; Jaksche, H.; Wong, C.-H. J. Am. Chem. Soc. 1996, 118, 10150. Wong, C.-H.; Hendrix, M.; Manning, D.D.; Rosenbohm, C.; Greenberg, W.A. J. Am. Chem. Soc. 1998, 120, 8319. St. Hilaire, P.M.; Lowary, T.L.; Meldal, M.; Bock, K. J. Am. Chem. Soc. 1998, 120, 13312. Lampe, T.F.J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. 1998, 37, 1707. Tsai, C.-Y.; Park, W.K.C.; Weitz-Schmidt, G.; Ernst, B.; Wong, C.-H. Bioorg. Med. Chem. Lett. 1998, 8, 2333. Lohse, A.; Jensen, K.B.; Lundgren, K.; Bols, M. Bioorg. Med. Chem. 1999, 7, 1965.
9. Liang, R.; Yan, L.; Loebach, J.; Ge, M.; Uozomi, Y.; Sekanina, K.; Horan, N.; Gildersleeve, J.; Thompson, C.; Smith, A.; Biswas, K.; Still, C.W.; Kahne, D. Science 1996, 274, 1520. Park, W.K.; Auer, M.; Jaksche, H.; Wong, C.-H. J. Am. Chem. Soc. 1996, 118, 10150. Wong, C.-H.; Hendrix, M.; Manning, D.D.; Rosenbohm, C.; Greenberg, W.A. J. Am. Chem. Soc. 1998, 120, 8319. St. Hilaire, P.M.; Lowary, T.L.; Meldal, M.; Bock, K. J. Am. Chem. Soc. 1998, 120, 13312. Lampe, T.F.J.; Weitz-Schmidt, G.; Wong, C.-H. Angew. Chem. Int. Ed. 1998, 37, 1707. Tsai, C.-Y.; Park, W.K.C.; Weitz-Schmidt, G.; Ernst, B.; Wong, C.-H. Bioorg. Med. Chem. Lett. 1998, 8, 2333. Lohse, A.; Jensen, K.B.; Lundgren, K.; Bols, M. Bioorg. Med. Chem. 1999, 7, 1965.
10. Nilsson, U.J.; Fournier, E.J.-L; Hindsgaul, O. Bioorg. Med. Chem. 1998, 6, 1563.
11. Bundle, D. In Glycosciences: Status and Perspectives.; Gabius, H.-J.; Gabius, S., Eds.; Chapman & Hall: Weinheim, 1997; pp. 311-331.
12. Borch, R.F.; Bernstein, M.D.; Durst, H.D. J. Am. Chem. Soc. 1971, 93, 2897.
13. Look, G.C.; Murphy, M.M.; Campbell, D.A.; Gallop, M.A. Tetrahedron Lett., 1995, 36, 2937.
14. Abdel-Magid, A.F.; Carson, K.G.; Harris, B.D. J. Org. Chem. 1996, 61, 3849.
15. Rajanikanth, B.; Seshadri, R. Tetrahedron Lett., 1987, 28, 2295.