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Volumn 5, Issue 6, 1999, Pages 403-409

Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: Response to therapy is linked to the duration of progressive disease

Author keywords

Cyclophosphamide; Immunosuppression; Multiple sclerosis

Indexed keywords

CYCLOPHOSPHAMIDE; IMMUNOSUPPRESSIVE AGENT; METHYLPREDNISOLONE;

EID: 0033391669     PISSN: 13524585     EISSN: None     Source Type: Journal    
DOI: 10.1191/135245899678846492     Document Type: Article
Times cited : (68)

References (49)
  • 1
    • 0026645658 scopus 로고
    • Immunological aspects of demyelinatmg diseases
    • Martin R et al. (1992) Immunological aspects of demyelinatmg diseases. Ann Rev Immunol 10: 153-187.
    • (1992) Ann Rev Immunol , vol.10 , pp. 153-187
    • Martin, R.1
  • 2
    • 0028938723 scopus 로고
    • Therapy for MS
    • Weiner HL et al. (1995) Therapy for MS. Neurologic Clinics 13: 173-196.
    • (1995) Neurologic Clinics , vol.13 , pp. 173-196
    • Weiner, H.L.1
  • 3
    • 0008678962 scopus 로고    scopus 로고
    • Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis
    • Jacobs LD et al. (1996) Intramuscular Interferon beta-1a for disease progression in relapsing multiple sclerosis. Ann Neurol 39: 285-294.
    • (1996) Ann Neurol , vol.39 , pp. 285-294
    • Jacobs, L.D.1
  • 4
    • 0029161628 scopus 로고
    • Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomized controlled trial
    • The IFNB MS Study Group and UBC MS/MRI Analysis Group. (1995) Interferon beta-1b in the treatment of multiple sclerosis: Final outcome of the randomized controlled trial. Neurology 45: 1277-1285.
    • (1995) Neurology , vol.45 , pp. 1277-1285
  • 5
    • 0029082566 scopus 로고
    • Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind, placebo-controlled trial
    • Johnson KP et al. (1995) Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind, placebo-controlled trial. Neurology 45: 1268-1276.
    • (1995) Neurology , vol.45 , pp. 1268-1276
    • Johnson, K.P.1
  • 6
    • 0028906384 scopus 로고
    • Low dose (7.5 mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis
    • Goodkin DE et al. (1995) Low dose (7.5 mg) oral methotrexate reduces the rate of progression in chronic progressive multiple sclerosis. Ann Neurol 37: 30-40.
    • (1995) Ann Neurol , vol.37 , pp. 30-40
    • Goodkin, D.E.1
  • 7
    • 0029983154 scopus 로고    scopus 로고
    • The treatment of chronic progressive multiple sclerosis with cladribine
    • Beutler E et al. (1996) The treatment of chronic progressive multiple sclerosis with cladribine. Proc Natl Acad Sci USA 93: 1716-1720.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1716-1720
    • Beutler, E.1
  • 8
    • 0029838040 scopus 로고    scopus 로고
    • Linomide reduces the rate of active lesions in relapsing-remitting multiple sclerosis
    • Anderson O et al. (1996) Linomide reduces the rate of active lesions in relapsing-remitting multiple sclerosis. Neurology 47: 895-900.
    • (1996) Neurology , vol.47 , pp. 895-900
    • Anderson, O.1
  • 9
    • 0029832923 scopus 로고    scopus 로고
    • Treatment of secondary progressive multiple sclerosis with the immunomodulator linomide: A double blind, placebo-controlled pilot study with monthly magnetic resonance imaging evaluation
    • Karussis DM et al. (1996) Treatment of secondary progressive multiple sclerosis with the immunomodulator linomide: a double blind, placebo-controlled pilot study with monthly magnetic resonance imaging evaluation. Neurology 47: 341-346.
    • (1996) Neurology , vol.47 , pp. 341-346
    • Karussis, D.M.1
  • 10
    • 0023636606 scopus 로고
    • Total lymphoid irradiation in multiple sclerosis. Blood lymphocytes and clinical course
    • Cook SD et al. (1987) Total lymphoid irradiation in multiple sclerosis. Blood lymphocytes and clinical course. Ann Neurol 22: 634-638.
    • (1987) Ann Neurol , vol.22 , pp. 634-638
    • Cook, S.D.1
  • 11
    • 0031040238 scopus 로고    scopus 로고
    • Therapeutic effect of mitoxanthrone combined with methylprednisolone in multiple sclerosis: A randomized multicenter study of active disease using MRI and clinical criteria
    • Edan G et al. (1997) Therapeutic effect of mitoxanthrone combined with methylprednisolone in multiple sclerosis: a randomized multicenter study of active disease using MRI and clinical criteria. J Neurol Psychiatr 62: 112-118.
    • (1997) J Neurol Psychiatr , vol.62 , pp. 112-118
    • Edan, G.1
  • 12
    • 0031744008 scopus 로고    scopus 로고
    • The Mayo Clinic-Canadian cooperative trial of sulfasalazine in active multiple sclerosis
    • Noseworthy JH et al. (1998) The Mayo Clinic-Canadian cooperative trial of sulfasalazine in active multiple sclerosis. Neurology 51: 1342-1352.
    • (1998) Neurology , vol.51 , pp. 1342-1352
    • Noseworthy, J.H.1
  • 13
    • 0032494792 scopus 로고    scopus 로고
    • Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis
    • European Study Group on Interferon β-1b in Secondary Progressive MS. (1998) Placebo-controlled multicentre randomised trial of Interferon β-1b in treatment of secondary progressive multiple sclerosis. Lancet 352: 1491-1497.
    • (1998) Lancet , vol.352 , pp. 1491-1497
  • 14
    • 0014007245 scopus 로고
    • Sclerose en plaques et processus d'autoimmunisation. Traitment par les anti-mitotiques
    • Aimard G et al. (1966) Sclerose en plaques et processus d'autoimmunisation. Traitment par les anti-mitotiques. Lyon Med 215: 345-352.
    • (1966) Lyon Med , vol.215 , pp. 345-352
    • Aimard, G.1
  • 15
    • 0016754809 scopus 로고
    • Treatment of the chronic progressive form of multiple sclerosis with a combination of cyclophosphamide and prednisone
    • Hommes OR et al. (1975) Treatment of the chronic progressive form of multiple sclerosis with a combination of cyclophosphamide and prednisone. Clinical Neurology and Neurosurgery 78: 59-73.
    • (1975) Clinical Neurology and Neurosurgery , vol.78 , pp. 59-73
    • Hommes, O.R.1
  • 16
    • 0017332050 scopus 로고
    • Intensive immunosuppression with cyclophosphamide in multiple sclerosis: Follow-up of 110 patients for 2-6 years
    • Gonsette R et al. (1977) Intensive immunosuppression with cyclophosphamide in multiple sclerosis: follow-up of 110 patients for 2-6 years. J Neuroimmunol 214: 173-181.
    • (1977) J Neuroimmunol , vol.214 , pp. 173-181
    • Gonsette, R.1
  • 17
    • 0018826728 scopus 로고
    • Effect of intensive immunosuppression on the course of chronic progressive multiple sclerosis
    • Hommes OR et al. (1980) Effect of intensive immunosuppression on the course of chronic progressive multiple sclerosis. J Neurol 223: 177-190.
    • (1980) J Neurol , vol.223 , pp. 177-190
    • Hommes, O.R.1
  • 18
    • 0342440622 scopus 로고
    • Prognostic factors in intensive immunosuppression on the course of chronic progressive multiple sclerosis
    • Bauer HJ, Poser S, Ritter G (eds) Berlin: Springer Verlag
    • Hommes OR et al. (1980) Prognostic factors in intensive immunosuppression on the course of chronic progressive multiple sclerosis. In: Progress in multiple sclerosis research. Bauer HJ, Poser S, Ritter G (eds) Berlin: Springer Verlag, pp. 396-400.
    • (1980) Progress in Multiple Sclerosis Research , pp. 396-400
    • Hommes, O.R.1
  • 19
    • 0020683886 scopus 로고
    • Intensive immunosuppression in progressive multiple sclerosis: A randomized, three-arm study of high dose intravenous cyclophosphamide, plasma exchange and ACTH
    • Hauser SL et al. (1983) Intensive immunosuppression in progressive multiple sclerosis: A randomized, three-arm study of high dose intravenous cyclophosphamide, plasma exchange and ACTH. N Engl J Med 308: 173-180.
    • (1983) N Engl J Med , vol.308 , pp. 173-180
    • Hauser, S.L.1
  • 20
    • 0023718266 scopus 로고
    • Immunosuppression with high-dose IV cyclophosphamide and ACTH in progressive multiple sclerosis; cumulative 6-year experience in 164 patients
    • Carter JL et al. (1988) Immunosuppression with high-dose IV cyclophosphamide and ACTH in progressive multiple sclerosis; cumulative 6-year experience in 164 patients. Neurology 38: 9-14.
    • (1988) Neurology , vol.38 , pp. 9-14
    • Carter, J.L.1
  • 21
    • 0023390969 scopus 로고
    • Cyclophosphamide 'pulses' in chronic progressive multiple sclerosis
    • Myers LW et al. (1987) Cyclophosphamide 'pulses' in chronic progressive multiple sclerosis. Arch Neurol 44: 828-832.
    • (1987) Arch Neurol , vol.44 , pp. 828-832
    • Myers, L.W.1
  • 22
    • 0023152206 scopus 로고
    • Correlation of clinical and immunological states in multiple sclerosis
    • Mickey MR et al. (1987) Correlation of clinical and immunological states in multiple sclerosis. Arch Neurol 44: 371-375.
    • (1987) Arch Neurol , vol.44 , pp. 371-375
    • Mickey, M.R.1
  • 23
    • 0023394826 scopus 로고
    • Cyclophosphamide in chronic progressive multiple sclerosis: Maintenance vs. nonmaintenance therapy
    • Goodkin DE et al. (1987) Cyclophosphamide in chronic progressive multiple sclerosis: maintenance vs. nonmaintenance therapy. Arch Neurol 44: 823-827.
    • (1987) Arch Neurol , vol.44 , pp. 823-827
    • Goodkin, D.E.1
  • 24
    • 0023836524 scopus 로고
    • Controlled pilot trial on monthly intravenous cyclophosphamide in multiple sclerosis
    • Killian JM et al. (1988) Controlled pilot trial on monthly intravenous cyclophosphamide in multiple sclerosis. Arch Neurol 45: 27-30.
    • (1988) Arch Neurol , vol.45 , pp. 27-30
    • Killian, J.M.1
  • 25
    • 0024514055 scopus 로고
    • Effective treatment of chronic progressive multiple sclerosis with low-dose cyclophosphamide with minor side-effects
    • Mauch E et al. (1989) Effective treatment of chronic progressive multiple sclerosis with low-dose cyclophosphamide with minor side-effects. Eur Arch Psych Neurol Sci 238: 115-117.
    • (1989) Eur Arch Psych Neurol Sci , vol.238 , pp. 115-117
    • Mauch, E.1
  • 26
    • 0024316667 scopus 로고
    • Immunosuppression intensive dans la sclerose en plaques progressive etude ouverte comparant trois groupes: Cyclophosphamide, cyclophosphamide-plasmaphereses et temoins resultats a trois ans
    • Trouillas P et al. (1989) Immunosuppression intensive dans la sclerose en plaques progressive etude ouverte comparant trois groupes: cyclophosphamide, cyclophosphamide-plasmaphereses et temoins resultats a trois ans. Rev Neurol 145: 369-377.
    • (1989) Rev Neurol , vol.145 , pp. 369-377
    • Trouillas, P.1
  • 27
    • 0026317943 scopus 로고
    • Intense immunosuppression in chronic progressive multiple sclerosis: The Kaiser study
    • Likosky WH et al. (1991) Intense immunosuppression in chronic progressive multiple sclerosis: the Kaiser study. J Neurol Neurosurg Psychiatr 54: 1055-1060.
    • (1991) J Neurol Neurosurg Psychiatr , vol.54 , pp. 1055-1060
    • Likosky, W.H.1
  • 28
    • 0025967752 scopus 로고
    • The Canadian Cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis
    • The Canadian Cooperative Multiple Sclerosis Study Group. (1991) The Canadian Cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis. Lancet 337: 442-446.
    • (1991) Lancet , vol.337 , pp. 442-446
  • 29
    • 0001430776 scopus 로고    scopus 로고
    • Treatment of fulminant multiple sclerosis with intravenous cyclophosphamide
    • Weinstock-Guttmann B et al. (1997) Treatment of fulminant multiple sclerosis with intravenous cyclophosphamide. The Neurologist 3: 178-185.
    • (1997) The Neurologist , vol.3 , pp. 178-185
    • Weinstock-Guttmann, B.1
  • 30
    • 0025904767 scopus 로고
    • Immunologic effects of cyclophosphamide/ACTH in patient with chronic progressive multiple sclerosis
    • Hafler DA et al. (1991) Immunologic effects of cyclophosphamide/ACTH in patient with chronic progressive multiple sclerosis. J Neuroimmunol 32: 149-158.
    • (1991) J Neuroimmunol , vol.32 , pp. 149-158
    • Hafler, D.A.1
  • 31
    • 0342440621 scopus 로고
    • Pilot study of three year intermittent pulse cyclophosphamide/methylprednisolone therapy in multiple sclerosis
    • Hohol MJ et al. (1992) Pilot study of three year intermittent pulse cyclophosphamide/methylprednisolone therapy in multiple sclerosis (abstract). Ann Neurol 32: 256-257.
    • (1992) Ann Neurol , vol.32 , pp. 256-257
    • Hohol, M.J.1
  • 32
    • 0027196941 scopus 로고
    • Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: Final report on the Northeast Cooperative Multiple Sclerosis Treatment Group
    • Weiner HL et al. (1993) Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report on the Northeast Cooperative Multiple Sclerosis Treatment Group. Neurology 43: 910-918.
    • (1993) Neurology , vol.43 , pp. 910-918
    • Weiner, H.L.1
  • 33
    • 0030767497 scopus 로고    scopus 로고
    • Immune deviation following cyclophosphamide/methylprednisolone treatment of multiple sclerosis; Increased IL-4 and associated eosinophilia
    • Smith D et al. (1997) Immune deviation following cyclophosphamide/methylprednisolone treatment of multiple sclerosis; Increased IL-4 and associated eosinophilia. Ann Neurol 42: 313-318.
    • (1997) Ann Neurol , vol.42 , pp. 313-318
    • Smith, D.1
  • 34
    • 0031828331 scopus 로고    scopus 로고
    • Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4 secreting T cells in multiple sclerosis patients
    • Takashima H et al. (1998) Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4 secreting T cells in multiple sclerosis patients. Clin Immunol Immunopathol 88: 28-34.
    • (1998) Clin Immunol Immunopathol , vol.88 , pp. 28-34
    • Takashima, H.1
  • 35
    • 0032528896 scopus 로고    scopus 로고
    • Elevated interleuken-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy
    • Cornabella M et al. (1998) Elevated interleuken-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy. J Clin Invest 102: 671-678.
    • (1998) J Clin Invest , vol.102 , pp. 671-678
    • Cornabella, M.1
  • 36
    • 0023889565 scopus 로고
    • Clinical and immunologic effects of monthly administration of intravenous cyclophosphamide in lupus erythematosis
    • McCune W et al. (1988) Clinical and immunologic effects of monthly administration of intravenous cyclophosphamide in lupus erythematosis. N Engl J Med 318: 1423-1431.
    • (1988) N Engl J Med , vol.318 , pp. 1423-1431
    • McCune, W.1
  • 37
    • 0030268581 scopus 로고    scopus 로고
    • Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis. A randomized controlled trial
    • Gourley M et al. (1996) Methylprednisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis. A randomized controlled trial. Ann Int Med 125: 549-557.
    • (1996) Ann Int Med , vol.125 , pp. 549-557
    • Gourley, M.1
  • 38
    • 0031817597 scopus 로고    scopus 로고
    • A phase II study of IV methylprednisolone in secondary-progressive multiple sclerosis
    • Goodkin DE et al. (1998) A phase II study of IV methylprednisolone in secondary-progressive multiple sclerosis. Neurology 51: 239-245.
    • (1998) Neurology , vol.51 , pp. 239-245
    • Goodkin, D.E.1
  • 39
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF. (1983) Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS). Neurology 33: 1444-1452.
    • (1983) Neurology , vol.33 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 40
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis; results on an international survey
    • Lublin FD et al. (1996) Defining the clinical course of multiple sclerosis; results on an international survey. Neurology 46: 907-911.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1
  • 41
    • 0029902571 scopus 로고    scopus 로고
    • Meta-analysis of the placebo-treated groups in clinical trials of progressive MS
    • Weinshenker BG, Issa M, Baskerville J. (1996) Meta-analysis of the placebo-treated groups in clinical trials of progressive MS. Neurology 46: 1613-1619.
    • (1996) Neurology , vol.46 , pp. 1613-1619
    • Weinshenker, B.G.1    Issa, M.2    Baskerville, J.3
  • 42
    • 0027225747 scopus 로고
    • An open-trial evaluation of mitoxanthrone in the treatment of progressive MS
    • Noseworthy JH et al. (1993) An open-trial evaluation of mitoxanthrone in the treatment of progressive MS. Neurology 43: 1401-1406.
    • (1993) Neurology , vol.43 , pp. 1401-1406
    • Noseworthy, J.H.1
  • 43
    • 0025817469 scopus 로고
    • A placebo-controlled, double-blind, randomized, two-center, pilot trial of Cop 1 in chronic progressive multiple sclerosis
    • Bornstein MB et al. (1991) A placebo-controlled, double-blind, randomized, two-center, pilot trial of Cop 1 in chronic progressive multiple sclerosis. Neurology 41: 533-539.
    • (1991) Neurology , vol.41 , pp. 533-539
    • Bornstein, M.B.1
  • 44
    • 0030034570 scopus 로고    scopus 로고
    • MRI dynamics of brain and spinal cord in progressive multiple sclerosis
    • Kidd D et al. (1996) MRI dynamics of brain and spinal cord in progressive multiple sclerosis. J Neurol Neurosurg Psychiatr 60: 15-19.
    • (1996) J Neurol Neurosurg Psychiatr , vol.60 , pp. 15-19
    • Kidd, D.1
  • 45
    • 0031027581 scopus 로고    scopus 로고
    • Increased IL-12 production in progressive multiple sclerosis: Induction by activated CD4+ cells via CD40 ligand
    • Balashov KE et al. (1997) Increased IL-12 production in progressive multiple sclerosis: Induction by activated CD4+ cells via CD40 ligand. Proc Natl Acad Sci USA 94: 599-603.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 599-603
    • Balashov, K.E.1
  • 46
    • 0021889168 scopus 로고
    • In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
    • Hafler DA et al. (1985) In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N Engl J Med 312: 1405-1411.
    • (1985) N Engl J Med , vol.312 , pp. 1405-1411
    • Hafler, D.A.1
  • 47
    • 0033013687 scopus 로고    scopus 로고
    • Interleukin-12: Amiss in MS
    • Karp C. (1999) Interleukin-12: Amiss in MS. Ann Neurol 45: 689-692.
    • (1999) Ann Neurol , vol.45 , pp. 689-692
    • Karp, C.1
  • 48
    • 0032975730 scopus 로고    scopus 로고
    • Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different stages in multiple sclerosis
    • Van Boxel-Dezaire, AHH et al. (1999) Decreased interleukin-10 and increased interleukin-12p40 mRNA are associated with disease activity and characterize different stages in multiple sclerosis. Ann Neurol 45: 695-703.
    • (1999) Ann Neurol , vol.45 , pp. 695-703
    • Van Boxel-Dezaire, A.H.H.1
  • 49
    • 0032879010 scopus 로고    scopus 로고
    • Effect of open label pulse cyclophosphamide therapy on MRI measures of disease activity in five patients with refractory relapsing-remitting multiple sclerosis
    • Gobbini MI et al 1999. Effect of open label pulse cyclophosphamide therapy on MRI measures of disease activity in five patients with refractory relapsing-remitting multiple sclerosis. J Neuroimmunol 99: 142-149.
    • (1999) J Neuroimmunol , vol.99 , pp. 142-149
    • Gobbini, M.I.1


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