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Volumn 47, Issue 4, 1996, Pages 895-900

Linomide reduces the rate of active lesions in relapsing-remitting multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOMODULATING AGENT; PLACEBO; QUINOLINE DERIVATIVE; ROQUINIMEX;

EID: 0029838040     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.47.4.895     Document Type: Article
Times cited : (100)

References (27)
  • 1
    • 0025802630 scopus 로고
    • Therapy of multiple sclerosis, with particular reference to recent clinical trials
    • Khoury SJ, Weiner HL. Therapy of multiple sclerosis, with particular reference to recent clinical trials. Curr Opin Neurol Neurosurg 1991;4:191-195.
    • (1991) Curr Opin Neurol Neurosurg , vol.4 , pp. 191-195
    • Khoury, S.J.1    Weiner, H.L.2
  • 2
    • 0022618553 scopus 로고
    • Effects of the novel immunomodulator LS 2616 on the delayed-type hypersensitivity reaction to Bordetella pertussis in the rat
    • Stålhandske T, Kalland T. Effects of the novel immunomodulator LS 2616 on the delayed-type hypersensitivity reaction to Bordetella pertussis in the rat. Immunopharmacology 1986;11: 87-92.
    • (1986) Immunopharmacology , vol.11 , pp. 87-92
    • Stålhandske, T.1    Kalland, T.2
  • 3
    • 0023265714 scopus 로고
    • Mechanism of action of the new immunomodulator LS2616 on T cell responses
    • Larsson E, Joki A, Stålhandske T. Mechanism of action of the new immunomodulator LS2616 on T cell responses. Int J Immunopharmacol 1987;9:425-431.
    • (1987) Int J Immunopharmacol , vol.9 , pp. 425-431
    • Larsson, E.1    Joki, A.2    Stålhandske, T.3
  • 4
    • 0023025518 scopus 로고
    • Effects of LS 2616 administration upon the autoimmune disease of (NZB × NZW) F1 hybrid mice
    • Tarkowski A, Gunnarsson K, Stålhandske T. Effects of LS 2616 administration upon the autoimmune disease of (NZB × NZW) F1 hybrid mice. Immunology 1986;59:589-594.
    • (1986) Immunology , vol.59 , pp. 589-594
    • Tarkowski, A.1    Gunnarsson, K.2    Stålhandske, T.3
  • 5
    • 0028559752 scopus 로고
    • Immunomodulation of experimental autoimmune myasthenia gravis with Linomide
    • Karussis D, Lehmann D, Brenner T, et al. Immunomodulation of experimental autoimmune myasthenia gravis with Linomide. J Neuroimmunol 1994;55:187-193.
    • (1994) J Neuroimmunol , vol.55 , pp. 187-193
    • Karussis, D.1    Lehmann, D.2    Brenner, T.3
  • 6
    • 0028046103 scopus 로고
    • Prevention of diabetes mellitus in non-obese diabetic mice by Linomide, a novel immunomodulating drug
    • Gross D, Sidi H, Weiss L, Kalland T, Rosenmann E, Slavin S. Prevention of diabetes mellitus in non-obese diabetic mice by Linomide, a novel immunomodulating drug. Diabetologia 1994;37:1195-1201.
    • (1994) Diabetologia , vol.37 , pp. 1195-1201
    • Gross, D.1    Sidi, H.2    Weiss, L.3    Kalland, T.4    Rosenmann, E.5    Slavin, S.6
  • 7
    • 0024512182 scopus 로고
    • Effects of the immunomodulator LS 2616 on lymphocyte subpopulations in murine Coxsackie virus B3 myocarditis
    • Ilbäck N, Fohlman J, Slorach S, Friman G. Effects of the immunomodulator LS 2616 on lymphocyte subpopulations in murine Coxsackie virus B3 myocarditis. J Immunol 1989;142: 3225-3228.
    • (1989) J Immunol , vol.142 , pp. 3225-3228
    • Ilbäck, N.1    Fohlman, J.2    Slorach, S.3    Friman, G.4
  • 8
    • 0024396936 scopus 로고
    • Linomide, a new immunomodulatory drug, shows different effects on homologous versus heterologous collagen-induced arthritis in rats
    • Kleinau S, Larsson P, Björk J, Holmdahl R, Klareskog L. Linomide, a new immunomodulatory drug, shows different effects on homologous versus heterologous collagen-induced arthritis in rats. Clin Exp Immunol 1989;78:138-142.
    • (1989) Clin Exp Immunol , vol.78 , pp. 138-142
    • Kleinau, S.1    Larsson, P.2    Björk, J.3    Holmdahl, R.4    Klareskog, L.5
  • 9
    • 0024375029 scopus 로고
    • Paradoxical effects of LS-2616 (Linomide) treatment in the type II collagen arthritis model in mice
    • Björk J, Kleinau S. Paradoxical effects of LS-2616 (Linomide) treatment in the type II collagen arthritis model in mice. Agents Actions 1989;27:319-321.
    • (1989) Agents Actions , vol.27 , pp. 319-321
    • Björk, J.1    Kleinau, S.2
  • 10
    • 0027496152 scopus 로고
    • Inhibition of acute, experimental autoimmune encephalomyelitis by the synthetic immunomodulator Linomide
    • Karussis DM, Lehmann D, Slavin S, et al. Inhibition of acute, experimental autoimmune encephalomyelitis by the synthetic immunomodulator Linomide. Ann Neurol 1993;34:654-660.
    • (1993) Ann Neurol , vol.34 , pp. 654-660
    • Karussis, D.M.1    Lehmann, D.2    Slavin, S.3
  • 11
    • 0027197490 scopus 로고
    • Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator Linomide (quinoline-3-carboxamide)
    • Karussis D, Lehmann D, Slavin S, et al. Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator Linomide (quinoline-3-carboxamide). Proc Natl Acad Sci USA 1993;90:6400-6404.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6400-6404
    • Karussis, D.1    Lehmann, D.2    Slavin, S.3
  • 12
    • 0029832923 scopus 로고    scopus 로고
    • Treatment of secondary progressive multiple sclerosis with the immunomodulator linomide: A double-blind, placebo-controlled pilot study with monthly magnetic resonance imaging evaluation
    • Karussis DM, Meiner Z, Lehmann D, Gomori J-M, Schwarz A, Linde A, Abramsky O. Treatment of secondary progressive multiple sclerosis with the immunomodulator linomide: a double-blind, placebo-controlled pilot study with monthly magnetic resonance imaging evaluation. Neurology 1996;47: 341-346.
    • (1996) Neurology , vol.47 , pp. 341-346
    • Karussis, D.M.1    Meiner, Z.2    Lehmann, D.3    Gomori, J.-M.4    Schwarz, A.5    Linde, A.6    Abramsky, O.7
  • 13
    • 0011095952 scopus 로고
    • Poser CM, Paty DW, Scheinberg L, McDonald WI, Ebers GC, eds. Stuttgart: Georg Thieme
    • Poser CM, Paty DW, Scheinberg L, et al. In: Poser CM, Paty DW, Scheinberg L, McDonald WI, Ebers GC, eds. The diagnosis of multiple sclerosis. Stuttgart: Georg Thieme, 1984;225-229.
    • (1984) The Diagnosis of Multiple Sclerosis , pp. 225-229
    • Poser, C.M.1    Paty, D.W.2    Scheinberg, L.3
  • 14
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33:1444-1452.
    • (1983) Neurology , vol.33 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 15
    • 0025741072 scopus 로고
    • Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: Concerted action guidelines
    • Miller D, Barkhof F, Berry I, Kappos L, Scotti G, Thompson A. Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: concerted action guidelines. J Neurol Neurosurg Psychiatry 1991;54:683-688.
    • (1991) J Neurol Neurosurg Psychiatry , vol.54 , pp. 683-688
    • Miller, D.1    Barkhof, F.2    Berry, I.3    Kappos, L.4    Scotti, G.5    Thompson, A.6
  • 16
    • 0030032317 scopus 로고    scopus 로고
    • Acyclovir treatment of relapsing-remitting multiple sclerosis
    • Lycke J, Svennerholm B, Hjelmquist E, et al. Acyclovir treatment of relapsing-remitting multiple sclerosis. J Neurol 1996; 243:214-224.
    • (1996) J Neurol , vol.243 , pp. 214-224
    • Lycke, J.1    Svennerholm, B.2    Hjelmquist, E.3
  • 17
    • 0017592811 scopus 로고
    • Principles of albumin and IgG analyses in neurological disorders
    • Tibbling G, Link H, Öhman S. Principles of albumin and IgG analyses in neurological disorders. Scand J Clin Lab Invest 1977;37:385-390.
    • (1977) Scand J Clin Lab Invest , vol.37 , pp. 385-390
    • Tibbling, G.1    Link, H.2    Öhman, S.3
  • 18
    • 0028793468 scopus 로고
    • Lymphocyte phenotype and subset distribution in normal cerebrospinal fluid
    • Svenningsson A, Andersen O, Edsbagge M, Stemme S. Lymphocyte phenotype and subset distribution in normal cerebrospinal fluid. J Neuroimmunol 1995;63:39-46.
    • (1995) J Neuroimmunol , vol.63 , pp. 39-46
    • Svenningsson, A.1    Andersen, O.2    Edsbagge, M.3    Stemme, S.4
  • 19
    • 0027237086 scopus 로고
    • Triple immunofluorescence flow cytometry, using whole blood, of CD4+ and CD8+ lymphocytes expressing CD45RO and CD45RA
    • Gruber R, Reiter C, Riethmuller G. Triple immunofluorescence flow cytometry, using whole blood, of CD4+ and CD8+ lymphocytes expressing CD45RO and CD45RA. J Immunol Methods 1993;163:173-179.
    • (1993) J Immunol Methods , vol.163 , pp. 173-179
    • Gruber, R.1    Reiter, C.2    Riethmuller, G.3
  • 20
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • The IFNB Multiple Sclerosis Study Group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993;43:655-661.
    • (1993) Neurology , vol.43 , pp. 655-661
  • 21
    • 0027946710 scopus 로고
    • Longitudinal MRI in multiple sclerosis: Correlation between disability and lesion burden
    • Khoury SJ, Guttmann CRG, Orav EJ, et al. Longitudinal MRI in multiple sclerosis: Correlation between disability and lesion burden. Neurology 1994;44:2120-2124.
    • (1994) Neurology , vol.44 , pp. 2120-2124
    • Khoury, S.J.1    Guttmann, C.R.G.2    Orav, E.J.3
  • 22
    • 0027381828 scopus 로고
    • Gadolinium enhancement increases the sensitivity of MRI in detecting disease activity in multiple sclerosis
    • Miller D, Barkhof F, Nauta J. Gadolinium enhancement increases the sensitivity of MRI in detecting disease activity in multiple sclerosis. Brain 1993;116:1077-1094.
    • (1993) Brain , vol.116 , pp. 1077-1094
    • Miller, D.1    Barkhof, F.2    Nauta, J.3
  • 23
    • 0025342659 scopus 로고
    • Heterogeneity of blood-brain barrier changes in multiple sclerosis: An MRI study with gadolinium-DTPA enhancement
    • Kermode A, Tofts P, Thompson A, et al. Heterogeneity of blood-brain barrier changes in multiple sclerosis: an MRI study with gadolinium-DTPA enhancement. Neurology 1990; 40:229-235.
    • (1990) Neurology , vol.40 , pp. 229-235
    • Kermode, A.1    Tofts, P.2    Thompson, A.3
  • 24
    • 0026598654 scopus 로고
    • Serial gadolinium-enhanced MRI in relapsing/remitting multiple sclerosis of varying disease duration
    • Thompson A, Miller D, Youl B, et al. Serial gadolinium-enhanced MRI in relapsing/remitting multiple sclerosis of varying disease duration. Neurology 1992;42:60-63.
    • (1992) Neurology , vol.42 , pp. 60-63
    • Thompson, A.1    Miller, D.2    Youl, B.3
  • 26
    • 0025999081 scopus 로고
    • Human tumor necrosis factor-alpha augments experimental allergic encephalomyelitis in rats
    • Kuroda Y, Shimamoto Y. Human tumor necrosis factor-alpha augments experimental allergic encephalomyelitis in rats. J Neuroimmunol 1991;34:159-164.
    • (1991) J Neuroimmunol , vol.34 , pp. 159-164
    • Kuroda, Y.1    Shimamoto, Y.2
  • 27
    • 0028985320 scopus 로고
    • Tumor necrosis factor-alpha messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity
    • Riekmann P, Albrecht M, Kitze B, et al. Tumor necrosis factor-alpha messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity. Ann Neurol 1995;37:82-88.
    • (1995) Ann Neurol , vol.37 , pp. 82-88
    • Riekmann, P.1    Albrecht, M.2    Kitze, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.