Extraneuronal monoamine transporter expression and DNA repair vis-a-vis 2-chloroethyl-3-sarcosinamide-1-nitrosourea cytotoxicity in human tumor cell lines

Clinical Cancer Research

Volumn 5, Issue 12, 1999, Pages 4186-4190

  Chen, Zhong Ping ^a   Remack, Joanna ^b   Brent, Thomas P ^b   Mohr, Gérard ^a   Panasci, Lawrence C ^a  

^a MCGILL UNIVERSITY   (Canada)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLOROETHYL 3 SARCOSINAMIDE 1 NITROSOUREA; MONOAMINE; NITROSOUREA DERIVATIVE; SULFORHODAMINE B; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; COLORIMETRY; CYTOTOXICITY; DNA REPAIR; EXCISION REPAIR; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGRESSION ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SPECIFICITY; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CARMUSTINE; CARRIER PROTEINS; DNA HELICASES; DNA REPAIR; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; HUMANS; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; ORGANIC CATION TRANSPORT PROTEINS; PROTEIN BIOSYNTHESIS; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED; XERODERMA PIGMENTOSUM GROUP D PROTEIN;

EID: 0033391609     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Lesser, G. J., and Grossman, S. The chemotherapy of high-grade astrocytomas. Semin. Oncol., 21: 220-235, 1994.
2. Carter, S. K., Schabel, F. M., Jr., Broder, L. E., and Johnston, T. P. 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU) and other nitrosoureas in cancer treatment: a review. Adv. Cancer Res., 16: 273-332, 1972.
3. Panasci, L. C., Marcantonio, D., and Noë, A. J. SarCNU (2-chloroethyl-3-sarcosinamide-1-nitrosourea): a novel analogue of chloroethylnitrosourea that is transported by the catecholamine uptake2 carrier, which mediates increased cytotoxicity. Cancer Chemother. Pharmacol., 37: 505-508, 1996.
4. Suami, T., Kato, T., Takino, H., and Hisamatsu, T. (2-Chloroethyl) nitrosourea congeners of amino acid amides. J. Med. Chem., 25: 829-832, 1982.
5. Grundemann, D., Schechinger, B., Rappold, G. A., and Schomig, E. Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat. Neurosci., 1: 349-351, 1998.
6. Skalski, V., Rivas, J., Panasci, L., McQuillan, A., and Feindel, W. The cytotoxicity of sarcosinamide chloroethylnitrosourea (SarCNU) and BCNU in primary gliomas and glioma cell lines: analysis of data in reference to theoretical peak plasma concentrations in man. Cancer Chemother. Pharmacol., 22: 137-140, 1988.
7. Panasci, L. C., Dufour, M., Chevalier, L., Isabel, G.. Lazarus, P., McQuillan, A., Arbit, E., Brem, S., and Feindel, W. Utilization of the HTSCA and CFU-C assay to identify two new 2-chloroethylnitrosourea congeners of amino acid amides with increased in vitro activity against human glioma compared with BCNU. Cancer Chemother. Pharmacol., 14: 156-159, 1985.
8. Marcantonio, D., Panasci, L. C., Hollingshead, M. G., Alley, M. C., Camalier, R. F., Sausville, E. A., Dykes, D. J., Carter, C. A., and Malspeis, L. 2-Chloroethyl-3-sarcosinamide-1-nitrosourea, a novel chloroethylnitrosourea analogue with enhanced antitumor activity against human glioma xenografts. Cancer Res., 57: 3895-3898, 1997.
9. Chen, Z. P., Wang, G., Huang, Q., Sun, Z. F., Zhou, L. Y., Wang, A. D., and Panasci, L. C. Enhanced antitumor activity of SarCNU in comparison to BCNU in an extraneuronal monoamine transporter positive human glioma xenograft model. J. Neuro-oncol., in press. 1999.
10. Noë, A. J., Malapetsa, A., and Panasci, L. C. Altered cytotoxicity of (2-chloroethyl)-3-sarcosinamide-1-nitrosourea in human glioma cell lines SK-MG-1 and SKI-1 correlates with differential transport kinetics. Cancer Res., 54: 1491-1496, 1994.
11. Noë, A. J., Marcantonio, D., Barton, J., Malapetsa, A., and Panasci, L. C. Characterization of the catecholamine extraneuronal uptake2 carrier in human glioma cell lines SK-MG-1 and SKI-1 in relation to (2-chloroethyl)-3-sarcosinamide-1-nitrosourea (SarCNU) selective cytotoxicity. Biochem. Pharmacol., 57: 1639-1648, 1996.
12. 6-Alkylguanine- DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans- 4-methylcyclohexyl)-1-nitrosourea. Proc. Natl. Acad. Sci. USA, 82: 2985-2989, 1985.
13. Chen, Z. P., Malapetsa, A., Marcantonio, D., Mohr, G., Brien, S., and Panasci, L. C. Correlation of chloroethylnitrosourea resistance with ERCC-2 expression in human tumor cell lines as determined by quantitative competitive polymerase chain reaction. Cancer Res., 56: 2475-2478, 1996.
14. Chen, Z. P., McQuillan, A., Mohr, G., and Panasci, L. C. Excision repair cross-complementing rodent repair deficiency gene 2 expression and chloroethylnitrosourea resistance in human glioma cell lines. Neurosurgery, 42: 1112-1119, 1998.
15. Chen, Z. P., Malapetsa, A., Mohr, G., Brien, S., and Panasci, L. C. Quantitation of ERCC-2 gene expression in human tumor cell lines by reverse transcription-polymerase chain reaction in comparison to northern blot analysis. Anal. Biochem., 244: 50-54, 1997.
16. 6-methylguanine- DNA methyltransferase-mediated innate chloroethylnitrosourea resistance in human tumor cell lines. Mol. Pharmacol., 52: 815-820, 1997.
17. 6-methylguanine-DNA methylferase levels and clinical response induced by chloroethylnitrosourea therapy in glioma patients. Can. J. Neurol. Sci., 26: 104-109, 1999.
18. 6-benzylguanine on the sensitivity of human tumor xenografts to 1.3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation. Cancer Res., 52: 1171-1175, 1992.
19. 6-benzylguanine plus BCNU. Cancer Res., 57: 4817-4823, 1997.
20. 6-methylguanine-DNA methyl- transferase levels with survival of malignant astrocytoma patients treated with his-chloroethylnitrosourea: a Southwest Oncology Group study. J. Clin. Oncol., 16: 3310-3315, 1998.
21. Belanich, M., Pastor, M., Randall, T., Guerra, D., Kibitel, J., Alas, L., Li, B., Citron, M., Wasserman, P., White, A., Eyre, H., Jaeckle, K., Schulman, S., Rector, D., Prados, M., Coons, S., Shapiro, W., and Yarosh, D. Retrospective study of the correlation between the DNA repair protein alkyltransferase and survival of brain tumor patients treated with carmustine. Cancer Res., 56: 783-788, 1996.
22. Streich, S., Bruss, M., and Bonisch, H. Expression of the extraneuronal monoamine transporter (uptake2) in human glioma cells. Naunyn-Schmiedebergs Arch. Pharmacol., 353: 328-333, 1996.