Spontaneous and chemically induced point mutations in HPRT cDNA of the metabolically competent human lymphoblastoid cell line, MCL-5

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 431, Issue 2, 1999, Pages 417-428

  Krause, Günter ^a   Garganta, Fátima ^a   Vrieling, Harry ^b   Scherer, Gerhard ^a  

^a ABF   (Germany)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

4 (N nitroso methylamino) 1 (3 pyridyl) 1 butanone; Benzo a pyrene; Chemical mutagenesis; Cigarette smoke condensate; Mutational specificity

Indexed keywords

2 BUTANONE; BENZO[A]PYRENE; CIGARETTE SMOKE CONDENSATE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ARTICLE; CHEMICAL MUTAGENESIS; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; LYMPHOCYTE CLONE; MOLECULAR CLONING; NUCLEIC ACID BASE SUBSTITUTION; OPEN READING FRAME; POINT MUTATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BENZO(A)PYRENE; CELL LINE; DNA, COMPLEMENTARY; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MUTAGENS; NITROSAMINES; PLANTS, TOXIC; POINT MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SMOKE; TOBACCO;

EID: 0033391476     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(99)00183-9     Document Type: Article

References (34)

1. Hollstein M., Sidransky D., Vogelstein B., Harris C.C. p53 mutations in human cancers. Science. 253:1991;49-53.
2. Garganta F., Krause G., Scherer G. Base-substitution profiles of externally activated polycyclic aromatic hydrocarbons and aromatic amines determined in a lacZ reversion assay. Environ. Mol. Mutagen. 33:1999;75-85.
3. Cariello N.F., Douglas G.R., Soussi T. Databases and software for the analysis of mutations in the human p53 gene, the human HPRT gene and the lacZ gene in transgenic rodents. Nucleic Acids Res. 24:1996;119-120.
4. Albertini R.J., Nicklas J.A., O'Neill J.P., Robinson S.H. In vivo somatic mutations in humans: measurement and analysis. Annu. Rev. Genet. 24:1990;305-326.
5. Vrieling H., Thijssen J.C., Rossi A.M., Van Dam F.J., Natarajan A.T., Tates A.D., Van Zeeland A.A. Enhanced HPRT mutation frequency but no significant difference in mutation spectrum between a smoking and a non-smoking human population. Carcinogenesis. 13:1992;1625-1631.
6. Steingrimsdottir H., Rowley G., Waugh A., Beare D., Ceccherini I., Cole J., Lehmann A.R. Molecular analysis of mutations in the HPRT gene in circulating lymphocytes from normal and DNA-repair-deficient donors. Mutat. Res. 294:1993;29-41.
7. Burkhart-Schultz K.J., Thompson C.L., Jones I.M. Spectrum of somatic mutation at the hypoxanthine phosphoribosyltransferase (HPRT) gene of healthy people. Carcinogenesis. 17:1996;1871-1883.
8. Podlutsky A., Österholm A.-M., Hou S.-M., Hofmaier A., Lambert B. Spectrum of point mutations in the coding region of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene in human T-lymphocytes in vivo. Carcinogenesis. 19:1998;557-566.
9. Furth E.E., Thilly W.G., Penman B.W., Liber H.L., Rand W.M. Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates. Anal. Biochem. 110:1981;1-8.
10. Lichtenauer-Kaligis E.G.R., Thijssen J.C.P., Den Dulk H., Van de Putte P., Giphart-Gassler M., Tasseron-de Jong J.G. Spontaneous mutation spectrum in the HPRT gene in human lymphoblastoid TK6 cells. Mutagenesis. 10:1995;137-143.
11. Morgenthaler P.-M.L., Holzhäuser D. Analysis of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human lymphoblastoid cells. Carcinogenesis. 16:1995;713-718.
12. Crespi C.L. Expression of cytochrome P450 cDNAs in human B lymphoblastoid cells: applications to toxicology and metabolite analysis. Methods Enzymol. 206:1991;123-129.
13. Crespi C.L., Gonzalez F.J., Steimel D.T., Turner T.R., Gelboin H.V., Penman B.W., Langenbach R. A metabolically competent human cell line expressing five cDNAs encoding procarcinogen-activating enzymes: application to mutagenicity testing. Chem. Res. Toxicol. 4:1991;566-572.
14. Busby W.F. Jr., Penman B.W., Crespi C.L. Human cell mutagenicity of mono- and dinitropyrenes in metabolically competent MCL-5 cells. Mutat. Res. 322:1994;233-242.
15. Crofton-Sleigh C., Doherty A., Ellard S., Parry E.M., Venitt S. Micronucleus assays using cytochalasin-blocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P450 and microsomal epoxide hydrolase. Mutagenesis. 8:1993;363-372.
16. Keohavong P., Melacrinos A., Shukla R. In vitro mutational spectrum of cyclopenta[cd]pyrene in the human HPRT gene. Carcinogenesis. 16:1995;855-860.
17. Dobo K.L., Eastmond D.A., Grosovsky A.J. Sequence specific mutations induced by N-nitrosodimethylamine at two marker loci in metabolically competent human lymphoblastoid cells. Carcinogenesis. 19:1998;755-764.
18. Garganta F., Krause G., Scherer G. Rapid characterization of mutations in amplified human HPRT cDNA by polyacrylamide gel electrophoresis. Mutat. Res. 406:1998;33-43.
19. F. Garganta, Spezifität der chemischen Mutagenese im HPRT-Gen in vitro behandelter menschlicher Lymphoblasten - Kulturen und im E. coli Reversionstest, PhD thesis, University of Munich, 1999.
20. Shimahara H., Kato T., Hirai Y., Akiyama M. Spectrum of in vivo HPRT mutations in T-lymphocytes from atomic bomb survivors: I. Sequence alterations in cDNA. Carcinogenesis. 16:1995;583-591.
21. ± human lymphoblastoid cells. Mutat. Res. 356:1996;129-134.
22. Morris S.M., Chen J.J., Domon O.E., McGarrity L.J., Bishop M.E., Manjanatha M.G., Casciano D.A. p53, mutations, and apoptosis in genistein-exposed human lymphoblastoid cells. Mutat. Res. 405:1998;41-56.
23. Österholm A.-M., Fält S., Lambert B., Hou S.-M. Classification of mutations at the human HPRT locus in T-lymphocytes of bus maintenance workers by multiplex-PCR and reverse transcriptase-PCR analysis. Carcinogenesis. 16:1995;1909-1912.
24. 6-methylthioguanine. Biochemistry. 36:1997;2501-2506.
25. Glaab W.E., Risinger J.I., Umar A., Barrett J.C., Kunkel T.A., Tindall K.R. Resistance to 6-thioguanine in mismatch-repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus. Carcinogenesis. 19:1998;1931-1937.
26. Tvdrik T., Marcus S., Hou S.-M., Fält S., Noori P., Podlutskaja N., Hanefeld F., Strömme P., Lambert B. Molecular characterization of two deletion events involving Alu-sequences, one novel base substitution and two tentative hotspot mutations in the hypoxanthine phosphoribosyltransferase (HPRT) gene in five patients with Lesch-Nyhan syndrome. Hum. Genet. 103:1998;311-318.
27. Finette B.A., O'Neill J.P., Vacek P.M., Albertini R.J. Gene mutations with characteristic deletions in cord blood T-lymphocytes associated with passive maternal exposure to tobacco smoke. Nat. Med. 4:1998;1144-1151.
28. Jiao J., Zielenska M., Anderson M.W., Glickman B.W. Mutational specificities of environmental carcinogens in the lacI gene of Escherichia coli: IV. The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Carcinogenesis. 12:1991;221-224.
29. Tiano H.F., Wang R.-L., Hosokawa M., Crespi C., Tindall K.R., Langenbach R. Human CYP2A6 activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): mutational specificity in the gpt gene of AS52 cells. Carcinogenesis. 15:1994;2859-2866.
30. Meuth M. The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells. Exp. Cell Res. 181:1989;305-316.
31. Rainaldi G., Meneveri R., Mariani L., Gineli E., Moretti A., Vatteroni L. dCTP misincorporation in a Chinese hamster mutator phenotype: the role of GGA genetic context. Mutagenesis. 11:1996;401-404.
32. Hanelt S., Helbig R., Hartmann A., Lang M., Seidel A., Speit G. A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo[a]pyrene-7,8-diol 9,10-oxide in cultured human cells. Mutat. Res. 390:1997;179-188.
33. Chen R.H., Maher V.M., Brouwer J., Van de Putte P., McCormick J.J. Preferential repair and strand-specific repair of benzo[a]pyrene diol epoxide adducts in the HPRT gene of diploid human fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 89:1992;5413-5417.
34. Kat A.G., Thilly W.G. Mutational spectra of endogenous genes in mammalian cells. Hemminki K., Dipple A., Shuker D.E.G., Kadlubar F.F., Segerbäck D., Bartsch H. DNA Adducts: Identification and Biological Significance. 1994;371-383 IARC Scientific Publications, Lyon.