Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine α1(I) collagen promoter in transgenic mice

Gene Expression

Volumn 8, Issue 3, 1999, Pages 151-163

  Krempen, Kimberly ^a   Grotkopp, Doris ^a   Hall, Keith ^a   Bache, Alexandra ^a   Gillan, Andrea ^b   Rippe, Richard A ^b   Brenner, David A ^b   Breindl, Michael ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

l(1) collagen; Enhancer Uterus; Green fluorescent protein; Transgenic mice Distal regulatory elements

Indexed keywords

COLLAGEN TYPE 1; DEOXYRIBONUCLEASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; GENE; GENE CONTROL; GENE EXPRESSION; MOUSE; NONHUMAN; TRANSGENIC MOUSE; UTERUS;

ANIMALS; COLLAGEN; FEMALE; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MICE; MICE, TRANSGENIC; PROMOTER REGIONS (GENETICS); REGULATORY SEQUENCES, NUCLEIC ACID; RESPONSE ELEMENTS; TRANSGENES; UTERUS;

ANIMALIA; EUKARYOTA; MURINAE; MUS MUSCULUS; RODENTIA;

EID: 0033391288     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Barsh, G. S.; Roush, C. L.; Gelinas, R. E. DNA and chromatin structure of the human alpha1(I) collagen gene. J. Biol. Chem. 259:14906-14913; 1984.
2. Bedalov, A.; Salvatori, R.; Dodig, M; Kronenberg, M. S.; Kapural, B.; Bogdanovic, Z.; Kream, B. E.; Woody, C. O.; Clark, S. H.; Mack, K.; Rowe, D. W.; Lichtler, A. L. Regulation of COL1A1 gene expression in type I collagen producing tissues: Identification of a 49 base pair region which is required for transgene expression in bone of transgenic mice. J. Bone Miner. Res. 10:-1443-1452; 1995.
3. Bogdanovic, Z.; Bedalov, A.; Krebsbach, P. H.; Pavlin, D.; Woody, C. O.; Clark, S. H.; Thomas, H. F.; Rowe, D. W.; Kream, B. E.; Lichtler, A. C. Upstream regulatory elements necessary for expression of the rat COL1A1 promoter in transgenic mice. J. Bone Miner. Res. 9:285-292; 1994.
4. Bornstein, P. Regulation of expression of the α1 (I) collagen gene: A critical appraisal of the role of the first intron. Matrix Biol. 15:3-10; 1996.
5. Bou-Gharios, G.; Garrett, L. A.; Rossert, J.; Niederreiter, K.; Eberspacher, H.; Smith, C.; Black, C.; deCrombrugghe. B. A potent far-upstream enhancer in the mouse pro α1(I) collagen gene regulates expression of reporter genes in transgenic mice. J. Cell Biol. 134: 1333-11344; 1996.
6. Breindl, M.; Harbers, K.; Jaenisch, R. Retrovirus-induced lethal mutation in collagen I gene of mice is associated with an altered chromatin structure. Cell 38: 9-16; 1984.
7. Brenner, D. A.; Rippe, R. A.; Rhodes, K.; Trotter, J. F.; Breindl, M. Fibrogenesis and type I collagen gene regulation. J. Lab. Clin. Med. 124:755-760; 1994.
8. Chang, W. Y.; Wilson, M. J.; Birch, L.; Prins, G. S. Neonatal estrogen stimulates proliferation of periductal fibroblasts and alters the extracellular matrix composition in the rat prostate. Endocrinology 140:405-415; 1999.
9. Driscoll, M. D.; Sathya, G.; Muyan, M.; Klinge, C. M.; Hilf, R.; Bambara, R. A. Sequence requirements for estrogen receptor binding to estrogen response elements. J. Biol. Chem. 273:29321-29330; 1998.
10. Dyer, R. F.; Sodek, J.; Heersche, J. M. N. The effect of 17β-estradiol on collagen and noncollagenous protein synthesis in the uterus and some periodontal tissues. Endocrinology 107:1014-1022; 1980.
11. Epner, E.; Rcik, A.; Cimbora, D.; Telling, A.; Bender, M. A.; Fiering, S.; Enver, T.; Martin, D. I. K.; Keller, G.; Groudine, M. The β-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse β-globin locus. Mol. Cell 2:447-455; 1998.
12. Festenstein, R.; Tolaini, M.; Corbella, P.; Mamalaki, C.; Parrington, J.; Fox, M.; Miliou, A.; Jones, M.; Kioussis, D. Locus control region function and heterochromatin-induced position effect variegation. Science 271:1123-1125; 1996.
13. Fischer, G. M. Comparison of collagen dynamics in different tissues under the influence of estradiol. Endocrinology 93:1216-1224; 1973.
14. Fraser, P.; Grosveld, F. Locus control regions, chromatin activation and transcription. Curr. Opin. Genet. Dev. 10:361-365; 1998.
15. Graham, J. D.; Clarke, C. L. Physiological action of progesterone in target tissues. Endocr. Rev. 18:502-519; 1997.
16. Higgs, D. R. Do LCRs open chromatin domains? Cell 95:299-302; 1998.
17. Inagaki, Y.; Truter, S.; Ramirez, F. Transforming growth factor-beta stimulates alpha 2 (I) collagen gene expression through a cis-acting element that contains an Spl-binding site. J. Biol. Chem. 296:14828-14834; 1994.
18. Kioussis, D.; Festenstein, R. Locus control regions: Overcoming heterochromatin-induced gene inactivation in mammals. Curr. Opin. Genet. Dev. 7:614-619; 1997.
19. Krempen, K. Analysis of upstream regulatory elements of the murine α1(I) collagen gene. Master's thesis, San Diego State University; 1998.
20. Mahonen, A.; Jukkola, A.; Risteli, L.; Risteli, L.; Mäenpää, P. Type I procollagen synthesis is regulated by steroids and related hormones in human osteosarcoma cells. J. Cell. Biochem. 68:151-163; 1998.
21. Mariotti, A.; Soderholm, K. J.; Johnson, S. The in vivo effects of bisGMA on murine uterine weight, nucleic acids and collagen. Eur. J. Oral Sci. 106:1022-1027; 1998.
22. Prockop, D. J.; Kivirikko, K. I. Collagens: Molecular biology, diseases, and potentials for therapy. Annu. Rev. Biochem. 64:403-434; 1995.
23. Qu, Q.; Perala-Heape, M.; Kapanen, A.; Dahllund, J.; Salo, J.; Vaananen, H. K.; Harkonen, P. Estrogen enhances differentiation of osteoblasts in mouse bone marrow culture. Bone 22:201-209; 1998.
24. Rhodes, K.; Rippe, R. A.; Umezavva, A.; Nehls, M.; Brenner, D. A.; Breindl, M. DNA methylation represses murine α1(I) collagen promoter by an indirect mechanism. Mol. Cell. Biol. 14:5950-5960; 1994.
25. Rhodes, K.; Hall, K.; Lee, K. E.; Razzaghi, H.; Breindl, M. Correct cell and differentiation-specific expression of a murine α1(I) collagen minigene in in vitro differentiating embryonal carcinoma cells. Gene Expr. 6:35-44; 1996.
26. Rippe, R. A.; Lorenzen, S.-I.; Brenner, D. A.; Breindl, M. Regulatory elements in the 5′-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. Mol. Cell. Biol. 9:2224-2227; 1989.
27. Rippe, R. A.; Umezawa, A.; Kimball, J. P.; Breindl, M.; Brenner, D. A. Binding of upstream stimulatory factor to an E-box in the 3′-flanking sequence stimulates α1(I) collagen gene transcription. J. Biol. Chem. 272:1753-1760; 1997.
28. Ritzenthaler, J. D.; Goldstein, R. H.; Fine, A.; Lichtler, A.; Rowe, D. W.; Smith, B. D. Transforming-growthfactor-β activation elements in the distal promoter regions of the rat eel type I collagen gene. Biochem. J. 280:157-162; 1991.
29. Rossert, J. A.; Eberspaecher, H.; deCrombrugghe, B. Separate cis-acting DNA elements of the mouse proα1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J. Cell Biol. 129:1421-1432; 1995.
30. Rossen, J. A.; Chen, S. S.; Eberspaecher, H.; Smith, C. D.; deCrombrugghe, B. Identification of a minimal sequence of the mouse α1 (I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts. Proc. Natl. Acad. Sci. USA 93:1027-1031; 1996.
31. Salimi-Tari, P.; Cheung, M.; Safar, C. A.; Tracy, J. T.; Tran, L; Harbers, K.; Breindl, M. Molecular cloning and chromatin structure analysis of the murine α1(I) collagen gene domain. Gene 198:61-72; 1997.
32. Schmidt, A.; Rossi, P.; deCrombrugghe, B. Transcriptional control of the mouse α2(I) collagen gene: Functional deletion analysis of the promoter and evidence for cell-specific expression. Mol. Cell. Biol. 6:347-354; 1986.
33. Slack, J. D.; Liska, D. J.; Bomstein, P. Regulation of expression of the type I collagen genes. Am. J. Med. Genet. 45:140-151; 1993.
34. Slack, J. L.; Parker, M. I.; Bornstein, P. Transcriptional repression of the α1(I) collagen gene by ras is mediated in part by an intronic API site. J. Cell. Biochem. 58:380-392; 1995.
35. Sokolov, B. P.; Mays, P. K.; Khillan, J. S.; Prockop, D. J. Tissue- and development-specific expression in transgenic mice of a type I procollagen (COL1A1) minigene construct with 2.3 kb of the promoter region and 2 kb of 3′-flanking region. Specificity is independent of the putative regulatory sequences in the first intron. Biochemistry 32:9242-9249; 1993.
36. Sokolov, B. P.; Ala-Koko, L.; Dhulipala, R.; Arita, M.; Khillan, J. S.; Prockop, D. J. Tissue-specific expression of the gene for type I procollagen (COL1A1) in transgenic mice. J. Biol. Chem. 270:9622-9629; 1995.
37. Sutherland, H. G. E.; Martin, D. I. K.; Whitelaw, E. A globin enhancer acts by increasing the proportion of erythrocytes expressing a linked transgene. Mol. Cell. Biol. 17:1607-1614; 1997.
38. Vuorio, E.; de Crombrugghe, B. The family of collagen genes. Annu. Rev. Biochem. 59:837-872; 1990.
39. Walters, M. C.; Magis, W.; Fiering, S.; Scalzo, D.; Groudine, M.; Martin, D. I. K. Transcriptional enhancers act in cis to suppress position-effect variegation. Genes Dev. 10:185-195; 1996.