Two related neurokinin-1 receptor antagonists have overlapping but different binding sites

Bioorganic and Medicinal Chemistry

Volumn 6, Issue 2, 1998, Pages 189-194

  Greenfeder, Scott ^a   Cheewatrakoolpong, Boonlert ^a   Anthes, John ^a   Billah, Motasim ^a   Egan, Robert W ^a   Brown, Joan E ^a   Murgolo, Nicholas J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

CP 96,345; CP 99,994; Ligand receptor interactions; NK 1 antagonists; Site directed mutagenesis

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; 3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; SUBSTANCE P;

ARTICLE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; HUMAN; MOLECULAR INTERACTION; PROTEIN CONFORMATION; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; BIPHENYL COMPOUNDS; COS CELLS; HUMANS; HYPNOTICS AND SEDATIVES; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; PIPERIDINES; RECEPTORS, NEUROKININ-1; STEREOISOMERISM; SUBSTANCE P;

EID: 0031835925     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)10019-0     Document Type: Article

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