Differential effect of interferon on hepatitis C virus 1b quasispecies in the nonstructural protein 5A gene

Journal of Infectious Diseases

Volumn 180, Issue 4, 1999, Pages 1001-1009

  Sakuma, Ikuo ^a   Enomoto, Nobuyuki ^a   Kurosaki, Masayuki ^a   Izumi, Namiki ^b   Marumo, Fumiaki ^a   Sato, Chifumi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b MUSASHINO RED CROSS HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2A INTERFERON; ALPHA2B INTERFERON; INTERFERON; VIRUS PROTEIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOTHERAPY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VIRUS GENE; VIRUS MUTATION;

ADULT; AGED; AMINO ACID SEQUENCE; FEMALE; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON ALFA-2A; INTERFERON ALFA-2B; INTERFERON-ALPHA; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PREDICTIVE VALUE OF TESTS; SEQUENCE ALIGNMENT; VIRAL NONSTRUCTURAL PROTEINS;

EID: 0033375004     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315000     Document Type: Article

References (29)

1. Hoofnagle JH. Therapy of acute and chronic viral hepatitis. Adv Intern Med 1994; 39:241-75.
2. Takada N, Takase S, Takada A, Date T. Differences in the hepatitis C virus genotypes in different countries. J Hepatol 1993; 17:277-83.
3. Yoshioka K, Kakumu S, Wakita T, et al. Detection of hepatitis C virus by polymerase chain reaction to interferon-alpha therapy: relationship to genotypes of hepatitis C virus. Hepatology 1992; 16:293-9.
4. Mita E, Hayashi N, Hagiwara H, et al. Predicting interferon therapy efficacy from hepatitis C virus genotype and RNA titer. Dig Dis Sci 1994; 39:977-82.
5. Kino K, Sainokami S, Shimoda K, et al. Genotypes and titers of hepatitis C virus for predicting response to Interferon in patients with chronic hepatitis C. J Med Virol 1994; 42:299-305.
6. Tsubota A, Chayama K, Ikeda K, et al. Factors predictive of response to interferon-alpha therapy in hepatitis C virus infection. Hepatology 1994; 19:1088-94.
7. Enomoto N, Takada A, Nakao T, Date T. There are two major types of hepatitis C virus in Japan. Biochem Biophys Res Commun 1990; 170:1021-5.
8. Nakao T, Enomoto N, Takada N, Takada A, Date T. Typing of hepatitis C virus genomes by restriction fragment length polymorphism. J Gen Virol 1991; 72:2105-12.
9. Kato K, Hijikata M, Ootsuyama Y, et al. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci USA 1990; 87:9524-8.
10. Enomoto N, Sakuma I, Asahina Y, et al. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 1995; 96:224-30.
11. Enomoto N, Sakuma I, Asahina Y, et al. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med 1996; 334:77-81.
12. Martell M, Esteban JI, Quer J, et al. Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution. J Virol 1992; 66:3225-9.
13. Sakuma I, Enomoto N, Kurosaki M, Marumo F, Sato C. Selection of hepatitis C virus quasispecies during interferon treatment. Arch Virol 1996; 141:1921-32.
14. Enomoto N, Kurosaki M, Marumo F, Sato C. Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single strand conformation polymorphism analysis. J Gen Virol 1994; 75:1361-9.
15. Okamoto H, Okada S, Sugiyama Y, et al. Detection of hepatitis C virus RNA by a two-stage polymerase chain reaction with two pairs of primers deduced from the 5′-noncoding region. Jpn J Exp Med 1990; 60:215-22.
16. Okamoto H, Sugiyama Y, Okuda S, et al. Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. J Gen Virol 1992; 73:673-9.
17. Davis GL, Lau JN, Urdea MS, et al. Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: definition of optimal conditions for specimen collection and clinical application in interferon-treated patients. Hepatology 1994; 19:1337-41.
18. Gale MJ, Korth MJ, Tang NM, et al. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 1997; 230:217-27.
19. Gale MJ, Korth MJ, Katze MG. Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: a potential mechanism of interferon resistance. Clin Diagn Virol 1998; 10:157-62.
20. Fukuma T, Enomoto N, Marumo F, Sato C. Mutations in the interferon-sensitivity determining region of hepatitis C virus and transcriptional activity of the nonstructural region 5A protein. Hepatology 1998; 28:1147-53.
21. Khorsi H, Castelain S, Wyseur A, et al. Mutations of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients. J Hepatol 1997; 27:72-7.
22. Zeuzem S, Lee JH, Roth WK. Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa. Hepatology 1997; 25:740-4.
23. Squadrito G, Leone F, Sartori M, et al. Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa. Gastroenterology 1997; 113:567-72.
24. Fukuda M, Chayama K, Tsubota A, et al. Predictive factors in cradicating hepatitis C virus using a relatively small dose of interferon. J Gastroenterol Hepatol 1998; 13:412-8.
25. Kurosaki M, Enomoto N, Murakami T, et al. Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-beta therapy. Hepatology 1997; 25:750-3.
26. Rispeter K, Lu M, Zibert A, Wiese M, de OJ, Roggendorf M. The "interferon sensitivity determining region" of hepatitis C virus is a stable sequence clement. J Hepatol 1998; 29:352-61.
27. Magrin S, Fabiano C, Gianguzza F, Cutrera M, Alaimo G, Pagliaro L. HCV NS5A mutations in Europeans infected by genotype Ib [letter]. Gastroenterology 1998; 115:244-5.
28. Saiz JC, Lopez LF, Ampurdanes S, et al. The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus. J Infect Dis 1998; 177:839-47.
29. Duverlie G, Khorsi H, Castelain S, et al. Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity. J Gen Virol 1998; 79:1373-81.