메뉴 건너뛰기




Volumn 97, Issue 6, 1999, Pages 657-669

Amino acid nutrition and immune function in tumour-bearing rats: A comparison of glutamine, arginine- and ornithine 2-oxoglutarate-supplemented diets

Author keywords

Anti tumour immune defence; Arginine; Cancer; Cytokines; Cytotoxicity; Glutamine; Macrophages; Nitric oxide; Ornithine 2 oxoglutarate; Splenocytes

Indexed keywords

AMINO ACID; ARGININE; CD23 ANTIGEN; CD4 ANTIGEN; CD5 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GLUTAMINE; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; ORNITHINE OXOGLUTARATE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0033374890     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0970657     Document Type: Article
Times cited : (36)

References (49)
  • 1
    • 0020324680 scopus 로고
    • Mechanisms of target recognition and destruction in macrophage-mediated tumor cytotoxicity
    • 1 Adams, D. O., Johnson, W. J. and Marino, P. A. (1982) Mechanisms of target recognition and destruction in macrophage-mediated tumor cytotoxicity. Fed. Proc. Fed. Am. Soc. Exp. Biol. 41, 2212-2221
    • (1982) Fed. Proc. Fed. Am. Soc. Exp. Biol. , vol.41 , pp. 2212-2221
    • Adams, D.O.1    Johnson, W.J.2    Marino, P.A.3
  • 2
    • 0028812719 scopus 로고
    • The role of natural killer cells in immune surveillance of cancer
    • 2 Whiteside, T. L. and Herberman, R. B. (1995) The role of natural killer cells in immune surveillance of cancer. Curr. Opin. Immunol. 7, 704-710
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 704-710
    • Whiteside, T.L.1    Herberman, R.B.2
  • 3
    • 0029146685 scopus 로고
    • Murine Th1 and Th2 cell clones differentially regulate macrophage nitric oxide production
    • 3 Taub, D. D. and Cox, G. W. (1995) Murine Th1 and Th2 cell clones differentially regulate macrophage nitric oxide production. J. Leukocyte Biol. 58, 80-89
    • (1995) J. Leukocyte Biol. , vol.58 , pp. 80-89
    • Taub, D.D.1    Cox, G.W.2
  • 4
    • 0027368542 scopus 로고
    • Impaired activation of tumoricidal function in macrophages from tumor bearers: The role of IFN-γ
    • 4 Sotomayor, E. M., Cheng, X., Fu, Y. X., Hawkins, A., Calderon-Higginson, C. and Lopez, D. M. (1993) Impaired activation of tumoricidal function in macrophages from tumor bearers: the role of IFN-γ. Int. J. Oncol. 3, 719-727
    • (1993) Int. J. Oncol. , vol.3 , pp. 719-727
    • Sotomayor, E.M.1    Cheng, X.2    Fu, Y.X.3    Hawkins, A.4    Calderon-Higginson, C.5    Lopez, D.M.6
  • 5
    • 0028948185 scopus 로고
    • Decreased macrophage-mediated cytotoxicity in mammary-tumor-bearing mice is related to alteration of nitric-oxide production and/or release
    • 5 Sotomayor, E. M., DiNapoli, M. R., Calderon, C., Colsky, A., Fu, Y. X. and Lopez, D. M. (1995) Decreased macrophage-mediated cytotoxicity in mammary-tumor-bearing mice is related to alteration of nitric-oxide production and/or release. Int. J. Cancer 60, 660-667
    • (1995) Int. J. Cancer , vol.60 , pp. 660-667
    • Sotomayor, E.M.1    DiNapoli, M.R.2    Calderon, C.3    Colsky, A.4    Fu, Y.X.5    Lopez, D.M.6
  • 6
    • 0029564277 scopus 로고
    • Role of nitric oxide in cell-mediated tumor cytotoxicity
    • 6 Cifone, M. G., Cironi, L., Meccia, M. A. et al. (1995) Role of nitric oxide in cell-mediated tumor cytotoxicity. Adv. Neuroimmunol. 5, 443-461
    • (1995) Adv. Neuroimmunol. , vol.5 , pp. 443-461
    • Cifone, M.G.1    Cironi, L.2    Meccia, M.A.3
  • 7
    • 0029975372 scopus 로고    scopus 로고
    • Reduced splenocyte metabolism and immune function in rats implanted with the Morris Hepatoma 7777
    • 7 Shewchuk, L. D., Baracos, V. E. and Field, C. J. (1996) Reduced splenocyte metabolism and immune function in rats implanted with the Morris Hepatoma 7777. Metab. Clin. Exp. 45, 848-855
    • (1996) Metab. Clin. Exp. , vol.45 , pp. 848-855
    • Shewchuk, L.D.1    Baracos, V.E.2    Field, C.J.3
  • 8
    • 0026673767 scopus 로고
    • Enhanced glutamine and glucose metabolism in cultured rat splenocytes stimulated by phorbol myristate acetate plus ionomycin
    • 8 Wu, G., Field, C. J. and Marliss, E. B. (1992) Enhanced glutamine and glucose metabolism in cultured rat splenocytes stimulated by phorbol myristate acetate plus ionomycin. Metab. Clin. Exp. 41, 982-988
    • (1992) Metab. Clin. Exp. , vol.41 , pp. 982-988
    • Wu, G.1    Field, C.J.2    Marliss, E.B.3
  • 9
    • 0030745596 scopus 로고    scopus 로고
    • Glutamine requirement of proliferating T lymphocytes
    • 9 Yaqoob, P. and Calder, P. C. (1997) Glutamine requirement of proliferating T lymphocytes. Nutrition 13, 646-651
    • (1997) Nutrition , vol.13 , pp. 646-651
    • Yaqoob, P.1    Calder, P.C.2
  • 10
    • 0031034378 scopus 로고    scopus 로고
    • Dietary L-glutamine supplementation reduces the growth of the Morris Hepatoma 7777 m exercise-trained and sedentary rats
    • 10 Shewchuk, L. D., Baracos, V. E. and Field, C. J. (1997) Dietary L-glutamine supplementation reduces the growth of the Morris Hepatoma 7777 m exercise-trained and sedentary rats. J. Nutr. 127, 158-166
    • (1997) J. Nutr. , vol.127 , pp. 158-166
    • Shewchuk, L.D.1    Baracos, V.E.2    Field, C.J.3
  • 12
    • 0028078582 scopus 로고
    • Glutamine requirements in the generation of lymphokine-activated killer cells
    • 12 Juretic, A., Spagnoli, G. C., Horig, H. et al. (1994) Glutamine requirements in the generation of lymphokine-activated killer cells. Clin. Nutr. 13, 42-49
    • (1994) Clin. Nutr. , vol.13 , pp. 42-49
    • Juretic, A.1    Spagnoli, G.C.2    Horig, H.3
  • 13
    • 0015288919 scopus 로고
    • The role of glutamine in the oxidative metabolism of malignant cells
    • 13 Kovacevic, Z. and Morris, H. P. (1972) The role of glutamine in the oxidative metabolism of malignant cells. Cancer Res. 32, 326-333
    • (1972) Cancer Res. , vol.32 , pp. 326-333
    • Kovacevic, Z.1    Morris, H.P.2
  • 14
    • 0025314287 scopus 로고
    • Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth
    • 14 Klimberg, V. S., Souba, W. W., Salloum, R. M. et al. (1990) Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth. J. Surg. Res. 48, 319-323
    • (1990) J. Surg. Res. , vol.48 , pp. 319-323
    • Klimberg, V.S.1    Souba, W.W.2    Salloum, R.M.3
  • 15
    • 0026512514 scopus 로고
    • The effects of glutamine-enriched total parenteral nutrition on tumor growth and host tissues
    • 15 Austgen, T. R., Dudrick, P. S., Sitren, H., Bland, K. I., Copeland, E. and Souba, W. W. (1992) The effects of glutamine-enriched total parenteral nutrition on tumor growth and host tissues. Ann. Surg. 215, 107-113
    • (1992) Ann. Surg. , vol.215 , pp. 107-113
    • Austgen, T.R.1    Dudrick, P.S.2    Sitren, H.3    Bland, K.I.4    Copeland, E.5    Souba, W.W.6
  • 17
    • 0025060851 scopus 로고
    • Immunologic effects of arginine supplementation in tumor-bearing and non-tumor-bearing hosts
    • 17 Reynolds, J. V., Daly, J. M., Shou, J., Sigal, R., Ziegler, M. M. and Naji, A. (1990) Immunologic effects of arginine supplementation in tumor-bearing and non-tumor-bearing hosts. Ann. Surg. 211, 202-210
    • (1990) Ann. Surg. , vol.211 , pp. 202-210
    • Reynolds, J.V.1    Daly, J.M.2    Shou, J.3    Sigal, R.4    Ziegler, M.M.5    Naji, A.6
  • 19
    • 0028014428 scopus 로고
    • L-Arginine stimulates host defenses in patients with breast cancer
    • 19 Brittenden, J., Park, K. G., Heys, S. D. et al. (1994) L-Arginine stimulates host defenses in patients with breast cancer. Surgery 115, 205-212
    • (1994) Surgery , vol.115 , pp. 205-212
    • Brittenden, J.1    Park, K.G.2    Heys, S.D.3
  • 20
    • 9444242166 scopus 로고    scopus 로고
    • Citrulline and arginine increase the growth of the Ward colon tumor in parenterally fed rats
    • 20 Grossie, Jr., V. B. (1996) Citrulline and arginine increase the growth of the Ward colon tumor in parenterally fed rats. Nutr. Cancer 26, 91-97
    • (1996) Nutr. Cancer , vol.26 , pp. 91-97
    • Grossie V.B., Jr.1
  • 22
    • 0026088451 scopus 로고
    • Depletion of dietary arginine inhibits growth of metastatic tumor
    • 22 Yeatman, T. J., Risley, G. L. and Brunson, M. E. (1991) Depletion of dietary arginine inhibits growth of metastatic tumor. Arch. Surg. 126, 1376-1381
    • (1991) Arch. Surg. , vol.126 , pp. 1376-1381
    • Yeatman, T.J.1    Risley, G.L.2    Brunson, M.E.3
  • 23
    • 0026545478 scopus 로고
    • Stimulation of human breast cancers by dietary L-arginine
    • 23 Park, K. G., Heys, S. D., Blessing, K. et al. (1992) Stimulation of human breast cancers by dietary L-arginine. Clin. Sci. 82, 413-417
    • (1992) Clin. Sci. , vol.82 , pp. 413-417
    • Park, K.G.1    Heys, S.D.2    Blessing, K.3
  • 25
    • 0029951239 scopus 로고    scopus 로고
    • Immunomodulatory effects of ornithine α-ketoglutarate in rats with burn injuries
    • 25 Roch-Arveiller, M., Tissot, M., Coudray-Lucas, C. et al. (1996) Immunomodulatory effects of ornithine α-ketoglutarate in rats with burn injuries. Arch. Surg. 131, 718-723
    • (1996) Arch. Surg. , vol.131 , pp. 718-723
    • Roch-Arveiller, M.1    Tissot, M.2    Coudray-Lucas, C.3
  • 26
    • 0001931807 scopus 로고
    • Ornithine-α-ketoglutarate enhances macrophage tumor cytotoxicity
    • abstr.
    • 26 Albina, J. E. (1993) Ornithine-α-ketoglutarate enhances macrophage tumor cytotoxicity. Clin. Nutr. 12, 51 (abstr.)
    • (1993) Clin. Nutr. , vol.12 , pp. 51
    • Albina, J.E.1
  • 27
    • 0028180152 scopus 로고
    • Ornithine α-ketoglutarate (OKG) limits muscle protein breakdown without stimulating tumor growth in rats bearing Yoshida ascites hepatoma
    • 27 Le Bricon, T., Cynober, L. and Baracos, V. E. (1994) Ornithine α-ketoglutarate (OKG) limits muscle protein breakdown without stimulating tumor growth in rats bearing Yoshida ascites hepatoma. Metab. Clin. Exp. 43, 899-905
    • (1994) Metab. Clin. Exp. , vol.43 , pp. 899-905
    • Le Bricon, T.1    Cynober, L.2    Baracos, V.E.3
  • 28
    • 0028793331 scopus 로고
    • Supplemental nutrition with ornithine α-ketoglutarate in rats with cancer-associated cachexia: Surgical treatment of the tumor improves efficacy of nutritional support
    • 28 Le Bricon, T., Cynober, L., Field, C. J. and Baracos, V. E. (1995) Supplemental nutrition with ornithine α-ketoglutarate in rats with cancer-associated cachexia: surgical treatment of the tumor improves efficacy of nutritional support. J. Nutr. 125, 2999-3010
    • (1995) J. Nutr. , vol.125 , pp. 2999-3010
    • Le Bricon, T.1    Cynober, L.2    Field, C.J.3    Baracos, V.E.4
  • 31
    • 0003721556 scopus 로고
    • National Academy of Science, Washington, DC
    • 31 National Research Council (US) (1978) Nutrient Requirements of Laboratory Animals, National Academy of Science, Washington, DC
    • (1978) Nutrient Requirements of Laboratory Animals
  • 32
    • 0031967107 scopus 로고    scopus 로고
    • Dietary long-chain (n - 3) fatty acids facilitate immune cell activation in sedentary, but not exercise-trained rats
    • 32 Robinson, L. E. and Field, C. J. (1998) Dietary long-chain (n - 3) fatty acids facilitate immune cell activation in sedentary, but not exercise-trained rats. J. Nutr. 128, 498-504
    • (1998) J. Nutr. , vol.128 , pp. 498-504
    • Robinson, L.E.1    Field, C.J.2
  • 33
    • 0031172076 scopus 로고    scopus 로고
    • Study of immune response to tumors in the rat
    • 33 Frey, A. B. (1997) Study of immune response to tumors in the rat. Methods 12, 173-188
    • (1997) Methods , vol.12 , pp. 173-188
    • Frey, A.B.1
  • 34
    • 0016884178 scopus 로고
    • Characterization of growth properties and demonstration of the tumor-specific transplantation antigens of Morris hepatomas
    • 34 Wepsic, H. T., Nickel, R. and Alaimo, J. (1976) Characterization of growth properties and demonstration of the tumor-specific transplantation antigens of Morris hepatomas. Cancer Res. 36, 246-250
    • (1976) Cancer Res. , vol.36 , pp. 246-250
    • Wepsic, H.T.1    Nickel, R.2    Alaimo, J.3
  • 35
    • 0024454809 scopus 로고
    • Effects of systemic inhibition of prostaglandin production on protein metabolism in tumor-bearing rats
    • 35 Strelkov, A. B., Fields, A. L. and Baracos, V. E. (1989) Effects of systemic inhibition of prostaglandin production on protein metabolism in tumor-bearing rats. Am. J. Physiol. 257, C261-C269
    • (1989) Am. J. Physiol. , vol.257
    • Strelkov, A.B.1    Fields, A.L.2    Baracos, V.E.3
  • 36
    • 0025633420 scopus 로고
    • Lactate production is the major metabolic fate of glucose in splenocytes and is altered in spontaneously diabetic BB rats
    • 36 Field, C. J., Wu, G., Metroz-Dayer, M. D., Montambault, M. and Marliss, E. B. (1990) Lactate production is the major metabolic fate of glucose in splenocytes and is altered in spontaneously diabetic BB rats. Biochem. J. 272, 445-452
    • (1990) Biochem. J. , vol.272 , pp. 445-452
    • Field, C.J.1    Wu, G.2    Metroz-Dayer, M.D.3    Montambault, M.4    Marliss, E.B.5
  • 37
    • 0030132082 scopus 로고    scopus 로고
    • Tumoricidal potential of human macrophages grown in vitro from blood monocytes
    • 37 Lopez, M., Bony, V., Martinache, C. et al. (1996) Tumoricidal potential of human macrophages grown in vitro from blood monocytes. J. Exp. Ther. Oncol. 1, 143-154
    • (1996) J. Exp. Ther. Oncol. , vol.1 , pp. 143-154
    • Lopez, M.1    Bony, V.2    Martinache, C.3
  • 41
    • 0027934750 scopus 로고
    • Effect of glutamine and chemotherapy on protein metabolism in tumor-bearing rats
    • 41 Kaibara, A., Yoshida, S., Yamasaki, K., Ishibashi, N. and Kakegawa, T. (1994) Effect of glutamine and chemotherapy on protein metabolism in tumor-bearing rats. J. Surg. Res. 57, 143-149
    • (1994) J. Surg. Res. , vol.57 , pp. 143-149
    • Kaibara, A.1    Yoshida, S.2    Yamasaki, K.3    Ishibashi, N.4    Kakegawa, T.5
  • 42
    • 0028117887 scopus 로고
    • Arginine-enriched solution induces a marked increase in muscle glutamine concentration and enhances muscle protein synthesis in tumor-bearing rats
    • 42 Oka, T., Ohwada, K., Nagao, M., Kitazato, K. and Kishino, Y. (1994) Arginine-enriched solution induces a marked increase in muscle glutamine concentration and enhances muscle protein synthesis in tumor-bearing rats. J. Parenter. Enteral Nutr. 18, 491-496
    • (1994) J. Parenter. Enteral Nutr. , vol.18 , pp. 491-496
    • Oka, T.1    Ohwada, K.2    Nagao, M.3    Kitazato, K.4    Kishino, Y.5
  • 43
    • 0029913684 scopus 로고    scopus 로고
    • The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduced expression of the inducible nitric oxide synthase gene
    • 43 DiNapoli, M. R., Calderon, C. L. and Lopez, D. M. (1996) The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduced expression of the inducible nitric oxide synthase gene. J. Exp. Med. 183, 1323-1329
    • (1996) J. Exp. Med. , vol.183 , pp. 1323-1329
    • DiNapoli, M.R.1    Calderon, C.L.2    Lopez, D.M.3
  • 44
    • 0028927045 scopus 로고
    • Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet versus placebo in cancer patients: An immunologic evaluation of impact
    • 44 Kemen, M., Senkal, M., Homann, H.-H. et al. (1995) Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet versus placebo in cancer patients: an immunologic evaluation of impact. Crit. Care Med. 23, 652-659
    • (1995) Crit. Care Med. , vol.23 , pp. 652-659
    • Kemen, M.1    Senkal, M.2    Homann, H.-H.3
  • 45
    • 0021235831 scopus 로고
    • Effects of natural and recombinant IL2 on regulation of IFN gamma production and natural killer activity: Lack of involvement of the Tac antigen for these immunoregulatory effects
    • 45 Ortaldo, J. R., Mason, A. T., Gerard, J. P. et al. (1984) Effects of natural and recombinant IL2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects. J. Immunol. 133, 779-783
    • (1984) J. Immunol. , vol.133 , pp. 779-783
    • Ortaldo, J.R.1    Mason, A.T.2    Gerard, J.P.3
  • 46
    • 0029950767 scopus 로고    scopus 로고
    • Involvement of nitric oxide in target-cell lysis and DNA fragmentation induced by murine natural killer cells
    • 46 Filep, J. G., Baron, C., Lachance, S., Perreault, C. and Chan, J. S. (1996) Involvement of nitric oxide in target-cell lysis and DNA fragmentation induced by murine natural killer cells. Blood. 87, 5136-5143
    • (1996) Blood , vol.87 , pp. 5136-5143
    • Filep, J.G.1    Baron, C.2    Lachance, S.3    Perreault, C.4    Chan, J.S.5
  • 49
    • 0020045422 scopus 로고
    • Modifications de l'amino-acidémie des cirrhotiques sous l'influence de sels d'ornithine
    • 49 Molinard, R., Charpentier, Ch. and Lemonnier, F. (1982) Modifications de l'amino-acidémie des cirrhotiques sous l'influence de sels d'ornithine. Ann. Nutr. Metab. 26, 25-36
    • (1982) Ann. Nutr. Metab. , vol.26 , pp. 25-36
    • Molinard, R.1    Charpentier, Ch.2    Lemonnier, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.