Dietary L-glutamine supplementation reduces the growth of the Morris Hepatoma 7777 in exercise-trained and sedentary rats

Journal of Nutrition

Volumn 127, Issue 1, 1997, Pages 158-166

  Shewchuk, Leann D ^a   Baracos, Vickie E ^a   Field, Catherine J ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

exercise; glutamine; natural killer cells; rats; tumor

Indexed keywords

GLUTAMINE;

ANIMAL CELL; ARTICLE; CANCER IMMUNOLOGY; CANCER INHIBITION; CONTROLLED STUDY; DIET SUPPLEMENTATION; EXERCISE; FEMALE; NATURAL KILLER CELL; NONHUMAN; RAT;

ANIMALIA; BUBALUS; RATTUS NORVEGICUS;

EID: 0031034378     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/127.1.158     Document Type: Article

References (33)

1. Alverdy, J. A., Aoys, P., Weiss-Carrington, P. & Burke, D. A. (1992) The effect of glutamine-enriched TPN on gut immune cellularity. J. Surg. Res. 52: 34-38.
2. Austgen, T. R., Dudrick, P. S. & Bland, S. H. (1992) The effects of glutamine-enriched total parenteral nutrition on tumor growth and host tissues. Ann. Surg. 215: 107-113.
3. Balducci, L. & Hardy, C. (1985) Cancer and malnutrition - a critical interaction: a review. Am. J. Hematol. 18: 91-103.
4. Baracos, V. E. (1989) Exercise inhibits progressive growth of the Morris Hepatoma 7777 in male and female rats. Can. J. Physiol. Pharmacol. 67: 84-870.
5. Chance, W. T., Zhang, F. H., Foley-Nelson, T. & Fischer, J. E. (1991) Hyperammonemia and anorexia in Morris hepatoma-bearing rats. Physiol. & Behav. 50: 397-401.
6. Chen, M. K., Espat, N. J., Bland, K. I., Copeland, E. M. & Souba, W. W. (1993) Influence of progressive tumor growth on glutamine metabolism in skeletal muscle and kidney. Ann. Surg. 217: 655-557.
7. Clandinin, M. T. & Yamashiro S. (1980) Effects of methionine supplementation on the incidence of dietary fat induced myocardial lesions in the rat. J. Nutr. 110: 1197-1203.
8. Fahr, M. J., Kornbluth, J., Blossom, S., Schaeffer, R. & Klimberg, V. S. (1994) Glutamine enhances immunoregulation of tumor growth. J. Parent. Enteral Nutr. 18: 471-476.
9. Felig, P. (1975) Amino acid metabolism in man. Ann. Rev. Biochem. 44: 933-955.
10. Field, C. J. (1995) A diet producing a low diabetes incidence modifies immune abnormalities in diabetes-prone BB rats. J. Nutr. 125: 2594-2603.
11. Field, C. J., Ryan, E. A., Thomson, A.B.R. & Clandinin, M. T. (1990) Diet fat composition alters membrane phospholipid composition, insulin binding and glucose metabolism in adipocytes from control and diabetic rats. J. Biol. Chem. 265: 11143-11151.
12. Hanna, N. (1985) The role of natural killer cells in the control of tumor growth and metastasis. Biochim. Biophys. Acta 780: 213-226.
13. Hoffman-Goetz, L. & Pedersen, B. K. (1994) Exercise and the immune system: a model of stress response. Immunol. Today 15: 382-387.
14. Holleran, A. L., Briscoe, D. A., Fiskum, G. & Kellerher, J. K. (1995) Glutamine metabolism in AS 30D hepatoma cells: evidence for its conversion into lipids via reductive carboxylation. Mol. Cell. Biochem. 152: 95-101.
15. Inoue, Y., Bode, B. P. & Souba, W. W. (1995) Dietary regulation of the hepatic system glutamine transporter in tumor-bearing rats. Am. J. Surg. 169: 173-178.
16. Jadeski, L. & Hoffman-Goetz, L. (1996) Exercise and in vivo natural cytotoxicity against tumor cells of varying metastatic capacity. Clin. Exp. Metab. 14: 138-144.
17. Klimberg, V. S., Souba, W. W. & Salloum, R. M. (1990) Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth. J. Surg. Res. 48: 319-323.
18. Le Bricon, T., Cynober, L., Field, C. J. & Baracos, V. E. (1995) Supplemental nutrition with ornithine α-ketoglutarate in cancer-associated cachexia: surgical treatment of a tumor improves efficacy of nutritional support. J. Nutr. 125: 2999-3010.
19. Longo, D. L. & Hubbard, S. M. (1991) Treatment-related morbidity in patients with lymphoma. Curr. Opin. Oncol. 3: 852-862.
20. Mares-Perlman, J. & Shrago, E. (1988) Energy substrate utilization in freshly isolated Morris Hepatoma 7777 cells. Cancer Res. 48: 602-608.
21. Marquez, J., Mates, J. M., Quesada, A. R., Medina, M. A., Nunez de Castro, I. & Sanchez-Jimenez, F. (1989) Altered ornithine metabolism in tumor-bearing mice. Life Sci. 45: 1877-1884.
22. Marten, N. W., Burke, E. J., Hayden, J. M. & Straus, D. S. (1994) Effect of amino acid limitation on the expression of 19 genes in rat hepatoma cells. FASEB J. 8: 538-544.
23. Pisters, P. W. & Pearlstone, D. B. (1993) Protein and amino acid metabolism in cancer cachexia: investigative techniques and therapeutic interventions. Crit. Rev. Clin. Lab. Sci. 30: 223-272.
24. Rennie, M. J., Edwards, R.H.T., Krywawych, S., Davies, C. T., Halliday, D., Waterlow, J. C. & Millward, D. J. (1981) Effect of exercise on protein turnover in man. Clin. Sci. 61: 627-639.
25. Sauer, L. A. & Dauchy, R. T. (1983) Ketone body, glucose, lactic acid, and amino acid utilization by tumors in vivo in fasted rats. Cancer Res. 43: 3497-3503.
26. Shewchuk, L. D., Baracos, V. E. & Field, C. J. (1996a) Dietary L-glutamine does not modify lymphocyte metabolism and function in exercise-trained rats. Sports Exer. Sci. Med. (in press).
27. Shewchuk, L. D., Baracos, V. E. & Field, C. J. (1996b) Reduced splenocyte metabolism and immune function in rats implanted with the Morris-Hepatoma 7777. Metabolism 45: 848-855.
28. Souba, W. W. (1993) Glutamine and cancer. Ann. Surg. 218: 715-728.
29. 31P-NMR studies of glucose and glutamine metabolism in cultured mammalian cells. Biochim. Biophys. Acta 1051: 131-137.
30. Steele, R.G.D. & Torrie, J. H. (1980) Principles and Procedures of Statistics, 2nd ed. McGraw-Hill, New York, NY.
31. Swails, W. S., Bell, S. J., Borlase, B. C., Forse, R. A. & Blackburn, G. L. (1992) Glutamine content of whole proteins: implications for enterai formulas. Nutr. Clin. Pract. 7: 77-80.
32. Van Buren, C., Kulkarni, A. D. & Rudolph, F. B. (1994) The role of nucleotides in adult nutrition. J. Nutr. 124: 160S-164S.
33. Welsch, C. W. (1994) Interrelationship between dietary lipids and calories and experimental mammary gland tumorigenesis. Cancer 74: 1055-1062.