Singly dehydroxylated A-ring analogues of 19-nor-1α,25- dihydroxyvitamin D3 and 19-nor-22-oxa-1α,25-dihydroxyvitamin D3: Novel vitamin D3 analogues with potent transcriptional activity but extremely low affinity for vitamin D receptor

Biological and Pharmaceutical Bulletin

Volumn 21, Issue 12, 1998, Pages 1300-1305

  Okano, Toshio ^a   Nakagawa, Kimie ^a   Tsugawa, Naoko ^a   Ozono, Keiichi ^b   Kubodera, Noboru ^c   Osawa, Ayako ^d   Terada, Masahiro ^d   Mikami, Koichi ^d  

^a KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

^b RESEARCH INSTITUTE FOR MATERNAL AND CHILD HEALTH   (Japan)

^c CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^d TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

19 nor 1 ,25 dihydroxyvitamin D3 analogue; 19 nor 22 oxa 1 ,25 dihydroxyvitamin D3 analogue; Anti proliferation; Cell differentiation; Transactivation

Indexed keywords

19 NOR 1ALPHA,25 DIHYDROXYVITAMIN D3; 19 NOR 22 OXA 1ALPHA,25 DIHYDROXYVITAMIN D3; CALCITRIOL DERIVATIVE; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HL 60; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; RECEPTOR BINDING; TRANSACTIVATION;

EID: 0032423194     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.21.1300     Document Type: Article

References (9)

1. Holick M. F., Schnoes H. K., Deluca H. F., Suda T., Cousins R. J., Biochemistry, 10, 2799-2804 (1971).
2. Minghetti P. P., Norman A. W., FASEB J., 2, 3043-3053 (1988).
3. Walters M. R., Endocr. Rev., 13, 719-764 (1992).
4. Abe E., Miyaura C., Sakagami H., Takeda M., Konno K., Yamazaki T., Yoshiki S., Suda T., Proc. Natl. Acad. Sci. U.S.A., 78, 4990-4994 (1981).
5. Pike J. W., Annu. Rev. Nutr., 11, 189-216 (1991).
6. Evans R. M., Science, 24, 889-895 (1988).
7. Umesono K., Murakami K. K., Thompson C. C., Evans R. M., Cell, 65, 3001-3011 (1991).
8. Kliewer S. A., Umesono K., Mangelsdorf D. J., Evans R. M., Nature (London), 355, 446-448 (1993).
9. Yu V. C., Delsert C., Andersen B., Holloway J. M., Devary O. V., Naar A. M., Kim S. Y., Boutin J. M., Glass C. K., Rosenfeld M. G., Cell, 67, 1251-1266 (1991).