Proteolysis of human prolactin: Resistance to cathepsin D and formation of a nonangiostatic, C-terminal 16K fragment by thrombin

Endocrinology

Volumn 140, Issue 9, 1999, Pages 4127-4132

  Khurana, Sudha ^a   Liby, Karen ^a   Buckley, Arthur R ^a   Ben Jonathan, Nira ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN D; HIRUDIN; PROLACTIN; THROMBIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; MASS SPECTROMETRY; MICROSOME; MITOGENESIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; UMBILICAL VEIN;

EID: 0033304969     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.9.6955     Document Type: Article

References (41)

1. Structural features of prolactins and growth hormones that can be related to their biological properties
2. Structural variants of prolactin: Occurrence and physiological significance
3. A novel 'cleaved prolactin' in the rat pituitary: Part II. In vivo mammary mitogenic activity of its N-terminal 16K moiety
4. A novel 'cleaved prolactin' in the rat pituitary: Part I. Biosynthesis, characterization and regulatory control
5. Glycosylation selectively alters the biological activity of prolactin
6. Glycosylated human prolactin
7. Isolation and characterization of phosphorylated bovine prolactin
8. Dephosphorylation of standard prolactin produces a more biologically active molecule: Evidence for antagonism between nonphosphorylated prolactin in the stimulation of NB2 cell proliferation
9. Biological and immunological characterization of cleaved and 16K forms of rat prolactin
10. The 16K fragment of prolactin specifically inhibits basal or fibroblast growth factor stimulated growth of capillary endothelial cells
11. The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis
12. Angiogenesis
13. Opposing actions of intact and N-terminal fragments of the human prolactin/growth hormone family members on angiogenesis: An efficient mechanism for the regulation of angiogenesis
14. Controlling the vasculature: Angiogenesis, anti-angiogenesis and vascular targeting of gene therapy
15. Proteolytic modification of rat prolactin by subcellular fractions of the lactating rat mammary gland
16. Mass spectrometric analysis of the fragments produced by cleavage and reduction of rat prolactin: Evidence that the cleaving enzyme is cathepsin D
17. A cleaved form of prolactin in the mouse pituitary gland: Identification and comparison of in vitro synthesis and release in strains with high and low incidences of mammary tumors
18. Cleaved prolactin: Evidence for its occurrence in human pituitary gland and plasma
19. Internalization of vitronectin-thrombin-antithrombin complex by endothelial cells leads to deposition of the complex into the subendothelial matrix
20. Fragments of human growth hormone produced by digestion with thrombin: Chemistry and biological properties
21. Action of thrombin on ovine, bovine and human pituitary growth hormones
22. Analysis of the proteolytic cleavage of prolactin by the mammary gland and liver of the rat: Characterization of the cleaved and 16K forms
23. Posterior pituitary cells: Isolation of subpopulations producing prolactin releasing factor
24. Prolactin-stimulated growth of cell cultures established from malignant Nb rat lymphomas
25. Rapid induction of pim-1 expression by prolactin and interleukin-2 in rat Nb2 lymphoma cells
26. Biological and clinical significance of cathepsin D in breast cancer metastasis
27. The physiology of decidual prolactin and other decidual protein hormones
28. Dopamine and prolactin in human pregnancy
29. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
30. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
31. Heparin-binding property of human prolactin: A novel aspect of prolactin biology
32. Proteolysis of insulin-like growth factor binding protein-5 by pregnancy serum and amniotic fluid
33. IGFBP-3 proteolysis by plasmin, thrombin, serum: Heparin binding, IGF binding, and structure of fragments
34. Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin
35. Thrombin as a hormonally regulated growth factor in estrogen-responsive tissue
36. Thrombin-antithrombin III complexes and antithrombin III in amniotic fluid
37. Trypsin activation, partial characterization, and distribution of kallikrein-like and thrombin-like protease in the neurointermediate lobe of the rat pituitary
38. A kininogenase resembling glandular kallikrein in the rat pituitary pars intermedia
39. Cellular localization of enzymatically active thrombin in intact human tissues by hirudin binding
40. Extrapituitary prolactin: Distribution, regulation, functions and clinical aspects
41. Detection of multiple PRL-and GH-like proteins in human pituitary by Western blot analysis