Insulin-like growth factor-binding protein-5 is cleaved by physiological concentrations of thrombin

Endocrinology

Volumn 139, Issue 4, 1998, Pages 1708-1714

  Zheng, Bo ^a   Clarke, Jane B ^a   Busby, Walker H ^a   Duan, Cunming ^a   Clemmons, David R ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HIRUDIN; METHIONINE; SERINE PROTEINASE; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C; SULFUR 35; THROMBIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; ENZYME SUBSTRATE; IMMUNOBLOTTING; MITOGENESIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SMOOTH MUSCLE FIBER; SWINE;

EID: 0031766631     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.4.5945     Document Type: Article

References (43)

1. Jones JI, Clemmons DR 1995 Insulin-like growth factors and their binding proteins: biological action. Endocr Rev 16:3-34
2. Nam TJ, Busby WH, Clemmons DR 1994 Human fibroblasts secrete a serine protease that cleaves insulin-like growth factor binding-5. Endocrinology 135:1385-1391
3. Lamson G, Giudice LC, Cohen P, Liu F, Gargosky S, Muller HL, Oh Y, Wilson KF, Hintz RL, Rosenfeld RG 1993 Proteolysis of IGFBP-3 may be a common regulatory mechanism of IGF action in vivo. Growth Regul 3:91-195
4. Parker A, Gockerman A, Busby BH, Clemmons DR 1995 Properties of an insulin-like growth factor-binding protein-4 protease that is secreted by smooth muscle cells. Endocrinology 136:2470-2476
5. Gockerman A, Clemmons DR 1994 Porcine aortic smooth muscle cells secrete a serine protease for insulin-like growth factor binding protein-2. Circ Res 76:514-521
6. Thrailkill KM, Quarles LD, Nagase H, Suzuki K, Serra DM, Fowlkes JI 1995 Characterization of insulin-like growth factor-binding protein-5-degrading proteases produced throughout murine osteoblast differentiation. Endocrinology 136:3527-33
7. Rajah R, Bhalo A, Numm SE, Peehl DM, Cohen P 1996 7S Nerve growth factor is an insulin-like growth factor binding protein protease. Endocrinology 137:2676-2682
8. Imai Y, Busby WH, Smith CE, Clark JB, Horvitz GD, Rees C, Clemmons DR 1997 Protease resistant form of insulin-like growth factor binding protein-5 is an inhibitor of insulin-like growth factor-I actions in porcine aortic smooth muscle cells in culture. J Clin Invest 100:2596-2605
9. Jones JI, Gockerman A, Busby WH, Camacho-Hubner C, Clemmons DR 1993 Extracellular matrix contains insulin-like growth factor binding protein-5: potentiation of the effects of IGF-I. J Cell Biol 121:679-687
10. Andress DL, Birnbaum RS 1992 Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action. J Biol Chem 267:22467-22472
11. Andress DL, Loop SM, Zapf J, Kiefer MC 1993 Carboxy-truncated insulin-like growth factor-5 sttimulates mitogenesis in osteoblast-like cell. Biochem Biophys Res Commun 195:25-30
12. Kanzaki S, Hilliker S, Baylink DJ, Mohan S 1994 Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases. Endocrinology 134:383-92
13. Claussen M, Zapf J, Braulke T 1994 Proteolysis of insulin-like growth factor binding protein-5 by pregnancy serum and amniotic fluid. Endocrinology 134:1964-1966
14. Fielder PJ, Pham H, Adashi EY, Rosenfeld RG 1993 Insulin-like growth factors(IGFs) block FSH-induced proteolysis of IGF-binding protein-5 (BP-5) in cultured rat granulosa cells. Endocrinology 133:415-418
15. Zacharski LR, Mernoli VA, Morain WD, Schlaeppi JM, Rousseau SM 1995 Cellular localization of enzymatically active thrombin in intact human tissues by hirudin binding. Thromb Hemost 73:793-797
16. Dryjski M, Olsson P, Swedenborg J 1975 Thrombin activity appearing on the vessel wall after trauma. Thromb Haemost 54:773-775
17. Klement P, Borm A, Hirsh J, Maraganore J, Wilson G, Weitz J 1992 The effect of thrombin inhibitors on tissue plasminogen activator induced thrombolysis in a rat model. Thromb Haemost 68:64-68
18. Hatton MWC, Moar SL 1991 Comparison of the effects of heparin and hirudin on thrombin binding to the normal and the de-endothelialized rabbit aorta in vitro. Thromb Haemost 66:208-212
19. Lam JYT, Chesebro JH, Steele PM, Heras M, Webster MWI, Badimon L, Fuster V 1991 Antithrombotic therapy for deep arterial injury by angioplasty: efficacy of common platelet inhibition compared with thrombin inhibition in pigs. Circulation 84:814-820
20. Glenn KC, Carney DH, Fenton JW, Cunningham DD 1980 Thrombin active site regions required for fibroblast receptor binding and initiation of cell division. J Biol Chem 255:6609-6616
21. Delafontaine P, Anwar A, Ku L 1996 G-Protein coupled and tyrosine kinase receptors: evidence that activation of the insulin-like growth factor I receptor is required for thrombin-induced mitogenesis of rat aortic smooth muscle cells. J Clin Invest 97:139-145
22. McNamara CA, Sarembock IJ, Gimple LW, Fenton JW, Coughlin SR, Owen GK 1993 Thrombin stimulates proliferation of cultured rat aortic smooth muslce cells by a proteolytically activated receptor. J Clin Invest 91:93-98
23. Harlan JM, Thompson PJ, Ross RR, Bowen-Pope DF 1986 Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cells. J Cell Biol 103:1129-1133
24. Weiss RH, Maduri M 1993 The mitogenic effect of thrombin in vascular smooth muscle cells is largely due to basic fibroblast growth factor. J Biol Chem 268:5724-3727
25. Camacho-Hubner C, Busby WH, McCusker RH, Wright G, Clemmons DR 1992 Identification of the forms of insulin-like growth factor-binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion. J Biol Chem 267:11949-11956
26. Busby WH, Klapper DG, Clemmons DR 1988 Purification of a 31,000 dalton insulin like growth factor binding protein from human amniotic fluid. J Biol Chem 263:14203-14210
27. Bourner MJ, Busby WH., Siegel NR, Krivi GG, McCusker RH, Clemmons DR 1992 Cloning and sequence determination of bovine insulin-like growth factor binding protein-2 (IGFBP-2): comparison of its structural and functional properties with IGFBP-1. J Cell Biochem 48:215-226
28. D'Ercole AJ, Underwood LE, Van Wyk JJ, Decedue CJ, Foushee DB 1976 Specificity, topography and ontogeny of the somatomedin C receptor in mammalian tissues. In: Pecile A, Muller R (eds) Growth Hormone and Related Peptides. Excepta Medica, Amsterdam, pp 190-205
29. Church FC, Whinna HC 1986 Rapid sulfopropyl-disk Chromatographic purification of bovine and human thrombin. Anal Biochem 157:77-83
30. Duan C, Hawes SB, Prevette T, Clemmons DR 1996 Insulin-like growth factor-I (IGF-I) regulates IGF-binding protein-5 synthesis through transcriptional activation of the gene in aortic smooth muscle cells. J Biol Chem 271:4280-4288
31. Brower MS, Levin RI, Garry K 1985 Human neutrophil elastate modulates platelet function by limited proteolysis of membrane glycoprotein. J Clin Invest 75:657-666
32. Le Bonniec BF, Guinto ER, MacGillivray RT, Stone SR, Esmon CT 1993 The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors. J Biol Chem 268:19055-191061
33. Nam TJ, Busby WH, Clemmons DR 1996 Characterization and determination of the relative abundance of two types of IGFBP-5 proteases that are secreted by human fibroblasts. Endocrinology 137:5530-5536
34. Booth BA, Boes M, Bar RS 1996 IGFBP-3 proteolysis by plasmin, thrombin, serum: heparin binding, IGF binding, and structure of fragments. Am J Physiol 271:E465-E470
35. Mann KG, Lungblad RL 1982 Biochemistry of thrombin. In: Colman RW, Hirsh J, Marder VJ, Salzman EW (eds) Hemostasis and Thrombosis, Lippincott, Philadelphia, pp 112-126
36. Ehrlich HJ, Gebbink RK, Preissner KT, Keijer J, Esmon NL, Mertens K, Pannekoek H 1991 Thrombin neutralizes plasminogen activator inhibitor 1 (PAI-I) that is complexed with vitronectin in the endothelial cell matrix. J Cell Biol 115:1773-1781
37. de Boer HC, Preissner, KT, Bouma BN, de Groot PG 1995 Internalization of vitronectin-thrombin-antithrombin complex by endothelial cells leads to deposition of the complex into the subendothelial matrix. J Biol Chem 270:30733-30740
38. Knudsen BS, Harpel PC, Nachman RL 1987 Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells. J Clin Invest 80:1082-1089
39. Seiffert D, Wagner NN, Loskutoff DJ 1990 Serum-derived vitronectin influences the pericellular distribition of type 1 plasminogen activator inhibitor. J Cell Biol 111:1283-1291
40. Cockell KA, Ren S, Sun J, Angel A, Shen GX 1995 Effect of thrombin on release of plasminogen activator inhibitor-1 from cultured primate arterial smooth muscle cells. Thromb Res 77:119-131
41. Nam TJ, Busby WH, Clemmons DR 1997 Insulin-like growth factor binding protein-5 binds to plasminogen activator inhibitor-1. Endocrinology 138:2972-2998
42. Molloy CJ, Pawlowski JE, Taylor DS, Turner CE, Weber H, Peluso M 1996 Thrombin receptor activation elecits rapid protein tyrosine phosphorylation and stimulation of the raf-1/MAP kinase pathway preceding delayed mitogenesis in cultured rat aortic smooth muscle cells: evidence for an obligate autocrine mechanism promoting cell proliferation induced by G-protein-coupled receptor agonist. J Clin Invest 97:1173-1183
43. Hayakawa Y, Tazawa S, Ishikawa T, Niiya K, Sakuragawa N 1995 Transcriptional regulation of tissue- and urokinase-type plasminogen activator genes by thrombin in human fetal lung fibroblasts. Thromb Haemost 74:704-710