The β-subunit of human choriogonadotropin interacts with the exodomain of the luteinizing hormone/choriogonadotropin receptor and changes its interaction with the α-subunit

Molecular Endocrinology

Volumn 13, Issue 8, 1999, Pages 1285-1294

  Hong, S ^a   Ji, I ^a   Ji, T H ^a  

^a UNIVERSITY OF WYOMING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN ALPHA SUBUNIT; CHORIONIC GONADOTROPIN BETA SUBUNIT; CHORIONIC GONADOTROPIN RECEPTOR; LUTEINIZING HORMONE RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; HUMAN; HUMAN CELL; PHOTOACTIVATION; PRIORITY JOURNAL; PROTEIN CROSS LINKING; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

EID: 0033304617     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.13.8.0328     Document Type: Article

References (28)

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4. Cloning and sequencing of porcine LH-CG receptor cDNA: Variants lacking transmembrane domain
5. Intronic nature of the rat luteinizing hormone receptor gene defines a soluble receptor subspecies with hormone binding activity
6. Extracellular domain of lutropin/choriogonadotropin receptor expressed in transfected cells binds choriogonadotropin with high affinity
7. Exons 1-10 of the rat LH receptor encode a high affinity hormone binding site and exon 11 encodes G-protein modulation and a potential second hormone binding site
8. Identification of the sites of N-linked glycosylation on the follicle-stimulating hormone (FSH) receptor and assessment of their role in FSH receptor function
9. Amino-terminal leucine-rich repeats in gonadotropin receptors determine hormone selectivity
10. Co-evolution of ligand-receptor pairs
11. Accessibility of rat and human follitropin receptor primary sequence (R265-S296) in situ
12. Reconstitution of a high-affinity functional lutropin receptor by coexpression of its extracellular and membrane domains
13. Determination of residues important in hormone binding to the extracellular domain of the luteinizing hormone/chorionic gonadotropin receptor by site-directed mutagenesis and modeling
14. Mutational analyses of the extracellular domain of the full-length lutropin/choriogonadotropin receptor suggest leucinerich repeats 1-6 are involved in hormone binding
15. The luteinizing hormone receptor
16. Activation of membrane receptors
17. Receptor binding dependent structural changes in human choriogonadotropin: Photochemical inter-subunit crosslinking
18. The amino acid sequence of human chorionic gonadotropin; the α subunit and β subunit
19. The six N-linked carbohydrates of the lutropin/choriogonadotropin receptor are not absolutely required for correct folding, cell surface expression, hormone binding, or signal transduction
20. Carbohydrates of the lutropin receptor
21. The amino-terminal region of the lutropin/choriogonadotropin receptor contacts both subunits of human choriogonadotropin. I. Mutational analysis
22. The amino-terminal region of the lutropin/choriogonadotropin receptor contacts both subunits of human choriogonadotropin. II. Photoaffinity labeling
23. Crystal structure of human chorionic gonadotropin
24. Lysine residues 2 and 104 of the human chorionic gonadotrophin beta subunit influence receptor binding
25. A label selection approach to assess the role of individual amino groups in human chorionic gonadotropin receptor binding
26. Structural aspects of luteinizing hormone actions
27. Receptor activation is distinct from hormone binding in intact lutropin-choriogonadotropin receptors and Asp397 is important for receptor activation
28. Both α and β subunits of human choriogonadotropin photoaffinity label the hormone receptor