In vitro and in vivo effects of the new nonpeptide bradykinin B2 receptor antagonist, LF 16-0335C, on guinea-pig and rat kinin receptors

Fundamental and Clinical Pharmacology

Volumn 13, Issue 1, 1999, Pages 75-83

  Pruneau, Didier ^a   Luccarini, Jean Michel ^a   Fouchet, Chantal ^a   Defrêne, Evelyne ^a   Franck, Rose Marie ^a   Loillier, Bruno ^a   Duclos, Hervé ^a   Robert, Claude ^a   Cremers, Béatrice ^a   Bélichard, Pierre ^a   Paquet, Jean Luc ^a  

^a Laboratoire de Pharmacochimie   (France)

Author keywords

Bradykinin B2 receptor; Competitive antagonist; LF 16 0335C; Nonpeptide

Indexed keywords

2 [[4 [4 (AMINOIMINOMETHYL)BENZOYL] 1 PIPERAZINYL]CARBONYL] 1 [2,4 DICHLORO 3 [(2,4 DIMETHYL 8 QUINOLINYL)OXYMETHYL]PHENYLSULFONYL]PYRROLIDINE; ACETYLCHOLINE; BRADYKININ; BRADYKININ B2 RECEPTOR; BRADYKININ B2 RECEPTOR ANTAGONIST; HISTAMINE; KALLIKREIN; KININ; LF 16 0335C; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRONCHOSPASM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG STRUCTURE; FEMALE; GUINEA PIG; HYPOTENSION; ILEUM CONTRACTION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; SPECIES DIFFERENCE; UTERUS CONTRACTION;

EID: 0033304230     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1999.tb00323.x     Document Type: Article

References (42)

1. Novel subtype-selective nonpeptide bradykinin receptor antagonists FR167344 and FR173657
2. 2 receptor antagonist, FR173657
3. Bioregulation of kinins: Kallikreins, kininogens, and kininases
4. A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding
5. The competitive antagonistic effect of compounds from Mandevilla Velutina on kinin-induced contractions of rat uterus and guinea-pig ileum
6. A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin
7. 50) of an enzymatic reaction
8. Release and properties of endothelium-derived relaxing factor (EDRF) from endothelial cells in culture
9. 1 kinin receptors in formalin-induced nociceptive response in the mouse
10. Bradykinin upregulates immediate-early gene mRNA in human keratinocytes
11. 2 receptors to release conjointly endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells
12. Regulation of mitogenesis by kinins in arterial smooth muscle cells
13. Bradykinin-induced activation of nociceptors: Receptor and mechanistic studies in the neonatal rat spinal cord-tail preparation in vitro
14. Bradykinin and inflammatory pain
15. Kinins and their receptors in hyperalgesia
16. Bradykinin stimulates c-los expression, AP-1 DNA binding activity and proliferation of rat glomerular mesangial cells
17. Spinal noradrenergic pathways in pressor responses to central angiotensin II
18. Airway bradykinin receptors
19. The effects of a kinin antagonist on changes in lung function and plasma extravasation into the airways following challenge of sensitized guinea-pigs
20. 2 receptor antagonist, Hoe 140, in isolated blood vessels from different species
21. Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases
22. Sensory neuropeptide release by bradykinin: Mechanisms and pathophysiological implications
23. 2 antagonist, on kinin-induced hypotension, visceral and peripheral oedema formation and bronchoconstriction
24. Bradykinin receptors: Pharmacological properties and biological roles
25. Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor
26. Bradykinin induces tubulin phosphorylation and nuclear translocation of MAP kinase in mesangial cells
27. Synergistic stimulation of DNA synthesis by bradykinin and vasopressin in Swiss 3T3 cells
28. Bradykinin-induced contraction of guinea pig lung in vitro
29. Focal adhesion-associated proteins p(125FAK) and paxillin are substrates for bradykinin-stimulated tyrosine phosphorylation in Swiss 3T3 cells
30. 2 receptor antagonist Hoe 140 in experimental pneumococcal meningitis in the rat
31. 2 receptor antagonist, FR173657, on plasma exudation in rat carrageenin-induced pleurisy
32. 2 receptors on the venoconstrictor action of bradykinin
33. 1 bradykinin receptor
34. 2 receptor in the guinea-pig
35. 2 receptor
36. Chemical activation of nociceptive peripheral neurons
37. Pharmacology of bradykinin and related kinins
38. 2 receptor antagonist
39. 2 receptor antagonists in rats
40. 2 kinin receptor
41. Kinins and kinin receptors in the nervous system
42. Endogenous nitric oxide inhibits bronchoconstriction induced by cold-air inhalation in guinea-pigs: Role of kinins