Effect of the bradykinin B2 receptor antagonist Hoe140 in experimental pneumococcal meningitis in the rat

European Journal of Pharmacology

Volumn 308, Issue 3, 1996, Pages 335-341

  Lorenzl, Stefan ^a   Ködel, Uwe ^a   Frei, Karl ^b   Pfister, Hans Walter ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Bradykinin; Brain edema; Cerebral blood flow; Hoe140; Intracranial pressure; Pneumococcal meningitis

Indexed keywords

BRADYKININ; BRADYKININ B2 RECEPTOR ANTAGONIST; ICATIBANT; INTERLEUKIN 6; NITRIC OXIDE; ANTIINFECTIVE AGENT; BRADYKININ B2 RECEPTOR; BRADYKININ RECEPTOR; DRUG DERIVATIVE; NITRITE;

ANIMAL MODEL; ARTICLE; BACTERIAL MENINGITIS; BRAIN BLOOD FLOW; BRAIN EDEMA; BRAIN WATER; CEREBROSPINAL FLUID CYTOLOGY; CONTROLLED STUDY; EXPERIMENTAL INFECTION; INTRACISTERNAL DRUG ADMINISTRATION; INTRACRANIAL PRESSURE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PATHOPHYSIOLOGY; PLEOCYTOSIS; PRIORITY JOURNAL; RAT; STREPTOCOCCUS PNEUMONIAE; SUBCUTANEOUS DRUG ADMINISTRATION; ANIMAL; BODY WATER; BRAIN; CEREBROSPINAL FLUID; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; LEUKOCYTE COUNT; VASCULARIZATION; WISTAR RAT;

ANIMALS; ANTI-INFECTIVE AGENTS; BODY WATER; BRADYKININ; BRAIN; DISEASE MODELS, ANIMAL; INTERLEUKIN-6; INTRACRANIAL PRESSURE; LEUKOCYTE COUNT; MALE; MENINGITIS, PNEUMOCOCCAL; NITRITES; RATS; RATS, WISTAR; RECEPTOR, BRADYKININ B2; RECEPTORS, BRADYKININ;

EID: 0030601143     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00375-5     Document Type: Article

References (26)

1. Berkowitz, I.D. and R.J. Traystman, 1993, Oxygen radical scavengers prevent impairment of microvascular autoregulation in H. influenzae type B meningitis in rats, FASEB J. 7, A530.
2. Buster, B.L., A.C. Weintrob, G.C. Townsend and W.M. Scheld, 1995, Potential role of nitric oxide in the pathophysiology of experimental bacterial meningitis in rats, Infect. Immun. 63, 3835.
3. Bhoola, K.D., C.D. Figuero and K. Worthy, 1992, Bioregulation of kinins: kallikreins, kininogens, and kininases, Pharmacol. Rev. 44, 1.
4. Boje, K.M.K., 1995, Inhibition of nitric oxide synthase partially attenuates alterations in the blood-cerebrospinal fluid barrier during experimental meningitis in the rat, Eur. J. Pharmacol. 272, 297.
5. Brian, J.E., D.D. Heistad and F.M. Faraci, 1995, Dilatation of cerebral arterioles in response to lipopolysaccharide in vivo, Stroke 26, 277.
6. Dray, A. and M. Perkins, 1993, Bradykinin and inflammatory pain, Trends Neurosci. 16, 99.
7. 2 receptor antagonist, Hoe 140, in isolated blood vessels from different species, Br. J. Pharmacol. 112, 683.
8. Frei, K., T.P. Leist, A. Meager, P. Gallo, D. Leppert, R.M. Zinkernagel and A. Fontana, 1988, Production of B cell stimulatory factor-2 and interferon γ in the central nervous system during viral meningitis and encephalitis, J. Exp. Med. 168, 449.
9. Guerra-Romero, G., J.H. Tureen, M.A. Fournier, V. Makrides and M.G. Täuber, 1993, Amino acids in cerebrospinal fluid and brain interstitial fluid in experimental pneumococcal meningitis, Pediatr. Res. 33, 510.
10. Hall, J.M., 1992, Bradykinin receptors: pharmacological properties and biological roles, Pharmacol. Ther. 50, 131.
11. Koedel, U., A. Bernatowicz, R. Paul, K. Frei, A. Fontana and H.W. Pfister, 1995, Experimental pneumococcal meningitis: cerebrovascular alterations, brain edema, and meningeal inflammation are linked to the production of nitric oxide, Ann. Neurol. 37, 313.
12. Kontos, H.A., E.P. Wei, J.T. Povlishock and C.W. Christman, 1984, Oxygen radicals mediate the cerebral arteriolar dilation from arachidonate and bradykinin in cats, Circ. Res. 55, 295.
13. Lembeck, F., T. Griesbacher, M. Eckhardt, S. Henke, G. Breipohl and J. Knolle, 1991, New long-acting, potent bradykinin antagonists, Br. J. Pharmacol. 102, 297.
14. Lopes, P., D. Regoli and R. Couture, 1993, Cardiovascular effects of intrathecally administered bradykinin in the rat: characterization of receptors with antagonists, Br. J. Pharmacol. 110, 1369.
15. McKnight, A.A., W.G. Keyes, M.L. Hudak and M.D. Jones Jr., 1992, Oxygen free radicals and the cerebral arteriolar response to group B streptococci, Pediatr. Res. 31, 640.
16. Pfister, H.W., U. Koedel, R.L. Haberl, U. Dimagl, W. Feiden, G. Ruckdeschel and K.M. Einhäupl, 1990, Microvascular changes during the early phase of pneumococcal meningitis in the rat, J. Cereb. Blood Flow Metab. 10, 914.
17. Pfister, H.W., W. Feiden and K.M. Einhäupl, 1993, The spectrum of complications during bacterial meningitis in adults: results of a prospective clinical study, Arch. Neurol. 50, 575.
18. Pfister, H.W., T. Kümpfel and U. Koedel, 1995, Involvement of substance P in pial arteriolar vasodilatation during pneumococcal meningitis in the rat, NeuroReport 6, 1301.
19. Quagliarello, V.J. and W.M. Scheld, 1992, Bacterial meningitis: pathogenesis, pathophysiology and progress, New Engl. J. Med. 327, 864.
20. 2 subtypes, Life Sci. 55, 735.
21. Tuomanen, E., K. Saukkonen, S. Sande, C. Cioffe and S.D. Wright, 1989, Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes, J. Exp. Med. 170, 659.
22. 2 levels in cerebrospinal fluid in experimental pneumococcal meningitis in rabbits, Pediatr. Infect. Dis. 6, 1151.
23. Wahl, M., A. Unterberg, A. Baethmann and L. Schilling, 1988, Mediators of blood-brain barrier dysfunction and formation of vasogenic brain edema, J. Cereb. Blood Flow Metab. 8, 621.
24. Walker, K., M. Perkins and A. Dray, 1995, Kinins and kinin receptors in the nervous system, Neurochem. Int. 26, 1.
25. Weber, J.R., K. Angstwurm, W. Bürger, K.M. Einhäupl and U. Dirnagl, 1995, Anti ICAM-1 (CD 54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis, J. Neuroimmunol. 63, 63.
26. Wirth, K.J., F.J. Hock, U. Albus, W. Linz, H.G. Alpermann, H. Anagnostopoulos, S. Henke, G. Breipohl, W. König, J. Knolle and B.A. Schölkens, 1991, Hoe140 a new potent and long acting bradykininantagonist: in vivo studies, Br. J. Pharmacol. 102, 774.