Anti-intercellular substance antibody log titres are correlated with serum concentrations of interleukin-6, interleukin-15 and tumor necrosis factor-alpha in patients with Pemphigus vulgaris relationships with peripheral blood neutrophil counts, disease severity and duration and patients' age

Journal of Biological Regulators and Homeostatic Agents

Volumn 13, Issue 4, 1999, Pages 220-224

  Ameglio, F ^a   D'Auria, L ^a   Cordiali Fei, P ^a   Trento, E ^a   D'Agosto, G ^a   Mastroianni, A ^a   Giannetti, A ^a   Giacalone, B ^a  

^a SAN GALLICANO DERMATOLOGICAL INSTITUTE   (Italy)

Author keywords

AICS; Cytokines; Disease severity; Neutrophils; PV

Indexed keywords

AUTOANTIBODY; CYTOKINE; INTERCELLULAR SUBSTANCE ANTIBODY; INTERLEUKIN 15; INTERLEUKIN 6; INTERLEUKIN 7; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGE; AGED; ANTIBODY TITER; ARTICLE; AUTOIMMUNE DISEASE; BLISTER; CELL TRANSFORMATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EROSION; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOFLUORESCENCE TEST; INTERSTITIUM; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; MUCOSA; NATURAL KILLER CELL; NEUTROPHIL; PEMPHIGUS VULGARIS; SKIN DISEASE;

EID: 0033303154     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. The blistering diseases. Review
2. The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile
3. The pathophysiological significance of nondesmoglein targets of pemphigus autoimmunity. Development of antibodies against keratinocyte cholinergic receptors in patients with pemphigus vulgaris and pemphigus foliaceus
4. Correlation of pemphigoid and pemphigus antibody titres with activity of disease
5. Preferential activation of the complement system in the lower epidermis of patients with pemphigus vulgaris
6. In vitro C3 mRNA expression in pemphigus vulgaris: Complement activation is increased by IL-1alpha and TNF-alpha
7. The desmosome and hemidesmosome in cutaneous autoimmunity
8. Development and characterization of desmoglein-3 specific T cells from patients with pemphigus vulgaris
9. Neutrophilic spongiosis in pemphigus
10. Cytokines in the sera of patients with pemphigus vulgaris: Interleukin-6 and tumor necrosis factor-alpha levels are significantly increased as compared to healthy subjects and correlate with disease activity
11. Bullous pemphigoid and pemphigus vulgaris: Correlated behaviour of serum VEGF, sE-selectin and TNF-alpha levels
12. Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cells. A mechanism for the loss of epidermal cohesion and blister formation
13. Functional involvement of urokinase-type plasminogen activator receptor in pemphigus acantholysis
14. The serum levels of sE-selectin are increased in patients with bullous pemphigoid or pemphigus vulgaris. Correlation with the number of skin lesions and recovery after corticosteroid therapy
15. Increased serum IL-6, TNF-alpha and IL- 10 levels in patients with bullous pemphigoid: Relationships with disease intensity
16. Increased serum interleukin-15 levels in bullous skin diseases: Correlation with disease intensity
17. Decreased interleukin-7 and transforming growth factor-beta1 levels in blister fluids as compared to the respective serum levels in patients with bullous pemphigoid
18. Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris
19. Cytokine pattern in blister fluid and serum of patients bullous pemphigoid: Relationships with disease intensity
20. Cytokines and bullous pemphigoid. Review
21. Interleukin-15 activates proinflammatory and antimicrobial function in polymorphonuclear cells
22. Interleukin-15 is a potent stimulant of intraepithelial lymphocytes
23. Evidence for cell-mediated autoimmunity in patients with pemphigus vulgaris and bullous pemphigoid
24. Generation of cytokine-induced killer cells using exogenous interleukin-2, -7 or 12
25. Characterization of lymphocytic infiltrate cells in bullous pemphigoid and pemphigus vulgaris