Pharmacological modulation of the IFNγ-induced accessory function of alveolar macrophages and peripheral blood monocytes

Inflammation Research

Volumn 48, Issue 12, 1999, Pages 662-668

  Zissel, G ^a   Ernst, M ^a   Schlaak, M ^a   Muller Quernheim J ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMBROXOL; B7 ANTIGEN; CD86 ANTIGEN; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DEXAMETHASONE; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 2; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; RECOMBINANT GAMMA INTERFERON;

ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOREACTIVITY; LEUKOCYTE ACTIVATION; LUNG ALVEOLUS MACROPHAGE; MACROPHAGE ACTIVATION; MONOCYTE; AGED; ANTIGEN PRESENTING CELL; CYTOLOGY; DOWN REGULATION; DRUG EFFECT; FEMALE; FLOW CYTOMETRY; IMMUNOLOGY; LUNG LAVAGE; MALE; MIDDLE AGED; PATHOLOGY; SARCOIDOSIS;

AGED; ANTIGEN-PRESENTING CELLS; BRONCHOALVEOLAR LAVAGE FLUID; CYCLOSPORINE; DOWN-REGULATION; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-GAMMA, RECOMBINANT; INTERLEUKIN-2; MACROPHAGES, ALVEOLAR; MALE; MIDDLE AGED; MONOCYTES; SARCOIDOSIS, PULMONARY;

EID: 0033257182     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050519     Document Type: Article

References (33)

1. [1] Toews GB, Vial WC, Dunn MM, Guzetta P, Nunez G, Stastny P, et al. The accessory cell function of human alveolar macrophages in specific T cell proliferation. J Immunol 1984; 132: 181-6.
2. [2] Ferro TF, Kern JA, Elias JA, Kamoun M, Daniele RP, Rossman MD. Alveolar macrophages, blood monocytes and density-fractionated alveolar macrophages differ in their ability to promote lymphocyte proliferation to mitogen and antigen. Am Rev Respir Dis 1987; 135:682-7.
3. [3] McCombs CC, Michalski JP, Westerfield BT, Light RW. Human alveolar macrophages suppress the proliferative response of peripheral blood lymphocytes. Chest 1982;. 82: 266-71.
4. [4] Fireman E, Ben-Effraim S, Spinrad S, Topilsky M, Greif J. Suppressive mechanisms of alveolar macrophages in interstitial lung diseases: role of soluble factors and cell to cell contact. Eur Respir J 1993; 6: 956-64.
5. [5] Ettensohn DB, Lalor PA, Roberts NJ. Human alveolar macrophage regulation of lymphocyte proliferation. Am Rev Respir Dis 1986; 133: 1091-6.
6. [6] Mayernik DO, Ul-Haq A, Rinehart JJ. Differentiation-associated alteration in human monocyte-macrophage accessory cell function. J Immunol 1983; 130: 2156-60.
7. [7] Ina Y, Takada K, Yamamoto M, Morishita M, Miyashi A. Antigen presenting capacity in patients with sarcoidosis. Chest 1990; 98: 911-6.
8. [8] Venet A, Hance A, Saltini C, Robinson BWS, Crystal RG. Enhanced alveolar macrophage-mediated antigen-induced T lymphocyte proliferation in sarcoidosis. J Clin Invest 1985; 75: 293-301.
9. [9] Lem VM, Lipscomb MF, Weissler JC, Nunez G, Ball EJ, Stastny P, et al. Bronchoalveolar cells from sarcoid patients demonstrate enhanced antigen presentation. J Immunol 1985; 135: 1766-71.
10. [10] Zissel G, Ernst M, Schlaak M, Müller-Quernheim J. Accessory function of alveolar macrophages from patients with sarcoidosis and other granulomatous and non-granulomatous lung diseases. J Invest Med 1997; 45: 75-86.
11. [11] Gillissen A, Bartling A, Schoen S, Schultze-Werninghaus G. Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung 1997; 175: 235-42.
12. [12] Pfeifer S, Zissel G, Kienast K, Müller-Quernheim J. Reduction of cytokine release of blood and bronchoalveolar mononuclear cells by ambroxol. Eur J Med Res 1997; 2: 129-32.
13. [13] Bianchi M, Mantovani A, Erroi A, Dinarello CA, Ghezzi P. Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells. Agents Actions 1990; 31: 275-9.
14. [14] Roosnek EE, Brouwer MC, Aarden LA. T cell triggering by lectins I. Requirements for interleukin 2 production; lectin concentration determines the accessory cell dependency. Eur J Immunol 1985; 15: 652-6.
15. [15] Zissel G, Aulitzky WE, Lorenz J, Huber, Müller-Quernheim J. Induction of accessory cell function of human alveolar macrophages by inhalation of human natural interleukin-2. Cancer Immunol Immunother 1996; 42: 122-6.
16. [16] Grage-Griebenow E, Lorenzen D, Fetting R, Flad HD, Ernst M. Phenotypical and functional characterization of Fc gamma receptor I (CD64)-negative monocytes, a minor human monocyte subpopulation with high accessory and antiviral activity. Eur J Immunol 1993; 23: 3126-35.
17. 4 + T cells. J Exp Med 1994; 180:2125-35.
18. [18] Gause WC, Mitro V, Via C, Linsley P, Urban JF Jr, Greenwald RJ. Do effector and memory T helper cells also need B7 ligand costimulatory signals? J Immunol 1997; 159: 1055-8.
19. [19] Girndt M, Sester U, Kaul H, Hunger F, Kohler H. Glucocorticoids inhibit activation-dependent expression of costimulatory molecule B7-1 in human monocytes. Transplantation 1998; 66: 370-5.
20. [20] Schmittel A, Scheibenbogen C, Keilholz U. Lipopolysaccharide effectively up-regulates B7-1 (CD80) expression and costimulatory function of human monocytes. Scand J Immunol 1995; 42: 701-4.
21. [21] Tormey VJ, Faul J, Leonard C, Burke CM, Dilmec A, Poulter LW. T-cell cytokines may control the balance of functionally distinct macrophage populations. Immunology 1997, 90: 463-9.
22. [22] Olikowsky T, Wang Z-q, Dudhane A, Horowitz H, Conti B, Hoffmann MK. Two distinct pathways of human macrophage differentiation are mediated by interferon-γ and IL-10. Immunology 1997; 91: 101-8.
23. [23] Chelen CJ, Fang Y, Freeman GJ, Secrist H, Marshall JD, Hwang PT, et al. Human alveolar macrophages present antigen ineffectively due to defective expression of B7 costimulatory cell surface molecules. J Clin Invest 1995; 95: 1415-21.
24. [24] Nicod LP, Songeon F, Isler P. High levels of CD86, CD40 and CD30L are coexpressed on alveolar macrophages in sarcoidosis. Am J Respir Cell Mol Biol 1997; 17: 91-6.
25. [25] Arras M, Strasser R, Mohri M, Doll R, Eckert P, Schaper W, et al. Tumor necrosis factor-alpha is expressed by monocytes/macrophages following cardiac microembolization and is antagonized by cyclosporine. Basic Res Cardiol 1998; 93: 97-107.
26. [26] Reisman L, Cooper D, Lieberman KV, Martinelli GP. Cyclosporine suppresses IL-1 production by isolated human monocytes and by the human histiocytoma cell line,THP-1. Transplant Proc 1990; 22: 1744-6.
27. [27] Heidenreich S, Kubis T, Schmidt M, Fegeler W. Glucocorticoid-induced alterations of monocyte defense mechanisms against Candida albicans. Cell Immunol 1994; 157: 320-7.
28. [28] Cheung DL, Hart PH, Vitti GF, Whitty GA, Hamilton JA. Contrasting effects of interferon-gamma and interleukin-4 on the interleukin-6 activity of stimulated human monocytes. Immunology 1990; 71: 70-5.
29. [29] Schmidt J, Fleissner S, Heimann-Weitschat I, Lindstaedt R, Pomberg B, Werner U, et al. Effect of corticosteroids, cyclosporin A, and methotrexate on cytokine release from monocytes and T-cell subsets. Immunopharmacology 1994; 27: 173-9.
30. [30] Falus A, Taga T, Hibi M, Murakami M, Kishimoto T. Regulation of IL-6 receptor and gp 130 expression on human cell lines of lymphoid and myeloid origin. Cytokine 1992; 4: 495-9.
31. [31] Sadeghi R, Hawrylowicz CM, Chernajovsky Y, Feldmann M. Synergism of glucocorticoids with granulocyte macrophage colony stimulating factor (GM-CSF) but not interferon gamma (IFN-gamma) or interleukin-4 (IL-4) on induction of HLA class II expression on human monocytes. Cytokine 1992; 4: 287-97.
32. [32] Sadeghi R, Feldmann M, Hawrylowicz C. Upregulation of HLA class II, but not intercellular adhesion molecule 1 (ICAM-1) by granulocyte-macrophage colony stimulating factor (GM-CSF) or interleukin-3 (IL-3) in synergy with dexamethasone. Eur Cytokine Netw 1992; 3: 373-80.
33. [33] Roth J, Goebeler M, Erpenstein U, Sorg C. Differential regulation of the macrophage-specific surface antigen RM3/1 by cyclosporine, azathioprine, and dexamethasone. Transplantation 1994; 57: 127-33.