Induction of accessory cell function of human alveolar macrophages by inhalation of human natural interleukin-2

Cancer Immunology Immunotherapy

Volumn 42, Issue 2, 1996, Pages 122-126

  Zissel, Gernot ^a   Aulitzky, Walter E ^b   Lorenz, Joachim ^b,c   Huber, Christoph ^b   Müller Quernheim, Joachim ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c Innere Abteilung   (Germany)

Author keywords

Accessory function; Alveolar macrophages; IL 2; Immunotherapy

Indexed keywords

INTERLEUKIN 2;

ADULT; ARTICLE; CANCER IMMUNOTHERAPY; CELL FUNCTION; CLINICAL ARTICLE; CLINICAL TRIAL; HELPER CELL; HUMAN; IMMUNOSTIMULATION; INHALATIONAL DRUG ADMINISTRATION; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; LUNG METASTASIS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL;

ADMINISTRATION, INHALATION; ADULT; AGED; ANTIGEN-PRESENTING CELLS; BRONCHOALVEOLAR LAVAGE FLUID; CARCINOMA, BRONCHOGENIC; CARCINOMA, RENAL CELL; EVALUATION STUDIES; HUMANS; INTERLEUKIN-2; KIDNEY NEOPLASMS; LUNG NEOPLASMS; MACROPHAGES, ALVEOLAR; MIDDLE AGED;

EID: 0029988511     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050261     Document Type: Article

References (32)

1. Bøyum A (1983) Isolation of human blood monocytes with Nycodenz, a new non-ionic iodinated gradient medium. Scand J Immunol 17:429
2. Bross KJ, Pangalis GA, Staatz CG, Blume KG (1978) Demonstration of cell surface antigens and their antibodies by the peroxidase-antiperoxidase method. Transplantation 25:331
3. Costabel U, Bross KJ, Matthys H (1985) The immunoperoxidase slide assay: a new method for the demonstration of the surface antigens on bronchoalveolar cells. Bull Eur Physiopathol Respir 21:381
4. Ettensohn DB, Lalor PA, Roberts NJ (1986) Human alveolar macrophage regulation of lymphocyte proliferation. Am Rev Respir Dis 133:1091
5. Farrar JJ, Mizel SB, Fuller-Farrar J, Farrar WL, Hilfiker ML (1980) Macrophage-independent activation of helper T cells I. Production of interleukin 2. J Immunol 125:793
6. Ferro TF, Kern JA, Elias JA, Kamoun M, Daniele RP, Rossman MD (1987) Alveolar macrophages, blood monocytes and density-fractionated alveolar macrophages differ in their ability to promote lymphocyte proliferation to mitogen and antigen. Am Rev Respir Dis 135:682
7. Fireman E, Ben-Effraim S, Spinrad S, Topilsky M, Greif J (1993) Suppressive mechanisms of alveolar macrophages in interstitial lung diseases: role of soluble factors and cell to cell contact. Eur Respir J 6:956
8. Gillis S, Ferm MM, Ou W, Smith KA (1978) T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol 120:2027
9. Gyetko MR, Toews GB (1993) Immunology of the aging lung. Clin Chest Med 14:379
10. Hancock WW, Muller WA, Cotran RS (1987) Interleukin 2 receptors are expressed by alveolar macrophages during pulmonary sarcoidosis and are inducible by lymphokine treatment of normal human lung macrophages, blood monocytes, and monocyte cell lines. J Immunol 138:185
11. Herrman F, Cannistra SA, Levine H, Griffen JD (1985) Expression of interleukin-2 receptors by gamma interferon-induced human leukemic and normal monocyte cells. J Exp Med 162:1111
12. Huland E, Huland H, Heinzer H (1992) Interleukin-2 by inhalation: local therapy for metastatic renal cell carcinoma. J Urol 147:344
13. Hunninghake GW, Crystal RG (1981) Pulmonary sarcoidosis: A disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N Engl J Med 305:429
14. Ina Y, Takada K, Yamamoto M, Morishita M, Miyashi A (1990) Antigen presenting capacity in patients with sarcoidosis. Chest 98:911
15. Kawakami K, Yamamoto Y, Kakimoto K, Onoue K (1989) Requirement for delivery of signals by physical interaction and soluble factors from accessory cells in the induction of receptor-mediated T cell proliferation - effectiveness of IFNγ modulation of accessory cells for physical interaction with T cells. J Immunol 142:1818
16. Kovacs EJ, Brock B, Varesio L, Young HA (1989) IL-2 induction of IL-1 beta mRNA expression in monocytes. Regulation by agents that block second messenger pathways. J Immunol 143:3532
17. Kragel AH, Travis WD, Feinberg L, Pittaluga S, Striker LM, Roberts WC, Lotze MT, Yang JJ, Rosenberg SA (1990) Pathologic-findings associated with interleukin-2-based immunotherapy for cancer: a postmortem study of 19 patients. Hum Pathol 21:493
18. Lem VM, Lipscomb MF, Weissler JC, Nunez G, Ball EJ, Stastny P, Toews GB (1985) Bronchoalveolur cells from sarcoid patients demonstrate enhanced antigen presentation. J Immunol 135:1766
19. Limb GA, Hamblin AS, Wolstencroft RA, Dumonde DC (1992) Rapid cytokine up-regulation of integrins, complement receptor 1 and HLA-DR on monocytes but not on lymphocytes. Immunology 77:88
20. Lorenz J, Wilhelm K, Kessler M, Thews A, Peschel C, Schwulera U, Huland E, Huber C, Aulitzky WE (1995) Phase I trial of inhalated natural interleukin-2 for treatment of pulmonary malignancy: toxicity, Pharmakokinetics, and biological effects. J Natl Cancer Inst, Paper submitted
21. Maas RA, Dullens HFJ, Den Otter W (1993) Interleukin-2 in cancer treatment: disappointing or (still) promising? A review. Cancer Immunol Immunother 36:141
22. Mayernik DG, Ul-Haq A, Rinehart JJ (1983) Differentiation-associated alteration in human monocyte-macrophage accessory cell function. J Immunol 130:2156
23. McCombs CC, Michalski JP, Westerfield BT, Light RW (1982) Human alveolar macrophages suppress the proliferative response of peripheral blood lymphocytes. Chest 82:266
24. Müller-Quernheim J, Pfeiffer S, Strausz J, Ferlinz R (1991) Correlation of clinical and immunologic parameters of the inflammatory activity of pulmonary sarcoidosis. Am Rev Respir Dis 144:1322
25. Nelson B, Danielpour D, Rossio JL, Turpin J, Nacy CA (1994) Interleukin-2 suppresses activated macrophage intracellular killing activity by inducing macrophages to secrete TGFβ. J Leukoc Biol 55:81
26. Roosnek EE, Brouwer MC, Aarden LA (1985) T cell triggering by lectins I. Requirements for interleukin 2 production; lectin concentration determines the accessory cell dependency. Eur J Immunol 15:652
27. Schmitt C, Ballet JJ (1983) A microcomputer program for the calculation of interleukin 2 activity. Lymphokine Res 2:145
28. Stricter RM, Remick DG, Lynch JPd, Spengler RN, Kunkel SL (1989) Interleukin-2-induced tumor necrosis factor-alpha (TNF-alpha) gene expression in human alveolar macrophages and blood monocytes. Am Rev Respir Dis 139:335
29. Toews GB, Vial WC, Dunn MM, Guzetta P, Nunez G, Stastny P, Lipscomp MF (1984) The accessory cell function of human alveolar macrophages in specific T cell proliferation. J Immunol 132:181
30. Venet A, Hance A, Saltini C, Robinson BWS, Crystal RG (1985) Enhanced alveolar macrophage-mediated antigen-induced T lymphocyte proliferation in sarcoidosis. J Clin Invest 75:293
31. Wahl SM, McCartney-Francis N, Hunt DA, Smith PD, Wahl LM, Katona IM (1987) Monocyte interleukin-2 receptor gene expression and interleukin-2 augmentation of microbicidal activity. J Immunol 139:1342
32. Williams IR, Unanue ER (1990) Costimulatory requirements of murine Th1 clones - the role of accessory cell-derived signals in responses to anti-CD3 antibody. J Immunol 145:85