Human monocyte activation by cleaved form of alpha-1-antitrypsin. Involvement of the phagocytic pathway

European Journal of Biochemistry

Volumn 265, Issue 3, 1999, Pages 875-882

  Janciauskiene, Sabina ^a   Lindgren, Stefan ^b  

^a Malmo University Hospital   (Sweden)

^b NONE

Author keywords

Alpha 1 antitrypsin; C terminal peptide C 36; Cytotoxicity; Lipid catabolism; Monocytes

Indexed keywords

ALPHA 1 ANTITRYPSIN; GLUTATHIONE REDUCTASE; INTERLEUKIN 1; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CELL CULTURE; CYTOTOXICITY; ENDOCYTOSIS; LIPOLYSIS; MONOCYTE; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ALPHA 1-ANTITRYPSIN; BASE SEQUENCE; CELLS, CULTURED; CLATHRIN; CLATHRIN HEAVY CHAINS; CYTOKINES; DNA PRIMERS; GLUTATHIONE REDUCTASE; HUMANS; LIPOPROTEINS, LDL; LYSOSOMES; MONOCYTES; PEPTIDE FRAGMENTS; PHAGOCYTOSIS; RECEPTORS, LDL; RNA, MESSENGER;

EID: 0033231181     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00821.x     Document Type: Article

References (62)

1. 1. Travis, J. & Salvesen, G.S. (1983) Human plasma proteinase inhibitors. Annu. Rev. Biochem. 52, 655-709.
2. 2. Perlmutter, D.H., Cole, F.S., Kilbridge, T.H., Rossing, T.H. & Colten, H.R. (1985) Expression of alpha-1-proteinase inhibitor gene in human monocytes and macrophages. Proc. Natl Acad. Sci. USA 82, 795-799.
3. 3. Issacson, P.D., Jones, D.B., Milward-Sadler, G.H., Judd, M.A. & Payne, S. (1981) Alpha-1-antitrypsin in human macrophages. J. Clin. Pathol. 34, 982-990.
4. 4. Knoell, D.L., Ralston, D.R., Coulter, K.R. & Wewers, M.D. (1998) Alpha1-antitrypsin and protease complexation is induced by lipopolysacchride, interleukin-1 in monocytes. Am. J. Respir. Crit. Care Med. 157, 246-255.
5. 5. Perlmuter, D.H. & Punsal, P.I. (1988) Distinct and additive of elastase and endotoxin on expression of alpha 1 proteinase inhibitor in mononuclear phagocytes. J. Biol. Chem. 263, 16499-16503.
6. 6. Perlmutter, D.H., May, L.T. & Sehgal, P.B. (1989) Interferon beta2/ interleukin 6 modulates synthesis of alpha 1-antitrypsin in human mononuclear phagocytes and in human hepatoma cells. J. Clin. Invest. 84, 138-144.
7. 7. Zay, K., Loo, S., Xie, C., Devine, D.V., Wright, J. & Churg, A. (1999) Role of neutrophils and alpha-1-antitrypsin in coal-and silica-induced connective tissue breakdown. Am. J. Physiol. 276, L269-L279.
8. 8. McEvoy, L.M., Jutila, M.A., Tsao, P.S., Cooke, J.P. & Butcher, E.C. (1997) Anti-CD43 inhibits monocyte-endothelial adhesion in inflammation and atherogenesis. Blood. 90, 3587-3594.
9. 9. Carrell, R.W. & Stein, P.E. (1996) The biostructural pathology of the serpins. critical function of sheet opening mechanism. Biol. Chem. Hoppe-Seyler. 377, 1-17.
10. 10. Carrell, R.W. & Lomas, D.A. (1997) Conformational disease. Lancet 350, 134-138.
11. 11. Bruch, M., Weiss, V. & Engel, J. (1988) Plasma serine proteinase inhibitors (serpins) exhibit major conformational changes and large increase in conformational stability upon cleavage at their reactive sites. J. Biol. Chem. 263, 166626-166630.
12. 12. Engh, R.A., Schulze, A.J., Huber, R. & Bode, W. (1993) Serpin structures. Behring Inst Mit. 93, 41-62.
13. 13. Michaelis, J., Vissers, M.C. & Winterbourn, C.C. (1990) Human neutrophil collagenase cleaves alpha-1-antitrypsin. Biochem. J. 270, 809-814.
14. 14. Winyard, P.G., Zhang, Z., Chidwick, K., Blake, D.R., Carrell, R.W. & Murphy, G. (1991) Proteolytic inactivation of human alpha-1-antitrypsin by human stromelysin. FEBS Lett 279, 91-94.
15. 15. Potempa, J., Watorek, W. & Travis, J. (1979) The inactivation of human plasma alpha-1-proteinase inhibitor by proteinases from Staphylococcus aureus. J. Biol. Chem. 254, 5317-5320.
16. 16. Virca, G.D., Lyerly, D., Kreger, A. & Travis, J. (1982) Inactivation of human plasma alpha-1-proteinase inhibitor by a metalloproteinase from Serratia marcescens. Biochim. Biophys. Acta 704, 267-271.
17. 17. Morihara, K., Tsuzuki, H., Harada, M. & Iwata, T. (1984) Purification of human plasma alpha-1-proteinase inhibitor and its inactivation by Pseudomonas aeruginosa elastase. J. Biochem. Tokyo. 95, 795-804.
18. 18. Joslin, G., Fallon, R.J., Bullock, J., Adams, S.P. & Perlmutter, D.H. (1991). The SEC receptor recognizes a pentapeptide neodomain of alpha 1-antitrypsin-protease complexes. J. Biol. Chem. 266, 11281-11288.
19. 19. Johansson, J., Gröndal, S., Sjövall, J., Jörnvall, H. & Curstedt, T. (1992) Identification of hydrophobic fragments of α-antitrypsin and C1 protease inhibitor in human bile, plasma and spleen. FEBS Lett. 299, 146-148.
20. 20. Niemann, M.A., Narkates, A.J. & Miller, A.J. (1992) Isolation and serine proteinase activity of the 44-residue C-terminal fragment of alpha-1-antitrypsin from human placenta. Matrix 12, 233-241.
21. 21. Ray, M.B., Geboes, K., Callea, F. & Desmer, V.J. (1977) Alpha-1-antitrypsin immunoreactivity in islet cells of adult human pancreas. Cell Tissues Res. 185, 63-68.
22. 22. Geboes, K., Ray, M.B., Rutgeerts, P., Callea, F., Desmet, V.J. & Vantrappen, G. (1982) Morphological identification of alpha-1-antitrypsin in the human small intestine. Histopathology 6, 55-60.
23. 23. Niemann, M.A., Baggott, J.E. & Miller, E.J. (1997) Binding of SPAAT, the 44-residue C-terminal peptide of alpha-1-antitrypsin, to proteins of the extracellular matrix. J. Cell Biochem. 66, 346-357.
24. 24. Bristow, C.L., Di Meo, F. & Arnold, R.R. (1998) Specific activity of alpha1proteinase inhibitor and alpha2macroglobulin in human serum. Application to inculin-dependent diabetes mellitus. Clin. Immunol. Immunopathol. 89, 247-259.
25. 25. Barbey-Morel, C. & Perlmutter, D.H. (1991) Effect of pseudomonas elastase on human mononuclear phagocyte alpha-1-antitrypsin expression. Pediatr. Res. 29, 133-140.
26. 26. Janciauskiene, S., AI Rayyes, O., Floren, C.-H. & Eriksson, S. (1997) Low density lipoprotein catabolism is enhanced by the cleaved form of alpha-1-antitrypsin. Scand. J. Clin. Lab. Invest. 57, 325-336.
27. 27. Janciauskiene, S., Lindgren, S. & Wright, T.H. (1998) The C-terminal peptide of α-1-antitrypsin increases low density lipoprotein binding in HepG2 cells. Eur. J. Biochem. 254, 460-467.
28. 28. Janciauskiene, S. & Lindgren, S. (1999). Effects of fibrillar C-terminal fragment of cleaved alpha-1-antitrypsin on cholesterol homeostasis in HepG2 cells. Hepatology 29, 434-442.
29. 29. Janciauskiene, S., Wright, H.T. & Lindgren, S. (1999) Atherogenic properties of human monocytes induced by the carboxyl terminal proteolytic fragment of alpha-1-anlitrypsin. Atherosclerosis in press.
30. 30. Takahashi, M., Yokota, T., Kawan, H., Gondo, Ishihara, T. & Uchino, F. (1989) Ultrastructural evidence for intracellular formation of amyloid fibrils in macrophages. Virchows Arch. A Pathol. Anat. Histopathol. 415, 411-419.
31. 31. Badman, M.K., Pryce, R.A., Charge, S.B.P., Morris, J.F. & Clark, A. (1998) Fibrillar islet amyloid polypeptide (amylin) is internalised by macrophages but resists proteolytic degradation. Cell Tissue Res. 291, 285-294.
32. 32. Jackson, T. (1998) Transport vesicles: coats of many colours. Curr. Biol. 8, R609-R612.
33. 33. Paccaud, J.P., Reith, W., Johansson, B., Magnusson, K.E., Mach, B. & Carpentier, J.L. (1993) Clathrin-coated pit-mediated receptor internalization. J. Biol. Chem. 268, 23191-23196.
34. 34. Doxsey, S.J., Brodsky, F.M., Blank, G.S. & Helenius, A. (1987) Inhibition of endocytosis by anti-clathrin antibodies. Cell. 50, 453-463.
35. 35. McFarlane, A.S. (1958) Efficient trace-labelling of proteins with iodine. Nature. 182, 53.
36. 36. Lowry, O.H., Rosebrough, N.J., Farr, A.L. & Randall, R.J. (1951) Protein measurements with folin phenol reagents. J. Biol. Chem. 193, 265-275.
37. 37. Böyum, A. (1976). Isolation of lymphocytes, granulocytes and macrophages. Scand. J. Immunol. Suppl. 5, 9-15.
38. 38. Davis, L.G., Dibner, M.D. & Battey, J.F. (1986). Preparation and analysis of RNA from eukaryotic cells. In Basic Methods in Molecular Biology (Davis, L.G., eds), pp. 129-156. Elsevier, New York.
39. 39. Choczynski, P. & Nicoletta, S. (1987) Single-Step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162, 156-159.
40. 40. Barrett, A.J. (1970) Purification of isoenzymes from human and chicken liver. Biochem. J. 117, 601-607.
41. 41. Norusis, M.J. (1993) SPSS for Windows, rel. 6.0. SPSS Inc. Chicago, IL.
42. 42. Schmitz, G., Herr, A.S. & Rothe, G. (1998) T-lymphocytes and monocytes in atherogenesis. Herz 23, 168-177.
43. 43. Murakami, T. & Yamada, N. (1996) Modification of macrophage function and effects on atherosclerosis. Curr. Opin. Lipidol. 7, 320-323.
44. 44. Ikeda, U., Takahashi, M. & Shimada, K. (1998) Monocyte-endothelial cell interaction in atherogenesis and thrombosis. Clin. Cardiol. 21, 11-14.
45. 45. Libby, P., Geng, Y.J., Aikawa, M., Schoenbeck, U., Mach, F., Clinton, S.K., Sukhova, G.K. & Lee, R.T. (1996) Macrophages and atherosclerotic plaque stability. Curr. Opin. Lipidol. 7, 330-335.
46. 46. Smith, E.B. (1977) Molecular interactions in human atherosclerotic plaques. Am. J. Pathol. 86, 665-674.
47. 47. Paakko, P., Kirby, M., du Bois, R.M.A., Gillisen, A., Ferrans, J. & Crystal, R.G. (1996) Activated neutrophils secrete stored alphal-antitrypsin. Am. J. Respir. Crit. Med. 154, 1829-1833.
48. 48. Hollander, W., Colombo, M.A., Kirkpatrick, B. & Paddock, J. (1979). Soluble proteins in the human atherosclerotic plaque. With spectral reference to immunoglobulins, C3-complement component, alpha1-antitrypsin and alpha2-macroglobulin. Atherosclerosis 34, 391-405.
49. 49. Abbink, J.J., Kamp, A.M., Swaak, A.J. & Hack, C.E. (1991) Production of monoclonal antibodies against inactivated alpha-1-antitrypsin. Cross-reactivity with completed alpha-1-antitrypsin and aplication in an assay to determine inactivated and complexed alpha-1-antitrypsin in biological fluids. J. Immunol. Methods 143, 197-208.
50. 50. Desrochers, P.E., Mookhtiar, K., Van Wart, H.E., Hasty, K.A. & Weiss, S.J. (1992) Proteolytic inactivation of alpha 1-proteinase inhibitor and alpha 1-antichymotrypsin by oxidatively activated human neutrophil metalloproleinases. J. Biol. Chem. 267, 5005-5012.
51. 51. Mast, A.E., Enghild, J.J., Nagase, H., Suzuki, K., Pizzo, S.V. & Salvesen, G. (1991) Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase)-2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin). J. Biol. Chem 266, 15810-15816.
52. 52. Kaslik, G., Kardos, J., Szabo, E., Szilagyi, L., Zavodszky, P., Westler, W.M., Markley, J.L. & Graf, L. (1997) Effects of serpin binding on the target proteinase. global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site. Biochemistry 36, 5455-5464.
53. 53. Hoff, H.F. & Cole, T.B. (1991) Macrophage uptake of low-density lipoprotein modified by 4-hydroxynonenal. An ultrastructural study. Lab. Invest. 64, 254-264.
54. 54. Pishvaee, B. & Payne, G.S. (1998) Clathrin coates-threads laid bare. Cell. 95, 443-446.
55. 55. Mirzabekov, T.A., Lin, M. & Kagan, B.L. (1996) Pore formation by the cytotoxic istel amyloid peptide amylin. J. Biol. Chem. 271, 1988-1992.
56. 56. Behl, C., Davis, J.B., Lesley, R. & Schubert, D. (1994). Hydrogen peroxide mediates amyloid β protein toxicity. Cell. 77, 817-827.
57. 57. Lorenzo, A. & Yankner, B.A. (1996) Amyloid fibril toxicity in Alzheimer's disease and diabetes. Ann. N.Y. Acad. Sci. 777, 89-95.
58. 58. Boskovic, G. & Twining, S.S. (1998) Local control of alpha1-proteinase inhibitor levels: regulation of alpha1-proteinase inhibitor in the human cornea by growth factors and cytokines. Biochim. Biophys. Acta 1403, 37-46.
59. 59. Weiss, S.J., King, G.W. & LoBuglio, A.F. (1977) Evidence for hydroxyl radical generation by human monocytes. J. Clin. Invest. 60, 370-373.
60. 60. Richter, J., Gullberg, U. & Lantz, M. (1995). TNF-induced superoxide anion production in adherent human neutrophils involves both the p55 and p75 TNF receptors. J. Immunol. 154, 4142-4149.
61. 61. Garcia-Garcia, M., Argiles, A., Gouin-Charnet, A., Durfort, M., Garcia-Valero, J. & Mourad, G. (1999) Impaired lysosomal processing of beta2-microglobulin by infiltrating macrophages in dialysis amyloidosis. Kidney Int. 55, 899-906.
62. 62. Ross, R. (1999). Atherosclerosis-an inflammatory disease. New Engl. J. Med. 340, 115-126.