Time course of iron overload and biochemical, histopathological and ultrastructural evidence of pancreatic damage in hypotransferrinaemic mice

Clinical Science

Volumn 93, Issue 5, 1997, Pages 453-462

  Simpson, Robert J ^a   Deenmamode, Jean ^a   Mckie, Andrew T ^a   Raja, Kishor B ^a   Salisbury, Jonathan R ^a   Iancu, Theodore C ^b   Peters, Timothy J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Amylase; Electron microscopy; Haemochromatosis; Haemosiderin; Lipase; Liver; Pancreatitis; Tissue iron

Indexed keywords

IRON; MESSENGER RNA; TRANSFERRIN; TRIACYLGLYCEROL LIPASE;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CELL STRUCTURE; CONTROLLED STUDY; EPITHELIUM CELL; HISTOLOGY; IRON OVERLOAD; IRON TRANSPORT; ISOTOPE LABELING; LIVER; MOUSE; NONHUMAN; PANCREAS INJURY; PANCREATITIS; PARENCHYMA; PRIORITY JOURNAL; PROTEIN DEFECT; TISSUE DISTRIBUTION; TISSUE LEVEL; TRIACYLGLYCEROL LIPASE BLOOD LEVEL; ULTRASTRUCTURE;

EID: 0030725150     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0930453     Document Type: Article

References (38)

1. Huggenvik JI, Craven CM, Idzerda RL, Bernstein S, Kaplan J and McKnight GS. A splicing defect in the mouse tranferrin gene leads to congenital atransferrinaemia. Blood 1989; 74: 482-6.
2. Bernstein SE. Hereditary hypotransferrinemia with hemosiderosis: a murine disorder resembling human atransferrinemia. J Lab Clin Med 1987; 110: 690-705.
3. Raja KB, Simpson RJ and Peters TJ. Plasma clearance of transferrin in control and hypotransferrinaemic mice: implications for regulation of transferrin turnover. Br J Haematol 1995; 89: 177-80.
4. Simpson RJ, Lombard M, Raja KR, Thatcher R, Peters TJ. Iron absorption by hypotransferrinaemic mice. Br J Haematol 1991; 78: 565-70.
5. Raja KB, Simpson RJ and Peters TJ. Intestinal iron absorption studies in mouse models of iron-overload. Br J Haematol 1994; 86: 156-62.
6. Kaplan J, Craven C, Alexander J, Kushner J, Lamb J, Bernstein S. Regulation of the distribution of tissue iron: lessons learned from the hypotransferrinemic mouse. Ann NY Acad Sci 1988; 526: 124-35.
7. Simpson RJ, Konijn AM, Lombard M, Raja KB, Salisbury JR and Peters TJ. Tissue iron loading and histopathological changes in hypotransferrinaemic mice. J Pathol 1993; 171: 237-44.
8. Iancu TC, Shiloh H, Raja KB, et al. The hypotransferrinaemic mice: ultrastructural and laser microprobe mass analysis observations. J Pathol 1995; 177: 83-94.
9. Awai M, Narasaki M, Yamanoi Y, Seno S. Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate. Am J Pathol 1979; 95: 663-74.
10. Pechet GS. Parenteral iron overload: organ and cell distribution. Lab Invest 1969; 20: 119-26.
11. Iancu TC, Ward RJ and Peters TJ. Ultrastructural changes in the pancreas of carbonyl iron-fed rats. J Pediatr Gastro Nutr 1990; 10: 95-101.
12. Iovanna J, Orelle B, Keim V and Dagorn JC. Messenger-RNA sequence and expression of rat pancreatitis-associated protein, a lectin-related protein overexpressed during acute experimental pancreatitis. J Biol Chem 1991; 266: 24664-9.
13. Austyn JM and Gordon S. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol 1981; 11: 805-15.
14. Chomczynski P and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987; 162: 156-9.
15. Feinburg AP and Vogelstein G. A technique for radiolabelling DNA restriction endonuclease fragments to a high specific activity. Anal Biochem. 1983; 132: 6-13.
16. Mather K. Statistical analysis in biology. London: Methuen Co. Ltd, 1965.
17. Wetherill GB. In: Elementary statistical methods. London: Methuen Co. Ltd, 1967.
18. Morgan EH. Comparative iron metabolism. In: Jacobs A, Worwood M, eds. Iron in biochemistry and medicine II. London: Academic Press, 1980; 641-87.
19. Sorbie J and Valberg LS. Iron balance in the mouse. Lab Anim Sci 1974; 24: 900-4.
20. Richter GW. The iron-loaded cell: the cytopathology of iron storage. Am J Pathol 1978; 91: 363-404.
21. Iancu TC. Ferritin and hemosiderin in pathological tissues. Electron Microsc Rev. 1992; 5: 209-29.
22. Proctor GB, Asking B and Garrett JR. Factors influencing the movement of parotid amylase into serum of rats on feeding. Exp Physiol. 1990; 75: 709-12.
23. Simpson RJ, Cooper CE, Raja KB, et al. Non-transferrin-bound iron species in the serum of hypotransferrinaemic mice. Biochim Biophys Acta 1992; 1156: 19-26.
24. LeSage GD, Kost LJ, Barham SS and LaRusso NF. Biliary excretion of iron from hepatocyte lysosomes in the rat: a major excretory pathway in experimental iron overload. J Clin Invest 1986; 77: 90-7.
25. Brissot P, Zanninelli G, Guyader D, Zeind J and Gollan J. Biliary-excretion of plasma non-transferrin-bound iron in rats: pathogenetic importance in iron-overload disorders. Am J Physiol 1994; 267: G135-42.
26. Lu JP, Hayashi K, Okada S and Awai M. Transferrin receptors and selective iron deposition in pancreatic b-cells of iron-overloaded rats. Acta Pathol Jpn 1991; 41: 647-52.
27. Hernandez-Yago J, Knecht E, Martinez-Ramon A, Grisolia S. Autophagy of ferritin incorporated in the cytosol of Hela cells by liposomes. Cell Tissue Res 1980; 205: 305-9.
28. Richter GW. Studies of iron overload: rat liver siderosome ferritin. Lab Invest 1984; 50: 26-35.
29. Roifman CM, Eytan GD, Iancu TC. Ferritin-phospholipid interaction: a model system for intralysosomal ferritin segregation in iron-overloaded hepatocytes. J Ultrastruct Res 1982; 79: 307-13.
30. Munichor M, Kemer H, Cohen H, Iancu TC. The lipofuscin-iron association in pigmentosis tubae. Ultrastruct Pathol 1997; 21: 273-80.
31. Suda K. Hemosiderin deposition in the pancreas. Arch Pathol Lab Med. 1985; 109: 996-9.
32. Iovanna JL, Keim V, Nordback L, et al. Serum levels of pancreatititis-associated protein as indicators of the course of acute pancreatitis. Gastroenterology. 1994; 106: 726-34.
33. Macdonald RA. Hemochromatosis and hemosiderosis. In: Haemochromatosis and hemosiderosis. Springfield: Charles C. Thomas, 1964: 306.
34. Kloppel G. Islet histopathology in diabetes mellitis. In: Kloppel G, Heitz PU, eds. Pancreatic pathology. Edinburgh: Churchill Uvingstone, 1984: 170-171.
35. Halliday JW and Searle J. Hepatic iron deposition in human disease and animal models. Biometals 1996; 9: 205-9.
36. Kozlov AV, Bini A, Gallesi D, et al. 'Free' iron, as detetected by electron paramagnetic resonance spectroscopy, increases unequally in different tissues during dietary iron overload in the rat. Biometals 1996; 9: 98-103.
37. Carthew P, Edwards RE, Smith AG, Dorman B and Francis JE. Rapid induction of hepatic fibrosis in the gerbil after the parenteral administration of iron-dextran complex. Hepatology 1991; 13: 534-9.
38. Olynyk J, Hall P, Reed W, Williams P, Kerr R and Mackinnon M. A long-term study of the interaction between iron and alcohol in an animal model of iron overload. J Hepatol 1995; 22: 671-6.