Molecular mechanism for sodium-dependent activation of G protein-gated K+ channels

Journal of Physiology

Volumn 520, Issue 3, 1999, Pages 645-651

  Ho, Ivan H M ^a   Murrell Lagnado, R D ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ASPARTIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; POLYPHOSPHOINOSITIDE; POTASSIUM CHANNEL; SODIUM ION; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL 1; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL 2; MUSCARINIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DOSE RESPONSE; GENE MUTATION; HUMAN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RECOMBINANT DNA TECHNOLOGY; REVERTANT; VOLTAGE CLAMP; XENOPUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; BINDING AFFINITY; ENZYME ACTIVATION; FEMALE; GENETIC CONSERVATION; MOLECULAR DYNAMICS; OVARIECTOMY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; STATIC ELECTRICITY;

ANIMALS; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GTP-BINDING PROTEINS; HUMANS; ION CHANNEL GATING; OOCYTES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; SODIUM; XENOPUS LAEVIS;

EID: 0033230296     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.00645.x     Document Type: Article

References (25)

1. ANDRADE, R., MALENKA, R. C. & NICOLL, R. A. (1986). A G protein couples serotonin and GABAB receptors to the same channels in hippocampus. Science 234, 1261-1265.
2. ATP channels. Science 282, 1141-1144.
3. BERRIDGE, M. J. (1993). Inositol triphosphate and calcium signaling. Nature 361, 315-325.
4. 2+ flux and single channel studies. Journal of Biological Chemistry 266, 7699-7705.
5. FAN, Z. & MAKIELSKI, J. C. (1997). Anionic phospholipids activate ATP-sensitive potassium channels. Journal of Biological Chemistry 272, 5388-5395.
6. HE, C., ZHANG, H., MIRSHAHI, T. & LOGOTHETIS, D. E. (1999). Identification of a potassium channel site that interacts with G protein βγ subunits to mediate agonist-induced signaling. Journal of Biological Chemistry 274, 12517-12524.
7. 2. Science 273, 956-959.
8. HINCHLIFFE, K. A., CIRUELA, A. & IRVINE, R. F. (1998). PIPkins, their substrates and their products: new functions for old enzymes. Biochimica et Biophysica Acta 1436, 87-104.
9. + channels. Journal of Biological Chemistry 274, 8639-8648.
10. 2 and its stabilization by Gβγ. Nature 391, 803-806.
11. + channel activation. Journal of Biological Chemistry 273, 16946-16952.
12. LIOU, H. H., ZHOU, S. S. & HUANG, C. L. (1999). Regulation of ROMK1 channel by protein kinase A via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. Proceedings of the National Academy of Sciences of the USA 96, 5820-5825.
13. + channel in heart. Nature 325, 321-326.
14. LUPU, V. D., KAZNACHEYEVA, E., KRISNA, U. M., FALCK, J. R. & BEZPROZVANNY, I. (1998). Functional coupling of phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate receptor. Journal of Biological Chemistry 273, 14067-14070.
15. 1A receptors on dorsal raphe neurones of the adult rat. Journal of Physiology 469, 387-405.
16. + ions. G-protein-dependent and -independent mechanisms. Biophysical Journal (abstract) 76, W-Pos54.
17. ATP channels. Science 282, 1138-1141.
18. + channels in Xenopus oocytes. Journal of Physiology 503, 547-562.
19. + channel by a G-protein-independent mechanism. Journal of General Physiology 108, 381-391.
20. + ions depends on the presence of phosphatidylinositol phosphates. Proceedings of the National Academy of Sciences of the USA 95, 1307-1312.
21. TRUSSELL, L. O. & JACKSON, M. B. (1987). Dependence of an adenosine-activated potassium current on a GTP-binding protein in mammalian central neurons. Journal of Neuroscience 7, 3306-3316.
22. WICKMAN, K. D., INIGUEZ-LLUHI, J. A., DAVENPORT, P. A., TAUSSIG, R., KRAPIVINSKY, G. B., LINDER, M. E., GILMAN, A. G. & CLAPHAM, D. E. (1994). Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel. Nature 368, 255-257.
23. +-gated nonselective cation channel. Journal of Neuroscience 19, 2929-2937.
24. + channels by distinct Ptdlns(4,5)P2 interactions. Nature Cell Biology 1, 183-188.
25. ZHANG, X. & MAJERUS, P. W. (1998). Phosphatidylinositol signalling reactions. Seminars in Cell and Developmental Biology 9, 153-160.