Characterization of the sequential non-covalent and covalent interactions of the antitumour antibiotic hedamycin with double stranded DNA by NMR spectroscopy

Journal of Molecular Recognition

Volumn 12, Issue 6, 1999, Pages 346-354

  Pavlopoulos, Spiro ^a   Bicknell, Wendy ^a   Wickham, Geoffrey ^b   Craik, David J ^c  

^a MONASH UNIVERSITY   (Australia)

^b Migenix Inc   (United States)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Alkylation; Drug DNA binding; Intercalation; Ligand titration; NMR; Sequence selectivity

Indexed keywords

ANTHRAPYRANTRIONE; CHROMATOPHORE; DOUBLE STRANDED DNA; DRUG DNA INTERACTION; HEDAMYCIN; LOW TEMPERATURE; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLURAMYCIN;

ALKYLATING AGENTS; AMINOGLYCOSIDES; ANTHRAQUINONES; ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTINEOPLASTIC; CHEMISTRY, PHYSICAL; COLD; DNA; INTERCALATING AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; OLIGODEOXYRIBONUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TITRIMETRY;

EID: 0033226350     PISSN: 09523499     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1352(199911/12)12:6<346::AID-JMR476>3.0.CO;2-L     Document Type: Article

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