Fluoxetine inhibits K+ transport pathways (K+ efflux, Na+-K+-2Cl- cotransport, and Na+ pump) underlying volume regulation in corneal endothelial cells

Journal of Membrane Biology

Volumn 171, Issue 1, 1999, Pages 75-85

  Hara, E ^a   Reinach, P S ^a,b   Wen, Q ^a   Iserovich, P ^a   Fischbarg, J ^a  

^a Columbia University ^*  (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Corneal endothelium; Na+ K+ 2Cl cotransporter; Na+ K+ ATPase; Prozac (fluoxetine); Regulatory volume decrease (RVD); Regulatory volume increase (RVI)

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BUMETANIDE; FLUOXETINE;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CELL VOLUME; COMPETITIVE INHIBITION; COMPUTER SIMULATION; CORNEA ENDOTHELIUM; DRUG EFFECT; ENDOTHELIUM CELL; ION TRANSPORT; LIGHT SCATTERING; MEMBRANE TRANSPORT; NONHUMAN; POTASSIUM TRANSPORT;

ANIMALS; BUMETANIDE; CARRIER PROTEINS; CATTLE; CELL SIZE; CELLS, CULTURED; CHLORIDES; ENDOTHELIUM, CORNEAL; FLUOXETINE; ION TRANSPORT; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NA(+)-K(+)-EXCHANGING ATPASE; OSMOTIC PRESSURE; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; SODIUM; SODIUM-POTASSIUM-CHLORIDE SYMPORTERS;

ANIMALIA; BOVINAE;

EID: 0033199036     PISSN: 00222631     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002329900560     Document Type: Article

References (33)

1. Altamura, A.C., Moro, A.R., Percudani, M. 1994. Clinical pharmacokinetics of fluoxetine. Clin. Pharmacokinet. 26:201-214
2. Blanco, G., Sanchez, G., Mercer, R.W. 1998. Differential regulation of Na,K-ATPase isozymes by protein kinases and arachidonic acid. Arch. Biochem. Biophys. 359:139-150
3. Burkert, U., Allinger, N.L. Molecular Mechanics. ACS Monograph 177, American Chemical Society, Washington, D.C.
4. + release in A6 epithelia. Am. J. Physiol. 275:C189-C199
5. + transport rate. Pfluegers Arch. 430:945-953
6. Diecke, F.P.J., Zhu, Z., Kang, F., Kuang, K., Fischbarg, J. 1998. Sodium, potassium, two chloride cotransport in corneal endothelium: characterization and possible role in volume regulation and fluid transport. Invest. Ophthalmol. Vis. Sci. 39:104-110
7. + conduction and selectivity. Science 280:69-77
8. + pump by tetraethyl-ammonium. Biochim. Biophys. Acta. 1372:289-300
9. Farrugia, G. 1996. Modulation of ionic currents in isolated canine and human jejunal circular smooth muscle cells by fluoxetine. Gastroenterology 110:1438-1445
10. Fischbarg, J. 1997. Mechanism of fluid transport across corneal endothelium and other epithelial layers: a possible explanation based on cyclic cell volume regulatory changes. Brit. J. Ophthalmol. 81:85-89
11. Fischbarg, J., Li, J., Kuang, K., Echevarría, M., Iserovich, P. 1993. Determination of volume and water permeability of plated cells from measurements of light scattering. Am. J. Physiol. 265:C1412-C1423
12. Fuller, R.W., Wong, D.T. 1977. Inhibition of serotonin reuptake. Fed. Proc. 36:2154-2158
13. Gomez-Hernandez, J.M., Lorra, C., Pardo, L.A., Stuhmer, W., Pongs, O., Heinemann, S.H., Elliott, A.A. 1997. Molecular basis for different pore properties of potassium channels from the rat brain Kv1 gene family. Pfluegers Arch. 434:661-668
14. Hallows, K.R., Knauf, P.A. 1994. Cellular and Molecular Physiology of Cell Volume Regulation. K. Strange, editor, pp. 3-29. CRC Press, Boca Raton
15. Hodson, S., Miller, F. 1976. The bicarbonate ion pump in the endothelium which regulates the hydration of the rabbit cornea. J. Physiol. 263:563-577
16. Iserovich, P., Reinach, P.S., Yang, H., Fischbarg, J. 1998. A novel approach to resolve cellular volume responses to an anisotonic challenge. Adv. in Exp. Biol. and Med. 438:687-692
17. Kuang, K., Cragoe, E.J., Fischbarg, J. 1993. Proc. Alfred Benzon Symposium 34, Water transport in leaky epithelia. H.H. Ussing, J. Fischbarg, F. Sten Knudsen, E.H. Larsen, N.J. Willumsen, editors, pp. 69-79. Munksgaard, Copenhagen
18. Li, J., Kuang, K., Nielsen, S., Fischbarg, J. 1999. Molecular identification and immunolocalization of the water channel protein Aquaporin I in CBCECs. Invest. Ophthalmol. Vis. Sci. 40:1288-1292
19. Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J. 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:265-275
20. Lytle, C. 1998. A volume-sensitive protein kinase regulates the Na-K-2CI cotransporter in duck red blood cells. Am. J. Physiol. 274:C1002-C1010
21. Nielsen, S., Smith, B.L., Christensen, E.I., Agre, P. 1993. Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc. Natl. Acad. Sci. USA 90:7275-7279
22. Rae, J.L., Watsky, M.A. 1996. Ionic channels in corneal endothelium. Am. J. Physiol. 270:C975-C989
23. Rae, J.L., Rich, A.C., Zamudio, A.C., Candia, O.A. 1995. Effect of Prozac on whole cell ionic currents in lens and corneal epithelia. Am. J. Physiol. 269:C250-C256
24. Shepard, A.R., Rae, J.L. 1998. Ion transporters and receptors in cDNA libraries from lens and cornea epithelia. Curr. Eye Res. 17:708-719
25. 2+-regulated myosin phosphorylation by fluoxetine and iprindole. Eur. J. Pharmacol. 121:65-71
26. Souza, M.E., Polizello, A.C., Uyemura, S.A., Castro-Silva, O., Curti, C. 1994. Effect of fluoxetine on rat liver mitochondria. Biochem. Pharmacol. 48:535-541
27. Srinivas, S.P., Bonanno, J.A. 1997. Measurement of changes in cell volume based on fluorescence quenching. Am. J. Physiol. 272:C1405-C1414
28. +)-channel inhibition. Life Sci. 50:2125-2138
29. Trenberth, S.M., Mishima, S. 1968. The effect of ouabain on the rabbit corneal endothelium. Invest. Ophthalmol. Vis. Sci. 7:44-52
30. Tytgat, J., Maertens, C., Daenens, P. 1997. Effect of fluoxetine on a neuronal, voltage-dependent potassium channel (Kv1.1). Br. J. Pharmacol. 122:1417-1424
31. Vaitla, R., Roshani, P., Holian, O., Cook, B., Kumar, R. 1997. Inhibition of skin protein kinase C by psychotropic drugs. Skin Pharmacology 10:191-199
32. 2+ release. J. Membrane Biol. 158:127-136
33. Yantorno, R.E., Coca-Prados, M., Krupin, T., Civan, M.M. 1989. Volume regulation of cultured, transformed, non-pigmented epithelial cells from human ciliary body. Exp. Eye Res. 49:423-437