Wild-type p53 induction mediated by replication-deficient adenoviral vectors

Cancer Research

Volumn 59, Issue 17, 1999, Pages 4247-4251

  McPake, Christina R ^a,b   Shetty, Sheetal ^a,c   Kitchingman, Geoffrey R ^a   Harris, Linda C ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c GENOME THERAPEUTICS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; VIRUS DNA; VIRUS PROTEIN; VIRUS VECTOR;

ADENOVIRUS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; GENE EXPRESSION; GENE THERAPY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOVIRIDAE; DNA DAMAGE; GENE THERAPY; GENETIC VECTORS; HUMANS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; VIRUS REPLICATION;

EID: 0033198508     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
2. Teodoro, J. G., and Branton, P. E. Regulation of apoptosis by viral gene products. J. Virol., 71: 1739-1746, 1997.
3. White, E. Regulation of apoptosis by the transforming genes of the DNA tumor virus adenovirus. Proc. Soc. Exp. Biol. Med., 204: 30-39, 1993.
4. Oren, M. Relationship of p53 to the control of apoptotic cell death. Semin. Cancer Biol., 5: 221-227, 1994.
5. Graham, F. L., Abrahams, P. J., Mulder, C., Heijneker, H. L., Warnaar, S. O., de Vries, F. A., and van de Eb, A. J. Studies on in vitro transformation by DNA and DNA fragments of human adenoviruses and simian virus 40. Cold Spring Harbor Symp. Quant. Biol., 39: 637-650, 1975.
6. Whyte, P., Buchkovish, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A., and Harlow, E. A. Association between an oncogene and an anti-oncogene: the adenovirus E1a proteins bind to the retinoblastoma gene product. Nature (Lond.), 334: 124-129, 1988.
7. Grand, R. J. A., Grant, M. L., and Gallimore, P. H. Enhanced expression of p53 in human cells infected with mutant adenoviruses. Virology, 203: 229-240, 1994.
8. Samow, P., Ho, Y., Williams, J., and Levine, A. J. Adenovirus E1B-58K tumour antigen and SV40 large tumour antigen are physically associated with the same 54K cellular protein in transformed cells. Cell, 28: 387-394, 1982.
9. Flint, S. J. Expression of adenoviral genetic information in productively infected cells. Biochim. Biophys. Acta, 651: 175-208, 1982.
10. Dobner, T., Horikoshi, N., Rubenwolf, S., and Shenk, T. Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. Science (Washington DC), 272: 1470-1473, 1996.
11. Roth, J., Konig, C., Weinzek, S., Weigel, S., Ristea, S., and Dobberstein, M. Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins. J. Virol., 72: 8510-8516, 1998.
12. Trapnell, B. C. Adenoviral vectors for gene transfer. Adv. Drug Dev. Rev., 12: 185-199, 1993.
13. Trapnell, B. C., and Gorziglia, M. Gene therapy using adenoviral vectors. Curr. Opin. Biotechnol., 5. 617-625, 1994.
14. Wold, W. S. M., and Gooding, L. R. Region E3 of adenovirus: a cassette of genes involved in host immunosurveillance and virus-cell interactions Virology, 184: 1-8, 1991.
15. Becker, T. C., Noel, R. J., Coats, W. S., Gomez-Foix, A. M., Alam, T., Gerard, R. D., and Newgard, C. B. Use of recombinant adenovirus for metabolic engineering of mammalian cells. Methods Cell Biol., 43: 161-189, 1994.
16. Zhang, W.-W., Koch, P. E., and Roth, J. A. Detection of wild-type contamination in a recombinant adenoviral preparation by PCR. BioTechniques, 18: 444-447, 1995.
17. Houghton, J. A., Harwood, F. G., and Tillman, D. M. Thymineless death in colon carcinoma cells is mediated via Fas signaling. Proc. Natl. Acad. Sci. USA, 94: 8144-8149, 1997.
18. McPake, C. R., Tillman, D. M., Poquette, C. A., George, E. O., Houghton, J. A., and Harris, L. C. Bax is an important determinant of chemosensitivity in pediatric tumor cell lines independent of Bcl-2 expression and p53 status. Oncol. Res., 10: 235-244, 1998.
19. Momand, J., Zambetti, G. P., Olson, D. C., George, D., and Levine, A. J. The MDM2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell, 69: 1237-1245, 1992.
20. Li, E., Stupak, D., Klemke, R., Cheresh, D. A., and Nemerow, G. R. Adenovirus endocytosis via ανv integrins requires phosphoinositide-3-OH kinase. J. Virol., 72: 2055-2061, 1998.
21. Reid, R. L., Lindholm, P. F., Mireskandari, A., Dittmer, J., and Brady, J. N. Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I. Oncogene, 8: 3029-3036, 1993.
22. Bergelson, J. M., Cunningham, J. A., Droguelt, G., Kurt-Jones, E. A., Krithivas, A., Hong, J. S., Horwitz, M. S., Crowell, R. L., and Finberg, R. W. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science (Washington DC), 275: 1320-1323, 1997.
23. Wickham, T. J., Mathias, P., Cheresh, D. A., and Nemerow, G. R. Integrins ανβ3 and ανβ35 promote adenovirus internalization but not virus attachment. Cell, 73: 309-319, 1993.
24. Miyamota, S., Akiyama, S. K., and Yamada, K. M. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science (Washington DC), 267: 883-885, 1995.
25. Chen, H-C., and Guan, J-L. Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc. Natl. Acad. Sci. USA, 91: 10148-10152, 1994.
26. Toker, A., and Cantley, L. C. Signalling through the lipid products of phosphoinositide. Nature (Lond.), 12: 673-676, 1997.
27. Janik, J. E., Huston, M. M., and Rose, J. A. Locations of adenovirus genes required for the replication of adenovirus-associated virus. Proc. Natl. Acad. Sci. USA, 78: 1925-1929, 1981.
28. Mosner, J., Mummenbrauer, T., Bauer, C., Sczakiel, G., Grosse, F., and Deppert, W. Negative feedback regulation of wild-type p53 biosynthesis. EMBO J., 14: 4442-4449, 1995.
29. Gingras, A-C., and Sonenberg, N. Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2. Virology, 237: 182-186, 1997.
30. Brown, J. M., and Wouters, B. G. Apoptosis, p53 and tumor cell sensitivity to anticancer agents. Cancer Res., 59: 1391-1399, 1999.