A composite C/EBP binding site is essential for the activity of the promoter of the IL-3/IL-5/granulocyte-macrophage colony-stimulating factor receptor βc gene

Journal of Immunology

Volumn 163, Issue 5, 1999, Pages 2674-2680

  Van Dijk, Thamar B ^a,b   Baltus, Belinda ^a   Raaijmakers, Jan A M ^a   Lammers, Jan Willem J ^a   Koenderman, Leo ^a   De Groot, Rolf P ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; INTERLEUKIN 3; INTERLEUKIN 5; UNCLASSIFIED DRUG;

ARTICLE; BETA CHAIN; BINDING SITE; BONE MARROW CELL; CELL STRAIN COS1; DNA FLANKING REGION; ENHANCER REGION; GENE CONTROL; GENE DELETION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR GENE; SIGNAL TRANSDUCTION; START CODON; TRANSCRIPTION INITIATION;

ANIMALS; BASE SEQUENCE; BINDING SITES; CCAAT-ENHANCER-BINDING PROTEINS; COS CELLS; CYTOKINE RECEPTOR COMMON BETA SUBUNIT; DNA-BINDING PROTEINS; DRUG SYNERGISM; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; HL-60 CELLS; HUMANS; INTERLEUKIN-5; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-3; RECEPTORS, INTERLEUKIN-5; TRANS-ACTIVATORS; U937 CELLS;

EID: 0033198185     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Ogawa, M. 1993. Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844.
2. Arai, K., F. Lee, A. Miyajima, S. Miyatake, N. Arai, and T. Yokota. 1990. Cytokines: coordinators of immune and inflammatory responses. Annu. Rev. Biochem. 59:783.
3. + cells by IL-5 and other growth factors. Cell. Immunol. 160:50.
4. Berliner, N., A. Hsing, T. Graubert, F. Sigurdsson, M. Zain, E. Bruno, and R. Hoffman. 1995. Granulocyte colony-stimulating factor induction of normal human bone marrow progenitors results in neutrophil-specific gene expression. Blood 85:799.
5. Miyajima, A., T. Hara, and T. Kitamura. 1992. Common subunits of cytokine receptors and the functional redundancy of cytokines. Trends Biochem. Sci. 17: 378.
6. Lopez, A. F., M. A. Vadas, J. M. Woodcock, S. E. Milton, A. Lewis, M. J. Elliott, D. Gillis, R. Ireland, E. Olwell, and L. S. Park. 1991. Interleukin-5, interleukin-3, and granulocyte-macrophage colony-stimulating factor cross-compete for binding to cell surface receptors on human eosinophils. J. Biol. Chem. 266:24741.
7. Mui, A., A. Muto, K. Sakamaki, N. Sato, T. Kinoshita, S. Watanabe, T. Yokota, K. Arai, and A. Miyajima. 1994. Function of the common β subunit of the GM-CSF/IL-3/IL-5 receptors. Adv. Exp Med. Biol. 365:217.
8. Hara, T., and A. Miyajima. 1996. Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis. Stem Cells 14:605.
9. Bagley, C. J., J. M. Woodcock, F. C. Stomski, and A. F. Lopez. 1997. The structural and functional basis of cytokine receptor activation: lessons from the common β subunit of the granulocyte-macrophage colony-stimulating factor, interleukin-3 (1L-3), and IL-5 receptors. Blood 89:1471.
10. Bazan, J. F. 1990. Structural design and molecular evolution of a cytokine receptor superfamily. Proc. Natl. Acad. Sci. USA 87:6934.
11. Kitamura, T., N. Sato, K. Arai, and A. Miyajima. 1991. Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors. Cell 66:1165.
12. Kitamura, T., and A. Miyajima. 1992. Functional reconstitution of the human interleukin-3 receptor. Blood 80:84.
13. Tavernier, J., R. Devos, S. Cornelis, T. Tuypens, J. Van der Heyden, W. Fiers, and G. Plaetinck. 1991. A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF. Cell 66:1175.
14. Sakamaki, K., I. Miyajima, T. Kitamura, and A. Miyajima. 1992. Critical cytoplasmic domains of the common β subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J. 11:3541.
15. Gorman, D. M., N. Itoh, T. Kitamura, J. Schreurs, S. Yonehara, I. Yahara, K.-I. Arai, and A. Miyajima. 1990. Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family. Proc. Natl. Acad. Sci. USA 87:5459.
16. Itoh, N., S. Yonehara, J. Schreurs, D. M. Gorman, K. Maruyama, A. Ishii, I. Yahara, K.-I. Arai, and A. Miyajima. 1990. Cloning of an interleukin-3 receptor: a member of a distinct receptor gene family. Science 247:324.
17. Hara, T., and A. Miyajima. 1992. A Two distinct functional high affinity receptors for mouse interleukin-3 (IL-3). EMBO J. 11:1875.
18. van Dijk, T. B., B. Baltus, E. Caldenhoven, H. Handa, J. A. M. Raaijmakers, J.-W. J. Lammers, L. Koenderman, and R. P. de Groot. 1998. Cloning and characterization of the IL-3/IL-5/GM-CSF receptor βc gene: regulation by Ets family members. Blood 92:3636.
19. Stomski, F. C., J. M. Woodcock, J. Zacharakis, C. I. Bagley, Q. Sun, and A. F. Lopez. 1998. Identification of a cys motif in the common β chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors. J. Biol. Chem. 273:1192.
20. IhIe, J. E. 1995. Cytokine receptor signalling. Nature 377:591.
21. Quelle, F. W., N. Sato, B. A. Witthuhn, R. C. Inhorn, M. Eder, A. Miyajima, J. D. Griffin, and J. N. Ihle. 1994. JAK2 associates with the β c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region. Mol. Cell. Biol. 14:4335.
22. Chin, H., N. Nakamura, R. Kamiyama, N. Miyasaka, J. N. Ihle, and O. Miura. 1996. Physical and functional interactions between Stat5 and the tyrosine-phosphorylated receptors for erythropoietin and interleukin-3. Blood 88:4415.
23. Mui, A. L., H. Wakao, A. M. O'Farrell, N. Harada, and A. Miyajima. 1995. Interleukin-3, granulocyte-macrophage colony-stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 14:1166.
24. Satoh, T., M. Nakafuku, A. Miyajima, and Y. Kaziro. 1991. Involvement of Ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4. Proc. Natl. Acad. Sci. USA 88:3314.
25. Okuda, K., J. S. Sanghera, S. L. Pelech, Y. Kanakura, M. Hallek, J. D. Griffin, and B. J. Druker. 1992. Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase. Blood 79:2880.
26. de Groot, R. P., T. B. van Dijk, E. Caldenhoven, P. J. Coffer, J. A. M. Raaijmakers, J.-W. J. Lammers, and L. Koenderman. 1997. Activation of 12-O-tetra-decanoylphorbol-13-acetate response element- and dyad symmetry element-dependent transcription by interleukin-5 is mediated by Jun N-terminal kinase/stress-activated protein kinase kinases. J. Biol. Chem. 272:2319.
27. Nagata, Y., T. Moriguchi, E. Nishida, and K. Todokoro. 1997. Activation of p38 MAP kinase pathway by erythropoietin and interleukin-3. Blood 90:929.
28. Corey, S., A. Eguinoa, K. Puyana Theall, J. B. Bolen, L. Cantley, F. Mollinedo, T. R. Jackson, P. T. Hawkins, and L. R. Stephens. 1993. Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells. EMBO J. 12:2681.
29. Coffer, P., N. Geijsen, L. M'Rabet, R. C. Schweizer, T. Maikoe, J. A. M. Raaijmakers, J.-W. J. Lammers, and L. Koenderman. 1998. Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function. Biochem. J. 329:121.
30. de Groot, R. P., P. Coffer, and L. Koenderman. 1998. Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family. Cell Signalling 10:619.
31. Sato, N., C. Caux, T. Kitamura, Y. Watanabe, K.-I. Arai, J. Bancherau, and A. Miyajima. 1993. Expression and factor-dependent modulation of the Interleukin-3 receptor subunits on human hematopoietic cells. Blood 82:752.
32. Clarke, S., and S. Gordon. 1998. Myeloid-specific gene expression. J. Leukocyte Biol. 63:153.
33. Zhang, D.-E., C. J. Hetherington, H. M. Chen, and D. G. Tenen. 1994. The macrophage transcription factor PU. 1 directs tissue specific expression of the macrophage colony-stimulating factor receptor. Mol. Cell. Biol. 14:373.
34. Smith, L. T., S. Hohaus, D. A. Gonzalez, S. E. Dziennis, and D. G. Tenen. 1996. PU. 1 (Spi-1) and C/EBPα regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells. Blood 88:1234.
35. Hohaus, S., M. S. Petrovick, M. T. Voso, Z. Sun, D.-E. Zhang, and D. G. Tenen. 1995. PU. 1 (Spi-1) and C/EBPa regulate the expression of the granulocyte-macrophage colony-stimulating factor receptor a gene. Mol. Cell. Biol. 15:5830.
36. Gorman, D. M., N. Itoh, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, and A. Miyajima. 1992. Chromosomal localization and organization of the murine genes encoding the β subunits (AlC2A and AlC2B) of the interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 receptors. J. Biol. Chem. 267:15842.
37. Klemz, M. J., S. R. McKercher, A. Celeda, C. van Beveren, and R. A. Maki. 1993. The macrophage and B cell-specific transcription factor PU. 1 is related to the ets oncogene. Cell 61:113.
38. van Dijk, T. B., E. Caldenhoven, J. A. M. Raaijmakers, J.-W. J. Lammers, L. Koenderman, and R. P. de Groot. 1998. The role of transcription factor PU.1 in the activity of the intronic enhancer of the eosinophil-derived neurotoxin (RNS2) gene. Blood 91:2126.
39. Ford, A. M., C. A. Bennett, L. E. Healy, M. Towatari, M. F. Greaves, and T. Enver. 1996. Regulation of the myeloperoxidase enhancer binding proteins PU. 1, CEBPα, β and δ during granulocytic-lineage specification. Proc. Natl. Acad. Sci. USA 93:10838.
40. Chen, H. M., D. Ray-Gallet, P. Zhang, C. J. Hetherington, D. A. Gonzalez, D.-E. Zhang, F. Moreau-Gachelin, and D. G. Tenen. 1995. PU. 1 (Spi-1) autoregulates its expression in myeloid cells. Oncogene 11:1549.
41. Scott, L. M., C. I. Civin, P. Rorth, and A. D. Friedman. 1992. A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells. Blood 80:1725.
42. Morosetti, R., D. J. Park, A. M. Chumakov, I. Grillier, M. Shiohara, A. F. Gombart, T. Nakami, K. Weinberg, and H. P. Koeffler. 1997. A novel, myeloid transcription factor, C/EBP∈, is upregulated during granulocytic, but not monocytic, differentiation. Blood 90:2591.
43. Yamanaka, R., G.-D. Kim, H. S. Radomska, J. Lekstrom-Himes, L. T. Smith, P. Antonson, D. G. Tenen, and K. G. Xanthopoulos. 1997. CCAAT/enhancer binding protein ∈ is preferentially up-regulated during granulocytic differentiation and is functionally versatility is determined by alternative use of promoters and differential splicing. Proc. Natl. Acad. Sci. USA 94:6462.
44. Johnson, P. F., W. H. Landschulz, B. J. Graves, and S. L. McKnight. 1987. Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes Dev. 1:133.
45. Zhang, D.-E, P. Zhang, N.-D. Wang, C. J. Hetherington, G. J. Darlington, and D. G. Tenen. 1997. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice. Proc. Natl. Acad. Sci. USA 94:569.
46. Yamanaka, R., C. Barlow, J. Lekstrom-Himes, L. H. Castilla, P. P. Liu, M. Eckhaus, T. Decker, A. Wynshaw-Boris, and K. G. Xanthopoulos. 1997. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ∈-deficient mice. Proc. Natl. Acad. Sci. USA 94:13187.
47. + hematopoietic stem cells. Stem Cells 16:397.
48. Luckow, B., and G. Schutz. 1987. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoter and regulatory elements. Nucleic Acids Res. 15:5490.
49. Ryffel, G. U., W. Kugler, A. Wagner, and M. Kalin. 1989. Liver cell specific gene transcription in vitro: the promoter elements HP1 and TATA box are necessary and sufficient to generate a liver-specific promoter. Nucleic Acids Res. 17:939.
50. Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488.
51. Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456.
52. Andrews, N. C., and D. V. Valler. 1991. A rapid micropreparation technique for extraction of DNA binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:2499.
53. Cooper, C., A. Henderson, S. Artandi, N. Avitahl, and K. Calame. 1995. Ig/EBP (C/EBPγ) is a transdominant negative inhibitor of C/EBP family transcriptional activators. Nucleic Acids Res. 23:4371.
54. McClanahan, T., S. Dalrymple, M. Barkett, and F. Lee. 1993 Hematopoietic growth factor receptor genes as markers of lineage commitment during in vitro development of hematopoietic cells. Blood 81:2903.
55. Tenen, D. G., R. Hromas, J. D. Licht, and D.-E. Zhang. 1997. Transcription factors, normal myeloid development, and leukemia. Blood 90:489.