The detection of somatic mutations of thyrotropin receptor gene in fine needle biopsy samples from thyroid nodules

Endocrine Regulations

Volumn 33, Issue 3, 1999, Pages 95-101

  Syrenicz, Anhelli ^a,b   Kurzawski, G ^a   Ciechanowicz, A ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

^b Dept Endocrinol Hypertension M ^*  (Poland)

Author keywords

Fine needle biopsy; Somatic mutations; Thyroid nodules; TSH receptor

Indexed keywords

ADENINE; CYTOSINE; DNA; PROLINE; THREONINE; THYROTROPIN; THYROTROPIN RECEPTOR;

ADULT; ARTICLE; BLOOD; FEMALE; GENETICS; GOITER; HETEROZYGOTE; HUMAN; ISOLATION AND PURIFICATION; MIDDLE AGED; MUTATION; NEEDLE BIOPSY; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; THYROID NODULE;

ADENINE; ADULT; BASE SEQUENCE; BIOPSY, NEEDLE; CYTOSINE; DNA; DNA MUTATIONAL ANALYSIS; FEMALE; GOITER; HETEROZYGOTE; HUMANS; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; PROLINE; RECEPTORS, THYROTROPIN; THREONINE; THYROID NODULE; THYROTROPIN;

EID: 0033183299     PISSN: 12100668     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. CELANI MF: Levothyroxine suppressive therapy in the medical management of nontoxic benign multinodular goiter. Exp Clin Endocrinol 101, 326-332, 1993
2. DERWAHL M: Molecular aspects of the pathogenesis of nodular goiters, thyroid nodules and adenomas. Exp Clin Endocrinol Diabetes 104, Suppl 4, 32-35, 1996
3. ESAPA CH, FOSTER S, JOHNSON S, JAMESON JL, KENDAL-TAYLOR P, HARRIS PHE: G protein and thyrotropin receptor mutations in thyroid neoplasia. J Clin Endocrinol Metab 82, 493-496, 1997
4. FUHRER D, HOLZAPFEL HP, WONEROW P, SCHERBAUM WA, PASCHKE R: Somatic mutations in the thyrotropin receptor gene and not in the Gsα protein gene in 31 toxic thyroid nodules. J Clin Endocrinol Metab 82, 3885-3891, 1997
5. GHARIB H, MAZZAFERRI EL: Thyroxine suppressive therapy in patients with nodular thyroid disease. Ann Int Med 128, 386-394, 1998
6. HOLZAPFEL HP, FUHRER D, WONEROW P, WEINLAND G, SCHERBAUM WA, PASCHKE R: Identification of constitutively activating somatic thyrotropin receptor mutations in a subset of toxic multinodular goiters. J Clin Endocrinol Metab 82, 4229-4233, 1997
7. KOPP P, KIMURA ET, AESCHIMANN S, OESTREICHER M, TOBLER A, FEY MF, STUDER H: Polyclonal and monoclonal thyroid nodules coexist with human multinodular goiters. J Clin Endocrinol Metab 79, 134-139, 1994
8. MATSUO K, FRIEDMAN E, GEJMAN PV, FAGIN JA: The thyrotropin receptor (TSH-R) is not an oncogene for thyroid tumors: structural studies of the TSH-R and the α-subunit of Gs in human thyroid neoplasms. J Clin Endocrinol Metab 76, 1446-1451, 1993
9. MAZZAFERRI EL, SANTOS ET, ROFAGHA-KEYHANI S: Solitary thyroid nodule. Med Clin North Am 72, 1177-1211, 1988
10. MAZZAFERRI EL: Management of a solitary thyroid nodule. N Engl J Med 328, 553-559, 1993
11. MORITA T, TAMAI H, OHSHIMA A, KOMAKI G, MATSUBAYASHI S, KUMA K, NAKAGAWA T: Changes in serum thyroid hormone, thyrotropin and thyroglobulin concentrations during thyroxine therapy in patients with solitary thyroid nodules. J Clin Endocrinol Metab 69, 227-230, 1989
12. NAGAYAMA Y, KAUFMAN KD, SETO P, RAPPAPORT B: Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. Biochem Biophys Res Commun 165, 1184-1190, 1989
13. PARMA J, DUPREZ L, VAN SANDE J, COCHAUX P, GERVY CH, MOCKEL J, DUMONT J, VASSART G: Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature 365, 649-651, 1993
14. 2+ cascades. Mol Endocrinol 9, 725-733, 1995
15. PARMA J, DUPREZ L, VAN SANDE J, HERMANS J, ROCMANS P, VAN VLIET G, COSTAGLIOLA S, RODIEN P, DUMONT JE, VASSART G: Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gsα genes as a cause of toxic thyroid adenom1 as. J Clin Endocrinol Metab 82, 2695-2701, 1997
16. PINDUCCIU C, BORGONOVO G, AREZZO A, TORRE GC, GIORDANO G, CORDERA R: Toxic thyroid adenoma: absence of DNA mutations of the TSH receptor and Gsα. Eur J Endocrinol 138, 37-40, 1998
17. PORCELLINI A, CIULLO I, LAVIOLA L, AMABILE G, FENZI G, AVVEDIMENTO VE: Novel mutations of thyrotropin receptor gene in thyroid hyperfunctioning adenomas. J Clin Endocrinol Metab 79, 657-661, 1994
18. PORCELLINI A, CIULLO I, PANNAIN S, FENZI G, AVVEDIMENTO E: Somatic mutations in the VI transmembrane segment of the thyrotropin receptor constitutively activate cAMP signaling in thyroid hyperfunctioning adenomas. Oncogene 11, 1089-1093, 1995
19. PORCELLINI A, FENZI G, AVVEDIMENTO EV: Mutations of thyrotropin receptor gene. J Mol Med 75, 567-575, 1997
20. RUSSO D, ARTURI F, WICKER R, CHAZENBALK GD, SCHLUMBERGER M, VILLARD JAD, CAILLOU B, MONIER R, RAPOPORT B, FILETTI S, SUAREZ HG: Genetic alterations in thyroid hyperfunctioning adenomas. J Clin Endocrinol Metab 80, 1347-1351, 1995
21. SAMBROOK J, FRITSCH EF, MANIATIS T: Molecular cloning: a laboratory manual. 9.16-9.19 , Cold Spring Harbor Laboratory Press, New York 1989
22. STUDER H, PETER HJ, GERBER H: Natural heterogeneity of thyroid cells: the basis for understanding thyroid function and nodular goiter growth. Endocrine Rev 10, 125-135, 1995
23. TAKESHITA A, NAGAYAMA Y, YOKOYAMA N, ISHIKAWA N, ITO K, YAMASHITA T, OBARA T, MURAKAMI Y, KUMA K, TAKAMATSU J, OHSAWA N, NAGATAKI S: Rarity of oncogenic mutations in the thyrotropin receptor of autonomously functioning thyroid nodules in Japan. J Clin Endocrinol Metab 80, 2607-2611, 1995
24. TAN GH, GHARIB H: Thyroid incidentalomas: management approaches to nonpalpable nodules discovered incidentally on thyroid imaging. Ann Int Med 126, 226-231, 1997
25. TONACCHERA M, CHIOVATO L, PINCHERA A, AGRETTI P, FIORE E, CETANI F, ROCCHI R, VIACAVA P, MICCOLI P, VITTI P: Hyperfunctioning thyroid nodules in toxic multinodular goiter share activating thyrotropin receptor mutations with solitary toxic adenoma. J Clin Endocrinol Metab 83, 492-498, 1998
26. VASSART G, DUMONT JE: The thyrotropin receptor and the regulation of thyrocyte function and growth. Endocrine Rev 13, 596-611, 1992