Integrin α6Aβ1 induces CD81-dependent cell motility without engaging the extracellular matrix migration substrate

Molecular Biology of the Cell

Volumn 8, Issue 11, 1997, Pages 2253-2265

  Domanico, Susan Z ^a   Pelletier, Anthony J ^a   Havran, Wendy L ^a   Quaranta, Vito ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Mail Drop SBR12 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CELL SURFACE PROTEIN; DNA; FIBRONECTIN; INTEGRIN; KALININ; LAMININ RECEPTOR; MONENSIN; TETRASPANIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; CROSS LINKING; EMBRYO; EXTRACELLULAR MATRIX; GENE TRANSFER; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALIA; MURINAE;

EID: 0030730986     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.8.11.2253     Document Type: Article

References (47)

1. Abe, T., Ohno, M., Sato, T., Murakami, M., Kajiki, M., and Kodaira, R. (1991). "Differentiation induction" culture of human leukemic myeloid cells stimulates high production of macrophage differentiation inducing factor. [Review]. Cytotechnology 5(suppl 2), S75-S93.
2. Berditchevski, F., Zutter, M.M., and Hemler, M.E. (1996). Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins). Mol. Biol. Cell 7, 193-207.
3. Boismenu, R., Rhein, M., Fischer, W.H., and Havran, W.L. (1996). A role for CD81 in early T cell development. Science 271, 198-200.
4. Calof, A.L., and Lander, A.D. (1991). Relationship between neuronal migration and cell-substratum adhesion: laminin and merosin promote olfactory neuronal migration but are anti-adhesive. J. Cell Biol. 115, 779-794.
5. Chan, B.M, Kassner, P.D., Schiro, J.A., Byers, H.R., Kupper, T.S., and Hemler, M.E. (1992). Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains. Cell 68, 1051-1060.
6. Collo, G., Domanico, S., Klier, G., and Quaranta, V. (1995). Gradient of integrin a6A distribution in the myocardium during early heart development. Cell Adhes. Commun. 3, 101-113.
7. Cooper, H.M., Tamura, R.N., and Quaranta, V. (1991). The major laminin receptor of mouse embryonic stem cells is a novel isoform of the α6β1 integrin. J. Cell Biol. 115, 843-850.
8. Dong, J.T., Lamb, P.W., Rinker-Schaeffer, C.W., Vukanovic, J., Ichikawa, T., and Barrett, J.C. (1995). KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 268, 884-886.
9. Echtermeyer, F., Schober, S., Poschl, E., von der Mark, H., and von der Mark, K. (1996). Specific induction of cell motility on laminin by alpha 7 integrin. J. Biol. Chem. 271, 2071-2075.
10. Filardo, E.J., Brooks, P.C., Deming, S.L., Damsky, C., and Cheresh, D.A. (1995). Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. J. Cell Biol. 130, 441-450.
11. Guan, J.L., Trevithick, J.E., and Hynes, R.O. (1991). Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regul. 2, 951-964.
12. Hangan, D., Morris, V.L., Boeters, L., von Ballestrem, C., Uniyal, S., and Chan, B.M. (1997). An epitope on VLA-6 (α6β1) integrin required for migration but not adhesion is involved in extravasation of murine melanoma B16F1 cells in liver. Cancer Res. 57, 3812-3817.
13. Hemler, M.E., Mannion, B.A., and Berditchevski, F. (1996). Association of TM4SF proteins with integrins: relevance to cancer. [Review]. Biochim. Biophys. Acta 1287, 67-71.
14. Hogervorst, F., Kuikman, I., Noteboom, E., and Sonnenberg, A. (1993). The role of phosphorylation in activation of the alpha 6A beta 1 laminin receptor. J. Biol. Chem. 268, 18427-18430.
15. Horwitz, A., Duggan, K., Buck, C., Beckerle, M.C., and Burridge, K. (1986). Interaction of plasma membrane fibronectin receptor with talin - a transmembrane linkage. Nature 320, 531-533.
16. Huttenlocher, A., Ginsberg, M.H., and Horwitz, A.F. (1996). Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity. J. Cell Biol. 134, 1551-1562.
17. Huttenlocher, A., Sandborg, R.R., and Horwitz, A.F. (1995). Adhesion in cell migration. [Review]. Curr. Opin. Cell Biol. 7, 697-706.
18. Hynes, R.O. (1992). Integrins: versatility, modulation and signaling in cell adhesion. Cell 69, 11-25.
19. 4 cytoplasmic domain. Mol. Biol. Cell 6, 661-674.
20. Kieffer, J.D., Plopper, G., Ingber, D.E., Hartwig, J.H., and Kupper, T.S. (1995). Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro. Biochem. Biophys. Res. Commun. 217, 466-474.
21. Knezevic, I., Leisner, T.M., and Lam, S.C.T. (1996). Direct binding of the platelet integrin GPIIb-IIIa to talin. J. Biol. Chem. 271, 16416-16421.
22. Lauffenburger, D.A., and Horwitz, A.F. (1996). Cell migration: a physically integrated molecular process. [Review]. Cell 84, 359-369.
23. Lenter, M., Uhlig, H., Hamann, A., Jeno, P., Imhof, B., and Vestweber, D. (1993). A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1. Proc. Natl. Acad. Sci. USA 90, 9051-9055.
24. Lewis, J.M., and Schwartz, M.A. (1995). Mapping in vivo associations of cytoplasmic proteins with integrin beta 2 cytoplasmic domain mutants. Mol. Biol. Cell 6, 151-160.
25. Liebert, M., Wedemeyer, G., Stein, J.A., Washington, R.W., Jr., Van Waes, C., Carey, T.E., and Grossman, H.B. (1993). The monoclonal antibody BQ16 identifies the alpha 6 beta 4 integrin on bladder cancer. Hybridoma 12, 67-80.
26. Maecker, H.T., Todd, S.C., and Levy, S. (1997). The tetraspanin superfamily: molecular facilitators. FASEB J. 11, 428-442.
27. Mercurio, A.M. (1995). Laminin receptors: achieving specificity through cooperation. Trends Cell Biol. 5, 419-423.
28. O'Toole, T.E., Katagiri, Y., Faull, R.J., Peter, K., Tamura, R.N., Quaranta, V., Loftus, J.C, Shattil, S.J., and Ginsberg, M.H. (1994). Integrin cytoplasmic domains mediate inside-out signal transduction. J. Cell Biol. 124, 1047-1059.
29. Palecek, S.P., Loftus, J.C., Ginsberg, M.H., Lauffenburger, D.A., and Horwitz, A.F. (1997). Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature 385, 537-540.
30. Pelletier, A.J., Bodary, S.C., and Levinson, A.D. (1992). Signal transduction by the platelet integrin alpha lib beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells. Mol. Biol. Cell 3, 989-998.
31. vβ3 involves a discrete cation-binding site that regulates conformation. J. Biol. Chem. 271, 1364-1370.
32. Plopper, G., Falk-Marzillier, J., Glaser, S., Fitchmun, M., Giannelli, G., Romano, T., Jones, J.C.R., and Quaranta, V. (1996). Changes in expression of monoclonal antibody epitopes on laminin-5r induced by cell contact. J. Cell Sci. 109, 1965-1973.
33. Robertson, E.J. (1987). Embryo-derived stem cell lines. In: Terato-carcinomas and Embryonic Stem Cells, A Practical Approach, ed. E.J. Robertson, Oxford: IRL Press, 71-112.
34. Rubinstein, E., Le Naour, F., Lagaudriere-Gesbert, C., Billard, M., ConjeaudH., and Boucheix, C. (1996). CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins. Eur. J. Immunol. 26, 2657-2665.
35. Ruiz, P., Dunon, D., Sonnenberg, A., and Imhof, B.A. (1993). Suppression of mouse melanoma metastasis by EA-1, a monoclonal antibody specific for alpha6 integrins. Cell Adhes. Commun. 1, 67-81.
36. Savage, B., Saldivar, E., and Ruggeri, Z. (1996). Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. Cell 84, 676-682.
37. Schwartz, MA., Schaller, M.A., and Ginsberg, M.H. (1995). Integrins: emerging paradigms of signal transduction. Arum. Rev. Cell Dev. Biol. 11, 549-599.
38. Shaw, A.R., Domanska, A., Mak, A., Gilchrist, A., Dobler, K., Visser, L., Poppema, S., Fliegel, L., Letarte, M., and Willett, B.J. (1995a). Ectopic expression of human and feline CD9 in a human B cell line confers beta 1 integrin-dependent motility on fibronectin and laminin substrates and enhanced tyrosine phosphorylation. J. Biol. Chem. 270, 24092-24099.
39. Shaw, L.M., Lotz, M.M., and Mercurio, A.M. (1993). Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line. J. Biol. Chem. 268, 11401-11408.
40. Shaw, L.M., and Mercurio, A.M. (1993). Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit. J. Cell Biol. 123, 1017-1025.
41. Shaw, L.M., and Mercurio, A.M. (1994). Regulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages. Mol. Biol. Cell 5, 679-690.
42. Shaw, L.M., Turner, C.E., and Mercurio, A.M. (1995b). The alpha 6A beta 1 and alpha 6B beta 1 integrin variants signal differences in the tyrosine phosphorylation of paxillin and other proteins. J. Biol. Chem. 270, 23648-23652.
43. Takebe, Y., Seiki, M., Fujisawa, J., Hoy, P., Yokota, K., Arai, K., and Yoshida, M. (1988). SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat. Mol. Cell. Biol. 8, 466-472.
44. Tamura, R.N., Cooper, H.M., Collo, G., and Quaranta, V. (1991). Cell-type specific integrin variants with alternative a chain cytoplasmic domains. Proc. Natl. Acad. Sci. USA 88, 10183-10187.
45. Thorsteinsdottir, S., Roelen, B.A., Freund, E., Gaspar, A.C., and Sonnenberg, A. (1995). Expression patterns of laminin receptor splice variants alpha 6A beta 1 and alpha 6B beta 1 suggest different roles in mouse development. Dev. Dyn. 204, 240-258.
46. Wayner, E.A., Gil, S.G., Murphy, G.F., Wilke, M.S., and Carter, W.G. (1993). Epiligrin, a component of epithelial basement membranes, is an adhesive ligand for alpha 3 beta 1 positive T lymphocytes. J. Cell Biol. 121, 1141-1152.
47. Yao, C.-C, Ziober, B.L., Squillace, R.M., and Kramer, R.H. (1996). Alpha 7 integrin mediates cell adhesion and migration on specific Laminin isoforms. J. Biol. Chem. 271, 25598-25603.