Functional complementation of the malvolio mutation in the taste pathway of Drosophila melanogaster by the human natural resistance-associated macrophage protein 1 (Nramp-1)

Journal of Experimental Biology

Volumn 202, Issue 14, 1999, Pages 1909-1915

  D'Souza, Jasmine ^a   Cheah, Peh Yean ^b   Gros, P ^c   Chia, W ^b   Rodrigues, V ^a  

^a TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Drosophila melanogaster; Feeding preference assay; Malvolio; Natural resistance associated macrophage protein; Nramp 1; Taste behaviour

Indexed keywords

CARRIER PROTEIN; DROSOPHILA PROTEIN; MALVOLIO PROTEIN, DROSOPHILA; MEMBRANE PROTEIN;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; DROSOPHILA MELANOGASTER; GENE EXPRESSION; GENE TRANSFER; GENETICS; HUMAN; ION TRANSPORT; MUTATION; PHYSIOLOGY; SEQUENCE HOMOLOGY; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BEHAVIOR, ANIMAL; CARRIER PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HUMANS; ION PUMPS; MEMBRANE PROTEINS; MUTATION; SEQUENCE HOMOLOGY;

EID: 0033166065     PISSN: 00220949     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Abel, L., Sanchez, F. O., Oberti, T. N. V, Hoa L. V., Lap, V. D., Skamene, E., Lagrange, P. H. and Schurr, E. (1998). Susceptibility to leprosy is linked to the human NRAMP1 gene. J. Infect. Dis. 177, 133-145.
2. Arora, K., Rodrigues, V., Shanbhag, S. and Siddiqi, O. (1987). A gene affecting the specificity of the chemosensory neurons of Drosophila. Nature 330, 62-63.
3. Ashburner, M. (1989). Drosophila: A Laboratory Manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
4. Balakrishnan, R. and Rodrigues, V. (1991). The shaker and shaking-B genes specify elements in the processing of gustatory information in Drosophila melanogaster. J. Exp. Biol. 157, 161-181.
5. Bellamy, R., Ruwende, C., Corrah, T., McAdam, K. P., Whittle, H. C. and Hill, A. V. (1998). Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. N. Engl. J. Med. 338, 640-644.
6. Cellier, M., Belouchi, A. and Gros, P. (1996). Resistance to intracellular infections: comparative genomic analysis of Nramp. Trends Genet. 12, 201-204.
7. Cellier, M., Prive, G., Belouchi, A., Kwan, T., Rodrigues, V., Chia, W. and Gros, P. (1995). Nramp defines a family of membrane proteins. Proc. Natl. Acad. Sci. USA 92, 10089-10093.
8. Engels, W. R. (1989). P elements in Drosophila melanogaster. In Mobile DNA (ed. D. E. Berg and M. Howe), pp. 437-484. Washington, DC: American Society for Microbiology.
9. Fleming, M. D., Romano, M. A., Su, M. A., Garrick, L. M. , Garrick, M. D. and Andrews, N. C. (1998). Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl. Acad. Sci. USA 95, 1148-1153.
10. Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. and Andrews, N. C. (1997). Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nature Genetics 16, 383-386.
11. Gros, P., Skamene, E. and Forget, A. (1981). Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J. Immunol. 127, 2417-2421.
12. Gruenheid, S., Cellier, M., Vidal, S. and Gros, P. (1995). Identification and characterisation of a second mouse Nramp gene. Genomics 25, 514-525.
13. Gruenheid, S., Pinner, E., Desjardins, M. and Gros, P. (1997). Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J. Exp. Med. 185, 717-730.
14. Inamdar, M., VijayRaghavan, K. and Rodrigues, V. (1993). The Drosophila homolog of the human transcription factor TEF-1, scalloped, is essential for normal taste behavior. J. Neurogenet. 9, 123-139.
15. Lindsley, D. L. and Zimm, G. G. (1992). The Genome of Drosophila melanogaster. San Diego, CA: Academic Press.
16. Murugasu-Oei, B., Balakrishnan, R., Yang, X., Chia, W. and Rodrigues, V. (1996). Mutations in masquerade, a novel serine-protease-like molecule, affect axonal guidance and taste behavior in Drosophila. Mech. Dev. 57, 91-101.
17. Orgad, S., Nelson, H., Segal, D. and Nelson, N. (1998). Metal ions suppress the abnormal taste behavior of the Drosophila mutant malvolio. J. Exp. Biol. 201, 115-120.
18. Pinner, E., Gruenheid, S., Raymond, M. and Gros, P. (1997). Functional complementation of the yeast divalent cation transporter family SMF by NRAMP2, a member of the mammalian natural resistance-associated macrophage protein family. J. Biol. Chem. 272, 28933-28938.
19. Robertson, H. M., Preston, C. R., Phillis, R. W., Johnson-Schlitz, D. M., Benz, W. K. and Engels, W. R. (1988). A stable genomic source of P element transposase in Drosophila melanogaster. Genetics 118, 461-470.
20. Rodrigues, V., Cheah, P. Y. K. and Chia, W. (1995). malvolio, the Drosophila homologue of mouse NRAMP-1(Bcg), is expressed in macrophages and in the nervous system and is required for normal taste behavior. EMBO J. 14, 3007-3020.
21. Rodrigues, V., Sathe, S., Pinto, L., Balakrishnan, R. and Siddiqi, O. (1991). Closely linked leisons in a region of the chromosome affect central and peripheral steps in gustatory processing in Drosophila. Mol. Gen. Genet. 226, 265-276.
22. Sambrook, J., Frisch, E. F. and Maniatis, T. (1989). Molecular Cloning: A Laboratory Manual. New York: Cold Spring Harbor Press.
23. 3H]MK-801 binding by ferrous (II) but not ferric (III) ions in a manner different from that by sodium nitroprusside (II) in rat brain synaptic membranes. J. Neurochem. 69, 744-752.
24. Siddiqi, O., Joshi, S., Arora, K. and Rodrigues, V. (1989). Genetic investigation of salt reception in Drosophila. Genome 31, 646-651.
25. Supek, F., Supekova, L., Nelson, H. and Nelson, N. (1996). A yeast manganese transporter related to the macrophage protein involved in conferring resistance to Mycobacterium. Proc. Natl. Acad. Sci. USA 93, 5105-5110.
26. Supek, F., Supekova, L., Nelson, H. and Nelson, N. (1997). Function of metal-ion homeostasis in the cell division cycle, mitochondrial protein processing, sensitivity to mycobacterial infection and brain function. J. Exp. Biol. 200, 321-330.
27. Tanimura, T., Isono, K., Takamura, T. and Shimada, I. (1982). Genetic dimorphism in taste sensitivity to trehalose in Drosophila melanogaster. J. Comp. Physiol. A 147, 265-269.
28. Vidal, S. M., Malo, D., Vogan, K., Skamene, E. and Gros, P. (1993). Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg. Cell 73, 469-485.
29. VijayRaghavan, K., Kaur, J. and Rodrigues, V. (1992). The east gene of Drosophila is expressed in the developing nervous system and is required for normal olfactory and gustatory responses of the adult. Dev. Biol. 154, 23-36.
30. Vulpe, C. and Gitschier, J. (1997). Ironing out anaemia. Nature Genetics 16, 319-320.