Effects of recombinant equine somatotropin on wound healing, carbohydrate and lipid metabolism, and endogenous somatotropin responses to secretagogues in geldings

Journal of Animal Science

Volumn 77, Issue 7, 1999, Pages 1815-1822

  Smith, Lori A ^a,b   Thompson Jr , Donald L ^a   French, Dennis D ^a   Leise, Britta S ^a  

^a LOUISIANA STATE UNIVERSITY AGRICULTURAL CENTER   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

Healing; Horses; Insulin like growth factor; Metabolites; Somatotropin

Indexed keywords

EQUIDAE; EQUUS CABALLUS;

ADRENALIN; ASPARTIC ACID; DIAGNOSTIC AGENT; FATTY ACID; GROWTH HORMONE;

ANIMAL; ARTICLE; BLOOD; BODY WEIGHT; CARBOHYDRATE METABOLISM; CASTRATION; DRUG EFFECT; GLUCOSE TOLERANCE TEST; HORSE; LIPID METABOLISM; MALE; METABOLISM; WOUND HEALING;

ANIMALS; ASPARTIC ACID; BODY WEIGHT; CARBOHYDRATE METABOLISM; CASTRATION; EPINEPHRINE; FATTY ACIDS, NONESTERIFIED; GLUCOSE TOLERANCE TEST; GROWTH HORMONE; HORSES; LIPID METABOLISM; MALE; WOUND HEALING;

EID: 0033162830     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/1999.7771815x     Document Type: Article

References (30)

1. Buonomo, F. C., D. S. Ruffin, J. P. Brendemeuhl, J. J. Veenhuizen, and J. L. Sartin. 1996. The effects of bovine somatotropin (bST) and porcine somatotropin (pST) on growth factor and metabolic variables in horses. J. Anim. Sci. 74:886-894.
2. Christensen, H., and H. Oxlund. 1994. Growth hormone increases the collagen deposition rate and breaking strength of left colonic anastomoses in rats. Surgery 116:550-556.
3. Christensen, R. A., K. Malinowski, S. L. Ralston, C. G. Scanes, and H. D. Hafs. 1996a. Chronic effects of equine growth hormone (eGH) on postprandial changes in plasma glucose, nonesterified fatty acids and urea nitrogen in aged mares. J. Anim. Sci. 74(Suppl. 1):296 (Abstr.).
4. Christensen, R. A., K. Malinowski, S. L. Ralston, C. G. Scanes, and H. D. Hafs. 1996b. Chronic effects of equine growth hormone (eGH) on postprandial changes in plasma insulin, insulin-like growth factor-I, and thyroid hormones in aged mares. J. Anim. Sci. 74(Suppl. 1):296 (Abstr.).
5. Colborn, D. R., D. L. Thompson, Jr., T. L. Roth, J. S. Capehart, and K. L. White. 1991. Responses of cortisol and prolactin to sexual excitement and stress in stallions and geldings. J. Anim. Sci. 69:2556-2562.
6. DePew, C. L., D. L. Thompson, Jr., J. M. Fernandez, L. S. Sticker, and D. W. Burleigh. 1994. Changes in concentrations of hormones, metabolites, and amino acids in plasma of adult horses relative to overnight feed deprivation followed by a pelleted-hay meal fed at noon. J. Anim. Sci. 72:1530-1539.
7. Fretz, P. B., and Z. Li. 1992. Low energy laser irradiation treatment for second intention wound healing in horses. Can. Vet. J. 33: 650-652.
8. Garrel, D. R., P. Gaudreau, L. Zhang, I. Reeves, and P. Brazeau. 1991. Chronic administration of growth hormone-releasing factor increases wound strength and collagen maturation in granulation tissue. J. Surg. Res. 51:297-302.
9. Gilpin, D. A., R. E. Barrow, R. L. Rutan, L. Broemeling, and D. N. Herndon. 1994. Recombinant human growth hormone accelerates wound healing in children with large cutaneous burns. Ann. Surg. 220:19-24.
10. Guyton, A. C. 1996. Textbook of Medical Physiology (9th Ed.). W. B. Saunders, Philadelphia, PA.
11. Harvey, S. 1995a. Growth hormone release: Inhibitory hypothalamic control. In: S. Harvey, C. G. Scanes, and W. H. Daughaday (Ed.) Growth Hormone, pp 115-130. CRC Press, Boca Raton, FL.
12. Harvey, S. 1995b. Growth hormone release: Integrative hypothalamic control. In: S. Harvey, C. G. Scanes, and W. H. Daughaday (Ed.) Growth Hormone, pp 131-162. CRC Press, Boca Raton, FL.
13. Jorgensen, P. H., C. Bang, T. T. Andreassen, A. Flyvbjerg, and H. Orkov. 1995. Dose-response study of the effect of growth hormone on mechanical properties of skin graft wounds. J. Surg. Res. 58:295-301.
14. Julen Day, T. R., G. D. Potter, E. L. Morris, L. W. Greene, and J. B. Simmons. 1998. Physiologic and skeletal response to exogenous equine somatotropin (eST) in two-year-old Quarter Horses in race training. J. Equine Vet. Sci. 18:321-328.
15. Knox, J., R. Demling, D. Wilmore, P. Sarraf, and A. Santos. 1995. Increased survival after major thermal injury: The effect of growth hormone therapy in adults. J. Trauma 39:526-532.
16. Lindsay, W. A. 1988. Wound healing in horses: Guidelines for classification. Vet. Med. 83:387-395.
17. Malinowski, K., R. A. Christensen, A. Konopka, C. G. Scanes, and H. D. Hafs. 1997. Feed intake, body weight, body condition score, musculation, and immunocompetence in aged mares given equine somatotropin. J. Anim. Sci. 75:755-760.
18. Nadal, M. R., D. L. Thompson, Jr., and L. A. Kincaid. 1997. Effect of feeding and feed deprivation on plasma concentrations of prolactin, insulin, growth hormone, and metabolites in horses. J. Anim. Sci. 75:736-744.
19. Nakamoto, J. M., J. M. Gertner, C. M. Press, R. L. Hintz, R. G. Rosenfeld, and M. Genel. 1986. Suppression of the growth hormone (GH) response to clonidine and GH-releasing hormone by exogenous GH. J. Clin. Endocrinol. Metab. 62: 822-826.
20. Nuytinch, H., J. Xavner, and W. Affermans. 1988. Whole body inflammation in trauma patients. Arch. Surg. 123:1519-1524.
21. Ralston, S. L., R. A. Christensen, K. Malinowski, C. G. Scanes, and H. D. Hafs. 1996. Chronic effects of equine growth hormone (eGH) on intake, digestibility and retention of nutrients in aged mares. J. Anim. Sci. 74(Suppl. 1):194 (Abstr.).
22. SAS. 1996. SAS/STAT® User's Guide (Release 6.11). SAS Inst Inc Cary, NC.
23. Snowden, J. M. 1981. Wound contraction. A quantitative interpretation. Aust. J. Exp. Biol. Med. Sci. 59:203-205.
24. Steenfos, H. H., and J. O. Jansson. 1992. Growth hormone stimulates granulation tissue formation and insulin-like growth factor-I gene expression in wound chambers in the rat. J. Endocrinol. 132:293-298.
25. Sticker, L. S., D. L. Thompson, Jr., L. D. Bunting, J. M. Fernandez, C. L. DePew, and M. R. Nadal. 1995a. Feed deprivation of mares: Plasma metabolite and hormonal concentrations and responses to exercise. J. Anim. Sci. 73:3696-3704.
26. Sticker, L. S., D. L. Thompson, Jr., J. M. Fernandez, L. D. Bunting, and C. L. DePew. 1995b. Dietary protein and(or) energy restriction in mares: Plasma growth hormone, IGF-I, prolactin, cortisol, and thyroid hormone responses to feeding, glucose, and epinephrine. J. Anim. Sci. 73:1424-1432.
27. Thompson, D. L., Jr., C. L. DePew, A. Ortiz, L. S. Sticker, and M. S. Rahmanian. 1994. Growth hormone and prolactin concentrations in plasma of horses: Sex differences and the effects of acute exercise and administration of growth hormone-releasing hormone. J. Anim. Sci. 72:2911-2918.
28. Thompson, D. L., Jr., F. Garza, Jr., P. S. Mitchell, and R. L. St. George. 1988. Effects of short-term stress, xylazine tranquilization and anesthetization with xylazine plus ketamine on plasma concentrations of cortisol, luteinizing hormone, follicle stimulating hormone and prolactin in ovariectomized pony mares. Theriogenology 30:937-946.
29. Thompson, D. L., Jr., R. Hoffman, and C. L. DePew. 1997. Prolactin administration to seasonally anestrous mares: Reproductive, metabolic, and hair-shedding responses. J. Anim. Sci. 75: 1092-1099.
30. Thompson, D. L., Jr., M. S. Rahmanian, C. L. DePew, D. W. Burleigh, C. J. DeSouza, and D. R. Colborn. 1992. Growth hormone in mares and stallions: Pulsatile secretion, response to growth hormone-releasing hormone, and effects of exercise, sexual stimulation, and pharmacological agents. J. Anim. Sci. 70:1201-1207.