Physiologic and skeletal response to exogenous equine somatotropin (eST) in two-year-old quarter horses in race training

Journal of Equine Veterinary Science

Volumn 18, Issue 5, 1998, Pages 321-328

  Julen Day, T R ^a   Potter, G D ^b   Morris, E L ^b   Greene, L W ^b   Simmons, J B ^b  

^a UTAH STATE UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0032358182     PISSN: 07370806     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0737-0806(98)80545-5     Document Type: Article

References (31)

1. Nielsen BD, Potter GD, Greene LW, Morris EL, Murray-Gerzik M, Smith WB, Martin MT; Does the onset of training alter mineral requirements in the young racing Quarter Horse? Proc Fourteenth Equine Nutr Physiol Symp 1995;70-75.
2. Jones WE: Racetrack breakdown epidemiology. Equine Vet Data 1989;10:190-191.
3. Jonhansson AG, Lindh E, Ljunghail S: IGFs: function and clinical importance of growth hormone, insulin-like growth factor I, and bone: a clinical review. J Int Med 1993;234:553-560.
4. Chalupa W Galligan DT: Nutritional implications of somatotropin for lactating cows. J Dairy Sci 1989;72:2510-2524.
5. Schwarz FJ, Schams D, Ropke R, Kirchgessner M, Kogel J, Matzke P: Effects of somatotropin treatment on growth performance, carcass traits, and the endocrine system in finishing beef heifers. J Anim Sci 1993;71:2721-2731.
6. Weeden TL, Nelssen JL, Goodband RD, Hansen JA, Fitzner GE, Friesen KG, Laurin JL: Effects of porcine somatotropin and dietary phosphorus on growth performance and bone properties of gilts. J Anim Sci 1993;71:2674-2682.
7. Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlanker RA, Cohn L, Rudman IW, Mattson DE: Effects of human growth hormone in men over 60 years old. N Eng J Med 1990;323:1-6.
8. O'Halloran DJ, Tastasoulis A, Whitehouse RW, Holmes SJ, Adams JE, Shalet SM: Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency. J Clin Endocrinol Metab 1993;76:1344-1348.
9. Ortoft G, Oxlund H, Jorgensen PH, Andreassen TT: Glucocorticoid treatment or food deprivation counteracts the stimulating effects of growth hormone on rat cortical bone strength. Acta Paediatrica 1992;81:912-917.
10. Thompson DL Jr, Rahmanian MS, DePew CL, Burleigh DW, DeSouza CJ, Colborn DR: Growth hormone in mares and stallions: Pulsatile secretion, response to growth hormone-releasing hormone, and effects of exercise, sexual stimulation, and pharmacological agents. J Anim Sci 1992;10:1201-1207.
11. Thompson DL Jr, DePew CL, Ortiz A, Sticker LS, Rahmanian MS: Growth hormone and prolactin concentrations in plasma of horses: sex differences and the effects of acute exercise and administration of growth hormone-releasing hormone. J Anim Sci 1994;72:2911-2918.
12. Stewart R, Goode JA, Allen WR: Growth hormone secretion in the horse: Unusual pattern at birth and pulsatile secretion through to maturity. J Endocrinol 1993;138:81-89.
13. DePew CL, Thompson Jr. DL, Fernandez JM, Sticker LS, Burleigh DW: Changes in concentrations of hormones, metabolites, and amino acid in plasma of adult horses relative to overnight feed deprivation followed by a pellet-hay meal fed at noon. J Anim Sci 1994;72:1530-1539.
14. Buonomo FC, Ruffin DS, Brendemeuhl JP, Veenhuizen JJ, Sartin JL: The effects of bovine somatotropin (bST) and porcine somatotropin (pST) on growth factor and metabolic variables in horses. J Anim Sci 1996;74:886-894.
15. National Research Council. Nutrient Requirements of Horses. 5th ed., Washington D.C: National Academy Press, 1989.
16. Henneke DR, Potter GD, Krieder JL, Yeates BF: Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet J 1983;15:371-372.
17. Fiske CH, Subbarow Y: The colorimetric determination of phosphorus. J Biol Chem 1925;66:375-400.
18. Hope E, Johnston SD, Hegstad RL, Geor RJ, Murphy MJ: Effects of sample collection and handling on concentration of osteocalcin in equine serum. Am J Vet Res 1993;54:1017-1020.
19. Sticker LS, Thompson DL Jr, Fernandes JM, Bunting LD, DePew CL: Dietary protein and(or) energy restriction in mares: Plasma growth hormone IGF-I, prolactin, cortisol, and thyroid hormone responses to feeding, glucose, and epinephrine. J Anim Sci 1995;73:1424-1432.
20. Meakim DW, Ott EA, Asquith RL, Feaster JP: Estimation of mineral content of the equine third metacarpal by radiographic photometry. J Anim Sci 1981;53:1019-1026.
21. Nielsen BD, Potter GD: Accounting for volumetric differences in estimates of bone mineral content from radiographic densitometry. Proc Fifteenth Equine Nutr Physiol Symp 1997;367-369.
22. SAS. SAS User's Guide: Statistics, Cary, North Carolina: SAS Inst., Inc. 1988.
23. Nielsen BD, Potter GD, Morris EL, Odom TW, Senor DM, Reynold JA, Smith WB, Martin MT: Modifications of the third metacarpal bone in young racing Quarter horses as a result of training, Proc Fourteenth Equine Nutr Physiol Symp 1995;102-107.
24. Cohick WS, Plaut K, Sechen SJ, Bauman DE: Temporal pattern of insulin-like growth factor-I response to exogenous bovine somatotropin in lactating cows. Domest Anim Endocrinol 1989;6:263-273.
25. Fronk TJ, Peel CJ, Bauman DE, Gorewit RC: Comparison of different patterns of exogenous growth hormone administration on milk production in holstein cows. J Anim Sci 1983;57:699-705.
26. Chung CS, Etherton TD, Wiggins JP: Stimulation of swine growth by porcine growth hormone. J Anim Sci 1985;60:118-130.
27. Rosemberg E, Thonney ML, Butler WR: The effects of bovine growth hormone and thyroxine on growth rate and carcass measurements in lambs. J Anim Sci 1989;67:3300-3312.
28. Julen Day TR: Physiological effects of exogenous equine somatotropin (eST) on young horses during the onset of training, PhD Dissertation. Texas A&M Univ., College Station, 1997.
29. Nielsen BD: Mineral balance and physiological responses associated with the bone modeling/remodeling process in young racehorses at the onset of training. PhD Dissertation. Texas A&M Univ., College Station, 1996.
30. Duncan JR, Prasse KW: Veterinary Laboratory Medicine. Ames, IA: Iowa State University Press.
31. Nielsen BD, Potter GD, Morris EL, Odom TW, Senor DM, Reynolds JA, Smith WB, Martin MT: Changes in the third metacarpal bone and frequency of bone injuries in young quarter horses during race training - observations and theoretical considerations. J Equine Vet Sci 1997;17:541-549.